RAT ANTI SUBSTANCE P 8450-0505 from Bio-Rad (Formerly AbD Serotec)

Product Specs
ItemRAT ANTI SUBSTANCE P
CompanyBio-Rad
Price $453.00Supplier Page View Company Product Page
Catalog Number8450-0505
TargetSUBSTANCE P
CloneNC1/34
ModificationsBovine Serum Albumin
NCBI Gene AliasesNPK, NK2, NKNA, Hs.2563, TAC2
IsotypeIgG2a
ApplicationsImmunohistology - Paraffin,Immunohistology - Frozen,Immunofluorescence
Quantity0.1 ml
FormatS/N
HostRat
ReactivityPig,Pigeon,Bichir,Rabbit,Human,Bovine,Guinea Pig,Calanus sp.,Cancer sp.,Panilurus sp.,Homarus sp.,Mudpuppy,Lamprey,Crayfish,Zebrafish,Bullfrog,Cockroach,Sheep,Cowbird,Rat,Spadefoot toad,Chicken,Chinchilla,Camel,Beaver,Chinchilla
ClonalityMonoclonal Antibody
NCBI Full Gene Nametachykinin precursor 1

Questions and Answers

Can this antibody be used to study the role of substance P in gastrointestinal disorders?

Yes, the rat anti-substance P antibody has been utilized in studies examining the expression of substance P in the gastrointestinal tract, particularly in relation to gastric ulcers and the enteric nervous system. For instance, it was used to investigate changes in substance P expression in pigs with experimentally induced gastric ulcers, highlighting its involvement in gastrointestinal motility and inflammation ().

Is this antibody effective for immunofluorescence applications?

The rat anti-substance P antibody has been shown to work effectively in immunofluorescence applications, as evidenced by its use in various studies, including those that analyzed the co-localization of substance P with other neuropeptides in the enteric nervous system and hypothalamic regions (, ).

What species can this antibody react with in research?

This antibody has broad reactivity, being effective for various species including human, rat, mouse, porcine, and others. It has been cited in studies involving multiple species, indicating its versatility in research applications across different animal models (, ).

How has this antibody been utilized in studies related to pain signaling?

The rat anti-substance P antibody has been employed in research investigating pain signaling mechanisms, particularly in tendinopathy and other pain-related conditions. For example, it was used to explore the distribution of substance P in the Achilles tendon, which is associated with excessive pain signaling in tendinopathy ().

Bio-Rad

Bio-Rad Laboratories, Inc. Life Science Research Group 2000 Alfred Nobel Drive

Hercules, California 94547

United States

Phone: 800-424 6723
800-879 2289

Company Profile

Website: http://discover.bio-rad.com

(1) Immunohistochemical characterization of nerve fibers supplying canine elbow joint capsuleBMC Veterinary ResearchMarch 6, 2026Jowita Jacewicz-Żurek, Waldemar Sienkiewicz, Tomasz Burzykowski, Beata DegórskaF,Cappel n-NOS,mouse,monoclonal,1:100,N2280,081K4815,Sigma-Aldrich VIP,mouse,monoclonal,1:500,MaVIP,"91,278",East Acres Biologicals SP,rat,monoclonal,1:150,8450 − 0505,NC134,"ABD Serotec, UK" Gal,rabbit,polyclonal,1:2000,RIN7153,990921-2,Peninsula Lab. DßH,rabbit,monoclonal,1:500,DZ1020-0050,0606031668,"Biomol,

(2) Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid usePainNovember 1, 2025Olivia C. Davis, Samuel Ferland, Louis-Etienne Lorenzo, Clare Murray-Lawson, Stephanie Shiers, Muhammad Saad Yousuf, Annemarie Dedek, Eve C. Tsai, Erin Vines, Peter Horton, et al.07–432), mouse anti-NeuN (1:500, Millipore, Cat#MAB377) and rat anti-substance P (1:100; Biorad, Cat# 8450–0505) in PBS with 0.3% triton and 5% normal goat serum, and left overnight at 4°C. Following 3 further rinses

(3) The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain statesCell ReportsApril 22, 2025Aman Upadhyay, Mark A. Gradwell, Thomas J. Vajtay, James Conner, Arnab A. Sanyal, Chloe Azadegan, Komal R. Patel, Joshua K. Thackray, Manon Bohic, Fumiyasu Imai, et al.anti-VGLUT1 (1:2000, IHC)",Millipore,AB5905; RRID:AB_2301751 "Rat anti-substance P (1:1000, IHC)",Bio-Rad,8450-0505; RRID:AB_2200292 Bacterial and viral strains,, pAAV-hSyn-DIO-EGFP (AAV1),Addgene,50457-AAV1 pAAV1-hSyn-DIO-hM4D(Gi)-mCherry

(4) Microplastic and the Enteric Nervous System: Effect of PET Microparticles on Selected Neurotransmitters and Cytokines in the Porcine IleumInternational journal of molecular sciencesOctober 30, 2024Gałęcka I, Całka J.Waltham, MA, USA" "ThermoFisher Scientific, Waltham, MA, USA",PGP 9.5,Mouse,1:1000,480012 SP,Rat,1:150,8450-0505,"BioRad, Hercules, CA, USA" VAChT,Rabbit,1:2000,H-V006,"Phoenix Pharmaceuticals, Inc., Burlingame,

(5) Oral Exposure to Microplastics Affects the Neurochemical Plasticity of Reactive Neurons in the Porcine JejunumNutrientsJuly 14, 2024Gałęcka I, Całka J.transporter,Rabbit,1:2000,H-V006 Galanin,Guinea pig,1:2000,T-5036,"Peninsula, San Carlos, CA, USA" Substance P,Rat,1:150,8450-0505,"BioRad, Hercules, CA, USA" Vasoactive intestinal peptide,Rabbit,1:2000,ab22736,"Abcam, Cambridge,

(6) Comparison of the Influence of Bisphenol A and Bisphenol S on the Enteric Nervous System of the Mouse JejunumInternational Journal of Molecular SciencesJune 25, 2024Krystyna Makowska, Sławomir GonkowskiHercules, CA, USA" VIP,11428,Rabbit,1:4000,"Cappel, Aurora, OH, USA, 11428, working dilution 1:5000" SP,8450-0505,Rat,1:1000,BioRad nNOS,AB5380,Rabbit,1:2000,"Sigma-Aldrich, Saint Louis, MO, USA" GAL,T-5036,Guinea pig

(7) The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain StatesbioRxivMay 10, 2024Aman Upadhyay, Mark A. Gradwell, Thomas J. Vajtay, James Conner, Arnab A. Sanyal, Chloe Azadegan, Komal R. Patel, Joshua K. Thackray, Manon Bohic, Fumiyasu Imai, et al.,Synaptic Systems,131011 "Guinea pig anti-VGLUT1 (1:2000, IHC)",Millipore,AB5905 "Rat anti-substance P (1:1000, IHC)",Bio-Rad,8450–0505 RNAScope probes,RNAScope probes,RNAScope probes vGAT,ACD Biosciences,319191 vGluT2,ACD Biosciences,456751 GlyT2,ACD

(8) Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenumParticle and fibre toxicologyFebruary 6, 2024Gałęcka I, Szyryńska N, Całka J.Carlos, CA, USA" nNOS,Rabbit,1:3000,PA1-033,"ThermoFisher Scientific, Waltham, MA, USA" SP,Rat,1:150,8450-0505,"BioRad, Hercules, CA, USA" VAChT,Rabbit,1:2000,H-V006,"Phoenix Pharmaceuticals, Inc., Burlingame,

