SCF (G-3) Antibody sc-13126 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSCF (G-3) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-13126
NCBI Gene AliasesClo, SHEP7, Mgf, FPHH, blz, KL-1, Kitl, DCUA, SF, DFNA69, WS2F, SCF, Gb, Con, Sl, SLF, contrasted, FPH2, Kitlg, MGF
Antibody TypePrimary Antibodies
Reactivitymouse, rat, human
CloneG-3
ApplicationsWB, IP, IF, IHC(P), ELISA
Quantity200 µg/ml
Hostmouse
ClonalityMonoclonal
Conjugate/TagUnconjugated
FormatPurified
NCBI Full Gene Namekit ligand, KIT ligand
TargetSCF
IsotypeIgG2b

Questions and Answers

What species does this antibody react with, and how has it been utilized in research?

The SCF (G-3) Antibody reacts with mouse, human, and rat species. It has been utilized in various applications, including immunohistochemistry, where it has been shown to label glandular cells in colon tissue sections and is used to assess the purity of germ cell preparations by confirming the immunonegativity of Sertoli cell markers in mouse models (; ).

Can this antibody be used in studies related to fertility, and if so, how?

Yes, the SCF (G-3) Antibody has been used in studies related to fertility. For instance, it was employed to investigate the role of stem cell factor in the migration of primordial germ cells, which is crucial for reproductive development (). Additionally, it has been implicated in restoring oogenesis in congenitally infertile mouse models through gene delivery methods ().

How has the SCF (G-3) Antibody been applied in cancer research?

The SCF (G-3) Antibody has been applied in cancer research, particularly in studies of pancreatic ductal adenocarcinoma. It has been shown to promote cell proliferation and invasion under hypoxic conditions, indicating its role in tumor progression (). The antibody was used in Western blot analyses to assess SCF expression levels in cancer cell lines and tissue samples.

What are some specific experimental techniques where this antibody has been effectively utilized?

The SCF (G-3) Antibody has been effectively utilized in several experimental techniques, including Western blotting, immunofluorescence, and immunohistochemistry. It has been cited in studies for its ability to detect SCF protein levels in various tissues and cell types, contributing to the understanding of its biological functions in different contexts (; ).

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Wu Zi Yan Zong Wan Improves Triptolide-Induced Testicular Spermatogenic Dysfunction Through the Spermatogenic Microenvironment and the PLCγ/PKC PathwayAm J Mens HealthOctober 2, 2025Lei Zhang, Binghao Bao, Weizhen Wu, Haolang Wen, Suyan Tong, Xueyan Wang, Baoxing LiuChina) Antibodies: PLZF: Santa Cruz Biotechnology (Cat. No. sc-28319; TX, USA)SCF: Santa Cruz Biotechnology (Cat. No. sc-13126; TX, USA)GFRα1: Santa Cruz Biotechnology (Cat. No. sc-271546; TX, USA)C-kit: Abcam (Cat. No. ab256345;

(2) Ameliorative effects of the mixed aqueous extract of Aurantii Fructus Immaturus and Magnoliae Officinalis Cortex on loperamide-induced STC miceHeliyonJuly 15, 2024Ting Cai, Yun Dong, Zeyu Feng, Bin Caiab259318, Abcam, UK), anti-AQP9 (1:100, sc-74409, Santa Cruz, USA), anti-stem cell factor (SCF) (1:200, sc-13126, Santa Cruz, USA), anti-c-Kit (1:1000, ab256345, Abcam, UK), and anti-α-tubulin (1:200, sc-5286, Santa Cruz

(3) Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffoldAsian Journal of AndrologyMay 1, 2024Yu-Zhuo Chen, Yi-Hong Zhou, Min-Bo Yan, Ming Xiao, Biao Liu, Ying-Hao Yin, Xiao-Li Tan, Yong-Quan Huang, Yu-Hong Lin, Ting Xie, et al.Santa Cruz), vascular endothelial growth factor A (VEGFA; sc-7269, Santa Cruz), stem cell factor (SCF; sc-13126, Santa Cruz), actin alpha 2, smooth muscle (ACTA2; Ab5694, Abcam, Cambridge, UK), CD31 (GB12064, Servicebio,

(4) Accumulation of Renal Fibrosis in Hyperuricemia Rats Is Attributed to the Recruitment of Mast Cells, Activation of the TGF-β1/Smad2/3 Pathway, and Aggravation of Oxidative StressInternational journal of molecular sciencesJune 29, 2023Zhang M, Cui R, Zhou Y, Ma Y, Jin Y, Wang L, Kou W, Wu X.membrane was sealed with 5% skim milk (dissolved in TBST) for one h and then incubated with anti-SCF (sc13126, Santa Cruz Bio., Dallas, TX, USA), anti-c-kit (sc365504, Santa Cruz Bio., Dallas, TX, USA), anti-TGF-β1

(5) DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathwayAgingOctober 13, 2022Zhou Y, Huangfu S, Li M, Tang C, Qian J, Guo M, Zhou Z, Yang Y, Gu C.Abcam, UK); FLAG (14793, Cell Signaling Technology, USA); GAPDH (60004-I-Ig, Proteintech, China); KITLG (sc-13126, Santa Cruz, USA); Puromycin was purchased from Merck KGaA (Darmstadt, Germany). Cell counting kit-8

