IL6ST/CD130 Rabbit Polyclonal Antibody orb10914 from Biorbyt

Product Specs
ItemIL6ST/CD130 Rabbit Polyclonal Antibody
CompanyBiorbyt
Price $250.00Supplier Page
Catalog Numberorb10914
ReactivityHuman, Mouse, Rat
TargetIL6ST
Conjugate/TagUnconjugated
Quantity50 ul, 100 ul, 200 ul
ApplicationsFC, IF, IHC-Fr, IHC-P, WB
ClonalityPolyclonal
FormatLiquid
ImmunogenKLH conjugated synthetic peptide derived from human IL6R beta (651-750/917aa)
Molecular Weight99 kDa
IsotypeIgG
HostRabbit
Concentration1mg/ml
NCBI Full Gene Nameinterleukin 6 cytokine family signal transducer
NCBI Gene AliasesCD130, CDW130, GP130, HIES4, HIES4A, HIES4B, IL-6RB, IMD94, STWS2, sGP130
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Research AreaApoptosis, Cardiovascular Research, Cell Cycle, Signal Transduction

Specifications/Features

Application Dilutions: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1µg/Test

Questions and Answers

What species does this gp130 antibody work with in my experiments?

The gp130 antibody has been shown to be reactive with mouse, human (Homo sapiens), and rat species, making it suitable for a variety of biological studies involving these organisms.

Can this antibody be used for immunohistochemistry, and if so, what are the recommended dilutions?

Yes, the gp130 antibody can be used for immunohistochemistry (IHC). The recommended dilution for IHC is between 1:100 and 1:500, depending on the specific conditions of your experiment.

I’m interested in using this antibody for flow cytometry. What is the suggested amount per test?

For flow cytometry applications, it is suggested to use 1 µg of the gp130 antibody per test, which should provide adequate sensitivity for detecting the target protein.

Are there any publications that have utilized this gp130 antibody in their research?

Yes, the gp130 antibody has been cited in 12 scientific articles, indicating its relevance and application in various research contexts, particularly in studies related to the interleukin 6 cytokine family and its signaling pathways.

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(1) Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate OsteoarthritisArthritis & rheumatology (Hoboken, N.J.)August 1, 2020Weber AE, Jalali O, Limfat S, Shkhyan R, Van Der Horst R, Lee S, Lin Y, Li L, Mayer EN, Wang L, et al.

(2) Caloric restriction reduces basal cell proliferation and results in the deterioration of neuroepithelial regeneration following olfactotoxic mucosal damage in mouse olfactory mucosaCell and tissue researchNovember 1, 2019Iwamura H, Kondo K, Kikuta S, Nishijima H, Kagoya R, Suzukawa K, Ando M, Fujimoto C, Toma-Hirano M, Yamasoba T.

(3) Proliferation of prostate epithelia induced by IL-6 from stroma reacted with Trichomonas vaginalisParasite immunologyJune 1, 2018Kim JH, Han IH, Kim YS, Noh CS, Ryu JS.

(4) Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancerApoptosis : an international journal on programmed cell deathJune 1, 2018Li S, Tian J, Zhang H, Zhou S, Wang X, Zhang L, Yang J, Zhang Z, Ji Z.

(5) Interleukin‑6 induces an epithelial‑mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migrationMolecular medicine reportsJune 1, 2017Zhou J, Zhang C, Pan J, Chen L, Qi ST.

(6) Glycoprotein 130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancerScientific reportsDecember 5, 2016Cao Y, Zhang H, Liu H, Lin C, Li R, Wu S, He H, Li H, Xu J.

(7) HLA class II (DRB1, DQA1 and DQB1) associated genetic susceptibility in Iranian multiple sclerosis (MS) patientsEuropean journal of immunogenetics : official journal of the British Society for Histocompatibility and ImmunogeneticsAugust 1, 1998Amirzargar A, Mytilineos J, Yousefipour A, Farjadian S, Scherer S, Opelz G, Ghaderi A.

(8) Insulin delivery methods. A review of today's choicesAdvance for nurse practitionersMay 1, 1998Nemchik R.

(9) Cellular levels of photosensitisers in tumours: the role of proximity to the blood supplyBritish journal of cancerOctober 1, 1994Korbelik M, Krosl G.

(10) Induction and suppression of immediate early genes in specific rat brain regions by the non-competitive N-methyl-D-aspartate receptor antagonist MK-801NeuroscienceApril 1, 1993Gass P, Herdegen T, Bravo R, Kiessling M.

(11) Local recurrence and survival in soft tissue sarcomas: the relation of biopsyLa Chirurgia degli organi di movimentoJanuary 1, 1990Thompson RC Jr, Hartman R, Swanson P, Dusenbury K.

(12) The mechanism of action of the C3b inactivator (conglutinogen-activating factor) on its naturally occurring substrate, the major fragment of the third component of complement (C3b)The Journal of experimental medicineMay 1, 1975Gitlin JD, Rosen FS, Lachmann PJ.

(13) Under siegeNursing timesJanuary 1, 1970Naish J.

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