DRP1 (D6C7) Rabbit mAb 8570S from Cell Signaling Technology

Product Specs
ItemDRP1 (D6C7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8570S
Quantity100 µl
ApplicationsW, W-S, IP, IF-IC
ReactivityH, M, R, Mk
TargetDRP1
IsotypeIgG
HostRabbit
NCBI Gene AliasesDLP1, DRP1, DVLP, DYMPLE, EMPF, EMPF1, HDYNIV, OPA5
NCBI Full Gene Namedynamin 1 like
CloneD6C7
Molecular Weight78-82
ClonalityMonoclonal
Research AreaCytoskeletal Signaling

Questions and Answers

Can this antibody be used to study mitochondrial dynamics in my experimental model?

Yes, the DRP1 (D6C7) Rabbit mAb has been utilized in various studies to investigate mitochondrial dynamics, particularly in the context of mitochondrial fission. For instance, it has been employed in Western blot analyses to assess DRP1 expression and phosphorylation in models of cardiac dysfunction and atherosclerosis, indicating its relevance in mitochondrial morphology and function studies.

What species can I use this antibody on for my research?

The DRP1 (D6C7) Rabbit mAb is reactive with multiple species, including humans, mice, rats, and non-human primates. This broad reactivity allows for its application in comparative studies across different model organisms.

Has this antibody been cited in any studies related to inflammatory diseases?

Yes, the DRP1 (D6C7) Rabbit mAb has been referenced in studies investigating inflammatory diseases, such as atherosclerosis. In one study, inhibition of DRP1-dependent mitochondrial fission using this antibody was shown to alleviate inflammation and M1 macrophage polarization, highlighting its potential role in understanding the mechanisms of inflammatory responses.

Is this antibody suitable for use in immunofluorescence applications?

Yes, the DRP1 (D6C7) Rabbit mAb has been shown to work effectively in immunofluorescence applications. It has been used to visualize DRP1 localization and dynamics in various cell types, providing insights into mitochondrial behavior under different physiological and pathological conditions.

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Website: Technical Support

(1) Protective role of fatty acid oxidation against epithelial barrier dysfunction in allergic asthmaRedox ReportDecember 31, 2026Muyun Wang, Yanan He, Haiyang Hu, Di Wu, Ximing Liao, Jing Gao, Shaoyong Gao, Huiming Yin, Kian Fan Chung, Qiang Li, et al.antibodies used were anti-CPT1A (Abcam, UK, ab234111), anti-DRP1 (Cell Signaling Technology, CST, USA, 8570), anti-FIS1 (CST, 32525), anti-OPA1 (CST, 80471), anti-MFN2 (CST, 9482), anti-NLRP3 (CST, 15101), Anti-Caspase-1

(2) A dual-responsive CO-releasing nanogel ameliorates retinal ischemia–reperfusion injury by restoring mitochondrial homeostasis and attenuating cGAS-STING pathway activationMaterials Today BioJune 1, 2026Duncheng Xiao, Jiaqi Qin, Fangpu Zhang, Tianchang Tao, Weiwei Tang, Xiaojun Cai, Liming Tao, Xianwen Wang, Zhengxuan Jiangovernight at 4 °C with primary antibodies. The following primary antibodies were used: Drp1 (CST, #8570, 1:1000, ∼80 kDa), Fis1 (Proteintech, 10956-1-AP, 1:1000, ∼17 kDa), Mfn1 (Abcam, ab104274, 1:1000, ∼84

(3) Blue Light Induces Retinal Ganglion Cell Damage by Stimulating Drp1-Dependent Mitochondrial Fission and Activating NF-κB/NOX4 AxisInvest Ophthalmol Vis SciMay 22, 2026Xin-Hao Han, Tao Wang, Gui-Feng Sun, Xin Xie, Kun Zhang, Xiao-Yu Wang, Zhen Zhang, Xing Wang, Xin-Hui Qu, Xiao-Jian Hanfollowing primary antibodies: OPA1 (no. 80471; Cell Signaling Technology, Danvers, MA, USA), Drp1 (no. 8570; Cell Signaling Technology), Phospho-Drp1 (no. 4494; Cell Signaling Technology), MFN2 (no. 9482; Cell Signaling Technology

(4) Age-Associated Impairment of Paneth Cells Driven by microRNA-152 Promotes Intestinal Epithelial Vulnerability to Pathological StressAging CellMay 13, 2026Bridgette Warner, Haonan Zhao, Hongxia Chen, Amy VanderStoep, Ana S. G. Cunningham, Dongyoon Yoo, Hee K. Chung, Christine Brantner, Jennifer Coleman, Joungil Choi, et al.,Cell Signaling Technology # 11998S Mitofusin,Cell Signaling Technology # 14739S DRP1,Cell Signaling Technology # 8570S GAPDH,Cell Signaling Technology # 2118S Anti‐rabbit IgG,Cell Signaling Technology # 7074S Anti‐mouse

(5) RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4-Mediated Mitochondrial Restoration and Inflammation SuppressionJ Cachexia Sarcopenia MuscleMay 1, 2026Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun#12829S), PGC‐1α (Abcam, #ab191838), Nrf2 (Abcam, #ab137550), p‐DRP1(Ser616) (CST, #4494), DRP1 (CST, #8570), MFF (CST, #84580), FIS1 (Proteintech, #10956‐1‐AP), NOX2 (Abcam, #ab129028), NOX4 (Invitrogen, #MA5‐32090)

(6) It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in MacrophagesbioRxivMay 1, 2026Marzieh Daniali, Breana Channer, Erin O. Curley, Amirali Amirfallah, Taylor Kist, John Montilla, Stephanie Kosashvili, Lexi Sheldon, Kelly Stauch, Joshua G. Jackson, et al.used included phospho-DRP1 (Ser616; #3455, Cell Signaling Technology, RRID: AB_2085352), total DRP1 (#8570, Cell Signaling Technology, RRID: AB_10950498), cGAS (D1D3G; #15102, Cell Signaling Technology, RRID:

(7) Hyperactive Muscle mTORC1 Attenuates Functional Adaptations to Endurance Training Despite Alterations in Mitochondrial and Lipid ProfilesJournal of Applied PhysiologyMay 1, 2026Hanna Kalenta, Erik D. Marchant, Sean P. Kilroe, Rosario Maroto, Jacquelyn T. May, Vladislav Bugay, Trevor B. Romsdahl, Jennifer J. Linares, Mandy R. Hinojosa, Zhao Lai, et al.Cell Signaling Catalog No. 9482), LC3A/B (1:1000, Catalog No. 4108), DRP1 (1:1000, Cell Signaling catalog No. 8570), P-ULK1 (Ser757) (1:500, Cell Signaling catalog no. 14202), OXPHOS rodent (1:2,000), abcam catalog

(8) Interleukin-13 Promotes Accumulation of Esophageal Epithelial Mitochondria With Translational Implications for Eosinophilic EsophagitisCellular and Molecular Gastroenterology and HepatologyApril 27, 2026Jazmyne L. Jackson, Reshu Saxena, Mary Grace Murray, Abigail J. Staub, Courtney Worrell, Jasmine Cruz, No’ad Shanas, Alena Klochkova, Travis H. Bordner, John M. Crespo, et al.(1:1000) Parkin,Cell Signaling,4211S,WB (1:1000) p-DRP1S616,Cell Signaling,3455S,WB (1:1000) DRP1,Cell Signaling,8570S,WB (1:1000) Toll-Like Receptor 9,Cell Signaling,2254S,WB (1:1000) cGAS,Cell Signaling,79978S,WB (1:1000) p-STINGS366,Cell Signaling

(9) A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAFV600E-Associated Mitochondrial Division in CancerAntibodies (Basel)April 20, 2026Shanon T. Nizard, Yiyang Chen, Madhavika N. Serasinghe, Ruben Fernandez-Rodriguez, Kamrin D. Shultz, Jesminara Khatun, Anthony Mendoza, Jesse D. Gelles, Juan F. Henao-Martinez, Ioana Abraham-Enachescu, et al.antibodies utilized for Western blot are total DRP1 (Cell Signaling Technology, Danvers, MA, USA, Cat. No. 8570), DRP1-S616Ⓟ (Cell Signaling Technology, Danvers, MA, USA, Cat. No. 3455S), DRP1-S637Ⓟ (Cell Signaling Technology

(10) Nanoparticle-Loaded Injectable Hydrogel Alleviates Titanium Particle-Induced Osteolysis by Disrupting GATA6/DDX3X-Mediated Macrophage InflammationBiomaterials ResearchApril 16, 2026Sipeng Lin, Taihe Liu, Qi Zhu, Zhuji Ouyang, Yifan Yu, Haopeng Sun, Changchuan Li, Shixun Li, Chenhao Pan, Wing Cheuk Ko, et al.67824, Cell Signaling Technology), p-IRF3 (Rabbit, 29047, Cell Signaling Technology), DRP1 (Rabbit, 8570, Cell Signaling Technology), FIS1 (Rabbit, 32525, Cell Signaling Technology), and GATA6 (Rabbit, 5851,

(11) Distinct HIF1α and HIF2α functions control skeletal muscle metabolism and erythropoiesisJournal of Clinical InvestigationApril 15, 2026Junhyeong Lee, Merc Emil Matienzo, Sangyi Lim, Edzel Evallo, Yeongsin Kim, Sujin Jang, Keon Kim, Chang Hyeon Choi, Youn Ho Han, Chang-Min Lee, et al.ABclonal), COX4 (4850; Cell Signaling Technology), Cre-recombinase (15036; Cell Signaling Technology), DRP1 (8570; Cell Signaling Technology), GLUT4 (sc53566; Santa Cruz Biotechnology), HIF1α (NB-100-105; Novus Biologicals),

(12) ALDOB K87 lactylation drives mitochondrial fission and metabolic reprogramming in pulmonary hypertensionCommunications BiologyMarch 27, 2026Liu Yi, Wenming He, Changqing He, Xianbao Shi, Xiaodong Deng, Jinyu Chang, Jie Ni, Li Liu, Lina Shanprimary antibodies against TOM20 (mitochondrial marker, 1:500, #ab186735; Abcam) and DRP1 (1:200, #8570; CST). Alexa Fluor 488/594-conjugated secondary antibodies (1:1000; Invitrogen) were applied for 1 h,

(13) Ca 2+ influx through ER-plasma membrane contacts is required for brown fat thermogenesis and metabolic healthbioRxivMarch 26, 2026J Zhou, C Dogan, L L Artico, K Rodrigues, S Hakam, T Kim, V Xu, K Lapenta, M Kang, D M Jorgens, et al.4107) ; Oxphos cocktail (Abcam, ab110413); pDRP1 ser616 (Cell Signaling, 4494); DRP1 (Cell Signaling, 8570), anti-rabbit IgG (Cell Signaling, 7074S), and anti-mouse IgG (Cell Signaling, 7076S). Gene expression analysis

(14) CtBP1 sustains activity-dependent muscle properties and dampens synaptic, contractile and metabolic changes triggered by denervationSkeletal MuscleMarch 23, 2026Olivia Cattaneo, Gaetan Lopez, Jayasimman Rajendran, Florent Chabry, Nicolas Liaudet, Sergei Startchik, Alexandre Prola, Perrine Castetsused: CtBP1 (PA582651; 1/2000 for IF on sections, 1/250 for IF on fibers) from ThermoFisher; DRP1 (8570), DRP1P637 (20990), DRP1P616 (4494), Pak1 (2602), CtBP1 (8684; 1/200 for IF), GAPDH (2118) and OPA1

(15) Nobiletin from Xiaoyu Xiezhuo Decoction: Restoring Mitochondrial Dynamics and Alleviating Renal Ischemia-Reperfusion Injury via M1 Macrophage ModulationKidney and Blood Pressure ResearchMarch 17, 2026Yuan Yuan, Jing Huang, Yinchao Zhou, Zhibo Weng, Yiru Weng, Zhouzhou Dongincubated with primary antibodies (whole night): dynamin-related protein 1 (Drp1) (1:1,000; 90 kDa, #8570, CST, USA), mitofusin 2 (Mfn2) (1:1,000; 92 kDa, #9482, CST, USA), and glyceraldehyde-3-phosphate dehydrogenase

