PDGF Receptor alpha (D1E1E) XP ® Rabbit mAb 3174S from Cell Signaling Technology

Product Specs
ItemPDGF Receptor alpha (D1E1E) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number3174S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC, FC-FP
ReactivityH, M
TargetPDGFR-a
HostRabbit
NCBI Gene AliasesCD140A, PDGFR-2, PDGFR2
ClonalityMonoclonal
NCBI Full Gene Nameplatelet derived growth factor receptor alpha

Questions and Answers

What applications has the PDGF Receptor alpha antibody been used for in research studies?

The PDGF Receptor alpha (D1E1E) XP Rabbit mAb has been shown to work in various applications including Western Blotting, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry on paraffin-embedded sections, and Immunoprecipitation.

Has this antibody been utilized in studies related to glioblastoma?

Yes, the PDGF Receptor alpha antibody has been cited in studies investigating glioblastoma, such as the research by Aldaz et al. (2021), which discusses the role of PDGFR signaling in glioblastoma cells and its implications for therapy.

Can this antibody be used to study PDGFRα expression in different species?

The PDGF Receptor alpha antibody is reactive to both human and mouse species, making it suitable for comparative studies involving these organisms.

What specific findings have been reported regarding PDGFRα in the context of cancer research?

Research has indicated that PDGFRα plays a significant role in tumor progression and survival signaling in various cancers, including gastrointestinal stromal tumors, where its expression is crucial for tumor growth and is often targeted in therapeutic strategies.

Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Diminished and Altered Cellular Senescence Response in Delayed Wound Healing of AgingAging CellApril 25, 2026Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Qiaoling Wang, Grace Haeun Shin, Jannat Dhillon, Daniel Sam RohMarlborough, MA, USA), primary antibodies (rabbit anti‐p16, Abcam #ab211542, 1:100; rabbit anti‐PDGFRα, CST #3174, 1:150) were incubated for 40 min at 37°C. Sections were then incubated with Vector ImmPress Goat Anti‐Rabbit

(2) Targeting enhancing myelin regeneration reverses cognitive deficits in a mouse model of intellectual disabilityNeurotherapeuticsApril 13, 2026Pingping Qiao, He Wang, Pingping Qu, Lifang Guo, Yanbo Zhou, Tingting Zeng, Jiang Chen, Jian Li, Yimin Hu, Guiquan ChenCat# MAB3418, 1:500), c-Fos (Oasis, Cat# OB-PGP080, 1:500), PDGFRα (Cell Signaling Technology, Cat# 3174, 1:500), CC1 (Calbiochem, Cat# op-80, 1:300) and ASPA (Millipore, Cat# ABN1698, 1:500). Nuclei were

(3) Astrocyte-derived PTPRZ1 regulates excitatory synapse density in the mouse cortexeNeuroApril 6, 2026Alex R. Eaker, Hayli E. Spence-Osorio, Madelyn G. Coble, Breana C. Dogan, Katherine T. Baldwin(1:100)/goat anti-mouse IgG1 Alexa Fluor 488 (1:200) and rabbit IgG anti-PDGFRα (Cell Signaling Technology 3174S, 1:500; RRID:AB_2162345)/goat anti-rabbit IgG Alexa Fluor 647 (Thermo Fisher Scientific A-21245, 1:200;

(4) The impact and potential mechanisms of long noncoding RNA ENST00000521141.1 on human white adipocyte differentiationJ EndocrinolApril 2, 2026Qiong Wu, Lianghui You, Shibo Lin, Tingting Yu, Rui Yin, Xinrong Ye, Lijian Xu, Hui Liang, Lingxia Pang1:1,000), anti-HGF (Proteintech, China; Cat. No. 26881-1-AP; diluted 1:1,000), anti-PDGFRA (CST; Cat. No. 3174T; diluted 1:1,000), anti-GPX3 (Abcam; Cat. No. ab275965; diluted 1:1,000), anti-TSHR (Proteintech; Cat.

(5) Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 InhibitionNature CommunicationsFebruary 28, 2026Elizabeth F. Redente, Tengyao Song, Nomin Javkhlan, Benjamin L. Edelman, Daniel G. Foster, Jasmine A. Wilson, Sangeeta Chakraborty, Joseph C. Cooley, Rohit Gaurav, Satria Saguthi, et al.1:100 Hercules, CA), Bcl-2 (Cell Signaling Technology # 3498, rabbit, 1:500), PDGFRα (Cell Signaling, #3174S rabbit, 1:100), PDGFRβ (R&D Systems #AF1032 goat, 1:100, Minneapolis, MN), GFP (which identifies CFP;

(6) AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets AccumulationAdvanced ScienceFebruary 1, 2026Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, et al.1:1000), anti‐MBP (Abcam, #ab7349, 1:500), anti‐Map2 (Bioworld, #BS3487, 1:100), anti‐Pdgfα (CST, #3174s, 1:500), anti‐SMI32 (BioLegend, #801702, 1:500), anti‐Smpd1 (Proteintech, #14609‐1‐AP, 1:300), anti‐Human

