LRP1 (5A6) Antibody sc-57351 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemLRP1 (5A6) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-57351
NCBI Gene AliasesLRP1A, APOER, TGFBR5, KPA, APR, A2mr, A2MR, IGFBP-3R, CD91, IGFBP3R, Lrp, b2b1554Clo, LRP, IGFBP3R1
Antibody TypePrimary Antibodies
Clone5A6
Quantity100 µg/ml
Reactivitymouse, rat, human
ApplicationsWB (non-reducing), IF, IHC(P), FCM
ClonalityMonoclonal
Hostmouse
Conjugate/TagUnconjugated
FormatPurified
NCBI Full Gene NameLDL receptor related protein 1, low density lipoprotein receptor-related protein 1
TargetLRP1
IsotypeIgG2b

Questions and Answers

What applications has the LRP1 (5A6) antibody been used for in scientific research?

The LRP1 (5A6) antibody has been shown to work in various applications including Western Blotting, Flow Cytometry, Immunofluorescence, and Immunohistochemistry. It has been utilized in studies investigating the role of LRP1 in processes such as cholesterol efflux and astrocytic phagocytosis in models of ischemic stroke and glioblastoma.

Can this antibody be used to study LRP1 in human brain pericytes?

Yes, the LRP1 (5A6) antibody has been used in research involving human brain pericytes, particularly in studies examining the activation of the liver X receptor signaling pathway and its effects on cholesterol metabolism in the context of neuroinflammation and Alzheimer's disease, as demonstrated in the literature.

Is the LRP1 (5A6) antibody effective for immunostaining in glioblastoma models?

The LRP1 (5A6) antibody has been effectively used for immunostaining in a microfluidic model of glioblastoma, where it helped assess the trafficking of nanoparticles across the blood-brain barrier, indicating its utility in studying tumor-associated vasculature.

What species does the LRP1 (5A6) antibody react with?

The LRP1 (5A6) antibody is reactive with multiple species, including humans, mice, and rats, making it versatile for comparative studies across different model organisms.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Temporal transcriptome features identify early skeletal commitment during human epiphysis development at single-cell resolutioniScienceAugust 18, 2023Deng Z, Rong S, Gan L, Wang F, Bao L, Cai F, Liao Z, Jin Y, Feng S, Feng Z, et al.monoclonal to CD63 antibody,Abcam,Cat#ab193349 Mouse monoclonal IgG2bLRP1 antibody,Santa Cruz,Cat#sc57351; RRID:AB_784362 Mouse monoclonal IgG2bκ Calregulin antibody,Santa Cruz,Cat#sc373863; RRID:AB_10915425 Mouse

(2) Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreasCommunications biologyJanuary 3, 2023Verma N, Velmurugan GV, Winford E, Coburn H, Kotiya D, Leibold N, Radulescu L, Despa S, Chen KC, Van Eldik LJ, et al.

(3) A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier-penetrant nanoparticlesProceedings of the National Academy of Sciences of the United States of AmericaJune 7, 2022Straehla JP, Hajal C, Safford HC, Offeddu GS, Boehnke N, Dacoba TG, Wyckoff J, Kamm RD, Hammond PT.achieved by staining the fixed devices with anti-CD31 (catalog no. ab3245, Abcam), anti-LRP1 (catalog no. sc-57351, Santa Cruz Biotechnology), and anti–ZO-1 (catalog no. 61-7300, ThermoFisher Scientific) at 1:200 in

(4) Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in miceNature communicationsMarch 3, 2022Wan T, Zhu W, Zhao Y, Zhang X, Ye R, Zuo M, Xu P, Huang Z, Zhang C, Xie Y, et al.and LCN2 (AF1857) were purchased from R&D Systems, USA; antibodies against Gbp2 (sc-166960) and LRP1 (sc-57351) were purchased from Santa Cruz Biotechnology, USA; antibody against pLRP1 (PA5-101013) was purchased

(5) Inflammatory Cytokine IL-1β Downregulates Endothelial LRP1 via MicroRNA-mediated Gene SilencingNeuroscienceJanuary 15, 2021Hsu HW, Rodriguez-Ortiz CJ, Zumkehr J, Kitazawa M.temperature for 1 hr, further incubated with one or two of the primary antibodies overnight: LRP1 (#sc-57351, 1:25, Santa Cruz Biotechnology), NF-κB (#8242, 1:1000, Cell Signaling Technology), IκB (#9242, 1:1000,

(6) Ketone Bodies Promote Amyloid-β(1-40) Clearance in a Human in Vitro Blood-Brain Barrier ModelInternational journal of molecular sciencesJanuary 31, 2020Versele R, Corsi M, Fuso A, Sevin E, Businaro R, Gosselet F, Fenart L, Candela P.

(7) Role of lactoferrin and its receptors on biliary epitheliumBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicineJune 1, 2018Mancinelli R, Olivero F, Carpino G, Overi D, Rosa L, Lepanto MS, Cutone A, Franchitto A, Alpini G, Onori P, et al.

(8) Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide BrambillaPharmaceutical researchDecember 1, 2017Vellonen KS, Ihalainen J, Boucau MC, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, et al.

(9) Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB DysfunctionFrontiers in neuroscienceJanuary 1, 2016Löffler T, Flunkert S, Temmel M, Hutter-Paier B.HRP-linked (GE-Healthcare, NA934; 1:5000); anti-LRP1 [alpha-2-macroglobulin receptor] (Santa Cruz, sc-57351; 1:500) + anti-mouse IgG, peroxidase linked (GE-Healthcare, NA931; 1:1000); anti-Cluster of Differentiation

(10) Low-density lipoprotein receptor-related protein 1 is an essential receptor for trichosanthin in 2 choriocarcinoma cell linesBiochemical and biophysical research communicationsJanuary 22, 2010Jiao Y, Liu W.

(11) Downregulation of LRP1 [correction of LPR1] at the blood-brain barrier in streptozotocin-induced diabetic miceNeuropharmacologyMay 1, 2009Hong H, Liu LP, Liao JM, Wang TS, Ye FY, Wu J, Wang YY, Wang Y, Li YQ, Long Y, et al.

(12) TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1International journal of molecular sciencesJanuary 1, 0001"Dib S, Loiola RA, Sevin E, Saint-Pol J, Shimizu F, Kanda T, Pahnke J, Gosselet F."(BCRP),72,Ab207732,Abcam,non-heated/reduced,1:1000 ABCG4,100,PA5-34855,Invitrogen,heated/reduced,1:1000 SR-BI,80,ab52629,Abcam,heated/reduced,1:1000 HMGCR,100,Mab90619,Sigma,non-heated/reduced,1:1000 LRP1,80,sc57351,Santa Cruz,heated/reduced,1:500 LDLR,140,ab52818,Abcam,heated/reduced,1:1000 APOE,34,ab1906,Abcam,heated/reduced,1:1000 COX2,70,NBD100-689SS,Novus,heated/reduced,1:1000 NLRP3,118,ab263899,Abcam,heated/reduced,1:1000 VCAM1,90–100,ab134047,Abcam,heated/reduced,1:1000 IL-6,22–28,NBD600-1131SS,Novus,heated/reduced,1:1000 PhosphoNF-κB,66–75,Mab72261,R&D,heated/reduced,1:1000 NF-κB,66–75,ab32536,Abcam,heated/reduced,1:1000 ACTIN,42,A5441,Sigma,heated/reduced,"1:10,000" Western blot

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LRP1 (5A6) Antibody

LRP1 (5A6) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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LRP1 (5A6) Antibody from Santa Cruz Biotechnology, Inc.

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