TrkB Antibody AF1494 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemTrkB Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF1494
NCBI Gene AliasesEIEE58, Tkrb, TRKB, GP145-TrkB/GP95-TrkB, trk-B, OBHD, DEE58, GP145-TrkB, trkB
ApplicationsBioassay,ELISA Development (Capture),IHC fixed frozen,IHC-F,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Proximity Ligation Assay,Simple Western,Blockade of Receptor-ligand Interaction,Neutralization,Immunocytochemistry,ELISA Capture
ReactivityAvian - Chicken,Human,Mouse,Primate,Primate - Callithrix jacchus (Common Marmoset),Rat,Transgenic Mouse
TargetTrkB
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Conjugate/TagUnconjugated
HostGoat
Quantity100 ug (also 25 ug)
IsotypeIgG
NCBI Full Gene Nameneurotrophic receptor tyrosine kinase 2, neurotrophic tyrosine kinase, receptor, type 2
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse TrkB, Cys32-His429, Accession # P15209
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse TrkB in direct ELISAs. Detects human, mouse, and rat TrkB in Western blots.

Sizes Available: 100 ug (also 25 ug)

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Questions and Answers

Can this antibody be used to detect TrkB in mouse tissues?

Yes, the TrkB antibody has been shown to detect mouse TrkB in direct ELISAs and in Western blots, making it suitable for use in mouse tissue studies.

Is this antibody effective for immunohistochemistry applications?

The TrkB antibody has been cited in multiple studies for use in immunohistochemistry, demonstrating its effectiveness in visualizing TrkB expression in tissue sections.

What species can this antibody react with?

This antibody is reactive with several species, including human, mouse, rat, and chicken, allowing for versatile applications across different biological models.

Are there any specific studies that have utilized this antibody in their research?

Yes, the TrkB antibody has been referenced in at least 76 scientific articles, indicating its widespread use in various research contexts, including studies on neurotrophic factors and sensory neuron differentiation.

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) BDNF/TrkB Signaling in Intracardiac Ganglia Modulates Cardiac Parasympathetic ToneInt J Mol SciAugust 19, 2026Jacopo Agrimi, Seungho Jun, Marie Anne Makoudjou, Roberto Luisetto, Lucia Bernardele, Giovanni Piccolo, Wenling Li, Elizabeth H. Smith, Megan D. Poston, Yoh-Suke Mukouyama, et al.No.,RRID,Dilution Anti-TrkB,goat,Mouse myeloma cell line NS0-derived recombinant mouse TrkB.,R&D Systems,AF1494,RRID: AB_2155264,1:200 Anti-BDNF,Rabbit,"Peptide (C)VLEKVPVSKQLK, corresponding to amino acid residues

(2) Targeting Supramolecular Active Complexes of Na v 1.7/Na v 1.8 to Relieve Chronic Neuropathic PainAdvanced ScienceMay 20, 2026Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, et al.antibodies against Nav1.7 (Abcam, ab85015, 1:800) and Nav1.8 (NeuroMab, 75–166, 1:1000), TrkB (R&D system, AF1494, 1:1000), GAPDH (Proteintech Group, 60004‐1‐Ig, 1:3000) and β‐ACTIN (Sigma‐Aldrich, A5441, 1:5000).

(3) CHRNA3⁺ nociceptors prime the cutaneous sensory interface to enhance electroacupuncture analgesiaChin MedMay 19, 2026Wenjie Xu, Dingdan Zhang, Yuanwei Tang, Ying Wang, Zijie Wang, Hanqing Xi, Xinyan Gao, Bing Zhu, Xiang Cui(Invitrogen, PA5-77501, 1:200), PIEZO2 (Novus, NBP2-58161, 1:50), TrkA (R&D, AF1056, 1:200), TrkA (NOVUS, AF1494, 1:200), p-ERK (Santa Cruz, sc-7383, 1:200), NeuN (Sigma, MAB377, 1:200). RNAscope Multiplex Fluorescent

(4) Teneurin-3 and latrophilin-2 are required for somatotopic map development and somatosensory topognosisCurrent BiologyMay 18, 2026Kevin T. Sangster, Xinying Zhang, Daniel del Toro, Christina Sarantopoulos, Ashley M. Moses, Shreya Mahasenan, Daniel T. Pederick, Sophie Perreault, Catherine Fallet-Bianco, R. Brian Roome, et al.Cell Signaling Technology, #2250S), Goat anti-TrkA (1:500, R&D Systems, AF1056), Goat anti-TrkB (1:500, R&D Systems, AF1494), and Goat anti-TrkC (1:500, R&D Systems, AF373). Donkey secondary antibodies conjugated to Alexa 488,