(9) Bisphenol A Effects on Neurons’ Neurochemical Character in the Urinary Bladder Intramural Ganglia of Domestic PigsInternational Journal of Molecular SciencesNovember 27, 2023Krystyna Makowska, Piotr Lech, Sławomir GonkowskiAntibodies Antigen,Code,Species,Working Dilution,Supplier "PGP 9,5",7863-2004,Mouse,1:1000,"Biogenesis Ltd., Poole, UK" SP,8450-0505,Rat,1:1000,"Bio-Rad (AbD Serotec), Kidlington, UK" CART,1-003-61,Rabbit,1:8000,"Phoenix Pharmaceuticals,

(10) Changes Caused by Bisphenols in the Chemical Coding of Neurons of the Enteric Nervous System of Mouse StomachInternational Journal of Environmental Research and Public HealthMarch 14, 2023Krystyna Makowska, Slawomir GonkowskiFarmingdale, NY, USA",[32] GAL,T-5036,Guinea Pig,1:2000,"Peninsula Labs., San Carlos, CA, USA;",[32] SP,8450-0505,Rat,1:1000,"Bio-Rad (AbD Serotec), Kidlington, UK",[32] VAChT,H-V006,Rabbit,1:2000,"Phoenix Pharmaceuticals,

(11) The Comparison of the Influence of Bisphenol A (BPA) and Its Analogue Bisphenol S (BPS) on the Enteric Nervous System of the Distal Colon in MiceNutrientsDecember 30, 2022Krystyna Makowska, Ewa Lepiarczyk, Slawomir GonkowskiAntibodies Antigen,Code,Species,Working Dilution,Supplier PGP 9.5,7863-2004,Mouse,1:1000,"Biogenesis Ltd., Poole, UK" SP,8450-0505,Rat,1:1000,"Bio-Rad (AbD Serotec), Kidlington, UK" VIP,VA 1285,Rabbit,1:1000,"Enzo Life Sciences; Farmingdale,

(12) Immunodetection of P2X2 Receptor in Enteric Nervous System Neurons of the Small Intestine of PigsAnimals : an open access journal from MDPIDecember 17, 2022Mozel S, Arciszewski MB.Cambridge, UK" Hu C/D,Mouse,1:400,A-21271,"Thermo Fisher Scientific, Waltham, MA, USA" sP,Rat,1:200,8450-0505,"BIO-RAD, Hercules, CA, USA" Galanin,Guinea pig,1:300,T-5036,"BMA Biomedicals, Augst, Switzerland" VIP,Mouse,1:100,9535-0504,"Biogenesis

(13) Changes in the Enteric Neurons Containing Selected Active Substances in the Porcine Descending Colon after the Administration of Bisphenol A (BPA)International Journal of Environmental Research and Public HealthDecember 3, 2022Krystyna Makowska, Sławomir GonkowskiAntibodies Antigen,Code,Species,Working dilution,Supplier "PGP 9,5",7863-2004,Mouse,1:1000,"Biogenesis Ltd., Poole, UK" SP,8450-0505,Rat,1:1000,"Bio-Rad (AbD Serotec), Kidlington, UK" VIP,VA 1285,Rabbit,1:2000,"Enzo Life Sciences; Farmingdale,

(14) Administration of Different Doses of Acrylamide Changed the Chemical Coding of Enteric Neurons in the Jejunum in GiltsInternational journal of environmental research and public healthNovember 4, 2022Bulc M, Całka J, Palus K.marker), substance P (SP, working dilution 1:150, rat monoclonal, AbD Serotec, Raleigh, NC, USA, code 8450-0505;), cocaine- and amphetamine-regulated transcript peptide (CART, working dilution 1:8000; rabbit, Phoenix

(15) The Influence of an Adrenergic Antagonist Guanethidine (GUA) on the Distribution Pattern and Chemical Coding of Dorsal Root Ganglia (DRG) Neurons Supplying the Porcine Urinary BladderInternational Journal of Molecular SciencesDecember 13, 2021Paweł Janikiewicz, Barbara Wasilewska, Urszula Mazur, Amelia Franke-Radowiecka, Mariusz Majewski, Agnieszka BossowskaAntigen,Code,Dilution,Host,Supplier Primary antibodies,Primary antibodies,Primary antibodies,Primary antibodies,Primary antibodies SP,8450-0505,1:300,Rat,"AbD Serotec; Oxford, UK" CGRP,PC205L,1:9000,Rabbit,"Merck Millipore; Temecula, CA, USA" SOM,MAB354,1:30,Rat,"Merck Millipore

