PI3 Kinase p110alpha (C73F8) Rabbit mAb 4249S from Cell Signaling Technology

Product Specs
ItemPI3 Kinase p110alpha (C73F8) Rabbit mAb
CompanyCell Signaling Technology
Price $399.00 Inquire
Catalog Number4249S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH, M, R, B
TargetPI3K p110 alpha
HostRabbit
NCBI Gene AliasesCCM4, CLAPO, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha
ClonalityMonoclonal
NCBI Full Gene Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Research AreaPI3K / Akt Signaling
CloneC73F8
Molecular Weight110

Questions and Answers

Can this antibody be used to study the role of PI3K p110α in cancer models?

Yes, the PI3 Kinase p110α (C73F8) Rabbit mAb has been utilized in various studies to investigate the PI3K/AKT signaling pathway in cancer. For instance, in a study on small cell lung cancer, the antibody was used to assess the expression levels of phosphorylated AKT, which is closely linked to the activity of the PI3K pathway and tumor sensitivity to inhibitors targeting this pathway ().

Is this antibody effective for detecting changes in p110α levels in osteoarthritis research?

The antibody has been shown to detect p110α protein levels in studies related to osteoarthritis. For example, in research examining the effects of quercitrin on osteoarthritis, immunohistochemical analysis utilized this antibody to observe p110α levels in articular cartilage, indicating its relevance in understanding the molecular mechanisms of osteoarthritis ().

What species can this antibody be used with for Western blotting?

The PI3 Kinase p110α antibody is reactive with multiple species, including human, mouse, rat, and bovine. This broad reactivity allows for its application in various experimental models across different species, making it versatile for comparative studies in cell biology and cancer research.

Are there any specific applications where this antibody has been cited in the literature?

Yes, the PI3 Kinase p110α antibody has been cited in numerous applications, including Western blotting and immunoprecipitation. It has been referenced in studies focusing on the PI3K/AKT signaling pathway, highlighting its role in cellular processes such as proliferation and apoptosis in various disease contexts, including cancer and metabolic disorders (, ).

Cell Signaling Technology

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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Ixazomib triggers autophagic degradation of MUC5AC/integrin-β4 and inhibits non-small cell lung cancer progressionCancer LettersMay 1, 2026Muthamil Iniyan Appadurai, Zahraa Wajih Alsafwani, Sanjib Chaudhary, Ashu Shah, Pranay Somavarapu, Sriman N. Dooshety, Ben S. Kubicek, Surinder K. Batra, Imayavaramban Lakshmanan, Apar Kishor Ganti(#9661), Bax (#2772), PARP (#9542), BCL2 (#3498), p21 (Cat. #2947), p27 (#3686), γH2AX (#80312), PI3K (#4249), UCHL1 (#33575), ubiquitin K-63 (#5621S) and RAD51 (#8875) were from Cell signaling Technology Inc.

(2) Multi-omics integration and Mendelian randomization reveal the mechanisms and experimental validation of curcumin targeting the RXRA-PI3K/AKT axis to enhance cisplatin sensitivity in gastric cancerFront OncolApril 15, 2026Xiaoran Sun, Na Wu, Xue Bai, Xiang Zhang, Rui Wang, Shuai Du, Li Liu, Duo Liincubated overnight at 4 °C with the following primary antibodies: PI3K (Cell Signaling Technology, CST, #4249; 1:1000); Phospho-PI3K (CST, #4228; 1:1000); AKT (CST, #9272; 1:1000); Phospho-AKT (Ser473) (CST, #4060;

(3) Exosomal-miR-32-5p directly targets FOXN2 to regulate the proliferation, migration and apoptosis of uterine corpus endometrial carcinoma via the PI3K/AKT/BCL-2 pathwayOncol LettApril 8, 2026Xin Chen, Huihui Li, Xiang Cheng, Yirong Cai, Guangyi GuoCell Signaling Technology), p-AKT (1:1,500; cat. no. #4060; Cell Signaling Technology), PI3K (1:1,500; cat. no. #4249; Cell Signaling Technology), Bcl-2 (1:1,500; cat. no. #3498; Cell Signaling Technology), FOXN2 (1:1,500;

(4) SphK1/S1P signaling-mediated crosstalk between pancreatic acinar cell and macrophage M1 polarization aggravates acute pancreatitis progressionInt J Biol SciMarch 25, 2026Jie Wang, Guangyu Zhao, Ping Hu, Shengbo Han, Yuhang Hu, Zhu Zeng, Yang Li, Yong Zhao, Yan Huang, Wenfeng Zhuo, et al.p65 (10745-1-AP, Proteintech), phospho-p65 (ab76302, abcam), S1PR2 (21180-1-AP, Proteintech), PI3K (4249, Cell Signaling TECHNOLOGY), phospho-PI3K (17366, Cell Signaling TECHNOLOGY), JNK (9252, Cell Signaling TECHNOLOGY

(5) Colistin-resistance among Acinetobacter baumannii and Pseudomonas aeruginosa from clinical specimens in Africa: a systematic review and meta-analysisJAC Antimicrob ResistMarch 17, 2026Yalewayker Gashaw, Assefa Sisay, Ermias Getachew, Zelalem Asmare, Alene Geteneh, Ephrem Tamrat, Wagaw Abebe, Getachew Bitew, Abebe Birhanu, Mitkie Tigabie, et al.al.,46",2022,S. Africa,2033,1525,1958,75 "Anane et al.,47",2020,S. Africa,100,100,100,0 Total isolates,,,4249,2443,3952,297 Description of the studies included to assess colistin resistance in A. baumannii isolates

(6) Procyanidin capsules attenuate PI3K/AKT-mediated mitochondrial dysfunction and accelerate skin wound healing in diabetic miceMater Today BioMarch 14, 2026Yifan Ping, Jiaying Wang, Shaoyin Wei, Wen Tong, Wanhang Li, Junxin Ren, Siyi Wang, Xinyi Yao, Liyang Zheng, Zelin Cao, et al.1:1000), p-PI3K (#AF3241, Affinity, China; 1:1000), total AKT (#2920, CST, USA; 1:1000), and PI3K (#4249, CST, USA; 1:1000). Horseradish peroxidase–conjugated secondary antibodies were applied (1.5 h, room

(7) Loss of PIK3CA Allows In Vitro Growth but Not In Vivo Progression of KRAS Mutant Lung Adenocarcinoma in a Syngeneic Orthotopic Implantation ModelCellsMarch 12, 2026Abigail L. Booth, Giuseppe Caso, Barbara Rosati, Ya-Ping Jiang, Wei-Xing Zong, Richard Z. Lin, Harold Bienwere cut into pieces that were probed with separate antibodies. Antibodies to AKT1 (#2938), PIK3CA (#4249), phospho-Ser473 AKT (#4060), AMPK (#2532), and phospho-Thr172 AMPK (#2531) were purchased from Cell Signaling Technology

(8) Dietary energy levels regulate feed intake of broilers through the brain-gut axisFront Vet SciMarch 5, 2026Yiwen Yang, Ling Zhou, Hongjing Liu, Zhiyong Huang, Jiancong Zhang, Li Lvtransduction,610650 SF1 (IF),Santa Cruz Biotechnology,sc-393592 PI3K,Cell signaling technology,Cat #4249 p-PI3K (Tyr458/Tyr199),Cell signaling technology,Cat #4228 Akt,Cell signaling technology,Cat #9272 p-Akt

(9) Mechanometabolism instructs hematopoietic stem cell specificationJournal of Experimental MedicineMarch 2, 2026Paulina D. Horton, Alina Syed, Michelle Winkler, Abishek B. Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, et al.(Phospho-mTOR (Ser2448) (D9C2) XP Rabbit mAb #5536, mTOR (7C10) Rabbit mAb #2983, PI3 Kinase p110α (C73F8) Rabbit mAb #4249, Phospho-p70 S6 Kinase (Thr389) Rabbit Antibody #9205, p70 S6 Kinase Rabbit Antibody #9202, Phospho-Akt

