cleaved PARP-1 (194C1439) Antibody sc-56196 from Santa Cruz Biotechnology, Inc.

Product Specs
Itemcleaved PARP-1 (194C1439) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-56196
NCBI Gene AliasesmsPARP, Adprp, parp-1, PPOL, ADPRT, ARTD1, PARP-1, ADPRT 1, Poly-PARP, PARS, Adprt1, PARP, 5830444G22Rik, sPARP-1, ADPRT1, pADPRT-1
Antibody TypePrimary Antibodies
Clone194C1439
Quantity50 µg/0.5 ml
Reactivitymouse, rat, human
ApplicationsWB, IP
FormatPurified
ClonalityMonoclonal
Hostmouse
Conjugate/TagUnconjugated
NCBI Full Gene Namepoly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) polymerase 1
TargetPARP-1
IsotypeIgG2b

Questions and Answers

Can this antibody be used to detect cleaved PARP in Western blotting experiments?

Yes, the cleaved PARP-1 (194C1439) antibody has been utilized in Western blotting to detect cleaved PARP, as evidenced by its application in various studies, including those that specifically mention its use for this purpose (, , ).

Is this antibody effective for use in immunoprecipitation assays?

The cleaved PARP-1 antibody has been shown to work in immunoprecipitation assays, as indicated by its applications in the literature, which highlight its role in studying apoptotic pathways ().

What species does this antibody react with?

This antibody is reactive with multiple species, including human, mouse, and rat, making it versatile for studies involving these organisms (, ).

Are there any specific studies that have cited the use of this antibody in cancer research?

Yes, the cleaved PARP-1 antibody has been cited in numerous studies related to cancer research, including investigations into the effects of various treatments on cancer cell apoptosis and viability, such as those involving adenine and cisplatin in hepatocellular carcinoma cells () and the effects of licochalcone A in lung cancer cells ().

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Exosomal misfolded α1-antitrypsin triggers a cytosolic GRP78-dependent unfolded protein response and pro-survival signaling in pre-metastatic tissuesJournal of Biological ChemistryJune 20, 2026Anuran Bhattacharya, Tiyasa Saha, Aditya Shukla, Ananya Banerjee, Himansu Roy, Urmi Chatterji"Santa Cruz Biotechnology, USA; SC-22140; RRID:AB_2259586",1:1000,- Anti-Cl-PARP,"Santa Cruz Biotechnology, USA; SC-56196; RRID:AB_785085",1:1000,- Anti-EDEM1,"Santa Cruz Biotechnology, USA; SC-377394",1:1000,- Anti-β-actin,"Santa Cruz Biotechnology

(2) Tetrahydrocurcumin Attenuates NaIO3-Induced Retinal Oxidative Injury via Suppression of NOX2-Derived ROS-Mediated ApoptosisAntioxidants (Basel)June 18, 2026Tzu-Chun Chen, Thuy-Lan-Thi Vo, Shang-Chun Tsou, Hui-Min David Wang, Inga Wang, Chen-Ju Chuang, Hui-Wen Lin, Yuan-Yen Changfollowing primary antibodies: cleaved-caspase-3 (sc-56053), Bax (sc-20067), Bcl-2 (sc-509), cleaved-PARP (sc-56196), K-RAS (sc-30), p-MEK1/2 (sc-81503), p-ERK1/2 (sc-31675), p47phox (sc-14015), β-actin (sc-47778), GAPDH

(3) Dietary Quercetin-3-Glucuronide Mitigates Oxidative Stress, Inflammation, and Fibroblast Transition by Regulating Nrf2 and Autophagy in Pulmonary FibrosisJournal of Agricultural and Food ChemistryJune 3, 2026Pei-Rong Yu, Chiao-Yun Tseng, Yu-Hsuan Liang, Yu-Ci Chang, Jing-Hsien Chen, Hui-Hsuan Lin(NBP2–33006) from Novus Biologicals (Centennial, CO); IL-1β (sc-12742), collagen (sc-25974), PARP-1 (sc-56196), caspase-3 (sc-7148), IL-6 (sc-32296), TGF-β (sc-130348), fibronectin (sc-8422), and vimentin (sc-373717)

(4) Targeting DHODH reveals a metabolic vulnerability in AR-positive and AR-negative prostate cancer cells via pyrimidine synthesis and metabolic crosstalk with the TCA and urea cyclesMolecular MetabolismFebruary 1, 2026Maxime Labroy, Marc-Oliver Paré, Line Berthiaume, Mélissa Thomas, Cynthia Jobin, Alain Veilleux, Martin Pelletier, Frédéric Pouliot, Jean-Yves Masson, Étienne Audet-Walshprimary antibodies DHODH (Cell Signaling Technology #26381), cleaved PARP (Santa Cruz Biotechnology #sc-56196), α-tubulin (Cell Signaling Technology #2125); ribosomal protein S6 (Santa Cruz Biotechnology #sc-74459);

(5) Downregulation of ZFP36L1 contributes to methotrexate resistance in osteosarcoma through enhanced NHEJ DNA repair mechanismsCell Death & DiseaseNovember 24, 2025Jiahao Zhuang, Mengjun Ma, Biao Yang, Yinliang Liu, Rujia Mi, Wen Yang, Yixuan Lu, Haoye Yu, Wangchang Wu, Yihui Song, et al.sections were incubated with primary antibody against ZFP36L1 (Solarbio, #K110803P), c-PARP (Santa Cruz, #sc-56196), c-caspase3 (CST, #9661S), DCLRE1C (Santa Cruz, #sc-518193), and γ-H2AX (CST, #2577S) overnight at

(6) HJ-4, a novel piperine derivative, inhibits tumor growth and angiogenesis via p53 activation and oncogenic pathway inhibition in colorectal cancer modelsScientific ReportsSeptember 29, 2025Luyao Zhang, Shunfang Liu, Dan Wang, Xingyu Zhang, Zhongke Hu, Xun Zou, Xiuming Li, Xiujun Wang, Dandan Xu, Wei Liu, et al.1:1000), PARP (Santa Cruz Biotechnology, sc-8007, 1:1000), cleaved PARP (Santa Cruz Biotechnology, sc-56196, 1:1000), caspase-3 (Beyotime, AF1213, 1:1000), cleaved caspase-3 (Beyotime, AF1261, 1:1000), and β-actin

(7) Targeting TGF-β–Smad2/3–JNK1-mediated SIRT1 activity overcomes the chemoresistance of KRAS mutation lung cancerExperimental & Molecular MedicineSeptember 12, 2025Dong Hoon Shin, Minyoung Choi, Chungyong Han, Sang Soo Kim(sc-37238) and antibodies including SIRT1 (sc-15454), KRAS (F234, sc-30), PARP (sc-8007) and cleaved PARP (sc-56196) were purchased from Santa Cruz Biotechnology. Antibodies against MKK4 (#9152), pMKK4 (Ser257/Thr261)

(8) Food insecurity impacts neuroblastoma pathogenesis in murine xenograft tumor modelsCommunications BiologyAugust 31, 2025Keyonna Williams, Sahiti Chukkapalli, Biao Hu, Delawrence Sykes, Kimber Converso-Baran, Olivia Tussing, Anjalika Dandamudi, Payton Thayer, Kendal Donnelly, Samantha Kaminsky, et al.(Cell Signaling #2118), anti-SMA Santa Cruz Biotechnology #sc-53015, anti-PARP1 (Santa Cruz Biotechnology #sc-56196), anti-MMP9 (Santa Cruz Biotechnology #sc-21733), anti-PCNA (Santa Cruz Biotechnology #sc-56). Membranes

(9) Exploring the Anticancer Properties of 1,2,3-Triazole-Substituted Andrographolide DerivativesPharmaceuticals (Basel)May 19, 2025Joana R. L. Ribeiro, Juliana Calheiros, Rita A. M. Silva, Bruno M. F. Gonçalves, Carlos A. M. Afonso, Lucília Saraiva, Maria-José U. Ferreirah with 5% skimmed milk. Membranes were then probed overnight with p21 (sc-6246) and cleaved PARP-1 (sc-56196) primary antibodies (from Santa Cruz Biotechnology, 1:100 dilution) and then with anti-mouse horseradish

(10) Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairmentMol MetabApril 3, 2025Barbara M. Crisol, Matheus B. Rocha, Beatriz Franco, Ana Paula Morelli, Carlos K. Katashima, Scylas J.A. Junior, Fernanda S. Carneiro, Renata R. Braga, Rafael S. Brícola, Graciana de Azambuja, et al.evaluations were performed by Western blotting using the following primary antibodies: anti-PARP1 (SC-56196) and anti-HSP60 (SC-59567) from Santa Cruz Biotechnology, Inc and anti-PAR (MABE1031) from Merck Life

(11) Tumor cell-derived EMP1 is essential for cancer-associated fibroblast infiltration in tumor microenvironment of triple-negative breast cancerCell Death DisFebruary 27, 2025Qi Wang, Dandan Li, Haixiu Ma, Zengyan Li, Juan Wu, Jinwan Qiao, Jun Liu, Jing Zhao, Ronghua Ma, Lin Tian, et al.Santa Cruz, Dallas, TX, USA), p-IκBα and total IκBα (Cat# sc-8007, Santa Cruz, Dallas, TX, USA), IL6 (Cat# sc- 56196, Santa Cruz, Dallas, TX, USA), FSP-1 (Cat# T40044, Abmart, Shanghai, China), monoclonal mouse anti-β-actin

(12) Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatmentFrontiers in PharmacologyFebruary 24, 2025Jing-Song Guan, Jing Jia, Ze-Xiu Huang, Yu-Qing Zhou, Jing-Jie Zheng, Qi-Man Lin, Yi-Fei Wang, Jiang-Lin Fan, Yao Wangpurchased from Cell Signaling Technology (Bost on, MA, United States). PARP (sc-8007), cleaved-PARP (sc-56196), Bcl-2 (sc-509), Caspase-3 (sc-56053), P62 (sc-28359), ATG5 (sc-133158), FSP1 (sc-377120), GPX4 (sc-166570),

