Hippocampus from aged control and nLrp1−/− mice (male, 20-24 months) with or without bexarotene treatment (100 mg/kg/day) for 8 weeks were analyzed by immunostaining for GFAP (A) and Iba-1 (B). Scale bars = 50 μm. C, D. The levels of GFAP (C) and CD11b (D) in the hippocampus of the above described mice were analyzed by ELISA (N=4-6/group). Data are plotted as mean ± SEM. *p<0.05, **p<0.01 by Tukey’s post-hoc analysis after two-way ANOVA. n.s., not significant. Source: 1. Tachibana M., et al. 2016. Exp Neurol. 277:1-9.