(10) PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive TumorigenesisCancer DiscoveryMarch 2, 2026Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang, Weihua Wang, Renlei Ji, Wendi Huang, Jiachen Wu, Yutong Li, Xiaochun Wan, et al.commercial vendors as noted below (Supplementary Table S1). PI3Kα (Cell Signaling Technology, cat. #4249, RRID: AB_2165248), PI3Kβ (Cell Signaling Technology, cat. #3011, RRID: AB_2165246), EPHA2 (Cell Signaling

(11) Qiangjing Tablets modulate oxidative stress and endoplasmic reticulum stress through the PI3K/Akt/NRF-2 signaling axis and regulate gut microbiota in ornidazole-induced asthenozoospermia ratsJournal of Traditional and Complementary MedicineMarch 1, 2026Guangsen Li, Dawei Gao, Degui Chang, Peihai Zhang, Ziyang Ma, Di'ang Chen, Xiaoqin Gao, Naijing Ye, Xiaopeng Huang, Yaodong Youabclonal, Wuhan, China; phosphorylated AKT (p-AKT), 1:1000, ab38449, Abcam, Cambridge, UK; PI3K, 1:1000, 4249, Cell Signaling Technology, Inc., Danvers, MA, USA; p-PI3K, 1:2000, AP0854, abclonal; ATF6, 1:2000,

(12) Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging MiceAging CellMarch 1, 2026Keru Ji, Hongde Wei, Ruguang Wang, Yutong Wu, Chen Li, Hongchang Gao, Liangcai Zhao2983S, Cell Signaling Technology), p‐PI3K (1:1000; 17366S, Cell Signaling Technology), PI3K (1:1000; 4249S, Cell Signaling Technology), MCT2 (1:1000; 20355‐1‐AP, Proteintech), LDHA (1:1000; 21799‐1‐AP, Proteintech),

(13) Effect of lumbrokinase on a rat model of hyperlipidemia-induced erectile dysfunctionTranslational Andrology and UrologyFebruary 28, 2026Xiaoxin Li, Yang Sun, Xinghao Zhang, Ziheng Zhang, Ziyang Han, Yun Chen(Thermo Fisher Scientific, Waltham, USA; #PA5-104853), PI3 kinase p110α (1:1,000, Cell Signaling Technology, Danvers, USA; #4249), phospho-Akt (Ser473, 1:2,000, Cell Signaling Technology, #4060), Akt (1:1,000, Cell Signaling Technology,

(14) Evaluating the Antioxidant Potential of Coumestrol in the Treatment of Tripterygium Glycoside-Induced Oligospermia in Rats and Its Potential MechanismsVeterinary SciencesFebruary 26, 2026Yongzheng Liu, Sikai Chen, Kang An, Long Chen, God’spower Bello-Onaghise, Yu Zhang, Shunda Li, Mo Chen, Haoran Wang, Qianwei Qu, et al.No.: 2938, Dilution: 1:1000, Danvers, MA, USA), PI3K (Cell Signaling Technology (CST), Catalog No.: 4249, Dilution: 1:1000, Danvers, MA, USA), ERK1/2 (Cell Signaling Technology (CST), Catalog No.: 4695, Dilution:

(15) Long noncoding RNA SRRM2-AS1 mediates coronary artery damage in Kawasaki disease by promoting endothelial-to-mesenchymal transitionClinical and Experimental MedicineFebruary 24, 2026Shiyang Song, Hui Zhang, Renchao Lin, Jingyi Zhang, Qianqian Zhang, Changhao Li, Yushan Xia, Jingjing Zeng, Kongchang Lu, Donghui Ge, et al.anti-UBC (1:200, Cat. No. NBP2-54692, Novus Biologicals, Littleton, CO), anti-PI3K (1:100, Cat. No. 4249 S, Cell Signaling Technology), anti-Phospho-Akt (1:1000, Cat. No. 4060 S, Cell Signaling Technology),

(16) Loss of PIK3CA allows in vitro growth but not in vivo progression of KRAS mutant lung adenocarcinoma in a syngeneic orthotopic implantation modelbioRxivFebruary 4, 2026Abigail L. Booth, Giuseppe Caso, Barbara Rosati, Ya-Ping Jiang, Wei-Xing Zong, Richard Z. Lin, Harold Biensometimes cut into pieces that were probed with separate antibodies. Antibodies to AKT1 (#2938), PIK3CA (#4249), phospho-Ser473 AKT (#4060), AMPK (#2532), and phospho-AMPK (#2531) were purchased from Cell Signaling Technology

(17) Astragalus polysaccharide promotes latent HIV-1 reactivation via exosome-mediated modulation of the PI3K/AKT/NF-κB axisExtracellular Vesicles and Circulating Nucleic AcidsJanuary 29, 2026Fang Xu, Shumin Luo, Pengpeng Lu, Yiyue Wang, Guannan Sun, Chuanyun Li, Weihua LiUK), β-actin (4970, Cell Signaling Technology, Danvers, MA, USA), phosphoinositide 3-kinase (PI3K, 4249, CST), phospho-PI3K (PA5-118549, Thermo Fisher Scientific), protein kinase B (AKT, 4691, CST), phospho-AKT

(18) Allyl isothiocyanate ameliorates metabolic dysfunction-associated steatotic liver disease via vitamin D receptors in hepatocytesWorld Journal of GastroenterologyJanuary 28, 2026Ting Gao, Kang-Peng Zhong, Jun-Zhuo Wang, Yi Chen, Chun-Xiao LiApoB (sc-393636; Santa Cruz), HNF-4α (sc-374229; Santa Cruz), phosphatidylinositol 3-kinase (PI3K) (4249; CST), acetyl-CoA carboxylase (3662; CST), SCD1 (ab236868; Abcam), FAS (sc-48357; Santa Cruz), VDR (ab3508;

(19) Therapeutic effects of IGF-2 on NMOSD by inhibiting astrocyte apoptosis through modulation of the IGF-1R/PI3K/AKT signaling pathwayScientific ReportsJanuary 27, 2026Yingyu Zhang, Na Xu, Kaikai Yu, Xiaoshuang Wang, Xianhui Jiang, Di Wang, Qiurong Yang, Yaxin Qu, Shuai Wang, Wensen Liu, et al.total AKT (1:1000, Cell Signaling Technology, USA, 9272), PI3K (1:1000, Cell Signaling Technology, USA, 4249), Bax (1:1000, Cell Signaling Technology, USA, 2772), Bcl-2 (1:2000, Abcam, UK, ab182858), IGF-1R (1:1000,

(20) High Frequency Loss of 17q11.2 and Downregulation of the Cancer Metastasis Suppression microRNA miR-193a-3p in Prostate Cancer Bone MetastasisCancers (Basel)January 27, 2026Elzbieta Stankiewicz, Sarah C. McCarley, Xueying Mao, Sakunthala Kudahetti, Tim Oliver, Jonathan Shamash, Trevor Graham, Daniel M. Berney, Yong-Jie LuMA, USA, 39224, 1:1000), anti-RAB27B (ab103418, Abcam), anti-PI3 Kinase p110α (C73F8, Cell Signaling 4249, 1:1000), anti-phospho-PI3 Kinase p85—Tyr458/p55—Tyr199 (Cell Signaling, 4228, 1:1000), anti-E-cadherin

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(1)

9/30/2020Great PI3 Kinase Antibody Sachin SamuchiwalI used this antibody to determine the endogenous levels of PI3 Kinase protein in human cancer cell lines. PI3 Kinase is one of the critical kinases that drives cancer cell proliferation and tumor ... Read Review
(1)

7/20/2017Good Working Antibody Kondaiah PalsaWe are investigating the mechanism pathway for regulation of transporter protein. In that we checked pi3k pathway. PI3Ks are composed of a catalytic subunit (p110) and a regulatory subunit. Various ... Read Review

PI3 Kinase p110alpha (C73F8) Rabbit mAb

PI3 Kinase p110alpha (C73F8) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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PI3 Kinase p110alpha (C73F8) Rabbit mAb from Cell Signaling Technology

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