The ACTN1 Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The ACTN1 Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins: including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells: the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions: where it is involved in binding actin to the membrane. In contrast: skeletal: cardiac: and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies: where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle: cytoskeletal: alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene