Fig 1: Ability of p53 to drive TLR8 expression in primary human cells depends on SNP in p53 response element of TLR8 promoter.The regulatory region of TLR8 was amplified by PCR and the product was analyzed for the presence of the A and/or the G version of the p53 RE. Presented are SNP genotypes and the expression levels of TLR8 following 24 h of treatment with (A) nutlin, (B) IR, (C) Doxo and (D) 5FU. Since the gene is X-linked, males have one copy and females have two copies of the allele. Presented are results with stimulated lymphocytes (black symbols) or alveolar macrophages (red symbols).