Fig 1: Kidney capsule transplantation of WT and KI UDET hPSC-derived cardiac organoids.a, Schematic illustrating timeline of humanization of NSG mice with human PBMCs as well as organoid transplantation and downstream analyses, FC = flow cytometry. b, Immunostaining of hPSC-CMs in cardiac organoid grafts (green, cTnT) and infiltrating T cells (red, CD3) in kidney capsules of mice injected with (left) WT cardiac organoids and (right) KI UDET hPSC-derived cardiac organoids. Dashed lines outlining graft area. c-e, Quantification of immunostaining displaying (c) cTnT+ area, (d) average cTnT+ area per graft, and (e) intragraft CD3+ area. f-g, Quantification of flow cytometry data evaluating CD3+ cells in circulation as percent of hCD45+ cells in mice receiving cardiac organoids kidney capsule transplantations, displayed as fold change from baseline. *=p<0.05, ****=p<0.001.