The SPINK5/LEKTI Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to serine peptidase inhibitor Kazal type 5, and SPINK5. This antibody recognizes Human, Mouse, and Rat antigen. The SPINK5/LEKTI Rabbit mAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin