beta-Catenin (6B3) Rabbit mAb 9582S from Cell Signaling Technology

Product Specs
Itembeta-Catenin (6B3) Rabbit mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number9582S
Quantity100 µl
ApplicationsW, IP, IHC-P
ReactivityH, M, R, Mk
TargetCatenin-beta
HostRabbit
NCBI Gene AliasesCTNNB, EVR7, MRD19, NEDSDV, armadillo
ClonalityMonoclonal
NCBI Full Gene Namecatenin beta 1
Research AreaDevelopmental Biology
IsotypeIgG
Clone6B3
Molecular Weight92

Questions and Answers

Can this antibody be used to study the role of β-catenin in cancer progression?

Yes, the β-Catenin (6B3) Rabbit mAb has been utilized in various studies to investigate the Wnt/β-catenin signaling pathway, which is known to play a critical role in cancer progression. For instance, in a study on triple-negative breast cancer, β-catenin was shown to be involved in regulating tumor progression through its interaction with long non-coding RNAs and downstream signaling pathways ().

Is this antibody effective for immunohistochemistry applications?

The β-Catenin (6B3) Rabbit mAb has been successfully employed in immunohistochemistry, as demonstrated in studies examining the expression of β-catenin in various tissues, including brain sections and cancer biopsies (, ). This suggests its utility in visualizing β-catenin localization in tissue samples.

What species can this antibody be used with in experimental settings?

This antibody is reactive with multiple species, including human, mouse, rat, and non-human primates. This broad reactivity allows for its application in comparative studies across different model organisms ().

Are there any specific cellular processes that this antibody has been shown to influence?

Yes, the β-Catenin (6B3) Rabbit mAb has been implicated in studies focusing on cell migration and invasion. For example, it was shown that β-catenin plays a crucial role in the migration of endometrial stromal cells, which is essential for processes such as trophoblast invasion during early pregnancy ().

Cell Signaling Technology

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Stereo-cell deciphers the spatial and functional heterogeneity of polyploid hepatocytesGigaScienceMarch 2, 2026Yongqing Yang, Jiahui Luo, Yier Cai, Pengcheng Guo, Qiang Guo, Hong Wu, Longqi Liu, Shijie Haobackground was blocked with appropriate blocking buffer (P0102) at RT. β-Catenin antibody (Cell Signaling, 9582) was diluted properly and incubated with samples at RT for 2 h. Corresponding secondary antibody was

(2) Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision RepairAdvanced ScienceJanuary 1, 2026Lan Wang, Shi‐Hao Bai, Shu‐Jin Song, Xiao‐Li Zhang, Xue‐Ying Shang, Zhao‐Ning Lu, Xiao‐Fang Cui, Xin‐Le Zhu, Ze‐Guang Hanab73593), anti‐Ki67 (Cell Signaling Technology, #12202), anti‐β‐Catenin (Cell Signaling Technology, #9582), anti‐Xpc (Abclonal, A8354), anti‐Xpa (Proteintech, 16462‐1‐AP), anti‐Ercc8 (Proteintech, 10818‐1‐AP),

(3) Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathwayAnnals of MedicineDecember 31, 2025Li Liu, Wenxuan Liu, Wenhong DengCell Signaling Technology), Snail-2 (catalogue #3879S, Cell Signaling Technology),β-catenin (catalogue #9582S, Cell Signaling Technology). 2.3. Cell transfection The pCMV6 plasmids used for transfection contained

(4) Targeting of the m6A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancerNature CommunicationsDecember 13, 2025Heming Zhou, Huarong Chen, Weixin Liu, Cong Liang, Shiyan Wang, Kai Yuan, Alvin Ho Kwan Cheung, Yuet Wu, Wei Kang, Henley Cheung, et al.default. Co-IP Protein lysates from colorectal CSC spheres were incubated with either anti-β-catenin (#9582, CST) or IgG for 4 h at room temperature. Then the antibody-bound proteins were incubated with protein

(5) BRUCE liver-KO enhances MASLD/MASH development in the steatotic PTEN-KO background by impairing mitochondrial metabolism and activating STAT3Cell Death & DiseaseDecember 11, 2025Lixiao Che, Camille K. Stevenson, David R. Plas, Jiang Wang, Chunying Dufor IHC). Cell Signaling: Actin (3700), AKT (9272), phospho-AKT (Ser473) (pAKT-S473, 4060), β-Catenin (9582), cleaved Caspase-3 (9961), F4/80 (70076), GSK3β (9315), phospho-GSK3β (Ser9) (pGSK3β-S9, 9336), γH2AX

(6) Targeting CXCR6 Disrupts β-Catenin Signaling and Enhances Sorafenib Response in Hepatocellular CarcinomaCancers (Basel)November 28, 2025Morgan Reeves, Anastasia Chambers, Abhishek Shrestha, Sergio Duarte, Ali Zarrinpar, Siobhan Malany, Satyamaheshwar PeddibhotlaWaltham, MA, USA; #PA5-19936, 1:500), anti-β-catenin (Cell Signaling Technology, Danvers, MA, USA #9582; 1:500), pCREB (Cell Signaling Technology, #9198S; 1:500), GSK3β (Cell Signaling Technology, #9832;

(7) Restoration of BAP1 activity via base editing suppresses anchorage-independent survival in kidney cancerCancer Cell InternationalNovember 25, 2025Daye Lee, Boram Lee, Jiyeon Lee, Jongbum Kwonanti-cyclobutane pyrimidine dimers (CPD; CAC-NM-DND-001) from Cosmo Bio; and anti-H2A (12349), anti-β-catenin (9582), anti-N-cadherin (13116), anti-vimentin (5741), and anti-Cas9 (19526) from Cell Signaling Technology. Generation

(8) GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1Journal of Clinical InvestigationNovember 17, 2025Heba S. Allam, Scarlett Acklin-Wehnert, Ratan Sadhukhan, Mousumi Patra, Fen Xia(Cell signaling, 9386S) P GSK3 (Tyr216) (Santa Cruz Biotechnology, sc-135653), B-Catenin (6B3; Cell signaling, 9582), BRCA1 (Santa Cruz Biotechnology, SC-6954), Anti-RPA32/RPA2 (phospho S33) (Novus Biologicals, NB100–544),

(9) SARS-CoV-2 Infection Influences Wnt/β-Catenin Pathway Components in AstrocytesPathogensOctober 2, 2025KaReisha F. Robinson, Avantika I. Ahiya, Justin M. Richner, Sarah E. Lutzantibody for 1 h at room temperature (RT) with either β-catenin (1:500; Rabbit, Cell Signaling, Cat. #9582, USA) or β-actin (1:10,000, Mouse, Abcam, Cat. #ab6276, Cambridge, UK) overnight at 4 °C in Intercept

(10) Dual-edged mechanisms of α-tomatine in hepatocellular carcinoma by suppression of Wnt/β-catenin signaling versus RelB-Driven resistance in tumor therapyFrontiers in PharmacologySeptember 22, 2025Tianzhen Wang, Chenyue Xu, Yanling Yuan, Bianhong ZhangCST), anti-p100 (1:1000, Cat 05–361, Sigma), anti-IKK1 (1:1000, Cat 2682, CST), β-catenin (1:2000, Cat 9582, CST), anti-Axin2 (1:1000, Cat 20540-1-AP, proteintech), anti-cyclin A (1:1000, Cat sc-271682, Santa Cruz

(11) USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitinationActa Pharmaceutica Sinica BSeptember 1, 2025Ling Xu, Zimu Zhang, Juanjuan Yu, Tongting Ji, Jia Cheng, Xiaodong Fei, Xinran Chu, Yanfang Tao, Yan Xu, Pengju Yang, et al.USA), HA-Tag (CST, 3724S, Danvers, USA), IgG (Abcam, ab172730, Cambridge, MA, USA), β-Catenin (CST, 9582S, Danvers, USA), GFP (Proteintech, 66002-1-Ig, Wuhan, China), GAPDH (Abcam, ab128915, Cambridge, MA,

(12) Wnt/β-Catenin Signaling Regulates Hepatitis B Virus cccDNA LevelsInt J Mol SciJuly 19, 2025Atsuya Ishida, Sadahiro Iwabuchi, Ying-Yi Li, Kazuhisa Murai, Takayoshi Shirasaki, Kazuyuki Kuroki, Tetsuro Shimakami, Koki Nio, Kazunori Kawaguchi, Tadashi Imafuku, et al.University of Science), anti-DOCK11 (GTX55982, 1:1000, GeneTex Inc, Irvine, CA, USA), anti-β-catenin (#9582, 1:1000, Cell Signaling Technology Inc, Danvers, MA, USA), anti-β-catenin (ab16051, 1:1,000, Abcam)

(13) Metabolically Engineered Extracellular Vesicles Released From a Composite Hydrogel Delivery System Regulate the Microenvironment for Periprosthetic Osteolysis TreatmentJ Extracell VesiclesJune 23, 2025Chenchen Wang, Jiang Ju, Chao Fu, Bingbo Bao, Tianhui Ren, Yanan Li, Yuan Wang, Sheng Han, Yuan Wang, Xuan Huang, et al.temperature. The membranes were scanned using a Tanon 4500. Primary antibodies included anti‐β‐catenin (CST, 9582, USA), anti‐P‐β‐catenin (CST, 4176, USA), WNT‐3a (CST, 2721, USA), anti‐osteopontin (Forevertech Biotechnology,

(14) Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarctionTheranosticsJune 18, 2025Ajit Magadum, Vandana Mallaredy, Rajika Roy, Darukeshwara Joladarashi, Charan Thej, Zhongjian Cheng, Maria Cimini, May Truongcao, Adam Chatoff, Claudia V Crispim, et al.Biosystems,AF3628 OHG,1:100,Abcam,ab62623 WGA,1:50,Life technology,W11261 β-catenin,1:200,Cell signaling,9582 DsRed,1:200,Living Colors,632496 Troponin I,1:200,Abcam,Ab47003 Troponin T,1:200,Invitrogen,MA5-12960 CD45,1:200,R&D

(15) Development of a reliable method for human triple-negative breast cancer organotypic culture: Improving imaging and genomic studies in 3D culturesJ Tissue EngMay 7, 2025Mercedes Olvera-Valencia, Verónica Garcia-Castillo, Rosalío Ramos-Payan, Maribel Aguilar-Medina, Samuel Trujano-Camacho, Alejandro López-Saavedra, Laurence A. Marchat, Cesar López-Camarillo, Ronen Sumagin, Eloy Pérez-Yepez, et al.Membranes were incubated overnight with primary antibodies at a 1:1000 dilution: β-catenin (Total, 9582S), Active p-β-catenin (Ser33/37/Thr41, 8814S), AKT (Cell Signaling, 9272S), p-AKT S473 (Cell Signaling,

(16) EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancerEMBO Molecular MedicineMay 6, 2025Dana Krauß, Veronica Moreno-Viedma, Emi Adachi-Fernandez, Cristiano de Sá Fernandes, Jakob-Wendelin Genger, Ourania Fari, Bernadette Blauensteiner, Dominik Kirchhofer, Nikolina Bradaric, Valeriya Gushchina, et al.,Cell Signaling Technology,"Cat# 4874, RRID:AB_2121214" beta-Catenin (6B3) Rabbit mAb (1:1000),Cell Signaling Technology,"Cat# 9582, RRID:AB_823447" EGF Receptor (D1P9C) Rabbit mAb (Mouse Preferred) (1:1000),Cell Signaling Technology,"Cat#

(17) Tobacco carcinogen NNK promotes pancreatic cancer proliferation via LINC00857/β-cateninTob Induc DisApril 29, 2025Cancan Zhou, Ruiqi Cao, Qiqi Wang, Jiantao Mo, Weikun Qian, Zhengyuan Feng, Shengzhan Zhang, Xin Chen, Jie Hao, Qingyong Ma, et al.ChemiDoc XRS System (Bio-Rad, Hercules, CA, USA). Primary antibodies included: anti-β-catenin (1:1000, #9582, Cell Signaling Technology), anti-PCNA (1:2000; 60097-1-Ig, Proteintech, Wuhan, China), anti-CyclinD1

(18) Isorhapontigenin Inhibits Cell Growth, Angiogenesis, Migration, and Invasion of Non-Small-Cell Lung Cancer Cells Through NEDD9 SignalingInternational Journal of Molecular SciencesApril 29, 2025Zhuo Zhang, Jingxia Li, Daneah Willis, Sophia Shi, Huailu Tu, Max CostaMD, USA). Primary antibodies against NEDD9 (Cat# 4044), non-p-β-Catenin (Cat# 19807), β-Catenin (Cat# 9582), and secondary antibodies against mice (Cat# 7056) and rabbits (Cat# 7054) were purchased from Cell Signaling

(19) HNF4α inhibits the malignancy of intrahepatic cholangiocarcinoma by suppressing the Wnt signaling pathwayTranslational OncologyMarch 1, 2025Bo-Nan Xu, Cheng-Hong Ding, Yi-Long Liu, Yuan-Yuan Luo, Juan Deng, Shu-Qing Liu, Meng-Chao Xiao, Nan Jiang, Xin Zhang, Wen-Ping Xu, et al.(Cell signaling Technology, 2920S), p-β-catenin (Cell signaling Technology, 9566S), and β-catenin (Cell signaling Technology, 9582T). Human ICC xenograft model Male BALB/c nude mice (6 weeks old) were purchased from Shanghai Bikai

(20) Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regenerationSci AdvFebruary 21, 2025Allen S. W. Oak, Amrit Bagchi, Matthew J. Brukman, Joshua Toth, Jamie Ford, Ying Zheng, Arben Nace, Ruifeng Yang, Jen-Chih Hsieh, James E. Hayden, et al.as follows: E-cadherin (Rabbit mAb no. 3195, Cell Signaling Technology), β-catenin (Rabbit mAb no. 9582, Cell Signaling Technology), GAPDH (glyceraldehyde-3-phosphate dehydrogenase; Rabbit polyclonal NB100-56875,

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beta-Catenin (6B3) Rabbit mAb

beta-Catenin (6B3) Rabbit mAb from Cell Signaling Technology

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Questions and Answers

Cell Signaling Technology

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beta-Catenin (6B3) Rabbit mAb from Cell Signaling Technology

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