Fig 1: In silico mapping of the interaction between HEV IRESl RNA and ribosomal proteins. (A) The interaction between HEV IRESl (cyan) and RPS3A (lime) is shown in the cartoon. The interacting nucleotides and amino acids are rendered in licorice and colored in atom-wise mode; C, cyan/white; O, red; N, blue; S, yellow. (B) The interaction between HEV IRESl (cyan) and RPS7 (lime) is shown in the cartoon. The interacting nucleotides and amino acids are rendered as shown in A. (C) The interaction between HEV IRESl (cyan) and RPL26 (lime) is shown in the cartoon. The interacting nucleotides and amino acids are rendered as shown in A. (D) The interaction between HEV IRESl (cyan) and RPL5 (lime) is shown in the cartoon. The interacting nucleotides and amino acids are rendered as shown in A. (E) The interaction between HEV IRESl (cyan) and GAPDH (green) is shown in the cartoon. The interacting nucleotides and amino acids are rendered as shown in A. (F to J) The quantitative polar contacts between nucleotide and amino acids are measured for the indicated complexes and are shown in bar graphs (y axis, hydrogen bond distance; x axis, interacting pair of nucleotides@amino acids). (K) Binding free energy for the indicated complexes.