Fig 1: Immunohistochemical assays (a) and relative expression (b) of CD27+ cells in the spinal cord and brain tissues of EAE mice (× 200). A and G. control at day 7; B and H, EAE mice at day 7; C and I, control at day 18; D and J, EAE mice at day 18, E and K. control at day 30 and F and L. EAE mice at day 30, respectively. A-F, spinal cord tissue; G-L, brain tissue. Arrows denote CD27++ cells. * denotes P < 0.05 vs control