ATM (D2E2) Rabbit mAb 2873S from Cell Signaling Technology

Product Specs
ItemATM (D2E2) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2873S
Quantity100 µl
ApplicationsW
ReactivityH, M
TargetATM
HostRabbit
NCBI Gene AliasesAT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
ClonalityMonoclonal
NCBI Full Gene NameATM serine/threonine kinase
Research AreaCell Cycle / Checkpoint Control
CloneD2E2
Molecular Weight350

Questions and Answers

Can this ATM antibody be used to study its role in neuroblastoma cell death?

Yes, the ATM (D2E2) Rabbit mAb has been utilized in research demonstrating its involvement in neuroblastoma cell death mechanisms. Specifically, it was shown that ATM phosphorylation is increased in neuroblastoma cells infected with a modified adenovirus, which promotes apoptosis through a pathway involving apoptosis-inducing factor and γ-H2AX ().

Is this antibody effective for detecting ATM in human and mouse samples?

The ATM (D2E2) Rabbit mAb is reactive with both human (Homo sapiens) and mouse (Mus musculus) samples, making it suitable for studies involving these species.

How has this antibody been applied in studies related to DNA damage response?

The ATM antibody has been cited in studies investigating the DNA damage response, particularly in the context of DNA double-strand breaks. For instance, it was used to assess ATM activation in response to DNA-PK inhibitors, highlighting its role in modulating the DNA damage response pathway ().

What specific applications has this antibody been validated for in the literature?

The ATM (D2E2) Rabbit mAb has been shown to work effectively in Western Blot applications, as evidenced by its use in various studies to analyze ATM protein levels and phosphorylation status in different cellular contexts (, ).

Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNANucleic Acids ResJune 8, 2026Amit Ketkar, Bethany C Paxton, Oscar E Zuniga, Reham S Sewilam, Martin Morales, John Schaller, Rowan J McCollum, Kathleen E Jackson, Kaitlin Lowran, Alyssa Paul, et al.(Abcam #183042; 1:1000 western blot), METTL3 (Abcam #195352; 1:1000 western blot), ATM (Cell Signaling #2873; 1:1000 western blot), TopBP1 (Cell Signaling #14342; 1:1000 western blot), NOP53/GLTSCR2 (Cell Signaling

(2) Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle controlElifeMay 27, 2026Thomas Moss, Alexandra Wooldredge, Koustav Bhakta, Matthew Cronin, Jason E Gestwicki, Shaeri Mukherjee"Anti-APE1 (rabbit, polyclonal)",Proteintech,10203-1-AP,WB (1:1000) Antibody,"Anti-ATM (rabbit, monoclonal)",Cell Signaling Technology,2873S,WB (1:1000) Antibody,"Anti-ATR (rabbit, polyclonal)",Cell Signaling Technology,2790S,WB (1:1000) "Strain,

(3) WEE1 kinase inhibition to overcome acquired resistance to targeted therapies in colorectal cancerEMBO Molecular MedicineMay 19, 2026Kristi Buzo, Laura Bizzozero, Marilena Lentini, Alena Opattova, Beatriz Hernández-Suárez, Michael Torres, Giulia Chiabotto, Clelia Nisticò, Giada De Lazzari, Eugenia R Zanella, et al.anti-phospho-ATM (Cell Signaling Technology, 4526S; 1:1000 RRID:AB_2062663), anti-ATM (Cell Signaling Technology, 2873S; 1:1000 RRID:AB_2062659), anti-Vinculin (clone V284) (MERCK-Millipore, 05-386; 1:1000 RRID:AB_309711).

(4) PARG inhibition in ATM-deficient prostate cancer: from mechanistic discovery to therapeutic potentialJ Transl MedMay 6, 2026Xuan Zhou, Chunyu Guo, Zhiguo Fan, Yihaoyun Lou, Zhiying Yue, Weidong Xu, Zhixiang Xin, Shancheng Renas described in our previous study [25]. Primary antibodies against β-actin (CST, #4967), ATM (CST, #2873), γ-H2AX (Millipore, 05–636), PARP1 (Proteintech, 13371-1-AP), Lamin B1 (Proteintech, 12987-1-AP), GAPDH

(5) Inhibition of ATM reverses radioiodine resistance in differentiated thyroid cancer via genotoxic stress amplificationJournal of Translational MedicineApril 27, 2026Xiaotong Qiu, Li Zhao, Yongji Jiang, Simin Liu, Zhongwei Lv, Chuanzi Zuo, Yanlei Huo, Ru Wang, Yichuan Pang, Chao Maethanol solution. Sections were then incubated overnight at 4 °C with an anti-ATM antibody (1:100; #2873T, CST) and followed by incubation with the secondary antibody. Two independent pathologists assessed

(6) SKA2 promotes gastric cancer progression by regulating glutathione metabolismiScienceApril 17, 2026Peng Zhang, Jianfeng Zhong, Ting Zhou, Depei Jiang, Zijing Wang, Meifang Ye, Lekun Fang, Huizhen Xiong, Honglei ChenAB_2307321 γ-H2AX,Cell Signaling Technology,Cat#9718; RRID: AB_2118009 ATM,Cell Signaling Technology,Cat# 2873; RRID: AB_2062659 p-ATM,Cell Signaling Technology,Cat# 5883; RRID: AB_10835213 p-chk2,Cell Signaling Technology

(7) Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP InhibitionCancer ResApril 2, 2026Joseph L. Sottnik, Madeleine T. Shackleford, Camryn S. Nesiba, Amanda L. Richer, Zoe Fleischmann, Jordan M. Swartz, Carmen E. Rowland, Maggie Musick, Rui Fu, Logan R. Myler, et al.(Ser139)(20E3) (Cell Signaling Technology #9718; RRID:AB_2118009); ATM (D2E2) (Cell Signaling Technology #2873; RRID:AB_2062659); Phospho-ATM (Ser1981)(D6H9)( Cell Signaling Technology #5883; RRID:AB_10835213);

(8) Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instabilityNature CommunicationsMarch 30, 2026Catherine Gutierrez, Marwan Kwok, Neil Ruthen, Peyton Waddicor, Christina Curran, Tamara Ouspenskaia, Doris Fu, Brendan Smalec, Samantha Sedor, Binyamin A. Knisbacher, et al.#PIPA562977, Thermo Fisher Scientific), RPL5 (1:1000; #14568S, Cell Signaling Technology), ATM (1:1000; #2873, clone D2E2, Cell Signaling Technology), p-ATM Ser1981 (1:250; #AF1655, R&D), SMC1 (1:1000; #4802, Cell Signaling Technology

(9) ATGL sensitizes hepatocellular carcinoma cells to genotoxic drugs by modulating p53 acetylation/phosphorylation statusCell Death DiscoveryMarch 20, 2026Serena Castelli, Angela De Cristofaro, Enrico Desideri, Emanuele Salvi, Fabio Ciccarone, Maria Rosa Ciriolo(Cell Signaling Technology, cat. number #5883, diluted 1:1000), ATM (Cell Signaling Technology, cat. number #2873, diluted 1:1000), p21 (Cell Signaling Technology, cat. number #2947, diluted 1:1000), PPARα (Santa Cruz Biotechnology

(10) Microenvironmental acidosis drives PARP- and ATM inhibitor resistance in p53 deficient pancreatic canceriScienceMarch 20, 2026Renata Ialchina, Thomas René Simonsen, Henriette Berg Andersen, Arnaud Stigliani, Yifan Dai, Jiayi Yao, Tanja Larsen, Dominika Czaplinska, Luis A. Pardo, Albin Sandelin, et al.,Cell Signaling Technology,Cat#CS-2577 PARP1 (total and cleaved),Cell Signaling Technology,Cat#CS-9542 ATM,Cell Signaling Technology,Cat#CS-2873 p-ATM/ATR,Cell Signaling Technology,Cat#6966 β-actin,Sigma Aldrich,A5441 ATP6V1B1,Santa Cruz Biotechnology,"Cat#Sc-55544,

(11) Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiformeCommun Med (Lond)March 18, 2026Ramcharan Singh Angom, Hari Krishnareddy Rachamala, Naga Malleswara Rao Nakka, Vijay Sagar Madamsetty, Paola Suarez-Meade, Beatriz I. Fernandez-Gil, Tanmay Kulkarni, Raegan M. Weil, Shamit Dutta, Enfeng Wang, et al.Anti-mTOR #2972), phospho-mTOR (Rabbit mAb #5536), Anti-EGFR (Rabbit mAb #4267), and Anti-ATM (Rabbit mAb #2873), were obtained from Cell Signaling Technology. Anti-ATR (sc-515173), Anti-Chk1 (sc-56288), and Anti-Chk2

(12) TNIK overexpression is sufficient for chemoradiation resistance in limited-stage small cell lung cancerMol Cancer TherMarch 16, 2026Dipanwita Dutta Chowdhury, Eddie Imada, Nick Connis, Jinhee Chang, Aaron Chan, Hwai Wei Tseng, Audrey Lafargue, Francesca A. Carrieri, Triet Nguyen, Danielle N. Waters, et al.(T68) (Cell Signaling Technology Cat# 2661S, RRID: AB_331479), ATM (Cell Signaling Technology Cat# 2873S, RRID: AB_2062659), p-ATM (S1981) (Cell Signaling Technology Cat# 5883S, RRID: AB_10835213), ATR (Cell Signaling Technology

(13) The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 PathwayDrug Des Devel TherMarch 16, 2026Lulin Zhu, Rong Dong, Gezi Yan, Haixin Zhu, Youyou Yan, Bo Zhang, Gang Wang, Nengming Lin, Biqin Tan(Cell Signaling Technology, Cat# 18583s), p-ATM (Abcam, Cat# ab81292), ATM (Cell Signaling Technology, Cat# 2873s), p-cdc25C (Cell Signaling Technology, Cat# 4901s), cdc25C (Cell Signaling Technology, Cat# 4688s),

(14) The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 PathwayDrug Des Devel TherMarch 16, 2026Lulin Zhu, Rong Dong, Gezi Yan, Haixin Zhu, Youyou Yan, Bo Zhang, Gang Wang, Nengming Lin, Biqin Tan(Cell Signaling Technology, Cat# 18583s), p-ATM (Abcam, Cat# ab81292), ATM (Cell Signaling Technology, Cat# 2873s), p-cdc25C (Cell Signaling Technology, Cat# 4901s), cdc25C (Cell Signaling Technology, Cat# 4688s),

(15) Genotype-Encoded UV Sensitivity in iPSC-Derived Human Melanocytes Reveals MX2 as a Physiological Amplifier of p53/p38-Mediated DNA Damage SignalingInt J Mol SciMarch 12, 2026Eric Ramirez-Salazar, Ana Slipicevic, Marina Juraleviciute, Ling Li, Mark Harland, Sally O'Shea, Sinead Field, Julia Newton-Bishop, Meenhard Herlyn1:5000, Cleaved Caspase 3 (#9664) 1:1000, GAPDH (#2188) 1:2000, phospho-ATM s1981 (#13050) 1:1000, ATM (#2873) 1:1000, phospho-CHK1 s345 (#2341) 1:1000, CHK1 (#2345) 1:1000, phospho-CHK2 t68 (#2661) 1:1000, CHK2

(16) FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor TherapyCancer ResMarch 10, 2026Daniel E. Gracilla, Shruti Menon, Marcus R. Breese, Yone Phar Lin, Filemon S. Dela Cruz, Tamar Y. Feinberg, Elisa de Stanchina, Ana-Florina Galic, Hannah Allegakoen, Shruthi R. Perati, et al.AB_2890610, 1:250), pATM (Invitrogen, MA5-32751, RRID: AB_2810028, 1:500), ATM (Cell Signaling Technology, 2873S, RRID: AB_2062659, 1:1,000), pCHK2-T68 (Cell Signaling Technology, 2661S, RRID: AB_331479, 1:1,000),

(17) Aptamer-functionalized exosomes combined with doxorubicin suppress GBM progression and enhance chemoradiosensitivity by promoting pyroptosisMater Today BioMarch 9, 2026Jing Wang, Li Peng, Xinxin Zhong, Siqi Zheng, Xiuhua Liang, Menghan Du, Xiangning Xia, Ting Guo, Lidan Zheng, Yingying Fang, et al.BM0627, 1:2000), anti-53BP1 (CST, 4937, 1:500), anti-pATM (Ser1981) (CST, 5883, 1:500), anti-ATM (CST, 2873, 1:1000), anti-EGFR (CST, 4267, 1:1000), anti-pEGFR (tyr1038) (CST, 3777, 1:1000), anti-pChk2 (T68)

(18) Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancerNature CommunicationsFebruary 25, 2026Yabing Nan, Kunyu Wang, Menghan Hu, Qingyu Luo, Xiaowei Wu, Xiao Yu, Xuantong Zhou, Li Chen, Bin Li, Zhumei Cui, et al.Cell Signaling Technology), anti-p-ATM (S1981) (1:1000; 13050, Cell Signaling Technology), anti-ATM (1:1000; 2873, Cell Signaling Technology), anti-p-CHK2 (T68) (1:1000; 2197, Cell Signaling Technology), anti-CHK2

(19) SIRT1 regulates dermal fibroblast senescence via impaired deacetylase function and mitochondrial dysfunction during skin aging induced by chronic oral cadmium exposureFrontiers in Public HealthFebruary 24, 2026Dehui Zhou, Gengsheng Yu, Xiaohui Fu, Qunchao Su, Chu Wang, Yonggang Ma, Hui Zou, Di Ran, Zongping LiuAntibody,Company,Cat. no.,Primary concentration Ace-SOD2,Abcam,ab214675,1:1000 Ace-P53,Abmart,MN50393,1:1000 ATM,CST,2873,1:1000 Histone H3,Abcam,ab1791,1:1000 P16INK4a,SANTA,sc-1661,1:200 P21CIP1,SANTA,sc-6246,1:200 P53,CST,32532,1:1000 SIRT1,CST,8469,1:1000 β-actin,CST,3700,1:1000 γH2AX,Abcam,ab26350,1:1000 Antibodies

(20) DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescenceNature CommunicationsFebruary 24, 2026Zhao Zhou, Xinmeng Li, Yushuang Wang, Long Liang, Chunyang Wang, Yongchang Sun, Dongmei Wu, Yifu QiupSTAT6(pS807) (ABclonal Tech, customized, 1:200), DNA-PK (Santa Cruz, #sc-390849, 1:500), ATM (Cell Signaling, #2873, 1:1000), ATR (Santa Cruz, #sc-515173, 1:500), CHK1 (Cell Signaling, #2360, 1:1500), CHK2 (Proteintech,

Write a Review

(1)

5/1/2026Great Antibody for Total ATM Western Blot Vanessa KelleyWe examined whether total ATM levels changed between a wildtype head and neck cancer cell line and a JAK1 knockout cell line. We quantified ATM levels via western blot over the course of a cell cycle... Read Review
(1)

2/9/2024Western Blot on A549 With ATM (D2E2) Rabbit mAb From Cell Signaling Daniel MercerThis antibody (#2873S) was used on A549 stimulated with TGF-b for 24 hours. The primary antibody was diluted 1:1000 in 5%BSA in 1xTBST
(1)

3/23/2016ATM Antibody Review Michaela RekowThis antibody was used for assessing ATM levels in bone marrow derived macrophages in virus infected mice.

ATM (D2E2) Rabbit mAb

ATM (D2E2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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ATM (D2E2) Rabbit mAb from Cell Signaling Technology

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