PI3 Kinase p110beta (C33D4) Rabbit mAb 3011S from Cell Signaling Technology

Product Specs
ItemPI3 Kinase p110beta (C33D4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number3011S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH
TargetPI3K p110 beta
HostRabbit
NCBI Gene AliasesP110BETA, PI3K, PI3KBETA, PIK3C1
ClonalityMonoclonal
NCBI Full Gene Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Research AreaPI3K / Akt Signaling
IsotypeIgG
CloneC33D4
Molecular Weight110

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive TumorigenesisCancer DiscoveryMarch 2, 2026Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang, Weihua Wang, Renlei Ji, Wendi Huang, Jiachen Wu, Yutong Li, Xiaochun Wan, et al.(Cell Signaling Technology, cat. #4249, RRID: AB_2165248), PI3Kβ (Cell Signaling Technology, cat. #3011, RRID: AB_2165246), EPHA2 (Cell Signaling Technology, cat. #6997, RRID: AB_10827743), p-EPHA2Tyr588

(2) FAM64A Potentiates Bladder Carcinoma Tumorigenesis and Metastasis Through PI3K/mTORC2/AKT Pathway ActivationCancers (Basel)February 6, 2026Tao Zhu, Cen Liufu, Cong Yin, Jinqing He, Junhua Luo, Bentao Shi, Yan WangKi-67 (Proteintech 241499E7, 1:10,000), AKT (CST 11E7, 1:1000), mTOR (CST 2983, 1:1000), PI3K (CST 3011, 1:1000), phospho-PI3K (MCE HY-P81211, 1:1000), phospho-AKT-Ser473 (CST 4060, 1:1000), phospho-AKT-Thr308

(3) Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndromeCell ReportsJanuary 27, 2026Sneha Shah, Daniel Barnes, Botao Liu, Tenzin Tseyang, Thang Do, Jodi L. Bubenik, Suna Jung, Mina N. Anadolu, Maria P. Ivshina, Verónica Martínez-Cerdeño, et al.,Cell Signaling Technology,Cat#4166; RRID: AB_1903991 Rabbit monoclonal anti-PI3 Kinase p110β (C33D4),Cell Signaling Technology,Cat#3011; RRID: AB_2165246 Rabbit monoclonal anti-Phospho-S6 (Ser240/244) (D68F8),Cell Signaling Technology,Cat#5364;

(4) SH3 domains selectively activate the PI3 kinase through non-conventional tertiary contactsCommunications BiologyJanuary 19, 2026Safia S. Aljedani, Anandsukeerthi Sandholu, Abdullah Aldehaiman, Siba Alharbi, Victor C. Y. Mak, Haiyan Wu, Panpan Wang, Afaque A. Momin, Upendra Singh, Adrien Lugari, et al.anti-p110α antibody (Cell Signaling Technology (CST), Beverly, MA; #4249; 1:1000), anti-p110β antibody (CST#3011; 1:1000), anti-p110δ antibody (CST#34050; 1:1000), anti-p110γ antibody (CST#5405; 1:1000), anti-p85α

(5) Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethalityCellular and Molecular Life SciencesNovember 19, 2025Sarah E. Conduit, Cindy X. W. Zhang, Wayne Pearce, Julie Guillermet-Guibert, Amanda N. Sferruzzi-Perri, Bart VanhaesebroeckIB 1:1,000), pAKT(T308) (4056, IB 1:500), AKT (9272, IB 1:1,000), p110α (4249, IB 1:1,000), p110β (3011, IB 1:1,000), pS6RP(S240/244) (2215, IB 1:1,000) and S6RP (2317, IB 1:1,000) were from Cell Signaling Technology

(6) Adenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling in human endothelial cellsJournal of Biological ChemistryNovember 13, 2025Fuqiang Geng, Mariko Kobayashi, Yang Lin, Jesus Maria Gomez-Salinero, Dominick Romano, Jean Kanyo, Jennifer Geng, Ying Liu, Michael Ginsberg, Jae-Hung Shieh, et al.ab1791, rabbit, 1:5000); VE-Cadherin (R&D AF938, goat); PI3K p110 (Cell Signaling 4249, p110α, 1:2000; 3011, p110β, 1:2000; both rabbit); p85α (Abcam ab191606, rabbit), p85β (Abcam ab180967, rabbit); p55γ (Proteintech

