IL-6 (10E5) Antibody sc-57315 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemIL-6 (10E5) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-57315
Antibody TypePrimary Antibodies
Clone10E5
Quantity100 µg/ml
ApplicationsWB, IP, FCM, ELISA
Reactivitymouse, rat
ClonalityMonoclonal
Conjugate/TagUnconjugated
Hostmouse
FormatPurified
TargetIL-6
IsotypeIgG2b
NCBI Full Gene Nameinterleukin 6
NCBI Gene AliasesIfnb2, Il-6, ILg6

Questions and Answers

Can this IL-6 antibody be used in Western blotting experiments?

Yes, the IL-6 (10E5) antibody has been shown to be effective in Western blot applications, as evidenced by its use in various studies, including those investigating inflammatory responses and cytokine expression.

What types of samples can I use this antibody on?

The IL-6 antibody is reactive with mouse and rat samples, making it suitable for experiments involving these species.

Has this antibody been utilized in any specific research contexts?

Yes, the IL-6 antibody has been cited in multiple studies, including those examining the role of IL-6 in inflammatory processes and its involvement in conditions such as metabolic syndrome and cancer, highlighting its relevance in various biological research areas.

What is the recommended dilution for using this antibody in immunofluorescence?

The IL-6 antibody has been used at a dilution of 1:100 in immunofluorescence applications, as noted in protocols from relevant scientific literature.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Subchronic GenX Exposure Induces Hepatic Alterations Accompanied by Changes in PPAR-Related Lipid Metabolism and Autophagy-Related Proteins in Adult Male C57BL/6J Mice: Partial Attenuation by Chlorogenic AcidPharmaceuticals (Basel)July 25, 2026Jinjin Zhang, Yu Liu, Yukui Chen, Qi Wang, Xiao-Li XieAbmart), tumor necrosis factor alpha (TNF-α, sc-52746, 100 µg/mL, Santa Cruz), interleukin-6 (IL-6, sc-57315, 100 µg/mL, Santa Cruz), and β-actin (sc-47778, 200 µg/mL, Santa Cruz). The secondary antibodies were

(2) Behavioral and Biochemical Evaluation of a Curcumin-Loaded Nano-Liposomal Formulation in a Scopolamine-Induced Mouse Model of Cognitive ImpairmentBiomolecules & TherapeuticsJuly 1, 2026Hwa-Young Lee, Muhammad Kamal Hossain, Gi-Hyun Jang, Hyewon Lee, Yu-Mi Kim, Han-Jung ChaeCell Signaling Technology (Danvers, MA, USA), COX-2 (1:1000, sc-19999), IL-1β (1:1000, sc-52012), IL-6 (1:1000, sc-57315 ), TNF-α (1:1000, sc-52746), BDNF (1:1000, sc-546), and β-actin (1:1000, sc-69879) were purchased from

(3) Early diabetes‐like phenotypes in germ‐free mice induced by gut microbiota from patients with type 2 diabetesAnimal Models and Experimental MedicineJune 26, 2026Jianghao Feng, Xing Liu, Hua Zhu, Yun Yang, Wei Liu, Xiaoliang Jiang, Zhiwei Yangagainst TNF‐α (1:1000; Santa Cruz Biotechnology, sc‐52746), IL‐6 (1:1000; Santa Cruz Biotechnology, sc‐57315), IL‐1β (1:2000; Abcam, ab234437), and GAPDH (1:5000; Proteintech, HRP‐60004). The membranes were then

(4) Exosomal misfolded α1-antitrypsin triggers a cytosolic GRP78-dependent unfolded protein response and pro-survival signaling in pre-metastatic tissuesJournal of Biological ChemistryJune 20, 2026Anuran Bhattacharya, Tiyasa Saha, Aditya Shukla, Ananya Banerjee, Himansu Roy, Urmi Chatterji"Santa Cruz Biotechnology, USA; SC-377511; RRID: AB_11150127",1:1000,- Anti-IL-6,"Santa Cruz Biotechnology, USA; SC-57315; RRID: AB_2127596",1:1000,- Anti-TNF-α,"Santa Cruz Biotechnology, USA; SC-12744",1:1000,- Anti-IL-4,"Santa Cruz Biotechnology

(5) Lutein Attenuates Synovial Hyperplasia, Cartilage Loss, and Bone Erosion by Suppressing Inflammatory Pathways in Rheumatoid ArthritisInt J Med SciJune 10, 2026Chi-Jen Chang, Tsung-Ming Chang, Ying-Sui Sun, Ji-Fan Lin, Skye Hsin-Hsien Yeh, Ju-Fang Liujoint disease. Material and Methods Materials The rabbit polyclonal antibodies against IL-1β (sc-52012) and IL-6 (sc-57315) were purchased from Santa Cruz Biotechnology (TX, USA). All other reagents were purchased from Sigma-Aldrich

(6) Chronic simultaneous inducible nitric oxide synthase (iNOS) and peripheral cannabinoid CB1 receptors blockade ameliorates pulmonary hypertension in monocrotaline-induced rat modelFrontiers in PharmacologyMay 26, 2026Piotr Ryszkiewicz, Patryk Remiszewski, Anna Pędzińska-Betiuk, Krzysztof Mińczuk, Marta Baranowska-Kuczko, Jolanta Weresa, Barbara MalinowskaCat# ab76198]; galectin-3 [1:5000, Abcam Cat# ab76245]; IL-6 [1:200, Santa Cruz Biotechnology Cat# sc-57315]; GAPDH [1:20000, Abcam Cat# ab181602]; iNOS [1:100, Abcam Cat# ab178945]; Nrf2 [1:1000, Abcam Cat#

(7) Hepatoprotective Effects of Black Ginseng Extract and Ginsenoside Rh1 Against Alcohol-Induced Liver Injury: Mechanistic Insights from Network Pharmacology, In Vitro, and In Vivo AnalysisAntioxidants (Basel)April 8, 2026Hyeon Seon Na, Jeon Hwang-Bo, Woo-Cheol Shin, Jin-Kyu Jang, Bo-Ram Choi, Dae Young LeeDallas, TX, USA, Cat no. sc-376861, Lot no. A0819), anti-IL-6 (Santa Cruz, Dallas, TX, USA Cat no. sc-57315, Lot no. I0816), anti-TNF-α (Santa Cruz, Dallas, TX, USA, Cat no. sc-52746, Lot no. C0119), and anti-HO-1

(8) Evaluation of probiotic properties and genome analysis of the new Pediococcus acidilactici strain 46A isolated from Chinese young adults: in vitro and in vivo studiesFrontiers in MicrobiologyFebruary 16, 2026Polina Makarycheva, Vincenzo Bellitto, Aristide Toussaint Nguele, Chiara Salvesi, Matteo Mozzicafreddo, Anna-Rita Attili, Dennis Fiorini, Daniele Tomassoni, Stefania Silvi, Cristina Micelipro-inflammatory cytokines like IL-1β (Cod. AAR15G, Bio-Rad Laboratories, Inc., California, USA) and IL-6 (Cod. sc-57315 Santa Cruz Biotechnology, Inc. Dallas, USA) antibodies evaluated using the Western blot technique. Samples

(9) Morpho-Functional Characterization and miRNA Profiling of the Retina in the 5xFAD Murine Model of Alzheimer's DiseaseInvest Ophthalmol Vis SciFebruary 12, 2026Lorenzo Guidotti, Martina Lucchesi, Eleonora Daghini, Rosario Amato, Giuseppe Neri, Francesca Corsi, Silvia Marracci, Claudia Gargini, Ugo Borello, Maurizio Cammalleri, et al.Skimmed milk,1:1000 in 5% skimmed milk Mouse monoclonal antibody anti-IL6,Santa Cruz Biotechnology,sc57315,5% Skimmed milk,1:200 in 5% skimmed milk Rabbit monoclonal antibody anti-Bax,Abcam,ab18273,5% Skimmed

(10) An Acebuche Oil-Enriched Diet Prevents Early-Stage Cerebrovascular Alterations in the 5xFAD Mouse Model of Alzheimer’s DiseaseNutrientsJanuary 5, 2026Lorenzo Guidotti, Dominga Lapi, Martina Lucchesi, Silvia Valori, Francesca Corsi, Lucia Giambastiani, Andrea Vornoli, Claudia Gargini, Maurizio Cammalleri, Massimo Dal Monteskimmed milk,1:1000 in 5% skimmed milk Mouse monoclonal antibody anti-IL-6,Santa Cruz Biotechnology,sc57315,5% skimmed milk,1:200 in 5% skimmed milk Rabbit monoclonal antibody anti-iNOS,Abcam,ab178945,5% skimmed

(11) Brain-derived extracellular vesicles circUsp32 polarized macrophages causing acute kidney injury after traumatic brain injuryScience advancesNovember 28, 2025Fu J, Wu J, Du M, Wang X, Shi Q, Fang Y, Lan Y, Wu Q, Zhang G, Xu L, et al.were against the following proteins: TNF-α (1:100; sc-33639; Santa Cruz Biotechnology), IL-6 (1:200; sc-57315; Santa Cruz Biotechnology), IL-1β (1:200; sc-52012; Santa Cruz Biotechnology), Bax (1:1000; 2772S; Cell Signaling Technology

(12) Inhibition of miR-4284 could reduce apoptosis and neuroinflammation by targeting APBA1/JAK1/STAT3 signaling in Alzheimer’s diseaseCell & BioscienceOctober 31, 2025Jiyun Choi, Jinsu Hwang, Dohee Kim, Eunjae Jang, Geupil Jang, Hyong-Ho Cho, Byeong C. Kim, Han-Seong Jeong, Sujeong Jang,Cell Signaling Technology,9145,1:1000 STAT3,Cell Signaling Technology,9139,1:1000 IL-6,Santa Cruz Biotechnology,sc57315,1:1000 TNF-α,Santa Cruz Biotechnology,sc52746,1:1000 IL-1β,Santa Cruz Biotechnology,sc52012,1:1000 IL-4,Santa Cruz Biotechnology

(13) Intestinal Ischemia/Reperfusion Injury Influences Hyaluronan Homeostasis in the Rat BrainInt J Mol SciOctober 16, 2025Annalisa Bosi, Nicolò Baranzini, Alessandra Ponti, Paola Moretto, Elisabetta Moro, Francesca Crema, Rossella Cianci, Evgenia Karousou, Manuela Viola, Alberto Passi, et al.(BC41) S100β,Rabbit,1:100,-,S100β [54],GeneTex (GTX129573) IL6,Mouse,-,1:200,IL6 [55],Santa Cruz (sc-57315) IL6,Rabbit,1:150,-,IL6 [55],Sigma Aldrich(I2143) CD44,Rabbit,,1:1000,CD44 [56],Invitrogen (PA5-21419) TLR4,Rabbit,,1:1000,TLR4

(14) Sublingual Dripping Pill Formulation of Ganoderma amboinense Fruiting Body Extract Attenuates CCl4-Induced Liver Fibrosis via Multi-Pathway RegulationCurrent Issues in Molecular BiologyAugust 28, 2025Chin-Feng Liu, Chong-Ming Pan, Chun-Lin Leepolyclonal antibody (AB2148P; EMD Millipore, Temecula, CA, USA), mouse anti-rat IL-6 monoclonal antibody (sc-57315; Santa Cruz Biotechnology, Dallas, TX, USA), anti-TGF-β1 polyclonal antibody (39303; Signalway Antibody,

(15) Neuroprotective Effects of Calpain Inhibition in Parkinson’s Disease: Insights from Cellular and Murine ModelsCellsAugust 24, 2025Vandana Zaman, Amy Gathings, Kelsey P. Drasites, Donald C. Shields, Narendra L. Banik, Azizul HaqueNLRP3 (1:1000, Abcam, cat# ab263899), IL-6 (1:500, Santa Cruz Biotechnology, Dallas, TX, USA, cat# sc-57315), and IL-1 β (1:500, Abcam, cat#ab283818) antibodies. The monoclonal antibody for β-actin (1:500, Santa Cruz Biotechnology

(16) Estrogen-related receptor alpha mitigates radiation-induced bowel injury through gut enrichment of Bacteroides vulgatusGut MicrobesAugust 19, 2025Seul Gi Shin, June-Young Lee, Jee-Won Choi, Ji-Ho Yoo, In-Chul Jeong, Do-Yeon Kim, Hyun Sik Kim, Seungwha Paik, Gyu-Yong Song, Kyung-Hee Kim, et al.13826S), a monoclonal rabbit antibody directed against IL-6 (1:400, Santa Cruz Biotechnology [SCBT], sc -57315), and a monoclonal mouse CD68 (clone PG-M1, Thermo Fisher Scientific). After washing, the sections were

(17) Baicalin Improves Skeletal Muscle Atrophy by Attenuating DRP-1-Mediated Mitochondrial Fission in Aged MiceMusclesAugust 19, 2025Hla Myat Mo Mo, Jong Han Leefactor α (TNF-α) (sc-12744, Santa Cruz Biotechnology, Dallas, TX, USA); anti-interleukin-6 (IL-6) (sc-57315, Santa Cruz Biotechnology, Dallas, TX, USA); anti-DRP-1 (sc-271583, Santa Cruz Biotechnology, Dallas,

(18) Inhibiting The uPA/uPAR Pathway Affords Photoreceptor Resilience and Preserves Retinal Function in a Mouse Model of Retinitis PigmentosaInvest Ophthalmol Vis SciAugust 12, 2025Rosario Amato, Alessio Canovai, Alberto Melecchi, Maria De Fenza, Linda Leone, Vincenzo Pavone, Daniele D'Alonzo, Maurizio Cammalleri, Massimo Dal Montemonoclonal anti-TNF-α,1:1000,Abcam,ab205587 Mouse monoclonal anti-IL-6,1:200,Santa Cruz Biotechnology,sc-57315 Rabbit monoclonal anti-iNOS,1:1000,Abcam,ab178945 Mouse monoclonal anti-ICAM-1,1:250,Thermo Fisher,MA5407 Goat

(19) Brown adipose tissue: a potential therapeutic target for preventing cardiovascular disease in metabolic disordersDiabetology & metabolic syndromeAugust 2, 2025Egan Beňová T, Sýkora M, Ondreják Andelová K, Farkašová V, Lepáček M, Šoltésová Prnová M, Babál P, Janko D, Andelová N, Ferko M, et al.United Kingdom, #ab39999" IL-6,1:500,Mouse,Monoclonal,"Santa Cruz Biotechnology, Dallas, TX, USA, #sc-57315" IL-10,1:500,Mouse,Monoclonal,"Santa Cruz Biotechnology, Dallas, TX, USA, #sc-365858" NfkB,1:500,Rabbit,Polyclonal,"Santa Cruz Biotechnology

(20) Phosphatidylcholine suppresses inflammatory responses in LPS-stimulated MG6 microglial cells by inhibiting NF-κB/JNK/p38 MAPK signalingPLoS OneJuly 28, 2025Sachiko Mizuno, Yuki Kurobe-Takashima, Daisuke Kuriki, Kenta Susaki, Kurataka Otsuka, Tomoko Tsuchihashi, Keiko Abe, Shoko Kobayashinumber TNFα,Proteintech,1:1000,60291-1-Ig IL-1β,Cell Signaling,1:500,12242 IL-6,Santa Cruz Biotechnology,1:1000,sc-57315 NF-κB p65,Cell Signaling,1:1000,8242 p-IκBα,Cell Signaling,1:2000,9246 IκBα,Cell Signaling,1:2000,4814 p-p38

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IL-6 (10E5) Antibody

IL-6 (10E5) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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IL-6 (10E5) Antibody from Santa Cruz Biotechnology, Inc.

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