IL-1β (11E5) Antibody sc-52012 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemIL-1β (11E5) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-52012
Quantity100 µg/ml
Reactivitymouse, rat, human
ApplicationsWB, IP, IF, IHC(P)
FormatPurified
Conjugate/TagUnconjugated
Antibody TypePrimary Antibodies
Clone11E5
Hostmouse
TargetIL-1beta
IsotypeIgG1
NCBI Gene AliasesIL1-BETA, IL-1, IL-1beta, IL1F2, Il-1b, IL1beta
ClonalityMonoclonal
NCBI Full Gene Nameinterleukin 1 beta

Questions and Answers

What species does this IL-1β antibody work with in experiments?

The IL-1β (11E5) antibody has been shown to react with mouse, human (Homo sapiens), and rat species, making it versatile for various biological studies.

In what types of applications has this antibody been utilized according to the literature?

This antibody has been utilized in several applications, including Western blotting, immunofluorescence, immunohistochemistry, and immunoprecipitation, demonstrating its utility in both protein detection and functional assays.

Are there any specific studies that have cited the use of this antibody in relation to inflammatory processes?

Yes, the IL-1β antibody has been cited in studies investigating inflammatory processes, such as its role in the expression of inflammatory cytokines in diabetic nephropathy models, where it was used to assess the levels of IL-1β in kidney tissues.

How has this antibody been applied in research involving oxidative stress and inflammation?

The IL-1β antibody has been used in studies examining the effects of various treatments on oxidative stress and inflammation, such as in the context of diabetic models, where it helped to evaluate the expression of IL-1β in response to therapeutic interventions.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) In silico and in vitro insights into the wound-healing potential of syringic acid: protective and regenerative effects on human fibroblastsBMC Pharmacol ToxicolApril 14, 2026Ufuk Okkay, İlkin Kazimov, Irmak Ferah Okkay, Azizeh Shadidizaji, Mehmet Ali Yoruk, Murat Ozdemir, Fatih Burak Yildiz, Fatma Yesilyurt, Mustafa Ozkaraca, Ahmet Hacimuftuoglu(TNF-α) (dilution 1:200, Santa Cruz, sc-133192), interleukin-1 beta (IL-1β) (dilution 1:200, Santa Cruz, sc-52012), transforming growth factor-beta (TGF-β) (Santa Cruz, sc-130348), and inducible nitric oxide synthase

(2) HSV-2 genome recognition by nuclear cGAS instigates IFN-β production and influences inflammasome activation during de novo infection in HFF cellsFront ImmunolApril 13, 2026Aditya Goel, Vatsala Kaul, Mir Faizan Ul Haq, Mohammad Akram, Nikita Chaudhary, David N. Everly, Mairaj Ahmed AnsariSanta Cruz, CA",Sc-69806 IL-1B(11E5),Mouse monoclonal,"Santa Cruz Biotechnology Inc., Santa Cruz, CA",Sc-52012 IFI16(D8B5T),Rabbit,"CST, Danvers, MA",14970 IFI16(IG7),Mouse monoclonal,"Santa Cruz Biotechnology Inc

(3) Ganoderma lucidum mediates microglial polarization and ameliorates experimental autoimmune encephalomyelitis by reducing oxidative stress and inhibiting NF-κB/STAT3 pathwayChin MedApril 10, 2026Lu Zhang, Jie Chen, Sauchu Yuen, Meiling Wu, Wenting Li, Shenyu Yan, Jiangang Shen(#8242, CST), β-actin (#3700, Cell Signaling), COX2(sc1747, Santa Cruz), IL-6 (ab290735, Αbcam), IL-1β(sc-52012, Santa Cruz), TNF-α (11948 T, CST), Anti-mouse antibody (7076 s, Cell Signaling), Anti-rabbit antibody

(4) PrP C Glycoprotein Modulates Atmospherically Relevant Artificial Particulate Matter-Induced Development of Lung Cancer in MiceEnvironmental Science & TechnologyApril 7, 2026Thi Thu Trang Kieu, Hyun-Jaung Sim, Govinda Bhattarai, Han-Sol So, Jeong-Chae Lee, Sung-Ho KookHuabio), PrPC (A03202-SPI bio), HIF-1α (NB-100-449-Novus Biologicals), COX2 (BS1076-BioWord), IL-1β (sc-52012-Santa Cruz Biotechnology), TNFα (AB1793-Abcam), 8-OHdG (Ab62623-Abcam), CD4 (25229-Cell Signaling),

(5) Potential gonadal-beneficial effect of sitagliptin against paclitaxel-induced testicular dysfunction via mediating PERK/CHOP/NLRP3/Sestrin2 signaling pathwaySci RepMarch 14, 2026Kareman M. El-Beheiry, Nagla A. El-Shitany, Magda El-Sayed El-Sayad, Alaa E. Elsisi(Novus Biologicals, cat# NB100-56503, USA), and anti-IL-1β monoclonal antibody (Santa Cruz Biotechnology, Cat# sc-52012, USA) were used to identify their targeted proteins via a standard immunohistochemical technique. Scoring