(16) The Influence of Bisphenol A (BPA) on the Occurrence of Selected Active Substances in Neuregulin 1 (NRG1)-Positive Enteric Neurons in the Porcine Large IntestineInternational Journal of Molecular SciencesSeptember 24, 2021Krystyna Makowska, Kamila Szymańska, Jarosław Całka, Sławomir Gonkowski198–229,Rabbit,1:1000,"Antibodies-online, Aachen, Germany" VIP,9535-0504,Mouse,1:1000,"Biogene, Kombolton UK" SP,8450-0505,Rat,1:1000,"BioRad, Hercules, CA, USA" nNOS,N218,Mouse,1:1000,"Sigma-Aldrich, Saint Louis, MO, USA" GAL,T-5036,Guinea Pig

(17) Cocaine and Amphetamine Regulated Transcript (CART) Expression Changes in the Stomach Wall Affected by Experimentally Induced Gastric UlcerationsInternational Journal of Molecular SciencesJuly 12, 2021Michal Zalecki, Adrianna Plywacz, Hanna Antushevich, Amelia Franke-Radowiecka7863–2004, clone 31A3, AbD Serotec, Raleigh, NC, USA) and CART (rabbit anti-CART, dilution 1:20,000, code 8450-0505, AbD Serotec), and corresponding secondary antibodies (AlexaFluor 488, goat anti-mouse, dilution 1:500,

(18) Characterization of the structure, vascularity, and stem/progenitor cell populations in porcine Achilles tendon (PAT)Cell and tissue researchMay 1, 2021Zhang J, Li F, Williamson KM, Tan S, Scott D, Onishi K, Hogan MV, Wang JH.(1:350, antibodies-online, Cat. ABIN925874, Atlanta, GA), and rat anti-substance P (1:500, Bio-RAD, Cat. 8450–0505, Farmingdale, NY) overnight at 4 °C. Sections were then washed twice in PBS for 5 min before being incubated

(19) Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine HeartAnimals (Basel)March 11, 2021Krystyna Makowska, Slawomir GonkowskiGuinea pig 1:1600 Peninsula, San Carlos, CA, USA NPY NA 1115 Rabbit 1:2000 Biomol, Hamburg, Germany SP 8450-0505 Rat 1:1000 Bio-Rad (AbD Serotec), Kidlington, UK TH MAB 318 Mouse 1:400 Millipore, Warszawa,

(20) Pancreas Optical Clearing and 3-D Microscopy in Health and DiabetesFrontiers in endocrinologyJanuary 1, 2021Campbell-Thompson M, Tang SC.work PGP9.5/UCHL1,Pan-neural,Chicken,EnCor,CPCA-UCHL1,1:100,Worked PGP9.5/UCHL1,Pan-neural,Rabbit,Abcam,ab108986,1:200,Worked Î²-Tubulin,Pan-neural,Mouse,EnCor,MCA-4E4,1:100,Worked Substance P,Sensory nerves,Rat,BioRad,8450-0505,1:200,Worked Tyrosine Hydroxylase,Sympathetic neurons,Rabbit,Millipore,AB152,1:200,Worked Tyrosine Hydroxylase

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RAT ANTI SUBSTANCE P

RAT ANTI SUBSTANCE P

RAT ANTI SUBSTANCE P

RAT ANTI SUBSTANCE P

RAT ANTI SUBSTANCE P from Bio-Rad (Formerly AbD Serotec)

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RAT ANTI SUBSTANCE P from Bio-Rad (Formerly AbD Serotec)

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