(13) ABL1-mediated phosphorylation promotes FOXM1-related tumorigenicity by Increasing FOXM1 stabilityCell death and differentiationOctober 1, 2024Dong Q, Wang D, Song C, Gong C, Liu Y, Zhou X, Yue J, Hu Y, Liu H, Zhu L, et al.(Novus, Cat# DCS-266), anti-Cleaved CASP3 (CST, Cat# 9664S), anti-Cleaved PARP-1 (Santa Cruz, Cat# SC-56196), anti-APC3 (proteintech, 10918-1-AP), anti-Ki67 (CST, Cat# 9129), anti-ABL1 pY412 (phosphosolutions,

(14) Radioprotective effect of the anti-diabetic drug metforminPLOS ONEJuly 23, 2024Silvia Siteni, Summer Barron, Krishna Luitel, Jerry W. ShayCell Signaling), anti β-actin (Cat. ab8227, Abcam), OGG1 (Cat. ab124741, Abcam), cleaved-PARP (Cat. sc56196, Santa Cruz). Pictures were acquired with a G:BOX Chemi Gel Imaging Western Blot Pred Chemi XRQ (Syngene,

(15) Brassinin alleviates cancer cachexia by suppressing diverse inflammatory mechanisms in miceMedComm (2020)June 1, 2024Min Hee Yang, Young Yun Jung, Jae‐Young Um, Gautam Sethi, Kwang Seok Ahnpreviously described methods. 67 , 68 Antibodies of Atrogin‐1: sc‐33782, MuRF‐1: sc‐398608, Cleaved PARP: sc‐56196, C/EBPα: sc‐61, PPARγ: sc‐7196, aP2: 2120s, Adiponectin: 2789s, Resistin: sc‐16117, p‐STAT3: 9145s,

(16) Pioglitazone enhances cisplatin’s impact on triple-negative breast cancer: Role of PPARγ in cell apoptosisSaudi Pharmaceutical JournalMay 1, 2024Qamraa Hamad Alqahtani, Layla Abdullah Alkharashi, Hanaa Alajami, Ishraq Alkharashi, Layan Alkharashi, Shoug Nasser Alhintimilk for 2 h. Following this, the membranes were exposed to primary antibodies targeting cleaved PARP (sc-56196), caspase-9 (sc-56076), and Bcl-2 (sc-7382), which were sourced from Santa Cruz (Santa Cruz, Texas,

(17) Stress-Induced Changes in Nucleocytoplasmic Localization of Crucial Factors in Gene Expression RegulationInternational journal of molecular sciencesMarch 31, 2024Khamit A, Chakraborty P, Zahorán S, Villányi Z, Orvos H, Hermesz E.(C.384.8): MA5-15031; Invitrogen (Waltham, MA, USA), mouse anti-cleaved PARP-1 monoclonal (194C1439): sc-56196; Santa Cruz Biotechnology (Dallas, TX, USA), rabbit anti-CNOT1 polyclonal: ab234642; Abcam (Cambridge,

(18) MicroRNA-451a inhibits gemcitabine-refractory biliary tract cancer progression by suppressing the MIF-mediated PI3K/AKT pathwayMolecular Therapy - Nucleic AcidsDecember 12, 2023Taisuke Obata, Koichiro Tsutsumi, Eijiro Ueta, Takashi Oda, Tatsuya Kikuchi, Soichiro Ako, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, et al.Cell Signaling Technology [CST], Danvers, MA, USA), ENT1 (sc-377283), dCK (sc-393099), cleaved PARP1 (sc-56196), macrophage MIF (sc-271631; both from Santa Cruz Biotechnology, Dallas, TX, USA), and Cytokeratin 19

(19) Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancerExperimental & Molecular MedicineOctober 2, 2023Dong Hoon Shin, Jeong Yeon Jo, Minyoung Choi, Kyung-Hee Kim, Young-Ki Bae, Sang Soo Kim(sc-15454), SIRT2 (sc-20966), KRAS (F234, sc-30), Tubulin (sc-32293), PARP (sc-8007), cleaved PARP (sc-56196), and p300 (sc-32244), were purchased from Santa Cruz Biotechnology Inc. (Dallas, TX, USA). Antibodies

(20) In Vitro Effects of Combining Genistein with Aromatase Inhibitors: Concerns Regarding Its Consumption during Breast Cancer TreatmentMolecules (Basel, Switzerland)June 21, 2023Bezerra PHA, Amaral C, Almeida CF, Correia-da-Silva G, Torqueti MR, Teixeira N.antibodies anti-pro-caspase-7 (1:200, sc-56063), anti-cyclin E (1:200, sc-377100), anti-cleaved-PARP (1:200, sc-56196), anti-CYP19A1 (1:200, sc-374176), anti-ERα (1:200, sc-8002), anti-AR (1:200, sc-7305) (Santa Cruz Biotechnology,

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cleaved PARP-1 (194C1439) Antibody

cleaved PARP-1 (194C1439) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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cleaved PARP-1 (194C1439) Antibody from Santa Cruz Biotechnology, Inc.

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