(6) Targeting AT1 receptors with telmisartan protects SH-SY5Y cells from 6-OHDA induced Parkinsonian neurotoxicityScientific ReportsMarch 6, 2026Omer Lutfi Gundogdu, Feyza Burul, Elif Tugce Akyol, Ufuk Okkay, Fatma Yesilyurt, Fatih Burak Yildiz, Irmak Ferah Okkay, Mustafa Ozkaraca, Ahmet Hacimuftuogluprimary antibodies against α-synuclein (Santa Cruz, Cat. no. sc-69977) and IL-1β (Santa Cruz, Cat. no. sc-52012) (1:200) overnight at 4 °C. The cells were then washed three times with PBS and incubated at room temperature

(7) Artesunate ameliorates experimental autoimmune uveitis by inhibiting the LCN2-STAT3 axis and suppressing microglial activationRedox RepFebruary 12, 2026Jingsai Gu, Qinyun Xia, Pingping Huang, Yilin Yuan, He Ren, Dihao Hua, Zhen ChenCST #9145), p-STAT3 (phosphorylated STAT3) (1:1000, CST), IL-1β (interleukin-1β) (1:1000, Santa Cruz, sc-52012), TNF-α (tumor necrosis factor-α) (1:1000, Santa Cruz, sc-52746), IL-6 (interleukin-6) (1:1000, GeneTex,

(8) TXNIP-Deficiency and Prdx6 Delivery Inhibit Aging/Oxidative Stress–Driven TXNIP-Nlrp3 Inflammasome Activation and Mitigate Pyroptosis in Lens Epithelial CellsAntioxidants (Basel)January 28, 2026Bhavana Chhunchha, Eri Kubo, Renuka R. Manoharan, Rakesh Kumar, Dhirendra P. SinghUSA), Nlrp3 (# PA5-79740; 1:1000 dilution, ThermoFisher Scientific, Waltham, MA, USA), IL-1β, and ASC (sc-52012 and sc-271054; 1:1000 dilution; Santa Cruz Biotechnology, Inc., Dallas, TX, USA). β-actin (A2066; 1:2000

(9) Manifold hepatoprotective actions of α-lipoic acid on metabolic function through redox regulation, inflammatory modulation, and anti-apoptosis after chronic sleep-deprived injuryFrontiers in NutritionJanuary 22, 2026Hung-Ming Chang, Hsing-Chun Lin, Ting-Yi Renn, Yu-Cheng Liu, Kai-Jung Yen, Chih-Kai Liao, Maria A. Tikhonova, Tamara G. Amstislavskaya, Sandeep Kumar Singh, Li-You Chensc-8008), TNF-α (1:200, Santa Cruz, sc-52746), IL-6 (1:500, Bioss, bs-0782R-TR), IL-1β (1:100, Santa Cruz, sc-52012), COX2 (1:200, Santa Cruz, sc-376861), activating transcription factor 6α (ATF6α) (1:200, Santa Cruz,

(10) High-entropy alloy Janus artificial enzymes for pH-gated sequential redox therapy of drug-resistant bacterial infectionNature CommunicationsJanuary 20, 2026Cong Han, Yongqi Wang, Shihuan Gao, Ting Wang, Huili Du, Jie Long, Weidong Tian, Mohsen Adeli, Liang Cheng, Zhi Liu, et al.Santa Cruz Biotechnology, USA, 1:200 dilution), F4/80 (sc-25830, Santa Cruz Biotechnology, USA, 1:100 dilution), IL-1β (sc-52012, Santa Cruz Biotechnology, USA, 1:200 dilution), TNF-α (sc-52746, Santa Cruz Biotechnology, USA, 1:200

(11) Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodelingNature CommunicationsJanuary 13, 2026Xiaojing Liu, Yuanxin Ye, Zhonghan Li, Li Liao, Qiang WeiCat No:ab188224), anti-CD45 (1:100, Abcam, Cat No:ab10558), anti-IL-1β (1:100, Santa cruz, Cat No: sc-52012), anti-H4AC(1:100, Abcam, Cat No:ab177790), rabbit polyclonal anti-FOXO1(1:100, Cell signaling, 2880S),

(12) Zn64 aspartate modulates inflammation, tryptophan metabolism, and pancreatic function in diet-induced obesitySci RepDecember 3, 2025Max Temnik, Sergey Gurin, Leonid Magidenko, Alexandr Balakin, Roman Byshovets, Olesia Kalmukova, Tetiana Vovk, Tetiana Halenova, Nataliia Raksha, Olexiy Savchukinterleukins, resistin, and ghrelin in serum and adipose tissue Quantification of interleukins (IL-1β (sc-52012), IL-6 (sc-32296), IL-10 (sc-32815), IL-12 (sc-365389), IFN-γ (sc-74106), IL-4 (sc-53084), TGF-β (sc-374433),

(13) Brain-derived extracellular vesicles circUsp32 polarized macrophages causing acute kidney injury after traumatic brain injuryScience advancesNovember 28, 2025Fu J, Wu J, Du M, Wang X, Shi Q, Fang Y, Lan Y, Wu Q, Zhang G, Xu L, et al.sc-33639; Santa Cruz Biotechnology), IL-6 (1:200; sc-57315; Santa Cruz Biotechnology), IL-1β (1:200; sc-52012; Santa Cruz Biotechnology), Bax (1:1000; 2772S; Cell Signaling Technology), Bcl-2 (1:1000; 2764S; Cell Signaling Technology

(14) Dose-dependent protective profile of trans-anethole in experimental traumatic brain injury in mice via modulation of apoptotic and inflammatory protein expression, and oxidative stressActa Cirúrgica BrasileiraNovember 10, 2025Aziz Çevik, Burak Atlas, Gamze Erdoğan, Mehmet Salih Atama, Barış Altun, Tevfik Yılmazsc-52746, Santa Cruz Biotechnology, Dallas, TX, United States of America) and IL-1β (catalogue no.: sc-52012, Santa Cruz Biotechnology, Dallas, TX, United States of America) levels were examined through immunohistochemistry

(15) Inhibition of miR-4284 could reduce apoptosis and neuroinflammation by targeting APBA1/JAK1/STAT3 signaling in Alzheimer’s diseaseCell & BioscienceOctober 31, 2025Jiyun Choi, Jinsu Hwang, Dohee Kim, Eunjae Jang, Geupil Jang, Hyong-Ho Cho, Byeong C. Kim, Han-Seong Jeong, Sujeong Jang,Santa Cruz Biotechnology,sc57315,1:1000 TNF-α,Santa Cruz Biotechnology,sc52746,1:1000 IL-1β,Santa Cruz Biotechnology,sc52012,1:1000 IL-4,Santa Cruz Biotechnology,sc53084,1:1000 IL-10,Santa Cruz Biotechnology,sc32815,1:1000 β-actin,Cell Signaling Technology

(16) Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female miceFront PharmacolOctober 8, 2025Edward Pajarillo, Alexis Digman, Itunu Ajayi, Sanghoon Kim, Deok-Soo Son, Michael Aschner, Eunsook Lee(sc-393296), CREB-binding protein (CBP)/p300 (sc-32244), ER-α (sc-542), ER-β (sc-6822), interleukin (IL)-1β (sc-52012), tumor necrosis factor (TNF)-α (sc-52746), glutamate transporter-1 (GLT-1, sc-365634), and β-actin

(17) Single-nucleus transcriptomics decodes the link between aging and lumbar disc herniationProtein & CellAugust 7, 2025Min Wang, Zan He, Anqi Wang, Shuhui Sun, Jiaming Li, Feifei Liu, Chunde Li, Chengxian Yang, Jinghui Lei, Yan Yu, et al.(Cell Signaling Technology, 2947S), anti-HERV-K-env (Austral Biologicals, HERM-1811-5), anti-IL-1β (Santa Cruz Biotechnology, sc-52012), anti-CD68 (Abcam, ab955), anti-Aggrecan (Abcam, ab3778), anti-PRRX1 (Abcam, ab211292), and anti-NFAT1

(18) Biochemical Insights into the Effects of a Small Molecule Drug Candidate on Imatinib-Induced Cardiac InflammationInt J Mol SciJuly 11, 2025Renáta Szabó, Denise Börzsei, András Nagy, Viktória Kiss, Zoltán Virág, Gyöngyi Kis, Nikoletta Almási, Szilvia Török, Médea Veszelka, Mária Bagyánszki, et al.Santa Cruz Biotechnology, Dallas, TX, USA; Nrf2: 1:100, ab31163, Abcam, Cambridge, UK; IL-1β: 1:50, sc52012, Santa Cruz Biotechnology, USA; IL-6: 1:50, ab9324, Abcam, Cambridge, UK; HO-1: 1:200, NBP1-97507, Novus Biologicals

(19) Antidepressant-like effects of Ashwagandha (Withania Somnifera) on chronic unpredictable mild stress-induced depression in adolescent ratsPsychopharmacology (Berl)June 25, 2025Gul Sahika Gokdemir, Ugur Seker, Nazan Baksi, Mukadder Baylan, Berjan Demirtaş, Mehmet Tahir GokdemirUSA, Catalog number: sc-52746), IL-1β (Santa Cruz Biotechnology (SCBT), DTX, MA, USA, Catalog number: sc-52012) and GFAP (Santa Cruz Biotechnology (SCBT), DTX, MA, USA, Catalog number: sc-33673) overnight at 4 °C.

(20) Therapeutic potential of young plasma in reversing age-related liver inflammation via modulation of NLRP3 inflammasome and necroptosisBiogerontologyMay 26, 2025Burcu Baba, Taha Ceylani, Hikmet Taner Teker, Seda Keskin, Aysun Inan Genc, Rafig Gurbanov, Eda Acikgozrate: 1:200), anti-ASC (Elabscience, E-AB-30582, dilution rate: 1:200), anti-IL-1β (Santa Cruz (11E5), sc-52012, dilution rate:1:200), anti- TNF-α (Bioss, BS-10802R, dilution rate: 1:200), and anti-VEGFR2 (Bioss,

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IL-1β (11E5) Antibody

IL-1β (11E5) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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IL-1β (11E5) Antibody from Santa Cruz Biotechnology, Inc.

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