CD206 (6A598) Antibody from Santa Cruz Biotechnology, Inc.

Yes, the CD206 antibody has been utilized in studies examining macrophage polarization, particularly in the context of inflammatory diseases. For instance, it was used in a study investigating the effects of secretome derived from periodontal ligament stem cells on macrophage polarization, where it helped identify the transition from M1 to M2 macrophages (su2023).

The CD206 antibody is reactive with multiple species, including humans, mice, and rats. This broad reactivity allows for its application in various experimental models involving macrophage studies across these species.

The CD206 antibody has been successfully employed in Western blotting to detect the expression of CD206 in macrophages. In one study, it was used at a dilution of 1:200 to analyze macrophage markers in renal tissues and RAW264.7 cells under different experimental conditions (zhao2024).

The CD206 antibody is significant in research on diabetic kidney disease as it helps in identifying macrophage phenotypes. Studies have shown that high glucose conditions promote macrophage switching to the M1 phenotype, and the CD206 antibody can be used to assess the expression of M2 markers, providing insights into the inflammatory processes involved in this condition (zhao2024).