FAPA Polyclonal Antibody bs-5758R from Bioss Inc.

Product Specs
ItemFAPA Polyclonal Antibody
CompanyBioss Inc.
Price $375.00Supplier Page View Company Product Page
Catalog Numberbs-5758R
HostRabbit
ClonalityPolyclonal
Quantity100ul, 20uL
ReactivityHuman, Mouse, Rat, Human, Bovine
IsotypeIgG
Molecular Weight84kDa
ApplicationsIF(IHC-P), WB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC), WB
TargetFAPA
ImmunogenKLH conjugated peptide, human FAPA
Concentration1ug/ul
Antibody TypePrimary Antibody
NCBI Gene AliasesSIMP, DPPIV, FAPA, FAPalpha
NCBI Full Gene Namefibroblast activation protein alpha
Format0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol
Conjugate/TagUnconjugated

Questions and Answers

Can this antibody be used to study the role of FAP in pulmonary fibrosis?

Yes, the FAPA Polyclonal Antibody has been utilized in studies investigating pulmonary fibrosis, particularly in the context of mesenchymal stromal cells and their secretome. In one study, the antibody was used to detect FAPa+ progenitors, which are implicated in the resolution of established pulmonary fibrosis, indicating its relevance in this area of research ().

Is this antibody effective for immunohistochemistry applications?

The FAPA Polyclonal Antibody has been shown to work in immunohistochemistry, as evidenced by its use in histological studies to detect FAPa in tissue samples. This application is crucial for understanding the localization and expression of FAP in various pathological conditions, including cancer and fibrosis ().

What species can this antibody react with, and is it suitable for cross-species studies?

This antibody is reactive with mouse, bovine, and human species. Its cross-reactivity makes it suitable for comparative studies across these species, which can be particularly useful in translational research where animal models are employed to study human diseases.

Are there any specific experimental conditions or controls recommended when using this antibody?

When using the FAPA Polyclonal Antibody, it is recommended to block nonspecific sites with normal serum from the animal donor of the secondary antibodies, as demonstrated in immunostaining protocols. This step is essential to reduce background staining and improve the specificity of the antibody detection ().

Bioss Inc.

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Suite 4610

Woburn, MA 01801

United States

Phone: 800.501.7654 (Toll free)
Phone: +1.781.569.5821 (International)

Email: info@biossusa.com
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Company Profile

Website: www.biossusa.com

(1) Modulation of Cancer-Associated Fibroblasts via the miR-624-5p/FAP Axis Drives Progression and Metastasis in Non-Small Cell Lung CancerCancers (Basel)January 16, 2026Yan Zhao, Shuman Zhen, Xiaoxu Li, Xiaolin Chen, Xue Zhang, Xinming Zhao, Lihua LiuChina), and blocking with 10% BSA, and then incubated overnight at 4 °C with antibodies against FAP (Bs-5758R, 1:100, Bioss, Woburn, MA, USA), α-SMA (ab124964, 1:100, Abcam, Cambridge, MA, USA), and EpCAM (ab71916,

(2) Oncolytic herpes simplex virus reprograms cancer-associated fibroblasts to enhance antitumor immunity in pancreatic cancerMolecular Therapy OncologySeptember 18, 2025Feilong Zhou, Kailu Yang, Haoran Wang, Minghui Han, Dongping Zhang, Jie Wang, Han Wang, Yi Wang, Fengcongzhe Gong, Hao Zheng, et al.manufacturer’s instructions. The isolated CAFs were then stained for α-SMA-APC (bs-0189R, Bioss) and FAP-PE/Cy7 (bs-5758R, Bioss) by flow cytometry to evaluate their activation status, with PSCs used as a control. Cytopathic

(3) Acomys cahirinus develop lung stroma distortion but not fibrosis after bleomycin-induced injuryInflamm RegenAugust 29, 2025Nataliya A. Basalova, Vladimir S. Popov, Yulia G. Antropova, Natalia V. Danilova, Victoria N. Biryukova, Uliana D. Dyachkova, Maksim A. Vigovskiy, Olga A. Grigorieva, Natalia I. Kalinina, Anastasia Yu. Efimenkoantibodies (Abcam, UK) in 1% BSA (PanEco, Russia). To detect the targets, first antibodies FAPα (Bioss, bs-5758R, USA), alpha-smooth muscle actin (αSMA, abcam, ab5694, UK or Biolegend, 904601, UK), CD206 (abcam, ab64693,

