4 Hydroxynonenal Polyclonal Antibody bs-6313R from Bioss Inc.

Product Specs
Item4 Hydroxynonenal Polyclonal Antibody
CompanyBioss Inc.
Price $375.00Supplier Page View Company Product Page
Catalog Numberbs-6313R
Quantity100ul, 20uL
ApplicationsWB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-P), IHC-F, IHC-P, WB
Concentration1ug/ul
Conjugate/TagUnconjugated
Format0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol
ReactivityRat, Mouse, Other Species, Monkey, Others
ClonalityPolyclonal
Target4 Hydroxynonenal
IsotypeIgG
HostRabbit
Antibody TypePrimary Antibody
Immunogen4 Hydroxynonenal conjugated to BSA
TissueIntestine, plantar skin, brain, Brain, Liver, cerebral cortex

Questions and Answers

What types of tissues have been studied using the 4 Hydroxynonenal Polyclonal Antibody?

The 4 Hydroxynonenal Polyclonal Antibody has been utilized in studies involving various tissues, including brain, intestine, liver, skin, and cerebral cortex, indicating its versatility in research related to oxidative stress and lipid peroxidation.

How has the 4 Hydroxynonenal Polyclonal Antibody been applied in immunohistochemistry?

In immunohistochemistry applications, the antibody has been used at a dilution of 1:600 to detect 4-Hydroxynonenal in tissue sections, as demonstrated in studies investigating oxidative stress-related conditions, such as psoriasis-like skin inflammation and renal injury models.

Are there any specific experimental models where the 4 Hydroxynonenal Polyclonal Antibody has been cited?

Yes, the antibody has been cited in studies involving mouse models, such as those examining colorectal cancer and renal carcinogenesis, where it was used to assess oxidative damage and lipid peroxidation levels in response to various treatments.

What role does 4-Hydroxynonenal play in cellular processes, and how is this relevant to the use of the antibody?

4-Hydroxynonenal is implicated as a key mediator in oxidative stress-induced cell death and has been hypothesized to influence cell signal transduction pathways, making the antibody valuable for studying its effects on cellular processes and disease mechanisms in various experimental contexts.

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Website: www.biossusa.com

(1) Ketogenic interventions enhance REM sleep in females and support memory in aged ratsFront Aging NeurosciApril 10, 2026Arianna R. S. Lark, Fayaz A. Mir, Naqiya Ambareen, Fangyun Tian, Abigail Hardy Carpenter, Eliza A. Crowley, Bryton A. Toro, Channing E. Syme, Sema Aygar, Ahil Thendral, et al.Core. The following primary antibodies were used: rabbit anti- 4-hydroxynonenal (4HNE) (1:500; Bioss bs-6313R), rabbit anti- 3-nitrotyrosine (3-NT) (1:200; Bioss BS-8551R), rabbit anti- triggering receptor expressed

(2) Ferroptosis-related mechanisms in prion diseases provide insights into neurodegeneration and reveal therapeutic implicationsRedox BiolApril 4, 2026Mohammed Zayed, Hilal Tayara, Byung-Hoon JeongSanta Cruz Biotechnology, sc-166570), SLC7A11 (1:100, ABclonal, A13685), 4-HNE antibody (1:50, Bioss Inc., bs-6313R), and NeuN (1:50, Abcam, ab177487) overnight in a humidity chamber at 4 °C. After washing with PBST,

(3) Optimized New Shengmai Powder suppresses ferroptosis in ischemic cardiomyocytes via cGMP-PKG signallingChin MedMarch 6, 2026Zeyu Zhang, Zhihua Yang, Zhuangzhuang Jia, Yuwei Song, Liuli Guo, Shuai Wang, Xianliang Wang, Jingyuan MaoBSA at room temperature for 30 min. For IHC, samples were incubated with primary antibodies (4-HNE: bs-6313R, BIOSS, Beijing, China; COX2: AF7003, Affinity, Liyang, Jiangsu, China) in a humidified chamber at 4

(4) Coq4 deficiency induces placental vascular development defects through FSP1/CoQ10 axis-mediated endothelial ferroptosisFront Cell Dev BiolMarch 2, 2026Rui Chen, Sikun Wang, Xueke He, Zhanbiao Wang, Miao JiangCoq4 antibody (0.04–0.4 μg/mL, Abcam, Cat: ab126295), 4-Hydroxynonenal antibody (1:2000, Bioss, Cat: BS-6313R), ACSL4 antibody (1:5000, Zenbio, Cat: R24265), SLC7A11 antibody (1:1000, CST, Cat: 98051S), FTH1 antibody

(5) CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A AxisAdvanced ScienceMarch 1, 2026Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, et al.(381204, ZenBioScience, China, 1:1000), anti‐GPX4 (R24461, ZenBioScience, China, 1:1000), anti‐4HNE (bs‐6313R, Bioss, China, 1:1000), and anti‐β‐actin (GB15003‐100, ServiceBio, China, 1:3000) as a loading control.

(6) AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets AccumulationAdvanced ScienceFebruary 1, 2026Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, et al.1:500), EGR1 (Proteintech, #22008‐1‐AP, 1:2500), SMPD1 (Proteintech, #14609‐1‐AP, 1:800), 4‐HNE (Bioss, #bs‐6313r, 1:2000), and β‐Actin (Bioworld, #AP0060, 1:5000). After incubation with horseradish peroxidase (HRP)‐conjugated

(7) Low-Intensity pulsed ultrasound reduces ovarian cryopreservation injury through the Notch signaling pathwayReproductive Biology and EndocrinologyJanuary 28, 2026Fengyu Zhu, Yiqing Zhang, Fang He, Ziyi Liu, Haonan Zhang, Chunhua Duan, Yayang Duan, Ying Zhu, Chaoxue Zhang, Yi Zhouagainst 3-nitrotyrosine (3-NT; catalog no. bs-8551R; Bioss, Beijing, China), 4-hydroxynonenal (4-HNE; bs-6313R; Bioss), 8-hydroxy-2-deoxyguanosine (8-OHdG; bs-1278R; Bioss), nuclear factor erythroid 2-related factor

(8) Qing-Chang-Hua-Shi granule ameliorates experimental colitis by modulating Lactobacillus gasseri-mediated ferroptosis metabolic pathwayChinese MedicineJanuary 26, 2026Cheng Cheng, Lei Zhu, Jingyi Hu, Wan Feng, Weiyang Li, Ryan Au, Yanan Li, Feng Xu, Yuguang Wu, Yuan Cui, et al.(ab211737), Claudin-5 (ab131259), and Muc-2 (ab272692) were purchased from Abcam. Antibodies against 4-HNE (bs-6313R) were purchased from Bioss. Antibodies against ACSL4 (66617-1), GPX4 (22401-1), and the secondary antibodies

(9) Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK–LCN2 pathwayEuropean Journal of Medical ResearchJanuary 26, 2026Boyang Liu, Shengxiang Ao, Li Luo, Lin Qiao, Tianyin Kuang, Hongyan Xiao, Jing Zhou, Shuangqin Yin, Huaping Liang, Fen Li, et al.sections were stained after overnight incubation at 4 °C with an Anti-4-hydroxynonenal (4-HNE; Bioss, bs-6313R, 1:100) antibody. The average optical density (AOD) of 4-HNE expression was quantified using image analysis

(10) Digoxin Attenuates Ocular Hypertension and Protects Trabecular Meshwork Cells via Ferroptosis InhibitionInvestigative Ophthalmology & Visual ScienceJanuary 21, 2026Xiaoyu Zhou, Zheng Li, Xinyue Zhang, Jiahao Xu, Ping Wu, Wenxiang Zhu, Dan Ji, Xuanchu Duanantigen retrieval, the sections were incubated overnight with 4-HNE antibody (BIOSS, Beijing, China, bs-6313R) at 4°C. The sections were then incubated with polymer–horseradish peroxidase goat anti-rabbit secondary

(11) Magnolol Ameliorates Cisplatin-Induced Acute Kidney Injury with Activation of Nrf2-Associated Antioxidant ResponsesCurrent Issues in Molecular BiologyJanuary 17, 2026Mi-Gyeong Gwon, Min Hui Park, Jaechan LeemCarlsbad, CA, USA; Cat# PA5-79590; 1:200) or 4-hydroxynonenal (4-HNE; Bioss, Woburn, MA, USA; Cat# BS-6313R; 1:200). Following several washes, a peroxidase-linked goat anti-rabbit IgG secondary antibody (Abcam,

(12) Intermittent fasting enhances cisplatin-metformin efficacy in therapy-resistant ovarian cancer PDXsiScienceJanuary 16, 2026Elena Capellini, Ludovica Perotti, Federica Guffanti, Giulia De Simone, Aurelia Morabito, Anna Maria Ronchi, Laura Sala, Eugenio Scanziani, Daniela Corna, Domenico Cerullo, et al.Peroxidase 4-GPX4 (Abcam, ab125066, Rabbit monoclonal, 1:5000), 4-hydroxynonenal-4-HNE (Bioss Antibodies, bs-6313R, Rabbit polyclonal, 1:4000), Malondialdehyde-MDA (LS Biosciences, LS-C72018, Rabbit polyclonal, 1:1500).

(13) HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosisJournal of NanobiotechnologyDecember 13, 2025Zheng Xiao, Peng Luo, Guoli Li, Huifang Tan, Chen Zhou, Dong Zeng, Yinyin Chen, Ying Li(Col-I, cat.no.AF7001) antibodies were obtained from Affinity Biosciences (Jiangsu, China). 4-HNE (cat.no.BS-6313R) antibodies were purchased from Bioss (Beijing, China). Secondary antibody and DAB chromogen were purchased

(14) EUK nanozyme-loaded PL&GA coacervate droplets attenuate ulcerative colitis through restoring gut homeostasis and restricting intestinal cell ferroptosisMaterials Today BioDecember 1, 2025Mingxia Zhou, Linping Lu, Xinyu Xu, Yefan Zhou, Huan Fang, Xue Wang, Dongxu Li, Xiaoyan Li, Jiaqi Hua, Jiahe Liu, et al.serum, and incubated overnight at 4 °C with an anti-4-hydroxynonenal (4-HNE) primary antibody (1:200, bs-6313R, Bioss, China). 2.4.3 16S rDNA sequencing Colonic contents were collected and submitted to Metware

(15) Sestrin2 Exerts a Novel Protective Effect Against LPS ‐Induced Ferroptosis via the Nrf2– SLC7A11 – GPX4 Signaling AxisThe FASEB JournalNovember 30, 2025Xuerui Zhang, Jiawei Yin, Yuan Yang, Jie Peng, Yu Xu, Wenting Zhang, Haodong Xiao, Zupeng Lu, Huanyu Liu, Yanjun Wen, et al.24127‐1‐AP, RRID:AB_2879437), GPX4 (Proteintech Cat# 30388‐1‐AP, RRID:AB_3086304), 4‐HNE (Bioss Cat# bs‐6313R, RRID:AB_2827741), NRF2 (Proteintech Cat# 80593‐1‐RR, RRID:AB_2918904), P‐NRF2 (Bioss Cat# BSM‐52179R,

(16) Rescuing fertility: C-Phycocyanin prevents ovarian damage through NRF2-mediated ferroptosis pathways in polycystic ovary syndrome modelsZoological ResearchNovember 18, 2025Zhang Jing, ¹安徽医科大学第一附属医院妇产科, 国家卫生健康委员会配子与生殖道异常研究重点实验室, 安徽合肥 230022, 中国 ²安徽粮食工程职业学院粮食工程学院, 安徽合肥 230011, 中国 ³教育部生物保存与人工器官工程研究中心, 安徽合肥 230032, 中国 ⁴郑州大学附属郑州市中心医院妇产科, 河南郑州 450007, 中国 ⁵郑州市多囊卵巢综合征内分泌代谢与免疫重点实验室, 河南郑州 450007, 中国, Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China, Shen Qun-Shan, Chen Ya-Xin, Cheng Hui-Ru, Zhang Wei, Xing Ting, Liu Ya-Jing, Cao Yun-Xia, et al.obtained from MedChemExpress (USA). Various antibodies were purchased, including antibodies against 4-HNE (bs-6313R; Bioss, China), histone H3 (4499; Cell Signaling Technology, USA), β-actin (66009-1; Proteintech, China),

(17) Silicon‐Based Agent Attenuates Age‐Related Spermatogenesis DisorderInternational Journal of UrologyNovember 1, 2025Sohei Kuribayashi, Shinichiro Fukuhara, Hiroaki Kitakaze, Go Tsujimura, Takahiro Imanaka, Norichika Ueda, Kentaro Takezawa, Hikaru Kobayashi, Ryoichi Imamura, Norio Nonomuramicroscope. The primary antibodies used included rabbit anti‐4‐hydroxy‐2‐nonenal (anti‐4HNE; 1:300; # bs‐6313R, Bioss Antibodies Inc., MA, USA) and rabbit anti‐Ki67 (1:300; # ab16667; Abcam, MA, USA). Ki67 immunostaining

(18) Identification of Connexin 26 on Extracellular Vesicles from Human Cardiomyocytes and Plasma: Novel Insights into miRNA Loading and Oxidative InjuryInt J Mol SciOctober 17, 2025Letizia Mattii, Alessandra Falleni, Enza Polizzi, Antonella Cecchettini, Antonietta R. Sabbatini, Manuela Cabiati, Silvia Del Ry, Valentina Casieri, Vincenzo Lionetti, Federico Vozzi, et al.anti-GAPDH (SIGMA, Merck, G9545, 1:20,000), rabbit polyclonal anti-4HNE (BIOSS Antibodies, Woburn, MA, USA, bs-6313R, 1:100), mouse monoclonal anti-caspase 3 (BIOSS Antibodies, bsm-33199M, 1:100), mouse anti-MYL2 (Santa Cruz Biotechnologies

(19) Nanocomposite-loaded hybrid microneedles reshape dermal microenvironment through senolytic delivery and collagen XVII-mediated barrier repairMater Today BioOctober 12, 2025Fan Yang, Yahui Xiong, Shuying Chen, Fan Bie, Zhanpeng Li, Hengdeng Liu, Lijuan Liu, Zhaoqiang Zhang, Lei ChenChina). Monoclonal antibodies including MMP1(10371-2-AP, Biotech) and MMP3(17873-1-AP, Biotech), 4-HNE(bs-6313R, Bioss), 8-OHdG(bs-1278R, Bioss), NRF2(GB113808, Servicebio), HO-1(10701-1-AP, Proteintech), γH2A.X(GB111841,

(20) Hydrogen Sulfide-Preconditioned Mesenchymal Stem Cells Attenuate Ferroptosis in Corneal Alkali Burn via the AMPK/Nrf2/HO-1 Pathway in an IL-10-Dependent MannerInvestigative Ophthalmology & Visual ScienceSeptember 24, 2025Mingxiong Chen, Yilin Jiang, Hanrui Yu, Haolan Qi, Xiaoqi Li, Junyi Wang, An Wang, Zhao Li, Qun Wang, Yifei Huang, et al.overnight: anti-GPX4 (1:1000, ab125066; Abcam), anti-SLC7A11 (1:1000, ab307601; Abcam), anti-4-HNE (1:1000, bs-6313R; Bioss), anti-FTH1 (1:1000, DF6278; Affinity), anti-p-AMPK (1:1000, 2535T; CST), anti-AMPK (1:1000,

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4 Hydroxynonenal Polyclonal Antibody from Bioss Inc.

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4 Hydroxynonenal Polyclonal Antibody from Bioss Inc.

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