The ITPR2 Rabbit pAb Antibody from AAA Biotech, LLC is a Rabbit Polyclonal antibody to PSRC1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The ITPR2 Rabbit pAb Antibody has been shown to work in the following applications: Immunohistochemistry.
Description
The protein encoded by this gene belongs to the inositol 1, 4, 5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]