CUL-1 (D-5) Antibody sc-17775 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemCUL-1 (D-5) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-17775
Antibody TypePrimary Antibodies
CloneD-5
ApplicationsWB, IP, IF, IHC(P), ELISA
Reactivitymouse, rat, human
Quantity200 µg/ml
Conjugate/TagUnconjugated
FormatPurified
Hostmouse
ClonalityMonoclonal
NCBI Full Gene Namecullin 1
TargetCUL-1
IsotypeIgG2a
NCBI Gene AliasesCul-1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) CDT1 acts with the replisome to remodel replication forksSci AdvAugust 14, 2026Caitlin Hathaway, Thanh Le, Yuki Hatoyama, Masato Kanemaki, Huzefa DungrawalaRRID:AB_2651122), CDT1 (PLA 1:200, sc-365305; Santa Cruz Biotechnology; RRID:AB_1084780), CUL1 (WB 1:500, sc-17775; Santa Cruz Biotechnology; RRID:AB_627325), CUL2 (WB 1:500, sc-166506; Santa Cruz Biotechnology; RRID:AB_2230072),

(2) COP9 signalosome deneddylation activity is required for proliferation but not dedifferentiation of vascular smooth muscle cells in neointimal hyperplasiaAmerican Journal of Physiology-Heart and Circulatory PhysiologyJuly 1, 2026Samiksha Giri, Xuejun Wangfor WB,https://www.abcam.com/pcna-antibody-ab15497.html 2,GAPDH,Santa Cruz,Sc-32223,Mouse,1:1000 for WB,https://www.scbt.com/p/gapdh-antibody-6c5 3,Cullin1,Santa Cruz,Sc-17775,Mouse,1:1000 for WB,https://www.scbt.com/p/cul-1-antibody-d-5 4,Sm22α,Abcam,Ab14106,Rabbit,1:400 for

(3) UBA3 reduction sensitizes cancer cells to NAE inhibitorsLife Sci AllianceApril 29, 2026Yu-Ling Miao, Li-Na Zhou, Shan-Shan Song, Xu-Bin Bao, Xia-Juan Huan, Jian Ding, Jin-Xue He(#4108s) were purchased from Cell Signaling Technology. Antibodies against UBA3 (sc-377272), Cul1 (sc-17775), p21 (sc-271610), and γH2AX (sc-101696) were obtained from Santa Cruz Biotechnology. The antibody against

(4) SDCBP/Syntenin-1 stabilizes BACH1 by disassembling the SCF(FBXO22)-BACH1 complex in triple-negative breast cancerThe EMBO journalJune 1, 2025Tran PL, Kim O, Hwangbo C, Kim HJ, Kim YM, Lee JH.1/500)",OriGene,Cat#TA501377 "CUL-1 (D-5), Mouse monoclonal antibody (WB, 1/1000)",Santa Cruz Biotechnology,Cat#sc-17775 "FBXO22 (FF-7), Mouse monoclonal antibody (WB, 1/1000)",Santa Cruz Biotechnology,Cat#sc-100736 "FLAG

(5) SCFβ-TrCP targets Ajuba for degradation in a GSK3β-dependent manner in colorectal cancerNeoplasiaMay 13, 2025Liangshan Li, Feng Zhu, Yupei Liang, Yuanyuan Chen, Yongfu Pan, Lijun Jia, Shiwen Wang, Hu Zhaoanti-normal mouse IgG (sc-2025), anti-Ajuba (sc-398008) for IP, anti-β-TrCP (sc-390629) for IF, anti-CUL1 (sc-17775) antibodies (Santa Cruz Biotechnology); anti-Ajuba (HPA006171) antibody for IHC (Merck). The secondary

(6) Neddylation inhibitor MLN4924 sensitizes head and neck squamous carcinoma cells to (S)-10-hydroxycamptothecinEuropean journal of medical researchSeptember 9, 2023Gu S, Lin C, Li Y, Wei Z, Cao B, Shen Z, Deng H.(9542#), cleaved-PARP (5625#), p-CHK1 (S345) (2348#), P21 (2947#) (Cell Signaling Technology), CUL 1 (sc-17775) and t-CHK1 (sc-8408) (Santa Cruz), actin (A5441#) and FLAG (F1804) (Sigma). Wound-healing assay Cells

(7) CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progressionExperimental hematology & oncologySeptember 7, 2023Luo D, Chen M, Li Q, Wang K, Wang K, Li J, Fu G, Shan Z, Liu Q, Yang Y, et al.follows: UTX (33510S, Cell Signaling Technology; GTX121246, GeneTex), COP1 (A300-894A, Bethyl), CUL1 (SC-17775, Santa Cruz Biotechnology), CUL2 (A5308, Abclonal), CUL3 (2759, Cell Signaling Technology), CUL4A (AB60215a,

(8) The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture modelCellular and molecular life sciences : CMLSAugust 19, 2023Tian Y, Milic J, Monasor LS, Chakraborty R, Wang S, Yuan Y, Asare Y, Behrends C, Tahirovic S, Bernhagen J.am Main, Germany), anti-NF-kB pI-kB-alpha (product #9246S, Cell Signaling), anti-cullin1 (product #sc-17775, Santa Cruz, Heidelberg, Germany), anti-NEDD8 (product #2745S, Cell Signaling), anti-VE-Cadherin (product

(9) Systemwide disassembly and assembly of SCF ubiquitin ligase complexesCellApril 27, 2023Baek K, Scott DC, Henneberg LT, King MT, Mann M, Schulman BA.AB_11178669" Vinculin,Abcam,"Cat# ab129002, RRID: AB_11144129" CUL1,Santa Cruz Biotechnology,"Cat #sc–17775, RRID: AB_627325" SKP1,Cell Signaling Technology,"Cat #2156, RRID: AB_2270271" BTRC,Cell Signaling Technology

(10) Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based methodThe Journal of biological chemistryFebruary 1, 2023Hayashida R, Kikuchi R, Imai K, Kojima W, Yamada T, Iijima M, Sesaki H, Tanaka K, Matsuda N, Yamano K.(89-173/025),Calbiochem,Catalog no.: 529534 Mouse monoclonal anti-CUL-1 (D-5),Santa Cruz Biotechnologies,"Catalog no.: sc-17775, RRID: AB_627325" Goat polyclonal anti-CUL-4 (C-19),Santa Cruz Biotechnologies,"Catalog no.: sc-8557,

(11) Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensorNature communicationsOctober 26, 2022Paul D, Kales SC, Cornwell JA, Afifi MM, Rai G, Zakharov A, Simeonov A, Cappell SD.

(12) SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapyNeoplasia (New York, N.Y.)October 1, 2022Zhou LN, Xiong C, Cheng YJ, Song SS, Bao XB, Huan XJ, Wang TY, Zhang A, Miao ZH, He JX.purchased from Santa Cruz Biotechnology (Dallas, TX, USA) against the following: UBA3 (sc-377272); Cul1 (sc-17775); Wee1 (sc-5285); p21 (sc-271610); Chk2 (sc-9604); PARP1 (sc-7150); BAX (sc-493); BCL-2 (sc-492); MCL-1

(13) FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cellsExperimental & molecular medicineJanuary 1, 2022An HJ, Lee CJ, Lee GE, Choi Y, Jeung D, Chen W, Lee HS, Kang HC, Lee JY, Kim DJ, et al.Antibodies including anti-cyclin E (Cat #: sc-247), anti-Myc (Cat #: sc-40), anti-cullin 1 (Cat #: sc-17775), and anti-β-actin (Cat #: sc-47778) used for Western blotting and/or immunoprecipitation (IP) were

(14) Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesisCell death and differentiationJanuary 1, 2022Liu P, Cong X, Liao S, Jia X, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, et al.

(15) Potassium Effects on NCC Are Attenuated during Inhibition of Cullin E3-Ubiquitin LigasesCellsDecember 29, 2021Murali SK, Little R, Poulsen SB, Ferdaus MZ, Ellison DH, McCormick JA, Fenton RA.NCC (pT58) [28], NCC (SPC-402D, StressMarq), pSPAK/OSR1 (07-2273, Millipore), SPAK/OSR1 [29], Cul1 (sc-17775, Santa Cruz), Cul2 (sc-166506, Santa Cruz), Cul3 (sc-166110, Santa Cruz), Cul4 (sc-377188, Santa Cruz),

(16) Muscle-specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodelingEMBO reportsDecember 6, 2021Górska AA, Sandmann C, Riechert E, Hofmann C, Malovrh E, Varma E, Kmietczyk V, Ölschläger J, Jürgensen L, Kamuf-Schenk V, et al.,Santa Cruz,sc‐515406,"WB, PLA" Grk5,Grk5 (D9),Mouse,Santa Cruz,sc‐518005,"WB, PLA" Cul1,Cul1 (D5),Mouse,Santa Cruz,sc‐17775,"WB, PLA" Cul1,Cul1,Rabbit,Bethyl Laboratories,A303‐373A‐M,"WB, PLA" Cand1,TIP120A (G‐3),Mouse,Santa Cruz

(17) FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycanEMBO reportsNovember 4, 2021Yamada A, Hikichi M, Nozawa T, Nakagawa I.

(18) Novel role of xanthine oxidase-dependent H(2)O(2) production in 12/15-lipoxygenase-mediated de novo lipogenesis, triglyceride biosynthesis and weight gainRedox biologyNovember 1, 2021Govatati S, Pichavaram P, Mani AM, Kumar R, Sharma D, Dienel A, Meena S, Puchowicz MA, Park EA, Rao GN.

(19) Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole ScaffoldJournal of medicinal chemistryMay 13, 2021Xiong C, Zhou L, Tan J, Song S, Bao X, Zhang N, Ding H, Zhao J, He JX, Miao ZH, et al.

(20) Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicityNature communicationsMay 11, 2021Zhou H, Lu J, Chinnaswamy K, Stuckey JA, Liu L, McEachern D, Yang CY, Bernard D, Shen H, Rui L, et al.analysis and GAPDH was used as the loading control. Antibodies were purchased commercially: cullin 1 (sc-17775, 1:500 dilution) and cullin 2 (sc-166506, 1:500 dilution) from Santa Cruz Biotech (Santa Cruz, CA);

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(1)

6/5/2020Good Santa Cruz CUL1 Antibody for Western Blot Wei XuI would recommend this antibody for CUL1 western blot.

CUL-1 (D-5) Antibody

CUL-1 (D-5) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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CUL-1 (D-5) Antibody from Santa Cruz Biotechnology, Inc.

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