The SARM1 Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The SARM1 Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,Contains 1 TIR domain.,Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta