PTEN (138G6) Rabbit mAb 9559L from Cell Signaling Technology

Product Specs
ItemPTEN (138G6) Rabbit mAb
CompanyCell Signaling Technology
Price $834.00 Inquire
Catalog Number9559L
Quantity300 µl
ApplicationsW, IP, IHC-Bond, IHC-P
ReactivityH, M, R, Mk
TargetPTEN
HostRabbit
NCBI Gene Aliases10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1
ClonalityMonoclonal
NCBI Full Gene Namephosphatase and tensin homolog
Research AreaPI3K / Akt Signaling
IsotypeIgG
Clone138G6
Molecular Weight54

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-lossCell Reports MethodsApril 20, 2026Jessica Kalla, Thomas Dillinger, Zlata Pavlovicova, Reema Jacob, Emine Atas, Katarina Mišura, Anil Baskan, Kristina Draganić, Andreas Tiefenbacher, Tanja Limberger, et al.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Rabbit monoclonal anti-PTEN (138G6),Cell Signaling Technology,Cat#9559; RRID:AB_390810 Rabbit monoclonal anti-STAT3 (D3Z2G),Cell Signaling Technology,Cat#12640; RRID:AB_2629499 Mouse

(2) Repurposing drugs for treating the Neurobehavioral manifestations of PTEN hamartoma tumour syndromeiScienceApril 17, 2026Tim Fieblinger, Judith Rudolph, Kerstin Müller, Petra Friess, Nicole Weigelt, Christina Thiede, Simone Modolo, Denise Federico, Malik Majandinow, Federico Tinarelli, et al.capillaries. The following antibodies and dilutions were used: rabbit anti-PTEN (138G6), Cell Signaling (#9559), 1:25; rabbit anti-phospho-AKT (Ser473), Cell Signaling (#3787), 1:40; rabbit anti-GAPDH, Cell Signaling

(3) PTEN restrains SHH medulloblastoma growth through cell autonomous and nonautonomous mechanismseLifeApril 17, 2026Zhimin Lao, Salsabiel El Nagar, Yinwen Liang, Daniel N Stephen, Alexandra L JoynerXP,Cell Signalling Tech,Cat# 9188,IF (1:300) Antibody,Rabbit monoclonal Pten,Cell Signalling Tech,Cat# 9559,IF (1:200) Antibody,Rabbit monoclonal pAKT (Ser473),Cell Signalling Tech,Cat# 4060,1IF (:400) Antibody,Mouse

(4) Jingangteng Capsule Attenuates Ulcerative Colitis via Maintaining the Homeostasis of Intestinal Microbiota and Metabolites, Inhibiting the PI3K-AKT-mTOR Signaling PathwayPharmaceuticals (Basel)April 7, 2026Jing Li, Yue Xiong, Shiyuan Cheng, Dan Liu, Qiong Wei, Xiaochuan YeChina). Antibodies PI3K (4257T), p-PI3K (4228T), AKT (4691T), p-AKT (4060T), p-PDK1 (3438T), PTEN (9559T), p-mTOR (5536T) were supplied by Cell Signaling Technology, Inc. (Danvers, MA, USA). 4.2. UPLC-QTOF-MS/MS Analysis

(5) Enhancing neural stem cell integration in the injured spinal cord through targeted PTEN modulationNeural Regeneration ResearchApril 1, 2026Simay Genişcan, Hee Hwan Park, Hyung Soon Kim, Seokjin Yoo, Hyunmi Kim, Byeong Seong Jang, Dong Hoon Hwang, Kevin K Park, Byung Gon Kimnon-fat skimmed milk and incubated with rabbit anti-PTEN (1:2000, Cell Signaling, Danvers, MA, USA, Cat# 9559), rabbit anti-phosphorylated 40S ribosome protein S6 (1:2000, Cell Signaling, Cat# 4856) for overnight

(6) Exosomal Long Noncoding RNA H19 as a Biomarker and Therapeutic Target in Atrial FibrillationInt J Biol SciMarch 17, 2026Ji-Young Kang, Dasom Mun, Malgeum Park, Gyeongseo Yoo, Nuri Yun, Boyoung Joung(ab47003, 1:1,000; Abcam, Cambridge, UK), MYL2 (sc-517244, 1:1,000; Santa Cruz Biotechnology Inc.), PTEN (9559S, 1:1,000; Cell Signaling Technology), AKT (9272S, 1:1,000; Cell Signaling Technology), p-AKT (9271S,

(7) Epilepsy-associated FOXJ3 variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical laminationNat CommunMarch 9, 2026Haw-Yuan Cheng, Chen Liu, Chiao-Wen Nien, Hui-Chin Huang, Hong-Jun Zhao, Fang-Shin Nian, Chien Chen, Helena Martins Custodio, Sanjay M. Sisodiya, Chien Lu, et al.https://www.affbiotech.com/goods-1139-AF0602-FOXJ3_Antibody.html), PTEN (Cell Signaling Technology, 9559S, 1:3000, https://www.cellsignal.com/products/primary-antibodies/pten-138g6-rabbit-mab/9559), TSC1 (Cell Signaling Technology

