HNF-4α (H-1) Antibody sc-374229 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemHNF-4α (H-1) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-374229
Hostmouse
ClonalityMonoclonal
Conjugate/TagUnconjugated
Reactivitymouse, rat, human
CloneH-1
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P), ELISA
NCBI Gene AliasesHNF4a9, HNF4a8, TCF14, FRTS4, HNF4a7, Hnf4alpha, HNF4, Tcf14, HNF-4, MODY1, NR2A21, MODY, TCF, Nr2a1, NR2A1, Hnf4, TCF-14, HNF4alpha
Antibody TypePrimary Antibodies
NCBI Full Gene Namehepatic nuclear factor 4, alpha, hepatocyte nuclear factor 4 alpha
TargetHNF-4alpha
FormatPurified
IsotypeIgG1

Questions and Answers

What applications has the HNF-4α antibody been used for in scientific research?

The HNF-4α antibody has been shown to work in various applications including Western Blotting, ELISA, Immunofluorescence, Immunohistochemistry, and Immunoprecipitation, as evidenced by its use in multiple studies.

Can this antibody be used to study the role of HNF-4α in liver-related diseases?

Yes, the HNF-4α antibody has been utilized in studies investigating liver diseases, such as its role in promoting hepatitis B virus replication and its involvement in alcohol-related liver disease, highlighting its relevance in hepatic research.

What species does the HNF-4α antibody react with?

The HNF-4α antibody is reactive with mouse, human, and rat species, making it suitable for comparative studies across these organisms.

How has the HNF-4α antibody contributed to understanding cellular mechanisms in cancer research?

The antibody has been used to identify interactions of HNF-4α with proteins involved in DNA repair in colorectal cancer cells, suggesting its role in tumorigenesis and cellular responses to DNA damage.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Allyl isothiocyanate ameliorates metabolic dysfunction-associated steatotic liver disease via vitamin D receptors in hepatocytesWorld Journal of GastroenterologyJanuary 28, 2026Ting Gao, Kang-Peng Zhong, Jun-Zhuo Wang, Yi Chen, Chun-Xiao LiCPT1α (sc-393070; Santa Cruz), PPARα (sc-398394; Santa Cruz), ApoB (sc-393636; Santa Cruz), HNF-4α (sc-374229; Santa Cruz), phosphatidylinositol 3-kinase (PI3K) (4249; CST), acetyl-CoA carboxylase (3662; CST),

(2) Numb-exon3 and full length Numb equivalently alleviate cholestatic liver fibrosis by inhibiting ductular reactionScientific ReportsNovember 14, 2025Yan-nan Xu, Meng-yao Zong, Wen Xu, Shi-hao Zhang, Dan-yang Wang, Xin-rui Zheng, Fei-fei Xing, Jun-yi Zhan, Jia-mei Chen, Gao-feng Chen, et al.Company, Newark, DE, USA); mouse monoclonal antibodies to hepatocyte nuclear factor 4 alpha (HNF4α; sc-374229) and Sox9 (E-9, sc-166505) (Santa Cruz Biotechnology, Inc., CA, USA); rabbit polyclonal antibody to

(3) Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric budCell stem cellJuly 3, 2025Shi M, Crouse B, Sundaram N, Pode Shakked N, Thorner K, King NM, Dutta P, Ester L, Zhang W, Govindarajah V, et al.RRID:AB_2819013 Rabbit anti-GATA3,Cell Signaling Technology,Cat# 5852; RRID:AB_2798212 Mouse anti-HNF4A,Santa Cruz,Cat# sc-374229; RRID:AB_10989766 Rabbit anti-HNF4A,Cell Signaling Technology,Cat# 3113; RRID:AB_2295208 Mouse anti-Human

(4) Comparative analysis of small molecule and growth factor-derived human induced pluripotent stem cell-derived hepatocyte-like cellsFrontiers in Cell and Developmental BiologyJune 26, 2025Faizal Z. Asumda, Shadia Alzoubi, Kiyasha Padarath, Kimya Jones, Ravindra Kolhe, Ashis Kumar Mondal, Ahmet Alptekin, Wenbo Zhi, Tae Jin Lee, Robert C. Huebert, et al.SSEA-1 (sc-21702), TRA-160 (sc-21705), TRA-180 (sc-21706), FOXA2 (sc-271103), CXCR4 (sc-53534), HNF4A (sc-374229), A1AT (sc-166018), ALBUMIN (sc-271605) and AFP (sc-80464) were from Santa Cruz Biotechnology, Inc (Santa

(5) Efficient Generation of Induced Pluripotent Stem Cell-Derived Definitive Endoderm Cells with Growth Factors and Small MoleculesCellsMay 30, 2025Faizal Z. Asumda, Shadia Alzoubi, Kiyasha Padarath, Nina John, Kimya Jones, Ravindra Kolhe, Ashis Kumar Mondal, Tae Jin Lee, Wenbo Zhi, Robert C. Huebert, et al.(Rockford, IL, USA). Antibodies against SOX17 (sc-130295), FOXA2 (sc-271103), CXCR4 (sc-53534), HNF4A (sc-374229), and AFP (sc-80464) were from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA, USA). Secondary FITC-conjugated

(6) Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesisNat CommunFebruary 10, 2025Qingwen Zhao, Xuan Cui, Qi Zhu, Feiyan Li, Ran Bao, Ting Shi, Haojie Liu, Wenjing Lv, Yingjiang Xu, Yue Gao, et al.Anti-PGC-1α (NBP1-04676 for IP), anti-RNF34 (NBP2-56413) from Novus bio; anti-HA (sc-805X), anti-HNF-4α (sc-374229), anti-CRTC2 (sc-271912) from Santa Cruz; anti-PPARα (ab314112) from abcam; anti-H4K20me3 (39672) from

(7) Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasisNat CommunJanuary 22, 2025Alireza Lorzadeh, George Ye, Sweta Sharma, Unmesh Jadhavagainst Cdx2 (Cell Signalling, D11D10), Ctcf (Diagenode, C15410210), or Hnf4a (Santa Cruz Biotechnology, sc-374229) and incubated overnight. Antibody-bound chromatin was digested at 4 °C for 30 min on a nutator. Fragment

(8) MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesisBiology DirectOctober 18, 2024Hong Cao, Zidi Wang, Qiwei Guo, Shanshan Qin, Dandan Liantibodies used in this study are listed as follows: BTF3L4 (Proteintech, 16500-1-AP), HNF4A (Santa Cruz, sc-374229), β-Actin (Proteintech, 20536-1-AP). Chromatin immunoprecipitation assay Chromatin immunoprecipitation

(9) Roles of Growth Hormone–Dependent JAK-STAT5 and Lyn Kinase Signaling in Determining Lifespan and Cancer IncidenceEndocrinologyOctober 8, 2024Yash Chhabra, Helle Bielefeldt-Ohmann, Tania Louise Brooks, Andrew James Brooks, Michael J Waters823664,Cell Signaling Technology INSRβ (4B8),3025,AB 2280448,Cell Signaling Technology HNF4α (H-1),sc-374229,AB 10989766,Santa Cruz Biotechnology P-STAT3 Y705 (D3A7),9145,AB 2491009,Cell Signaling Technology STAT3

(10) A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and AnalysisAdvanced Healthcare MaterialsAugust 1, 2024Soo‐Yeon Kang, Masaki Kimura, Sunil Shrestha, Phillip Lewis, Sangjoon Lee, Yuqi Cai, Pranav Joshi, Prabha Acharya, Jiafeng Liu, Yong Yang, et al.concentration,Vendor,Catalog # Albumin,Rabbit,10 μg/mL,Abcam,ab2406 HNF4α,Mouse,5 μg/mL,Santa Cruz,sc-374229 E-cadherin,Mouse,5 μg/mL,Santa Cruz,sc-21791 CDX2,Mouse,10 μg/mL,ThermoFisher,39–7800 Alexa Fluor

(11) Krüppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4α-mediated metabolic pathwaysMetabolism: clinical and experimentalJune 1, 2024Pan X, Hu S, Xu Y, Gopoju R, Zhu Y, Cassim Bawa FN, Wang H, Wang J, Batayneh Z, Clark A, et al.antibody against KLF10 (cat # H00007071-M15) was purchased from Abnova. The antibody against HNF4α (cat # sc-374229) was purchased from Santa Cruz Biotechnology. Antibodies against CYP7A1 (cat # TA351400) or CYP8B1 (cat

(12) DNA methylation-dependent and -independent binding of CDX2 directs activation of distinct developmental and homeostatic genesbioRxivMarch 7, 2024Alireza Lorzadeh, George Ye, Sweta Sharma, Unmesh Jadhavagainst Cdx2 (Cell Signalling, D11D10), Ctcf (Diagenode, C15410210), or Hnf4a (Santa Cruz Biotechnology, sc-374229) and incubated overnight. Antibody bound chromatin was digested at 4 °C for 30 minutes on a nutator.