(7) Analysis of the spatial-temporal distribution and functional morphology of telocytes in goat testesScientific ReportsJanuary 20, 2026Jiasen Feng, Chunyuan Dai, Qi Wang, Imran Tarique, Zhaoxuan Zhu, Yisheng Wang, Xinzi Guo, Ping Yang(1:100)/Vimentin (1:100, BM0135, Boster Biological Technology Co., Ltd), α-SMA (1:100)/PDGFR-α (1:100, 3174 S, CellSignaling Technology). The negative control used phosphate-buffered saline (PBS, pH = 7.4) in

(8) The Prolyl Isomerase PIN1 Affects Fibroblast Differentiation States and Cross-talk in Pancreatic CancerCancer ResearchDecember 15, 2025Chloe L. Bowman, Colin J. Daniel, Eric J. Carlson, Vidhi M. Shah, Amy S. Farrell, Kayleigh M. Kresse, Xiaoyan Wang, Kyra A. Lindley, Madeline R. Kuhn, Kevin MacPherson-Hawthorne, et al.(25H2; Cell Signaling Technology Cat# 3127, RRID: AB_331361, 1:1000), PDGFRA (D1E1E; Cell Signaling Cat# 3174S, RRID: AB_2162345, 1:1000), PDPN (D9D7; Cell Signaling Cat# 9047S, RRID: AB_2797694, 1:1000), KRT8/18

(9) Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast nichesCancer CellDecember 8, 2025Xiongfeng Chen, Zhuan Zhou, Luyu Xie, Kailiang Qiao, Yiyue Jia, Shunheng Liu, Zeynep Yazgan, Francesca Rossi, Yang Liu, Bo Zhang, et al.97971 Anti-I-A/I-E Antibody (Brilliant Violet 421),BioLegend,Cat# 107632 Anti-PDGFRα Antibody,Cell Signaling,Cat# 3174 Anti-PDGFRα Antibody (Alexa Fluor 488),R&D Systems,Cat# FAB1062G Anti-SPINK4 Antibody,Thermo Fisher Scientific

(10) INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell modelNat CommunDecember 7, 2025Patrick A. DeSouza, Matthew Ishahak, Xuan Qu, Colin McCornack, Devi Annamalai, Diane D. Mao, Rajanikanth Vangipurapu, Yiwei Fu, Alexandre T. Vessoni, Ryan T. Cleary, et al.Pierce ECL western blotting substrate (Thermo Scientific #32106). Antibodies used include PDGFRA (CST, #3174S, 1:1000), phospho-PDGFRA (Y754, Abcam #ab5460, 1:750), phospho-ERK (T202/4, CST #9101S, 1:1000), phospho-AKT

(11) Tenascin-C from the tissue microenvironment promotes muscle stem cell maintenance and function through Annexin A2Commun BiolDecember 5, 2025Alessandra Cecchini, Mafalda Loreti, Collin D. Kaufman, Cedomir Stamenkovic, Gabriele Guarnaccia, Alma Renero, Chiara Nicoletti, Anais Kervadec, Daphne Mayer, Shawn Delaware, et al.Cell Signaling Technology), rabbit anti-α-tubulin (catalog number: ab18251, Abcam), rabbit anti-Pdgfra (catalog number: 3174T, Cell Signaling), rabbit anti-MyoD (catalog number: sc-760, Santa Cruz, 1:100 dilution), mouse anti-MyoD

(12) The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathwayPLoS BiolDecember 4, 2025Yizhun Zeng, Xiaopeng Song, Qi Chen, Yue Gu, Jie Zhang, Tao Zhou, Zhihao Li, Tao Wang, Le Chang, Hongwei Yao, et al.normal donkey serum for 1 h at room temperature. Anti-PDGFRα antibody (1:500, Cell Signaling Technology, 3174S) was then added and incubated overnight at 4°C. The next day, after washing three times with PBS, they

(13) Age-dependent immune responses and resident cell dynamics in young mice following pneumoniaiScienceNovember 26, 2025Sylvia N. Michki, Javier V. Perez, Dharma A. Varapula, Aaron J. Thomas, Tiffaney L. Vincent, Benjamin D. Singer, Jarod A. Zepp, Sharon A. McGrath-MorrowRRID:AB_2563543 CD326-FITC,Biolegend,Cat# 118207; RRID:AB_1134106 PDGFR-alpha-APC,Cell Signaling Technology,Cat# 3174; RRID:AB_2162345 Rat anti-SAA3,Abcam,Cat# ab231680; RRID:AB_2904196 Mouse anti-LAMP3,Synaptic Systems,Cat#

