eIF4G (C45A4) Rabbit mAb 2469S from Cell Signaling Technology

Product Specs
ItemeIF4G (C45A4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2469S
Quantity100 µl
ApplicationsW, IHC-P, IF-IC, FC-FP
ReactivityH, M, R, Mk
TargeteIF4G
HostRabbit
NCBI Gene AliasesEIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18
ClonalityMonoclonal
NCBI Full Gene Nameeukaryotic translation initiation factor 4 gamma 1
Research AreaTranslational Control
CloneC45A4
Molecular Weight220

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferaseNature CommunicationsJanuary 7, 2026Na Wang, Fanjia Hou, Sihui Ma, Silan Liu, Haimei Wei, Weicheng Fang, Ke Zhang, Yun GeIB), anti-HA (Proteintech #66006-2-Ig, 1:400 IF; CST #3724, 1:800 IF, 1:1000 IB), anti-eIF4G (CST #2469; 1:300 IF, 1:1000 IB), anti-UBAP2L (CST #40199; 1:300 IF), anti-G3BP1 (Abcam #ab56574; 1:300 IF, 1:1000

(2) Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma DedifferentiationAdvanced ScienceNovember 1, 2025Kang Ning, Bu Zou, Yongchao Yu, Taonong Cai, Zhenyu Luo, Yu Guo, Yi Wu, Xiujiao Shen, Hao Li, Mengyuan Fang, et al.Technology Cat#2013), eIF4E (Cell Signaling Technology Cat#2067), eIF4G (Cell Signaling Technology Cat#2469). Multiplex Immunofluorescence (MIF) and Immunohistochemistry (IHC) To evaluate the expression of

(3) The Nucleocapsid protein of Crimean Congo hemorrhagic fever virus interacts with eIF4A to promote the translation of viral mRNA in cellsJournal of Biological ChemistryMay 4, 2025Saima Ali, Songyang Ren, Alexis Agsaoa, Sheema Mir, Mohammad A. Mirsecondary antibodies diluted in blocking buffer. The primary antibodies for eIF4A (Cat# 2013S), eIF4G (Cat# 2469S), eIF4E (Cat# 2067S), phosphor-4EBP1 (Cat# 2855), 4EBP1 (Cat# 9452), and ant-His tag antibody (Cat#

(4) Small molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cellsJournal of Clinical InvestigationJanuary 27, 2025Michelle A. Lum, Kayla A. Jonas, Shreya Parmar, Adrian R. Black, Caitlin M. O'Connor, Stephanie Dobersch, Naomi Yamamoto, Tess M. Robertson, Aidan Schutter, Miranda Giambi, et al.sc-9976, 1:2,000–1:4,000), phospho-eIF4E Ser209 (CST-9741, 1:1,000), eIF4G (sc-133155, 1:1,000, or CST-2469, 1:100,000), AKT (CST-9272, 1:3,000), phospho-AKT S473 (CST-4060, 1:20,000), phospho-AKT T308 (CST-2965,

(5) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E functionNat CommunNovember 20, 2024Swee Y. Sharp, Marianna Martella, Sabrina D'Agostino, Christopher I. Milton, George Ward, Andrew J. Woodhead, Caroline J. Richardson, Maria G. Carr, Elisabetta Chiarparin, Benjamin D. Cons, et al.(rabbit anti-eIF4E, Cell Signalling, Cat#9742, RRID:AB_823488), eIF4G1 (rabbit anti-eIF4G, CST, Cat# 2469, RRID:AB_2096028) or 4E-BP1 (rabbit anti-4E-BP1, CST, Cat#9452, RRID:AB_331692). Plates were then washed

(6) The RNA binding protein Arid5a drives IL-17–dependent autoantibody-induced glomerulonephritisJournal of Experimental MedicineSeptember 2, 2024Yang Li, Shachi P. Vyas, Isha Mehta, Nariaki Asada, Ipsita Dey, Tiffany C. Taylor, Rami Bechara, Nilesh Amatya, Felix E.Y. Aggor, Bianca M. Coleman, et al.Santa Cruz Biotechnology), β-actin (ab49900; Abcam), Puromycin (12D10; Millipore), RPL7A (15340-1-AP; Proteintech), eIF4G (2469S; Cell Signaling), eIF4E (9742S; Cell Signaling), FLAG M2 (F3165; Sigma-Aldrich), YY1 (sc1703; Santa Cruz Biotechnology

(7) Formation of the NLRP3 inflammasome inhibits stress granule assembly by multiple mechanismsThe Journal of BiochemistryMay 31, 2024Daisuke Yoshioka, Takanori Nakamura, Yuji Kubota, Mutsuhiro Takekawa611126, 1:2000), anti-G3BP2 (Abcam, ab86135, 1:5000), anti-eIF4G C45A4 (Cell Signaling Technology, #2469, 1:2000), anti-p68 RNA helicase (DDX5) D-7 (Santa Cruz Biotechnology, sc-365164, 1:200), anti-DHX33

(8) Ribonuclease inhibitor and angiogenin system regulates cell type–specific global translationScience AdvancesMay 31, 2024Martina Stillinovic, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Frédéric Greub, Giuseppe Bombaci, Camille Ansermet, Marco Zatti, Dipanjali Saha, Jieyu Xiong, et al.,Santa Cruz Biotechnology,sc-32318 Anti-eIF4E,Human,Santa Cruz Biotechnology,sc-9976 Anti-eIF4G,Human,Cell Signaling,2469T Anti-LARP1,Human,Santa Cruz Biotechnology,sc-515873 Anti-eIF2a,"Human, mouse",Santa Cruz Biotechnology,sc-133132 Anti–P-eIF2a,"Human,

(9) Pifithrin-µ Induces Stress Granule Formation, Regulates Cell Survival, and Rewires Cellular SignalingCellsMay 21, 2024Hicham Mahboubi, Henry Yu, Michael Malca, David McCusty, Ursula Stochaj,Santa Cruz Biotechnology,sc-28237,1:1000,NA Hsp70 (hsp72),"Enzo Life Sciences, Toronto, ON, Canada",SPA-812,1:1000,NA eIF4G,Cell Signaling,#2469,NA,1:250 Lamin A,Santa Cruz Biotechnology,sc-20680,1:1000,NA PARP1,Santa Cruz Biotechnology,sc-25780,1:1000,NA p-AMPK-α1/2,Cell Signaling

(10) Major Group-B Enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditisPLoS pathogensMay 1, 2024Callon D, Glenet M, Lebreil AL, Heng L, Bouland N, Fichel C, Fornes P, Andreoletti L, Berri F.#4947); IRF-3 (D614C) Rabbit mAb (Cell Signaling, #11904); EiF4G (C45A4) Rabbit mAb (Cell Signaling, #2469) and β-Actin (8H10D10) antibody (Cell Signaling, #3700). HRP-coupled anti-mouse (NA9310V, GE Healthcare)

(11) Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasisNature MetabolismFebruary 9, 2024Krithika Ramachandran, Christopher R. Futtner, Meredith A. Sommars, Mattia Quattrocelli, Yasuhiro Omura, Ellen Fruzyna, Janice C. Wang, Nathan J. Waldeck, Madhavi D. Senagolage, Carmen G. Telles, et al.(12741), α-phospho-4EBP1 Thr37/Thr46 (2855), α-non-phospho4EBP1 Thr46 (4923), α−4EBP1 (9644), α-eIF4G (2469), α-phospho-S6 Ser240/Ser244 (5364), α-total S6 (2217), α-phospho-FOXO1 Ser256 (9461), α-FOXO1 (2880),

(12) Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model miceCell reportsAugust 29, 2023Longo F, Aryal S, Anastasiades PG, Maltese M, Baimel C, Albanese F, Tabor J, Zhu JD, Oliveira MM, Gastaldo D, et al.,Bethyl Laboratories,"Cat# A301-154A, RRID:AB_2097708" Rabbit monoclonal anti-eIF4G,Cell Signaling Technology,"Cat# 2469, RRID:AB_2096028" Mouse monoclonal anti-FMRP,BioLegend,"Cat# 834701, RRID:AB_2564993" Mouse monoclonal

(13) mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switchingCell reportsAugust 29, 2023Shin S, Han MJ, Jedrychowski MP, Zhang Z, Shokat KM, Plas DR, Dephoure N, Yoon SO.AB_823488" Anti-eIF4E2,Cell Signaling Technology,"79940, RRID: AB_2936837" Anti-eIF4G,Cell Signaling Technology,"2469, RRID: AB_2096028" Anti-eIF4G2,Cell Signaling Technology,"5169, RRID: AB_10622189" Anti-cyclin D3,Cell Signaling Technology

(14) Transcriptional-translational conflict is a barrier to cellular transformation and cancer progressionCancer cellMay 8, 2023Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, et al.(Cell Signaling Technology, 3597), anti-ATF4 (Cell Signaling Technology, 11815 ), anti-eIF4G (Cell Signaling Technology, 2469), anti- eIF4E (Santa Cruz Biotechnology, sc-271480), anti-eIF4A (Cell Signaling Technology, 2013), anti-p-4EBP1

(15) Implications of differential transcription start site selection on chronic myeloid leukemia and prostate cancer cell protein expressioniScienceDecember 22, 2022Surani AA, Spriggs KA, Ufer C, Polytarchou C, Montiel-Duarte C.,Cell Signaling Technology,Cat#2067; RRID:AB_2097675 Rabbit monoclonal anti-eIF4G (clone C45A4),Cell Signaling Technology,Cat#2469; RRID:AB_2096028 Rabbit monoclonal anti-eIF4H (clone D85F2),Cell Signaling Technology,Cat#3469; RRID:AB_2096038 "Anti-rabbit IgG, HRP-linked

(16) Replication Activities of Major 5′ Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta CellsVirusesDecember 13, 2022Domitille Callon, Aurélien Guedra, Anne-Laure Lebreil, Laetitia Heng, Nicole Bouland, Paul Fornès, Fatma Berri, Laurent AndreolettiTransfer Cell. The following antibodies were used: anti-VP1 (1/500, Dako, 5D8/1), anti-eIF4G (1/1000, #2469S, Cell Signaling Technology, Danvers, MA, USA) and monoclonal anti-β-actin antibody (1/1000, #3700, Cell

(17) GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcomaJCI insightDecember 8, 2022Morales J, Allegakoen DV, Garcia JA, Kwong K, Sahu PK, Fajardo DA, Pan Y, Horlbeck MA, Weissman JS, Gustafson WC, et al.4EBP1 (9644); (p)-4EBP1 (2855); 4EBP2 (2845); AKT (4691); (p)-AKT Ser473 (4060); EIF4E (2067); EIF4G (2469); EIF4E (2067); ERK (4695); (p)-ERK (4370); FGFR4 (8562); FOXO1 (2880); HA (3724); P70S6K (2708); (p)-p70S6K

(18) Thyroid Hormone Receptor β Knockdown Reduces Suppression of Progestins by Activating the mTOR Pathway in Endometrial Cancer CellsInternational journal of molecular sciencesOctober 19, 2022Ren B, Zhou J, Hu Y, Zhong R, Lv Q, Xie S, Li G, Yang B, Chen X, Zhu Y.(Ser65) (#9451, 15–20 kDa), 4EBP1 (#9644, 15–20 kDa), phospho-eIF4G (Ser1108) (#2441, 220 kDa), eIF4G (#2469, 220 kDa) and β-actin (#4970, 45 kDa) were diluted at 1:1000 (CST, Danvers, Massachusetts, USA). TRα

(19) Evaluation of Agar Dilution Method in Susceptibility Testing of Polymyxins for Enterobacteriaceae and Non-Fermentative Rods: Advantages Compared to Broth Microdilution and Broth MacrodilutionAntibiotics (Basel)October 11, 2022Xinxin Hu, Lilan Sun, Tongying Nie, Yan Yang, Xiukun Wang, Jing Pang, Xi Lu, Xue Li, Yun Lu, Congran Li, et al.19606,2,0.5,0.5,1,0.5,1 PMB,P. aeruginosa ATCC 27853,2,0.5,1,2,1,2 CST,E. coli ATCC 25922,2,1,1,1,0.5,1 CST,E. coli ATCC 2469,2,0.5,0.5,1,0.5,0.5 CST,K. pneumoniae ATCC 700603,4,0.5,0.5,1,0.5,1 CST,K. pneumoniae ATCC 2146,2,0.5,0.5,1,0.5,1 CST,A.

(20) Viral proteases activate the CARD8 inflammasome in the human cardiovascular systemThe Journal of experimental medicineOctober 3, 2022Nadkarni R, Chu WC, Lee CQE, Mohamud Y, Yap L, Toh GA, Beh S, Lim R, Fan YM, Zhang YL, et al.(Asp275; 36425; Cell Signaling Technology), GSDMDC1 (NBP2-33422; Novus Biologicals), anti-eIF4G(C45A4) (2469; Cell Signaling Technology), anti-PABP (10910-1-AP; Proteintech), anti–IL-18 (ab201324; Abcam), anti–IL-1β

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6/18/2020Great Antibody for eIF4G from CST Hong SunGreat antibody from Cell Signaling.

eIF4G (C45A4) Rabbit mAb

eIF4G (C45A4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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eIF4G (C45A4) Rabbit mAb from Cell Signaling Technology

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