DUSP4/MKP2 (D9A5) Rabbit mAb 5149S from Cell Signaling Technology

Product Specs
ItemDUSP4/MKP2 (D9A5) Rabbit mAb
CompanyCell Signaling Technology
Price $399.00 Inquire
Catalog Number5149S
Quantity100 µl
ApplicationsW, W-S
ReactivityH, Mk
ClonalityMonoclonal
TargetDUSP4
HostRabbit
NCBI Full Gene Namedual specificity phosphatase 4
NCBI Gene AliasesHVH2, MKP-2, MKP2, TYP
Research AreaMAP Kinase Signaling
CloneD9A5
Molecular Weight42

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 978-867-2388
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Quantitative Proteomics of Nitrosylated Proteins in Melanoma Using the Biotin-Switch Technique Combined With Tandem Mass Tag LabelingBio ProtocDecember 5, 2025Vipin K. Yadav, Bin Fang, John M. Koomen, Jyoti Srivastava, Sanjay PremiSignaling Technology, catalog number: 9102S) 36. DUSP4 (Cell Signaling Technology, catalog number: 5149S) 37. RhoC (Cell Signaling Technology, catalog number: 3430S) 38. RSK-1 (Cell Signaling Technology, catalog

(2) Disruption of the Clock Component BMAL1 in HDM-induced Asthma Causes GC Resistance in Airway Epithelial Cells by Regulating GR Phosphorylation through the DUSP4-p38MAPK PathwayInternational Journal of Biological SciencesOctober 10, 2025Haohua Huang, Hua Liao, Yixin Chen, Minxuan Hu, Xiaoxiao Jiang, Qi Yu, Yimei Gao, Huimin Yang, Jinzhong Zhuo, Dongyu Liu, et al.Anti-phospho-GR-Ser211 (4161), anti-GR (3660), anti-phospho-p38MAPK (4511), anti-p38MAPK (8690), and DUSP4 (5149) and DUSP6 (50945) were purchased from Cell Signaling Technology (CST, USA). Anti-phospho-NFκB p65 (sc-136548)

(3) BRAF V600E -Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor SignalingbioRxivMay 25, 2025Melanie Angelina Dacheux, Meng-Jung Wu, Michael T. Scherzer, Monique Nillson, Brandon Murphy, Sophia Schuman, Zhenlin Ju, Trever Bivona, Piro Lito, Matthew Gumbleton, et al.4432); Anti-CRAF (D5X6R); Cell Signaling (Catalog # 12552); Anti-DUSP4 (D9A5); Cell Signaling (Catalog #5149); Anti-pS6 S235/S236; Cell Signaling (Catalog # 2211); Anti-pCDC2 Y15 (10A11); Cell Signaling (Catalog

(4) Exosomal miR-122-5p for regulation of secretory functions of fibroblasts and promotion of breast cancer metastasis by targeting MKP-2: an experimental studyCancer Biol TherMay 4, 2025Yun Lv, Yue Li, Jie Zhou, Xin Liu, Dandan Wang, Dongmei Wang, Dandan Tong, Shuhuai Wang, Hanxiang An, Xinmei KangSanta Cruz Biotechnology), anti-TSG101 (sc-7964, Santa Cruz Biotechnology), α-SMA (ab5831, Abcam), MKP-2 (#5149, Cell Signaling Technology). 4.6. Fluorescent labeling exosomes The PKH67 green fluorescence kit (Sigma-Aldrich)

(5) Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylationActa pharmaceutica Sinica. BJanuary 1, 2025Tang L, Shi Y, Liao Q, Wang F, Wu H, Ren H, Wang X, Fu W, Shou J, Wang WE, et al.Rabbit, 1:1000), anti-dual-specificity phosphatases 4 (DUSP4) antibody (Cell Signaling Technology; 5149, Rabbit, 1:1000), anti-dual-specificity phosphatases 12 (DUSP12) antibody (Proteintech, Wuhan, China;