(13) Acanthopanax senticosus ameliorates steatohepatitis through HNF4 alpha pathway activation in miceScientific reportsJanuary 2, 2024Kawano Y, Tanaka M, Satoh Y, Sugino S, Suzuki J, Fujishima M, Okumura E, Takekoshi H, Uehara O, Sugita S, et al.antibodies used were HNF4 alpha (1:1000; Santa Cruz Biotechnology, Inc., Dallas, TX, USA; cat. no. sc-374229), ABCG8 (1:2000; Abcam Inc. Cambridge, MA, USA; cat. No. ab223056), Ces2 (1:1000; Thermo Fisher Scientific,

(14) CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variantsOncoImmunologyDecember 31, 2023Na Qiu, Akshaya Srikanth, Medhanie Mulaw, Umesh Tharehalli, Shanthiya Selvachandran, Martin Wagner, Thomas Seufferlein, Katja Stifter, André Lechel, Reinhold SchirmbeckSubsequently, cells were incubated with the primary antibodies (#70-HG15S, Fitzgerald; #181598, Abcam; #sc374229, Santa Cruz) at 4°C overnight, washed and incubated with the corresponding secondary antibodies AP106C

(15) Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloidsCellAugust 31, 2023Liu L, Oura S, Markham Z, Hamilton JN, Skory RM, Li L, Sakurai M, Wang L, Pinzon-Arteaga CA, Plachta N, et al.

(16) Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive marginCellAugust 17, 2023Ruf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, et al.ICRF44),Biolegend,Cat #: 301312; RRID: AB_314164 HNF-4alpha (H-1) antibody (Clone: H-1),Santa Cruz,Cat #: sc-374229; RRID: AB_10989766 HLA-DR-BX026 (L243)—ATTO 550-RX026 Kit (Clone: L243),Akoya Biosciences,Cat #: 4250006;

(17) BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reactionStem cell research & therapyMarch 20, 2023Xu YN, Xu W, Zhang X, Wang DY, Zheng XR, Liu W, Chen JM, Chen GF, Liu CH, Liu P, et al.Company, Newark, DE, USA); mouse monoclonal antibodies anti-hepatocyte nuclear factor 4 alpha (HNF4α; sc-374229) and Sox9 (E-9, sc-166505) (Santa Cruz Biotechnology, Inc., CA, USA); rabbit polyclonal antibody anti-RBP-Jκ

(18) A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and AnalysisbioRxivMarch 17, 2023Soo-Yeon Kang, Masaki Kimura, Sunil Shrestha, Phillip Lewis, Sangjoon Lee, Yuqi Cai, Pranav Joshi, Prabha Acharya, Jiafeng Liu, Yong Yang, et al.concentration,Vendor,Catalog # Albumin,Rabbit,10 μg/mL,Abcam,ab2406 HNF4α,Mouse,5 μg/mL,Santa Cruz,sc-374229 E-cadherin,Mouse,5 μg/mL,Santa Cruz,sc-21791 CDX2,Mouse,10 μg/mL,ThermoFisher,39–7800 Alexa Fluor

(19) Recapitulating thyroid cancer histotypes through engineering embryonic stem cellsNature communicationsMarch 11, 2023Veschi V, Turdo A, Modica C, Verona F, Di Franco S, Gaggianesi M, Tirrò E, Di Bella S, Iacono ML, Pantina VD, et al.

(20) Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functionsPloS oneJanuary 1, 2023Inui J, Ueyama-Toba Y, Mitani S, Mizuguchi H.,Bethyl Laboratories,A80-129A,1:200 CYP3A4,goat,Santa Cruz Biotechnology,sc-27639,1:50 HNF4α,rabbit,Santa Cruz Biotechnology,sc-374229,1:200 αAT,rabbit,Dako,A0012,1:200 Alexa Fluor 488 anti-goat IgG,donkey,Thermo Fisher Scientific,A11055,1:1000 Alexa

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2/17/2023Good HNF-4alpha Antibody for Paraffine Embedded Tissue Filippo MassaHNF4a is expressed in the liver by the hepatocytes once they are differentiated. This antibody allowed us to visualise and distinguish this particular cell type from the other components of the liver ... Read Review

HNF-4α (H-1) Antibody

HNF-4α (H-1) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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HNF-4α (H-1) Antibody from Santa Cruz Biotechnology, Inc.

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