(8) PKC-eta promotes breast cancer metastasis by regulating the Hippo–YAP signaling pathwaySignal Transduction and Targeted TherapyFebruary 17, 2026Vijayasteltar B. Liju, Kamran Waidha, Amitha Muraleedharan, Divya Ram Jayaram, Hodaya Haimov, Sankar Jagadeeshan, Dinesh Babu Manikandan, Raghda Abu Shareb, Livingstone Nurukurti, Menachem Sklarz, et al.(CST, #53749), pYAP (Ser397) (CST, #13619), pTAZ (Ser89) (CST, #75275), TAZ (CST, #83669), PTEN (CST, #9559) Lamin B1 (CST, #13435), AKT (pan) (CST, #4691), AXL (CST, #8661), Pan-TEAD (CST, #13295), CYR61 (CST,

(9) ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expressionNatureFebruary 4, 2026Siva Kumar Natarajan, Joanna Lum, James Haggerty Skeans, Minal Nenwani, Sanjana Eyunni, Mateus Mota, Jill M. Bayliss, Akash Deogharkar, Erin Taya Hamanishi, Matthew Pun, et al.GLS-mouse (Invitrogen, PA5-35365, 1:1,000); MYC (Abcam, 32072, 1:1,000); PTEN (Cell Signaling Technology, 9559, 1:1,000); pAKT (S473) (Cell Signaling Technology, 9271, 1:1,000); AKT (Cell Signaling Technology, 4056,

(10) Decay of driver mutations shapes the landscape of intestinal transformationNatureJanuary 15, 2026Filipe C. Lourenço, Iannish D. Sadien, Kim Wong, Sam Adler, Ashley Sawle, Leonor Schubert Santana, Lee Hazelwood, Giada Giavara, Anna M. Nicholson, Matthew D. Eldridge, et al.SQX-SQM001, Squarix Biotechnology), GFP (10 µg ml−1, chicken, ab13970, Abcam), PTEN (1:300, rabbit, 9559, Cell Signalling), BrdU (2.6 µg ml−1, sheep, ab1893, Abcam), CD326 (EPCAM) AlexaFluor 647 antibody (1:2,000,

(11) EML4−ALK Variant-Specific Genetic Interactions Shape Lung TumorigenesisCancer DiscoveryJanuary 12, 2026Alberto Diaz-Jimenez, Emily G. Shuldiner, Kalman Somogyi, Karen Y. Shih, Óscar González-Velasco, Mulham Najajreh, Stewart Kim, Filiz Akkas, Christopher W. Murray, Laura Andrejka, et al.RRID:AB_1950412), Rabbit Anti-Rb (Abcam Cat#ab181616, RRID:AB_2848193), Rabbit anti-Pten138G6 (Cell Signaling Cat#9559 RRID:AB_390810), Rabbit Anti-pStat3(Tyr705) D3A7 (Cell Signaling Cat# 9145, RRID:AB_2491009), Rabbit

(12) Targeting Tumor Microenvironment–Derived NRG1-HER2/3 Signaling with Zenocutuzumab Restores Sensitivity to AR Inhibition in PTEN Wild-type Prostate CancerMolecular Cancer TherapeuticsDecember 30, 2025Brian M. Shinder, Young Sun Lee, Ninghui Mao, Nazifa Salsabeel, Zeda Zhang, Harmanpreet Kaur, Xiaoping Chen, Qing Chang, Elisa de Stanchina, Anuradha Gopalan, et al.(Cell Signaling Technology, 8245, RRID:AB_10831198), AR (Abcam, ab108341, RRID:AB_10865716), PTEN (Cell Signaling Technology, 9559, RRID:AB_390810), COL1A2 (Proteintech, 66761-1-IG, RRID:AB_2882107). The following cytokines were used

(13) Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR1) in lupus nephritis: A novel therapeutic targetJ Cell Commun SignalDecember 19, 2025Yuehong Ma, Yi Wang, Peng Zhao, Li Cheng, Lei Li, Rongshan Li, Xiaoshuang Zhouprimary rabbit antibodies, including C5aR (1:500, Catalog #21316‐1‐AP, Proteintech), PTEN (Catalog #9559, Cell Signaling Technology), phosphorylated‐AKT (p‐AKT, Ser473; Catalog #4060, Cell Signaling Technology),