(6) ASCL1 Restrains ERK1/2 to Promote Survival of a Subset of Neuroendocrine Lung CancersMolecular Cancer TherapeuticsDecember 3, 2024Ana Martin-Vega, Svetlana A. Earnest, Alexander Augustyn, Chonlarat Wichaidit, Luc Girard, Michael Peyton, John D. Minna, Jane E. Johnson, Melanie H. Cobbsc-47724; RRID:AB_627678), DUSP6 (Abcam, ab76310; RRID:AB_1523517), DUSP4 (Cell Signaling Technology, 5149S; RRID:AB_2750867). Immunofluorescence microscopy. Cells were plated on Falcon 96-well culture plates,

(7) Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancersProceedings of the National Academy of Sciences of the United States of AmericaFebruary 27, 2024Jansen RA, Mainardi S, Dias MH, Bosma A, van Dijk E, Selig R, Albrecht W, Laufer SA, Zender L, Bernards R.Ser235/236 (#2211), S6 Ribosomal Protein (#2217), Phospho-HER3/ErbB3 Tyr1197 (#4561), DUSP4/MKP2 (#5149), and MAP2K4 (#9152) were used at a concentration of 1:1,000 and purchased from Cell Signaling Technology.

(8) Inhibition of microRNA-122 alleviates pyroptosis by targeting dual-specificity phosphatase 4 in myocardial ischemia/reperfusion injuryHeliyonJuly 13, 2023Hongjin Wu, Qiang Fu, Zhong Li, Huamin Wei, Shuyan QinIDs,Dilution ratio Caspase 1,"24,232",CST,E2Z1C,1:1000 Caspase 11,"14,340",CST,17D9,1:1500 DUSP4,5149,CST,D9A5,1:1500 HRP-GAPDH,8884,CST,D16H11,1:6000 A table to include the primary antibodies listed

(9) Transcriptional coactivation by EHMT2 restricts glucocorticoid-induced insulin resistance in a study with male miceNature communicationsMay 30, 2023Lee RA, Chang M, Yiv N, Tsay A, Tian S, Li D, Poulard C, Stallcup MR, Pufall MA, Wang JC.10494-1-AP), EHMT2 1:1000 (Sigma, St. Louis, MO, SAB 2100657), DUSP4 1:500 (Cell Signaling, Danvers, MA, 5149), H3k9ME2 1:1000 (Abcam, Cambridge UK, ab32521), IRS2 1:1000 (Cell Signaling, Danvers, MA, 3089 S),

(10) CRISPR screens identify gene targets at breast cancer risk lociGenome biologyMarch 29, 2023Tuano NK, Beesley J, Manning M, Shi W, Perlaza-Jimenez L, Malaver-Ortega LF, Paynter JM, Black D, Civitarese A, McCue K, et al.Trans-Blot®Turbo™ Transfer System and visualized using ECL (Bio-Rad Chemidoc). Antibodies used in this study are DUSP4 (CST#5149), Cyclin D1 (CST#2978), Cyclin E1 CST#4129), ATF7IP (Sigma#16,578), ATF7IP (Sigma#HPA023505), ADCY3

(11) O-GlcNAcylation regulates extracellular signal-regulated kinase (ERK) activation in Alzheimer's diseaseFrontiers in aging neuroscienceJanuary 1, 2023Ephrame SJ, Cork GK, Marshall V, Johnston MA, Shawa J, Alghusen I, Qiang A, Denson AR, Carman MS, Fedosyuk H, et al.44-454G), Total MEK (ThermoFisher Catalog # 13-3500), APP (CST Catalog # 2452), and DUSP4 (CST Catalog # 5149). Statistical analysis Statistical significance of all results was assessed using t-test (paired for

(12) Investigating the Role of DUSP4 in Uveal MelanomaTranslational vision science & technologyDecember 1, 2022Aughton K, Sabat-Pospiech D, Barlow S, Coupland SE, Kalirai H.Antibody,Antigen,Dilution,Species,Technique Abcam Ab72593,DUSP4,1:100,Rabbit,IHC Cell Signalling 5149S,DUSP4,1:500,Rabbit,WB Invitrogen PA1-027A,Cyclophilin B,1:1000,Rabbit,WB Cell Signalling 9102,ERK1/2,1:1000,Rabbit,WB Cell Signalling

(13) Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancerBreast Cancer ResearchDecember 1, 2022Ann Hanna et al.Technology), HDAC1 (5356; Cell Signaling Technology), cJUN (9165; Cell Signaling Technology), DUSP4 (5149; Cell Signaling Technology), ETS-1 (SC-350, Santa Cruz), p21 (6246; Cell Signaling Technology), Phospho-AKT(Ser473)

(14) DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITFLife science allianceSeptember 1, 2022Gutierrez-Prat N, Zuberer HL, Mangano L, Karimaddini Z, Wolf L, Tyanova S, Wellinger LC, Marbach D, Griesser V, Pettazzoni P, et al.with primary antibodies diluted with blocking buffer. The following antibodies were used: DUSP4 (# 5149, 1:1,000; Cell Signaling), DUSP6 (# 39441, 1:500; Cell Signaling), MITF (#12590, 1:500; Cell Signaling),

(15) Methylation of dual-specificity phosphatase 4 controls cell differentiationCell reportsJuly 27, 2021Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, Xavier-Ferrucio J, Jin S, Tran NT, Liu SM, et al.available anti-DiMethyl-R #2,Guo et. al. 2014a,Not commercially available anti-DUSP4,Cell Signaling,Cat# 5149; RRID:AB_2750867 anti-Erk,Cell Signaling,"Cat# 9102, RRID:AB_330744" anti-FLAG,Sigma-Aldrich,Cat#

(16) Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibitionCell reportsJune 29, 2021Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, et al.,Cell Signaling Technology,Cat # 4694 ,,RRID: AB_10695868 Rabbit monoclonal anti-DUSP4,Cell Signaling Technology,Cat # 5149 ,,RRID: AB_2750867 Rabbit polyclonal anti-DUSP6,Cell Signaling Technology,Cat # 39441 ,,RRID: AB_2799156 Rabbit

(17) miR‑122‑5p suppresses the oncogenesis of PTC by inhibiting DUSP4 expressionMolecular Medicine ReportsMarch 16, 2021Ning Hu, Yanhua Tian, Yanmei Song, Leilei Zangroom temperature, PVDF membranes were incubated with the antibodies against DUSP4 (1:10,000; cat. no. 5149) and β-tubulin (1:10,000; cat. no. 2146) (both from Cell Signaling Technology, Inc.) overnight at 4°C.

(18) DUSP4 appears to be a highly localized endogenous inhibitor of epileptic signaling in human neocortexNeurobiology of DiseaseNovember 1, 2020A. Kirchner, S. Bagla, F. Dachet, J.A. Loebincubated overnight in primary antibodies against EGR1 (Abcam, AV32241) (1:500), DUSP4 (Cell Signaling, #5149S) (1:1000), diphospho-ERK1/2 (dp-ERK) (Cell Signaling, #4370) (1:1000), ERK1/2 (ERK) (Cell Signaling,

(19) DUSP4 directly deubiquitinates and stabilizes Smad4 protein, promoting proliferation and metastasis of colorectal cancer cellsAging (Albany NY)September 7, 2020Weifeng Xu, Beibei Chen, Dianshan Ke, Xiaobing Chenbeing blocked for 1 hour at room temperature, the layer was brooded with anti-Rabbit DUSP4 (1:1000) (#5149, CST, USA), GAPDH (1:1000) (#2118, CST, USA), Cyclin D1 (1:1000) (#2978 CST, USA), PCNA (1:1000) (#13110

(20) Kinetic Heterogeneity of Cancer Cell Fractional KillingCell reportsJuly 7, 2020Inde Z, Forcina GC, Denton K, Dixon SJ.,Cell Signaling Technology,Cat# 4370; RRID: AB_2315112 Anti-DUSP4 (MKP2) Rabbit mAb,Cell Signaling Technology,Cat# 5149; RRID: AB_2750867 Anti-Bim Rabbit mAb,Cell Signaling Technology,Cat# 2933; RRID: AB_1030947 Anti-Bcl-xL

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DUSP4/MKP2 (D9A5) Rabbit mAb

DUSP4/MKP2 (D9A5) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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DUSP4/MKP2 (D9A5) Rabbit mAb from Cell Signaling Technology

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