(5) Pericytes are organ-specific regulators of tissue morphogenesisNat CommunMay 12, 2026Seyed Javad Rasouli, Kai Kruse, Rodrigo Diéguez-Hurtado, Parisa Ghanbari, Anusha Aravamudhan, Mara E. Pitulescu, Ralf H. Adamsrabbit anti-Cleaved Caspase-3 (1:100, Cell Signaling, #9664), and Goat anti-TrkB (1:50, Biotechne; AF1494). Brain sample preparation and immunohistochemistry For immunohistochemical analysis of mouse brains,

(6) TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamineSci AdvMay 1, 2026Anisul Arefin, Jihye Kim, Manas Pratim Chakraborty, Silvia Martinelli, Betty Bai, Francis S. Lee, Joshua Levitzserum and 3% BSA PBS solution for 30 min at RT. Primary antibodies for endogenous TrkB (R&D Systems, AF1494; 1:1000) were added overnight in 3% donkey serum and 3% BSA PBS solution at 4°C. After three 5-min washes,

(7) Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neuronsCell death & diseaseFebruary 11, 2026Blackburn E, Birsa N, Lopes AT, Fisher EMC, Lazo OM, Schiavo G.pAKT(Ser473) (Cell Signalling Technology 4060S, RRID:AB_2315049, IF 1:250, WB 1:1,000), TrkB (R&D Systems, AF1494, RRID:AB_2155264, IF 1:250, WB 1:500), EEA1 (BD Transduction Laboratories, 610457, RRID:AB_397830, IF

(8) Fluoxetine minimally affects hearing loss but induces gene expression changes in the cochlear nuclei after noise exposurePLoS OneFebruary 3, 2026Hyun-Ju An, Sujin Choi, Soonchul Lee, Hyunjeong Yeo, So Young Kimrabbit monoclonal [EPR1292] IgG anti-BDNF [ab108319, Abcam], 1:5000; polyclonal goat IgG anti-TrkB [AF1494, R&D systems], 1:150; rabbit monoclonal [EPR25743–59] IgG anti-brevican (BCAN) [ab285162, Abcam], 1:1000;

(9) Molecular and biophysical characterization of cultured DRG neurons in response to focused ultrasoundScientific reportsJanuary 8, 2026Brunet E, Parpaite T, Yoo S, Debieu E, Metwally K, Mensah S, Malapert P, Saurin A, Macherey O, Franceschini E, et al.Sigma-Aldrich, N4142), rabbit anti-CGRP (1:200, Calbiochem, PC205L), goat anti-TrkB (1:500, R&D Systems, AF1494), goat anti-TrkC (1:500, R&D Systems, AF1404), rabbit anti-TRPV1 (1:1000, Interchim, A8564) and rat

(10) Rebalancing NTRK2 isoforms promotes vascular regeneration in bronchopulmonary dysplasiaCell Stem CellJanuary 8, 2026Yunpei Zhang, Cheng Tan, Ziyi Liu, Xiangdi Mao, Cheng Jiang, Afzaal Nadeem Mohammed, Xiaolei Li, Renzhong Lu, Anmin Wang, Wusiman Maihemuti, et al.RESOURCEAntibodies,SOURCE,IDENTIFIER CD31 (PECAM-1) microBeads,Miltenyi biotec,Cat#: 130-091-935 Goat anti NTRK2 antibody,Bio-Techne,Cat#: AF1494 TrkB (80E3) Rabbit mAb,Cell Signaling,Cat#: 4603S Anti-TrkB.T1 [FH1D12],Absolute Antibody,Cat#: Ab02622-10.3 Anti-TrkB

(11) Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum DisorderAutism ResearchNovember 1, 2025Alejandra Fernandez, Nick Sarn, Charis Eng, Kevin M. Wright(TH),Rabbit,Millipore,AB152,AB_390204,1:1000 TrkA,Goat,Fisher (R&D systems),AF1056,AB_2283049,1:100 TrkB,Goat,Fisher (R&D systems),AF1494,AB_2155264,1:100 TrkC,Goat,Fisher (R&D systems),AF1404,AB_2155412,1:100 Casp3,Rabbit,Cell signaling,9661S,AB_2341188,1:500 CGRP,Igg2a,Abcam,ab81887,AB_1658411,1:300 Etv1,Rabbit,Invitrogen,PA5‐77975,AB_2735767,1:250 Anti‐Kv4.3

(12) hPSC-derived sacral neural crest cells restore erectile function in pelvic ganglia injuryStem Cell Res TherOctober 29, 2025Ting Yang, Wenwei Liu, Yuxin Wu, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yongxin Zhang, Hufei Wang, Yebohao Zhou, Wu Song104/well) were seeded in 96-well plates. The cells were treated with H2O2 (Guangzhou), CM, anti-BDNF (AF1494, R&D Systems), anti-GDNF (AF-212-NA, R&D Systems), and anti-NGF (AF-256-NA, R&D Systems) for 24 h. Next,

