Fig 1: Relative mRNA expression changes of melanoma PDTX tissue upon vemurafenib treatment. All panels show relative expressions, normalized to control RPLP0. All measurements were analyzed in a common study to ensure the common threshold values for cT determination. Genes systematically upregulated (GPR39, CD27, SLC15A3, PDGFA, ABCB1) or downregulated (IFI27) after vemurafenib treatment. *: p < 0.05; **: p < 0.01.
Fig 2: Protein expression patterns upon vemurafenib treatment in melanoma. (A) Quantitative analysis of positive and negative cells from whole-section scanned images. N = 3 tumors in each groups. (B) Representative immunohistochemical staining pictures of P-gp, GPR39, F4/80, and GNRHR proteins. Black arrows indicate F4/80-positive macrophages. Scale bars: 50 µm. (C) Western blot images showing protein level changes of CD27 and IFI27. Three control and three treated animal samples were measured.
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