(4) PDGF-BB/EGR1 Axis Drives Fibroblast Activation Protein Expression to Promote Abdominal Aortic AneurysmInt J Med SciJune 5, 2025Zhihao Zhou, Lin Huang, Hui Luo, Rongzhou He, Ridong Wu, Rui Wang, Kangjie Wang, Chen YaoPDGF-BB was purchased from Medchemexpress (HY-P7087, respectively, MCE). The primary antibodies for FAP (bs-5758R, Bioss, ab207178, abcam), EGR1 (4154, Cell Signaling Technology), ACTA2(67735, Proteintech), F4/80 (28463,

(5) Targeting CALR reduces energy metabolism of esophageal cancer cells and inhibits tumor‑associated fibroblast infiltrationInt J OncolMay 19, 2025Yu Miao, Xiaofei Wang, Fang He, Feixiong Zhang, Ying Huang, Yafang Lai, Yuanzhen Wang, Lina Zhang, Hua Yin, Xiangkun Meng, et al.no. Bs70000; Biogot Technology Co., Ltd.), fibroblast activation protein (FAP; all 1:1,000; cat. no. bs-5758R; BIOSS), ferroptosis suppressor protein 1 (FSP-1) (1:4,000; cat. no. 20886-1-AP), Platelet-derived growth

(6) DAB2 (+) macrophages support FAP (+) fibroblasts in shaping tumor barrier and inducing poor clinical outcomes in liver cancerTheranosticsJanuary 1, 2024Long F, Zhong W, Zhao F, Xu Y, Hu X, Jia G, Huang L, Yi K, Wang N, Si H, et al.(1:1000, Abcam Cat# ab955, RRID:AB_307338), SPP1 (1:200; PB0589, BOSTER) or FAP (1:200, Bioss Cat# bs-5758R, RRID:AB_11072621) antibodies and incubated flat in a wet box at 4°C overnight. The slides were then

(7) Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transferExperimental & molecular medicineJuly 1, 2023Nataliya B, Mikhail A, Vladimir P, Olga G, Maksim V, Ivan Z, Ekaterina N, Georgy S, Natalia D, Pavel M, et al.For detection of the targets, primary antibodies against CD163 (Abcam; ab182422), FAPa (Bioss, Inc.; bs-5758R), αSMA (Abcam; ab5694, or BioLegend; 904601), and CD90 (Invitrogen; PA5-80127) overnight. Detection

(8) Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive mannerThe Journal of clinical investigationJune 1, 2022Saeki N, Inoue K, Ideta-Otsuka M, Watamori K, Mizuki S, Takenaka K, Igarashi K, Miura H, Takeda S, Imai Y.mouse Fap (mFap; R&D Systems, MAB9727); rabbit polyclonal antibody against human FAP (hFAP; Bioss, bs-5758R); rabbit monoclonal antibody against human and mouse Thy-1 (Cell Signaling Technology, 13801); rabbit

(9) Exploring Metabolic Configurations of Single Cells within Complex Tissue MicroenvironmentsCell metabolismNovember 7, 2017Miller A, Nagy C, Knapp B, Laengle J, Ponweiser E, Groeger M, Starkl P, Bergmann M, Wagner O, Haschemi A.

(10) Stromal fibroblasts derived from mammary gland of bovine with mastitis display inflammation-specific changesScientific reportsJune 7, 2016Chen Q, He G, Zhang W, Xu T, Qi H, Li J, Zhang Y, Gao MQ.

(11) Enhanced Antitumor Activity of EGFP-EGF1-Conjugated Nanoparticles by a Multitargeting StrategyACS applied materials & interfacesApril 13, 2016Bo Zhang, Ting Jiang, Li Ling, Zhonglian Cao, Jingjing Zhao, Yanyan Tuo, Xiaojian She, Shun Shen, Xinguo Jiang, Yu Hu, Zhiqing Pang

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FAPA Polyclonal Antibody

FAPA Polyclonal Antibody from Bioss Inc.

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Bioss Inc.

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FAPA Polyclonal Antibody from Bioss Inc.

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