(7) Neutrophil extracellular trap-borne C3-driven endothelial dysfunction in Klebsiella pneumoniae liver abscessVirulenceOctober 28, 2025Hongguang Wang, Lulu Chen, Chuanzhuo Wang, Zhihui ChangUSA), anti-PI3 Kinase p110γ (Cat: 5405, Cell Signaling Technology, USA), anti-PI3 Kinase p110β (Cat: 3011, Cell Signaling Technology, USA), anti-PI3 Kinase p85 (Cat: 4257, Cell Signaling Technology, USA), anti-phospho-AKT

(8) Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistancebioRxivSeptember 25, 2025Yubao Wang, Cherubin Manokaran, Jiajia Chen, Hao Gu, David Liu, Philippe Bousso, Jean J Zhao, Thomas M Roberts,Cell Signaling Technology,4858 S6,5G10,Cell Signaling Technology,2217 PI3 Kinase p110β,C33D4,Cell Signaling Technology,3011 β-tubulin,Tu27/Tubulin,BioLegend,903401 p-STAT1 (Y701),A17012A,BioLegend,666401 p-STAT1 (S727),A15158B,BioLegend,686401 STAT1,1/STAT1,BD Biosciences

(9) Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expressionFrontiers in Bioengineering and BiotechnologyAugust 20, 2025Yuanxi Mo, An Jin, Wanzi Hong, Jiahui Peng, Rui Yang, Qiqi Song, Yaoxin Liu, Yuqi Cheng, Wing-Tak Wong, Qian Huang, et al.anti-PI3K(1:1,000, Cell Signaling Technology, 4292), anti-p-PI3K(1: 1,000, Cell Signaling Technology, 3011S), anti-beta-actin (1:2,000, Proteintech, 66009-1-Ig), followed by anti-mouse (1:400, Cell Signaling Technology

(10) Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrierCell ReportsJune 24, 2025Quinn Lee, Wan Ching Chan, Shuangping Zhao, Harry M. Hailemeskel, Riya Thomas, Mohsin Zafar, Fozia Mir, Peter T. Toth, Kamran Avanaki, Leon M. Tai, et al.Akt (#9272, Cell Signaling Technology), PI3K p110α (#4249, Cell Signaling Technology), PI3K p110β (#3011, Cell Signaling Technology), PI3K p110δ (#34050, Cell Signaling Technology), ZO-1 (#33–9100, Invitrogen),

(11) PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitorsCell Death DisJune 18, 2025Xu Zhang, Jiao Xu, Xuan Wang, Lan Xu, Xi Zhang, Yi Wang, Shujuan Jiang, Yixiang Zhang, Jian Ding, Chen Qing, et al.phospho-Erk (Thr185/Tyr187; #4370), GAB1 (#93804), phospho-GAB1 (Tyr 659; #12745), PI3Kα (#4249), PI3Kβ (#3011), PTEN (#9559) (Cell Signaling Technology, Danvers, USA) and GAPDH (#G8795) (Sigma, St. Louis, USA).

(12) FHL2 Facilitates LUSC Growth and Therapy Resistance through PI3K/AKT/mTOR ActivationJournal of Biological ChemistryJune 6, 2025Lingxian Zhang, Dingguo Wang, Lei Zeng, Shiwei Chen, Kunchao Li, Tiankai Yuan, Jing Wang, Xiong Ma, Shuqiang Zhu, Yongbing WuInvitrogen), anti-p-P85 (1:1000, PA5-104853, Invitrogen), anti-P110α (1:1000, 4249S, CST), anti-P110β (1:1000, 3011S, CST), anti-PDK1 (1:1000, 18262-1-AP, Proteintech), anti-c-Jun (1:1000, 9165S, CST), anti-AKT (1:1000,

(13) Small-molecule RNA therapeutics to target prostate cancerCancer CellMay 12, 2025Duygu Kuzuoglu-Ozturk, Hao G. Nguyen, Lingru Xue, Emma Figueredo, Vishvak Subramanyam, Isabelle Liu, Kenya Bonitto, Ashish Noronha, Adrianna Dabrowska, Janet E. Cowan, et al.,Cell Signaling Technology,Cat# 55506; RRID: AB_2827374 Rabbit monoclonal anti-PI3 Kinase p110β,Cell Signaling Technology,Cat# 3011; RRID: AB_2165246 Rabbit polyclonal anti-DNAJA1,Thomas Scientific,Cat# 11713-1-AP RRID: AB_10637266 Rabbit