(13) Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophyNature communicationsSeptember 30, 2025Moradi M, Weingart J, Deng C, Nasouti M, Briese M, Jablonka S, Sauer M, Sendtner M.1:250), anti-TuJ1 (Neuromics, MO15013, 1:1000), and polyclonal goat anti-TrkB (Bio-Techne Sales Corp, AF1494, 1:500). Secondary antibodies are as followed: donkey anti-mouse IgG (H + L) (Alexa Fluor 488, Jackson ImmunoResearch

(14) Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza InfectionJournal of Visualized ExperimentsSeptember 19, 2025Sachin Gaurav, Arnav Sharma, Francisco Lobo, Terren K. Niethamerdifferent viral titer, ACK Lysis Buffer,Quality Biological,118–156-101,, Anti-TRKB Antibody,R&D Systems,AF1494,, Bleach,Clorox,,10% Bleach, Bovine Serum Albumin,Sigma Aldrich,A8022,, CO2 Anesthesia Induction

(15) Clusters of deep intronic RbFox motifs embedded in large assembly of splicing regulators sequences regulate alternative splicingPLOS GeneticsSeptember 9, 2025Francesco Tomassoni-Ardori, Mary Ellen Palko, Melissa Galloux, Lino Tessarolloab76291 Abcam, 1:1000), anti-TrkB.T1 C13 (sc-119; Santa Cruz) 1:1000 (discontinued; replaced by anti-TrkB AF1494 R&D Systems, 1:1000), anti-Rbfox1 (MABE985, clone 1D10, Millipore-Sigma) 1:1000, anti-Rbfox2 (A300-864A,

(16) A Spinal Circuit for Modular Gating of Organ SomatosensationbioRxiv : the preprint server for biologySeptember 1, 2025Zhang Y, Liu F, Yang L, Hahm HJ, Heitmeier MR, Okuda T, Kawatani M, Harrigan JT, Morrison-Rodriguez EC, Petukhova A, et al.1:500), Anti- TH (Chicken, Aves Labs, Cat# TYH; 1:1000), Anti-TrkB (Goat polyclonal, R&D Systems, Cat# AF1494; 1:500), Anti-TrkC (Goat polyclonal, R&D Systems, Cat# AF1404; 1:500), Anti-PV (Mouse monoclonal, Synaptic Systems

(17) Truncated NTRK2 is induced in CAP1 endothelial cells during mouse lung injury-repairiScienceJuly 18, 2025Celine Shuet Lin Kong, Mitheera V, Jezreel Pantaleón-García, Scott E. Evans, Jichao Chenantibodies were used for immunofluorescence: goat anti-Tropomyosin receptor kinase B (TrkB/NTRK2, 1:250, AF1494, R&D Systems), rabbit anti-Avian erythroblastosis virus E-26 (v-ets) oncogene related (ERG, 1:5000,

(18) A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signalingiScienceJune 20, 2025Anders Dalby, Mathias Kaas, Lars Meinertz Byg, Signe Bundgaard Christiansen, Christian M. Longworth, Simon Bøggild Hansen, Per Qvist, Jens R. Nyengaard, Peder Madsen, Simon Mølgaard, et al.coverslips were then incubated with primary antibodies (1:500 goat anti human/mouse TrkB, R&D Systems #AF1494; 1:1000 rabbit anti-mouse MAP2, Millipore #AB5622; 1:200 mouse anti-mouse PSD95, Sigma #P246; 1:100

(19) Oral 7,8-Dihydroxyflavone Protects Retinal Ganglion Cells by Modulating the Gut-Retina Axis and Inhibiting Ferroptosis via the Indoleacrylic Acid-AhR-ALDH1A3-FSP1 PathwayCNS neuroscience & therapeuticsMay 1, 2025Zhou Y, Feng Y, Zhao Y, Wu Y, Li M, Yang X, Wu X, Chen X.#SAB4503785, Sigma), rabbit anti‐pY706‐TrkB (1:1000, #SAB4300702, Sigma), goat anti‐TrkB (0.1 μg/mL, #AF1494, R&D Systems), and rabbit anti‐β‐actin (1:2000, #AF5003, Beyotime). Intracellular levels of nrf2, NQO1,

(20) Temporal refinement of Dach1 expression contributes to the development of somatosensory neuronsThe EMBO JournalApril 9, 2025Tünde Szemes, Alba Sabaté San José, Abdulkader Azouz, Maren Sitte, Gabriela Salinas, Younes Achouri, Sadia Kricha, Laurence Ris, Kristy Red-Horse, Eric J Bellefroid, et al.39.4D5), guinea pig anti-PRDM12 (1:1000) (Desiderio et al, 2019), goat anti-TrkB (1:500, R&D System, AF1494), goat anti-TrkC (1:500, R&D System, AF1404), goat anti-TrkA (1:500, R&D System, AF761), guinea pig

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TrkB Antibody

TrkB Antibody

TrkB Antibody

TrkB Antibody

TrkB Antibody

TrkB Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

Questions and Answers

R&D Systems, a Bio-Techne Brand

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TrkB Antibody from R&D Systems, a Bio-Techne Brand

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