(14) Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancerCommunications BiologyDecember 17, 2025Lisa M. Ooms, Daniel T. Ferguson, Samuel J. Rodgers, Karmanpreet K. Sukhija, Emily I. Jones, Mariah P. Csolle, Hon Yan Kelvin Yip, Roger J. Daly, Tony Tiganis, Catriona A. McLean, et al.pS6Ser235/236 (#4858), pS6Ser240/244 (#5364), HA (#3724), PI3K p110α (clone C73F8, #4249), PTEN (clone 138G6, #9559) Cell Signaling Technology (Boston, MA, all diluted 1/1000); Ki67 (RM-9106-SO, diluted 1/800), GAPDH

(15) Selective anti-cancer effects of cannabidiol and Δ9-tetrahydrocannabinol via PI3K/AKT/mTOR inhibition and PTEN restoration in ovarian cancer cellsFront PharmacolDecember 15, 2025Siyao Tong, Watcharin Loilome, Nisana Namwat, Poramate Klanrit, Arporn Wangwiwatsin, Zar Zar Win, Preeya Koyabuth, Bandit Chumworathayianti-Akt (Cell Signaling Technology, Cat# 4691), rabbit anti-PTEN (Cell Signaling Technology, Cat# 9559), rabbit anti-phospho-Akt (Cell Signaling Technology, Cat# 4060), and rabbit anti-GAPDH (Cell Signaling Technology

(16) The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcomaNat CommunDecember 10, 2025Qiqi Yang, Yueyang Wang, Luis A. Corchete Sanchez, Sabateeshan Mathavarajah, Qian Qin, Yun Wei, Eric Alpert, Lauren Whelton, Priyanshu Sharma, Stephanie Strom, et al.Western blot analysis was performed as previously described25. Primary antibodies used included PTEN (CST, 9559), p-PTEN (Ser380/Thr382/383) (CST, 9551), EGFR (abcam, ab52894), PI3K p85 (CST, 4292), p-PI3K p85 (Tyr458)

(17) Systemic miR-26a deficiency attenuates pulmonary fibrosis via PTEN upregulation and downstream TIMP-1 suppressionMolecular Therapy Nucleic AcidsDecember 9, 2025Arisa Hamada, Kiyofumi Shimoji, Taku Nakashima, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Hiroshi Iwamoto, Hironobu Hamada, Yun Guo, et al.rabbit anti-TIMP-1 antibody (BS-0415R, 1:200, Bioss, Woburn, MA, USA) and rabbit anti-PTEN antibody (#9559, 1:1,000; CST, USA). Next, HRP-labeled anti-rabbit immunoglobulin G (IgG) antibody (#424144, Nichirei,

(18) Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusionJournal of Clinical InvestigationDecember 1, 2025Fen Ma, Sen Chen, Luigi Cecchi, Betul Ersoy-Fazlioglu, Joshua W. Russo, Seiji Arai, Seifeldin Awad, Carla Calagua, Fang Xie, Larysa Poluben, et al.3063, 1:1,000), AKT2 pS474 (Cell Signaling Technology, 8599, 1:1,000), PTEN (Cell Signaling Technology, 9559, 1:1,000), PHLPP1 (Abcam, ab305295, 1:1,000), and PHLPP2 (Bethyl Laboratories, A300-661A, 1:2,000). Immunohistochemistry. Primary

(19) Ferroptotic resistance involved in PTEN-loss prostate cancer progressionDiscover OncologyNovember 25, 2025Yaoyao Jing, Donghui Xing, Zhigang Zhao, Xiaofang Wangpromotes GPX4 transcription. Materials and methods Antibodies and reagents The antibodies to PTEN (#9559), AKT (#9272) and p-AKT (#4060) were purchased from Cell Signaling Technology (Danvers, MA, USA). The

(20) BMP-7 Treatment Ameliorates PTEN-Akt Mediated Apoptosis and Adverse Cardiac Remodeling in Ponatinib-Induced CardiotoxicityPharmaceuticals (Basel)November 22, 2025Jonatas M. Rolando, Dinender K. Singlacaspase-3 (Cell Signaling; Cat. #9662S), Bcl2 (Cell Signaling; Cat. #3498S), PTEN (Cell Signaling; Cat. #9559L), pAkt (Cell Signaling; Cat. #4058L), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Cell Signaling;

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(1)

11/23/2015Decent Antibody to Work With Shikha SainiPTEN is a tumor suppressor gene and has crucial role in MAPK signaling and apoptotic pathway. I used PTEN antibody from Cell signaling and it worked Ok for me. I would recommend to use this antibody ... Read Review
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5/20/2015PTEN Antibody in Western Blot Ipek EvenThe main purpose of our work is to identify new functional roles of candidate genes in the cellular network. In order to understand their functional roles, we downregulate the candidate genes in ... Read Review
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1/23/2014PTEN Detection by WB Raul PeñaPTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of ... Read Review

PTEN (138G6) Rabbit mAb

PTEN (138G6) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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PTEN (138G6) Rabbit mAb from Cell Signaling Technology

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