(6) HGF Secreted by Mesenchymal Stromal Cells Promotes Primordial Follicle Activation by Increasing the Activity of the PI3K-AKT Signaling PathwayStem cell reviews and reportsJune 1, 2022Mi X, Jiao W, Yang Y, Qin Y, Chen ZJ, Zhao S.with primary antibodies against p-AKT (CST, 9271), AKT (CST, 9272), KITL (Santa Cruz Biotechnology, sc-13126), and β-actin (Proteintech, 66009–1) at 4 °C overnight. β-Actin was used as the internal control. The

(7) Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile miceCell reports. MedicineMay 17, 2022Kanatsu-Shinohara M, Lee J, Miyazaki T, Morimoto H, Shinohara T.AB_476744; Source 22190126; Batch 0000088083 Mouse anti-KITL antibody,Santa Cruz Biotechnology,Cat# sc-13126; RRID: AB_628238; Lot K2817 Mouse anti-MCHERRY antibody,Takara,Cat# 632543; RRID: AB_2307319; Lot 1706595A HRP

(8) Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signalingCell reportsNovember 23, 2021Young IC, Wu B, Andricovich J, Chuang ST, Li R, Tzatsos A, Wu RC, Wu MY.Mouse on Mouse Blocking Reagent (Vector Laboratories), followed by incubation with the anti-KITLG (sc-13126, Santa Cruz Biotechnology) antibody in blocking solution. Sections were washed with 0.1% Triton X-100/PBS

(9) Effects of liver-regulating herb compounds on testicular morphological and ultrastructural changes in varicocele rats through SCF/C-KIT pathwayAndrologiaOctober 1, 2020Lu X, Liu J, Yin H, Ding C, Wang Y, Zhang F, Jin G, Ma Y, Dong L, Qin Q.

(10) c-KIT oncogene expression in PRKAR1A-mutant adrenal cortexEndocrine-Related CancerOctober 1, 2020Kiran Nadella, Fabio R. Faucz, Constantine A. Stratakis(Perkin-Elmer, Inc., Waltham, MA). The following primary antibodies were used. KIT (SC-17806), SCF (SC-13126), from Santa Cruz Biotechnology, Inc. (Dallas, TX) phospho-KIT (Y568+Y570 ab78247) GAPDH (ab9485) and

(11) Long-Term Advantages of Ovarian Reserve Maintenance and Follicle Development Using Adipose Tissue-Derived Stem Cells in Ovarian Tissue TransplantationJournal of clinical medicineSeptember 15, 2020Cacciottola L, Nguyen TYT, Chiti MC, Camboni A, Amorim CA, Donnez J, Dolmans MM.

(12) Altered expression of activator proteins that control follicle reserve after ovarian tissue cryopreservation/transplantation and primordial follicle loss prevention by rapamycinJournal of assisted reproduction and geneticsSeptember 1, 2020Celik S, Ozkavukcu S, Celik-Ozenci C.

(13) AURKA destruction is decoupled from its activity at mitotic exit but is essential to suppress interphase activityJournal of cell scienceJune 16, 2020Abdelbaki A, Akman HB, Poteau M, Grant R, Gavet O, Guarguaglini G, Lindon C.

(14) Melanogenic Properties and Expression Profiles of Melanogenic Paracrine Molecules in Riehl's MelanosisInternational journal of molecular sciencesMarch 2, 2020Woo YR, Park HE, Jeong SW, Park HJ.

(15) Altered hormonal milieu and dysregulated protein expression can cause spermatogenic arrest in ectopic xenografted immature rat testisScientific reportsMarch 11, 2019Goel S, Minami N.(sc-271639, 1:100), HSD3B (sc-51520, 1:200), SOX9 (sc-20095, 1:200), CLDN11 (sc-271232, 1:200), SCF (sc-13126, 1:200), ACTB (sc-47778, 1:200), INHBB (sc-376971, 1:100), FSHR (sc-7798, 1:200) (all from Santa Cruz Biotechnology

(16) Long-term follow-up of vitrified and autografted baboon (Papio anubis) ovarian tissueHuman reproduction (Oxford, England)February 1, 2019Amorim CA, Donnez J, Dehoux JP, Scalercio SR, Squifflet J, Dolmans MM.

(17) Evaluation of a new freezing protocol containing 20% dimethyl sulphoxide concentration to cryopreserve human ovarian tissueReproductive biomedicine onlineDecember 1, 2018Gallardo M, Paulini F, Corral A, Balcerzyk M, Lucci CM, Ambroise J, Merola M, Fernandez-Maza L, Risco R, Dolmans MM, et al.

(18) A novel system-level approach using RNA-sequencing data identifies miR-30-5p and miR-142a-5p as key regulators of apoptosis in myocardial infarctionScientific reportsOctober 2, 2018Kim JO, Park JH, Kim T, Hong SE, Lee JY, Nho KJ, Cho C, Kim YS, Kang WS, Ahn Y, et al.CA), anti-Picalm (sc-271224, Santa Cruz, Dallas, TX, USA), anti-Ghr (sc-137185, Santa Cruz), anti-SCF (sc-13126, Santa Cruz), and anti-SnoN (sc-136958 Santa Cruz). MTT cell viability assay Cell viability was measured

(19) Cadmium exposure in newborn rats ovary induces developmental disorders of primordial follicles and the differential expression of SCF/c-kit geneToxicology lettersOctober 5, 2017Zhang W, Wu T, Zhang C, Luo L, Xie M, Huang H.

(20) Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytesBiochemical and biophysical research communicationsJune 10, 2017Cho KA, Park M, Kim YH, Woo SY.