(16) A preclinical candidate of cyclophilin D inhibition improves alcohol-associated liver injuryCell Rep MedMarch 17, 2026Zhaoyi Che, Zhihui Luo, Dong Xiao, Fashu Ma, Haoxiong Zhou, Yali Song, Shanshan Guo, Yuan Yuan, Hao Wang, Ching-Pong Mak, et al.RRID:AB_868694 Anti-CYP2E1 antibody,Abcam,Cat#ab28146; RRID:AB_2089985 Anti-DRP1 antibody,Cell Signaling Technology,Cat#8570; RRID:AB_10950498 Anti-FIS1 antibody,Cell Signaling Technology,Cat#32525; RRID:AB_2927422 Anti-OPA1

(17) DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸBNature CommunicationsMarch 16, 2026Yanhao Lai, Rebecca Z. Fan, Harry J. Brown, Said S. Salehe, Ethan K. Tieu, Kim Tieucontrol (2 µg; CST #2729), Anti–NF-κB p65 antibody (2 µg; CST #8242), and Anti-DRP1 antibody (2 µg; CST #8570). Immune complexes were captured using sheared salmon sperm DNA–coated protein A agarose beads for 2

(18) Heart-Specific and Conditional Deletion of the Immt Gene Reveals Its Role in Regulating Mitochondrial Structure and Total Heart MetabolismCellsMarch 12, 2026Yasuhide Kuwabara, Caitlin Keezer, Suh-Chin J. Lin, Akanksha Rajput, Jeffery D. Molkentinanti-OPTN (#10837-1-AP, Proteintech, 1:5000), anti-OPA1 (#ab157457, abcam, 1:1000), and anti-DRP1 (#8570, Cell Signaling Technology, 1:1000). 2.6. RNA Isolation, Bulk RNA Sequencing, and Bioinformatic Analysis Total

(19) Pathogenic roles of the IMNEPD-associated PTRH2 mutants in aggravating mitochondrial dynamics and its rescueMolecular MedicineMarch 10, 2026DoHyeong Na, Seungmin Yoo, Muhah Jeong, Nahyun Lee, Youngwon Kim, Youbin Kim, Dong-Hyung Cho, Yong-Keun JungSigma-Aldrich; RFP (PM005) from MBL Life Science; TIM23 (611,222) and OPA1 (612,607) from BD Biosciences; DRP1 (8570), pDRP1-S616 (4494), pDRP1-S637 (6319), S6 (2317), and pS6 (5364) from Cell Signaling Technology; FKBP8

(20) Trans-Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of GlycosphingolipidsMedComm (2020)March 7, 2026Zhen Ni, Chenyin Cao, Yanlin Tian, Jinming Mu, He Tian, Zehua Wang, Shaohua Zhang, Mingjun Cao, Yuntian Yang, Wei Ling Florence Lim, et al.anti‐p53 (Cell Signaling, 2524S, 1:500), anti‐OPA1 (abcam, ab42364, 1:1000), anti‐DRP1 (Cell Signaling, 8570, 1:1000), anti‐mTOR (Immunoway, YT2913, 1:1000), anti‐p‐mTOR (Abmart, T56571, 1:1000), anti‐S6K (Cell Signaling

Write a Review

(1)

1/29/2024DRP1 Rabbit mAb From Cell Signaling Has Good Signal Hannah LiuThe goal of our research is to study the drug treatment effect on mitochondrial dynamics. Dynamin-related protein 1 (DRP1) affects mitochondrial morphology and is important in mitochondrial fission. ... Read Review
(1)

5/16/2022Good DRP1 Antibody for Western Blot Marco PilliI used this antibody several times and it always worked. Cells were stimulated with TGFb that it can induce renal fibrosis and higher expression of DRP1. Cells were stimulated for 24 hours.
(1)

1/7/2016Immunocytochemistry of DRP1 Lakshmi Reddy BolluOur research lab is focused on understanding the role of oncogenes, such as EGFR, in the metabolism, signaling pathways, growth and metastasis of human cancers including prostate, breast, colon and ... Read Review

DRP1 (D6C7) Rabbit mAb

DRP1 (D6C7) Rabbit mAb from Cell Signaling Technology

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DRP1 (D6C7) Rabbit mAb from Cell Signaling Technology

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