Fig 2: The possible mechanism of Ac2-26 hepatoprotection during HIRI.The ischemia-reperfusion injury induced the secretion of IL-22 by Th cell and NK cell. The action of IL-22 was mediated by binding to the heterodimeric receptors of IL-22R1 and IL-10R2, which could phosphorylate the JAK2/STAT3 signaling. Subsequently, p-STAT3 molecule appeared to be dimerized, translocated into the nucleus, and bound to specific DNA sequence to induce the transcription of many gens that regulating apoptosis and proliferation. Ac2-26 could reduce ischemia-reperfusion induced hepatocytes damage via inhibiting the secretion of IL-22 and inhibition of the JAK2/STAT3 signaling pathway.