(14) USP14-mediated stabilization of ACTN1 maintains mesenchymal characteristics in glioblastomaCommunications BiologyNovember 25, 2025Wenjin Qiu, Xueping Shi, Ruting Wei, Jiaquan Song, Yuanguo Ling, Yunjia Hu, Shibin Song, Yimin Chen, Hua Yang, Peng Luo, et al.#AF2599; WB 1:1000), Olig2 (Santa Cruz, #sc-293163; WB 1:500), PDGFRα (Cell Signaling Technology, #3174; WB 1:1000), MET (Santa Cruz, #sc-8057; WB 1:200), COL5A1 (Cell Signaling Technology, #86903; WB 1:1000),

(15) Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease stricturesCellNovember 13, 2025Khristian E. Bauer-Rowe, Benjamin Pham, Michelle Griffin, Norah E. Liang, Alexia Kim, John M. Lu, Michael Januszyk, Jason L. Guo, Stefania De Santis, Yue Xing, et al.mounting. TSA was used for staining YAP1. Primary antibodies used for IF included: Rabbit anti-PDGFRA (CST #3174, 1:200), Chicken anti-GFP (Abcam, #ab13970, 1:10K), Goat anti-POSTN (R&D, #AF2955, 1:300), Rabbit anti-Caspase3

(16) Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growthNeuronNovember 5, 2025Corina Anastasaki, Rui Mu, Chloe M. Kernan, Xuanwei Li, Rasha Barakat, Joshua P. Koleske, Yunqing Gao, Olivia M. Cobb, Xinguo Lu, Charles G. Eberhart, et al.NIR,Bio-Techne Sales Corp.,Cat# 042-206 Olig2,GeneTex,Cat# GTX132732 PDGFRa,Cell Signaling Technologies,Cat# 3174S Phospho-AKT Thr308,Cell Signaling Technologies,Cat# 9275S Phospho-AKT Ser473,Cell Signaling Technologies,Cat#

(17) Tyrosine kinase targeting uncovers oncogenic pathway plasticity in Tasmanian devil transmissible cancersThe EMBO JournalNovember 3, 2025Anna Schönbichler, Anna Orlova, Carmen Kreindl, Lukas Endler, Richard Wilson, Lindsay Kosack, Anna Hofmann, Csilla Viczenczova, Jocelyn Darby, Fettah Erdogan, et al.,Cell Signaling Technology,5241 Anti-PDGFR alpha,Abcam,ab124392 Anti-PDGFR alpha,Cell Signaling Technology,3174 Anti-PDGFR beta,Cell Signaling Technology,8044 Anti-PDGFR beta,Cell Signaling Technology,4564 Anti-HER2/ErbB2,Cell Signaling Technology

(18) Phenotype disruption of umbilical cord derived MSC by cyclic mechanical stretch and hyperoxia mediated by p21Sci RepOctober 7, 2025Maurizio J. Goetz, Judith Behnke, Frank Oehmke, Lena Holzfurtner, Pauline Korte, Stefano Rivetti, Saverio Bellusci, Harald Ehrhardtincubation was done for 1 h in dry milk 5% in TBS-T at room temperature. Primary antibodies were PDGFRα (#3174) and p21 (#2947S) both from Cell Signaling (Danvers, US), αSMA (#sc-58669, Santa Cruz, Dallas, US),

(19) Repeated ablations of mature Tmem10+ oligodendrocytes recapitulates key pathological features of multiple sclerosis with prolonged demyelinationCell Death DisOctober 6, 2025Feiyan Zhu, Haijiao Huang, Yuting Shu, Guoru Ren, Bo Jing, Honglin Tan, Wanxiang Jiang, Yiyuan Cui, Paul F. Worley, Bo Xiao, et al.Sox10 (Oasis, OB-PRB001; 1:200), MYRF (Oasis, OB-PRB007; 1:200), PDGFRα (Cell Signaling Technology, 3174S; 1:200), BCAS1 (Santa Cruz Biotechnology, sc-136342; 1:200), GFAP (Millipore, MAB360; 1:500), Iba1 (WAKO,

(20) Cardiomyocyte Janus kinase 1 (JAK1) signaling is required for cardiac homeostasis and cytokine-dependent activation of STAT3Journal of Molecular and Cellular CardiologyOctober 1, 2025Arasakumar Subramani, Kobina Essandoh, Michael Y. Young, Francesca H. Marino, James P. Teuber, Kay-Uwe Wagner, Matthew J. Brody(Cell Signaling Technology, #9145, 1:500), α-sarcomeric actin (Sigma, #A2172, 1:20,000), PDGFRα (Cell Signaling Technology, #3174, 1:1000) [50], α-tubulin (Santa Cruz, sc-5286, 1:500), and Gapdh (Fitzgerald, #10R-G109A, 1:50,000).

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PDGF Receptor alpha (D1E1E) XP ® Rabbit mAb

PDGF Receptor alpha (D1E1E) XP ® Rabbit mAb from Cell Signaling Technology

Questions and Answers

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PDGF Receptor alpha (D1E1E) XP ® Rabbit mAb from Cell Signaling Technology

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