Bioassay Technology Laboratory's PSMD1 Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes: a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base: which contains 6 ATPase subunits and 2 non-ATPase subunits: and a lid: which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome: the immunoproteasome: is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid: which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene