PARP-1 (5A5) Antibody sc-56197 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemPARP-1 (5A5) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-56197
Antibody TypePrimary Antibodies
NCBI Gene AliasesmsPARP, Adprp, parp-1, PPOL, ADPRT, ARTD1, PARP-1, ADPRT 1, Poly-PARP, PARS, Adprt1, PARP, 5830444G22Rik, sPARP-1, ADPRT1, pADPRT-1
Quantity200 µg/ml
Clone5A5
ApplicationsWB, IP, IF
Reactivitymouse, rat, human
Conjugate/TagUnconjugated
FormatPurified
ClonalityMonoclonal
Hostmouse
NCBI Full Gene Namepoly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) polymerase 1
TargetPARP-1
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Increased efficacy of PARP inhibitors against cisplatin-sensitive and -resistant ovarian cancer cells mediated via ATR and ATM inhibitionCell Death DiscovOctober 6, 2025Philipp König, Leon Bade, Julia Maria Eichhorn, Helena Skalski, Jindrich Cinatl, Martin Michaelis, Gerd Bendas(#13050 T) (purchased from Cell Signaling Technology, Frankfurt am Main, Germany), mouse anti-PARP1 (#sc-56197), mouse anti-α-tubulin (#sc-8035), (purchased from Santa Cruz Biotechnology, Heidelberg, Germany) and

(2) A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancersCell reports. MedicineMarch 19, 2024Alruwaili MM, Zonneville J, Naranjo MN, Serio H, Melendy T, Straubinger RM, Gillard B, Foster BA, Rajan P, Attwood K, et al.RRID:AB_785249" "anti-PARP1 (mouse monoclonal antibody, Clone 5a5)",Santa Cruz Biotechnology,Cat# sc-56197; RRID:AB_630080 anti-phospho-Ser139 H2AX (γH2AX; rabbit polyclonal),Abcam,Cat# ab-11174; RRID:AB_297813 anti-Thymidylate

(3) A synthetic lethal strategy using PARP and ATM inhibition for overcoming trastuzumab resistance in HER2-positive cancersOncogeneAugust 1, 2022Oh KS, Nam AR, Bang JH, Seo HR, Kim JM, Yoon J, Kim TY, Oh DY.

(4) Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathwayBMC cancerDecember 7, 2021Xu N, Lu M, Wang J, Li Y, Yang X, Wei X, Si J, Han J, Yao X, Zhang J, et al.Cell Signaling), anti-IκBα (4814T; L35A5; Cell Signaling), anti-pIκBα (2859T; 14D4; Cell Signaling), anti-PARP-1 ( sc-56197; 194C1439; Santa Cruz Biotechnology), anti-cleaved PARP-1 (sc-56196; 5A5; Santa Cruz Biotechnology),

(5) AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axisInvestigational new drugsAugust 1, 2021Carlos JAEG, Lima K, Costa-Lotufo LV, Leitão A, Machado-Neto JA.

(6) The protective mechanism of action of plantamajoside on a rat model of acute spinal cord injuryExperimental and therapeutic medicineApril 1, 2021Hu H, Jian X.(sc‑20067; 1:1,000), anti‑caspase‑3 (sc‑56053; 1:1,000), anti‑caspase‑9 (sc‑81650; 1:1,000), anti‑PARP (sc‑56197; 1:1,000) and anti‑GAPDH (sc‑293335; 1:1,000) antibodies, which were purchased from Santa Cruz Biotechnology, Inc

(7) Effect of claudin 1 on cell proliferation, migration and apoptosis in human cervical squamous cell carcinomaOncology reportsFebruary 1, 2021Shen Z, Song W, Qian L, Zhu J, Li Y, Li M, Zhang T, Zhao W, Zhou Y, Yang X.Cell Signaling Technology, Inc.; cat. no. 13255), PARP-1 (dilution 1:500; Santa Cruz Biotechnology Inc.; cat. no. sc56197), cleaved PARP (dilution 1:500; Cell Signaling Technology, Inc.; cat. no. 9548), caspase-3 (dilution

(8) Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemiaNature communicationsJanuary 4, 2021Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, et al.sc-100630, Lot J3013), Ubiquitin (1:500, sc-8017, Lot H0409), GFP (1:500, sc-9996, Lot J0813), PARP1 (1:500, sc-56197), PCNA (1:500, sc-53407), p53 (1:500, sc-126) antibodies were purchased from Santa Cruz Biotechnology

(9) The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR PathwayNutrientsNovember 29, 2020Won YS, Kim JH, Lizardo RCM, Min HJ, Cho HD, Hong SM, Seo KI.

(10) Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiationCommunications biologyAugust 21, 2020Park JW, Kang JY, Hahm JY, Kim HJ, Seo SB.BML-pw-8810-0100, dilution (1:1000)), β-actin (sc-47778 dilution (1:1000)), H3 (sc-8654, dilution (1:1000)), PARP1 (sc-56197, dilution (1:1000)), and tubulin (sc-9103, dilution (1:1000)) (all from Santa Cruz Biotechnology, Dallas,

(11) Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factorFood and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationApril 1, 2020Won YS, Seo KI.

(12) Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer CellsNutrientsFebruary 14, 2020Won YS, Seo KI.

(13) Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathwayFood and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationJanuary 1, 2020Won YS, Seo KI.

(14) Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 ExpressionFrontiers in oncologyJanuary 1, 2020Congrains A, Niemann FS, Duarte ADSS, Ferro KPV, Olalla-Saad ST.(Abcam, ab32969), SF3B2 (ProteinTech, 10919-1-AP), HnRNPA1 (ProteinTech, 11176-1-AP), PARP1 (Santa Cruz, sc-56197), Lamin B1 (Santa Cruz, sc-6127), and GAPDH (Santa Cruz, sc-32233) antibodies. K-562 protein samples

(15) Trk inhibitor GNF‑5837 suppresses the tumor growth, survival and migration of renal cell carcinomaOncology reportsNovember 1, 2019Chen Y, Wang H, Chen Y, Wang M, Ding G, Li T.dilution 1:200), c‑Myc (cat. no. sc‑40; dilution 1:200), poly(ADP‑ribose) polymerase‑1 (PARP‑1) (cat. no. sc‑56197; dilution 1:200), and survivin (cat. no. sc‑17779; dilution 1:200) were purchased from Santa Cruz Biotechnology

(16) A robust strategy for proteomic identification of biomarkers of invasive phenotype complexed with extracellular heat shock proteinsCell stress & chaperonesNovember 1, 2019Griffiths SG, Ezrin A, Jackson E, Dewey L, Doucette AA.

(17) KAT5 Negatively regulates the proliferation of prostate cancer LNCaP cells via the caspase 3-dependent apoptosis pathwayAnimal cells and systemsJanuary 1, 2019Kim CH, Lee DH.h, the membrane was washed 3 times with TBST and incubated with antibodies against PARP-1 (1:1000, sc-56197, Santa Cruz), Caspase 3 (1:1000, #9662, Cell Signaling), Bax (1:500, #2772, Cell Signaling), Cytochrome

(18) REDD-1 aggravates endotoxin-induced inflammation via atypical NF-κB activationFASEB journal : official publication of the Federation of American Societies for Experimental BiologyAugust 1, 2018Lee DK, Kim JH, Kim J, Choi S, Park M, Park W, Kim S, Lee KS, Kim T, Jung J, et al.

(19) Metformin exerts multitarget antileukemia activity in JAK2^V617F-positive myeloproliferative neoplasmsCell death & diseaseFebruary 22, 2018Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, et al.Antibodies against STAT3 (sc-7179), STAT5 (sc-835), p-p70S6KT421/S424 (sc-7984), p70S6K (sc-8418), PARP1 (sc-56197) and actin (sc-1616) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Antibodies

(20) Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitorsEuropean journal of medicinal chemistryJanuary 20, 2018Lin HY, Han HW, Sun WX, Yang YS, Tang CY, Lu GH, Qi JL, Wang XM, Yang YH.

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PARP-1 (5A5) Antibody

PARP-1 (5A5) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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PARP-1 (5A5) Antibody from Santa Cruz Biotechnology, Inc.

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