(14) Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cellsCell Mol Life SciFebruary 22, 2025Myoung Sup Shim, Ethan J. Sim, Kevin Betsch, Vaibhav Desikan, Chien-Chia Su, Diego Pastor-Valverde, Yang Sun, Paloma B. Liton(1:2000; Cell Signaling Technology, 4249S), anti-PIK3CB antibody (1:2000; Cell Signaling Technology, 3011S), anti-PIK3CD antibody (1:2000; Abcam, ab109006), anti-PIK3C2A (1:1000, Santa Cruz Biotechnology, SC-365290),

(15) The Role of Placental MFF-Mediated Mitochondrial Fission in Gestational Diabetes MellitusDiabetes Metab Syndr ObesFebruary 20, 2025Lijie Wei, Chenyun Fang, Yi Jiang, Huiting Zhang, Peng Gao, Xuan Zhou, Shenglan Zhu, Yuanyuan Du, Rui Su, Lili Guo, et al.Western blot to evaluate the expression of p110α(1:500, #4249, Cell Signaling Technology, USA), p110β(1:1000, #3011, Cell Signaling Technology, USA), p-p85(1:1000, #17366, Cell Signaling Technology, USA), p85(1:500,

(16) Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer developmentOncogeneFebruary 18, 2025Cancan Lyu, Prasanna Kuma Vaddi, Said Elshafae, Anirudh Pradeep, Deqin Ma, Songhai Chenphospho-ERK1/2T202/Y204 (# 4370), raptor (# 2280), rictor (# 2114), PI3K kinase p110 (# 4249) and p110 (# 3011), and PTEN (# 9559) were obtained from Cell Signaling Technology (Danvers, MA, USA); p53 (ab154036)

(17) The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitroNature communicationsFebruary 17, 2025Yang Q, Guo H, Li H, Li Z, Ni F, Wen Z, Liu K, Kong H, Wei W.anti-PI3K-p110α antibody (Cell Signaling Technology, 4249); anti-PI3K-p110β antibody (Cell Signaling Technology, 3011); anti-Akt antibody (Cell Signaling Technology, 4691); rCXCL8 (Abcam, ab259397); SX682 (MCE, HY-119339);

(18) A Novel Role for the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Delta Isoform in Hepatocellular ProliferationThe American Journal of PathologyFebruary 1, 2025Nicole J. Martucci, John Stoops, William Bowen, Anne Orr, Mary-Claire Cotner, George K. Michalopoulos, Bharat Bhushan, Wendy M. Marsnumber,Experimental use,Dilution p110α,Cell Signaling Technologies,4249,WB,1:1000 p110β,Cell Signaling Technologies,3011,WB,1:1000 p110δ,Cell Signaling Technologies,34050,WB,1:1000 p-Y458 p85,Cell Signaling Technologies,4228,WB,1:1000 p85,Cell Signaling Technologies

(19) Degradation‐Based Protein Profiling: A Case Study of CelastrolAdvanced ScienceJuly 1, 2024Zhihao Ni, Yi Shi, Qianlong Liu, Liguo Wang, Xiuyun Sun, Yu Raoincubated with 1:1000 anti‐IKKβ (Abcam, ab124957), anti‐PI3K p110α (CST, 4249S), anti‐PI3K p110β (CST, 3011S), anti‐PI3K p110γ (CST, 5405S), anti‐CHK1 (Abcam, ab32531), anti‐Flag (Abmart, M20008), anti‐NEK7 (Abcam,

(20) Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase betaiScienceJune 21, 2024Kevin J. Pridham, Kasen R. Hutchings, Patrick Beck, Min Liu, Eileen Xu, Erin Saechin, Vincent Bui, Chinkal Patel, Jamie Solis, Leah Huang, et al.RRID:AB_331163 Anti-p110α,Cell Signaling Technology,Cat#4249; RRID:AB_2165248 Anti-p110β,Cell Signaling Technology,Cat#3011; RRID:AB_2165246 Anti-β-actin,Millipore-Sigma,Cat#A3854; RRID:AB_262011 ,, "Chemicals, peptides,

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PI3 Kinase p110beta (C33D4) Rabbit mAb

PI3 Kinase p110beta (C33D4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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PI3 Kinase p110beta (C33D4) Rabbit mAb from Cell Signaling Technology

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