HER4/ErbB4 (111B2) Rabbit mAb 4795S from Cell Signaling Technology

Product Specs
ItemHER4/ErbB4 (111B2) Rabbit mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number4795S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M
TargetHER4/ErbB4
HostRabbit
NCBI Gene AliasesALS19, HER4, p180erbB4
ClonalityMonoclonal
NCBI Full Gene Nameerb-b2 receptor tyrosine kinase 4
Research AreaRTK
Clone111B2
Molecular Weight180

Questions and Answers

Can this antibody be used to study ErbB4 signaling in human cancer models?

Yes, the HER4/ErbB4 (111B2) Rabbit mAb has been utilized in various studies to investigate ErbB4 signaling pathways in human cancer models. For instance, it was employed in Western blot analysis to assess ErbB4 expression in Ewing Sarcoma cells, demonstrating its role as a target gene for microRNA regulation in this context ().

Is this antibody effective for immunoprecipitation applications?

The HER4/ErbB4 (111B2) Rabbit mAb has been shown to work effectively in immunoprecipitation applications, as indicated by its use in studies examining receptor tyrosine kinase signaling pathways, including those involving ErbB4 ().

What species can this antibody detect, and is it specific to ErbB4?

This antibody detects endogenous levels of ErbB4 protein specifically in human and mouse samples. Importantly, it does not cross-react with other members of the ErbB family, ensuring specificity in experimental applications ().

How has this antibody been utilized in research related to drug resistance in cancer?

The HER4/ErbB4 (111B2) Rabbit mAb has been used in studies investigating therapeutic resistance mechanisms in cancer. For example, it was part of a panel of antibodies used to analyze the effects of receptor tyrosine kinase inhibitors on ErbB4 phosphorylation in breast cancer models, highlighting its relevance in understanding resistance to targeted therapies ().

Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Investigating PAK inhibition in combination with PD-1 blockade to enhance cytotoxic CD8+ T cell-mediated killing and suppress invasion of ovarian cancer cellsBritish Journal of CancerMarch 6, 2026Alexandria R. Mitchell, Yiran Chen, Giuseppe Pugliese, Gabriela Vino Flores, David M. Davies, John Maher, Claire M. WellsTex,GTX127915,Rabbit,1:1000 HER2 (29D8),Cell Signaling,2165,Rabbit,1:1000 HER4 (111B2),Cell Signaling,4795,Rabbit,1:500 β-Catenin (D10A8) XP®,Cell Signaling,8480S,Rabbit,1:1000 pβ-catenin (S675),Cell Signaling,9567S,Rabbit,1:1000 Akt

(2) Necl-4/CADM4 regulates GABAergic synaptic strength on GABAergic inhibitory neurons via ErbB4 activation and prevents neuronal impairmentsMolecular neurobiologyDecember 1, 2025Komaki R, Shiotani H, Kuriu T, Kameyama T, Miyata M, Kedashiro S, Katanazaka K, Nishii S, Chihara N, Matsumoto R, et al.anti-EAAT2 pAb (FRONTIER INSTITUTE, GLT1-Go-Af760), rabbit anti-ErbB4 mAb (Cell Signaling Technology, #4795), rabbit anti-ErbB4/HER4 (phospho Y1284) pAb (Abcam, ab61059), mouse anti-FLAG M2 mAb (Sigma Aldrich,

(3) Exploration of schizophrenia-related behavioral and molecular abnormalities in a mutant mouse model with a mutation in the TVV motif of the ErbB4 geneMolecular brainOctober 9, 2025Khan AA, Wang S, Wang Z, Rehman Z, Chen L, Kuang Y, Zhang X, Li Y, Yang J, Ye J, et al.and immunoprecipitated for 14 h via an equal amount of primary antibodies: rabbit anti-ErbB4 (Cat No. 4795, CST), mouse anti-PSD-95 (Cat No. MAB1598, Sigma Aldrich), normal rabbit IgG (Cat No. 2729, CST), and

(4) Blocking cancer-fibroblast mutualism inhibits proliferation of endocrine therapy resistant breast cancerMolecular Systems BiologyMay 8, 2025Jason I Griffiths, Feng Chi, Elena Farmaki, Eric F Medina, Patrick A Cosgrove, Kimya L Karimi, Jinfeng Chen, Vince K Grolmusz, Frederick R Adler, Qamar J Khan, et al.(Tyr1173) (21A9) (#4757), HER2/ErbB2 Antibody (#2242), HER3/ErbB3 (1B2E) (#4754), HER4/ErbB4 (111B2) (#4795), from Cell Signaling, β-actin (C4) (sc-47778) from Santa Cruz Biotechnology, EGFR Antibody (EPR806Y)

(5) Liver-derived Neuregulin1α stimulates compensatory pancreatic β cell hyperplasia in insulin resistanceNat CommunMarch 13, 2025Takatomo Arai, Eriko Hayashi, Sumie Maeda, Tsutomu Matsubara, Hideki Fujii, Koya Shinohara, Arisu Sogabe, Sadatomo Wainai, Daishi Tanaka, Yutaro Ono, et al.(#2243, 1:1000), HER3/ERBB3 (#12708, 1:1000), phospho-HER3/ERBB3 (Tyr1289) (#2842, 1:1000), HER4/ERBB4 (#4795, 1:1000), phospho-HER4/ERBB4 (Tyr1284/1173) (#4757, 1:1000), Ki-67 (for immunohistochemical analysis,

(6) LncRNA GAS5 reduces blood glucose levels and alleviates renal fibrosis in diabetic nephropathy by regulating the miR-542-3p/ERBB4 axisDiabetol Metab SyndrJanuary 23, 2025Qinghua Yin, Na Guo, Ruoxi Liaosecondary antibodies ((ab6721, 1:2000, Abcam) for 1 h at ambient temperature. Primary antibodies: ERBB4 (4795, 1:1000, Cell Signaling Technology, USA) and GAPDH (2118, 1:1000, Cell Signaling Technology). After

(7) Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven CancersCancer DiscoveryJanuary 13, 2025Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius, Neil Gibson, Irene C. Waizenegger, Daniel Gerlach, Martin Augsten, Fiona Spreitzer, et al.Cell Signaling Technology, HER2 (#4290)]: pHER2 [#6942 (p-Y1196) or #2247 (p-Y1248)], HER3 (#12708), HER4 (#4795), pERK (#4370), ERK (#9102), pAKT (#4058), AKT (#9272), and beta-Actin (#4967). Goat anti-rabbit horseradish

(8) Small-molecule-induced ERBB4 activation to treat heart failureNature communicationsJanuary 10, 2025Cools JMT, Goovaerts BK, Feyen E, Van den Bogaert S, Fu Y, Civati C, Van Fraeyenhove J, Tubeeckx MRL, Ott J, Nguyen L, et al.polyclonal pERK1/2,Rabbit,"1:1,000",CST-9101,Primary polyclonal ERK1/2,Rabbit,"1:1,000",CST-9102,Primary polyclonal ERBB4,Rabbit,1:250,CST-4795,Primary monoclonal 111B2 b),Secondary antibody,Secondary antibody,Secondary antibody,Secondary antibody Channel,Species,Dilution,Manufacturer,– 680RD,Goat

(9) Isothiocyanates attenuate heparin‐induced proliferation of colon cancer cells in vitroFood Science & NutritionOctober 1, 2024Yizi Zhang, Karabi Saha, Raj Nandani, Jiahui Yuan, Moul Dey, Zhengrong Gutyrosine‐protein kinase erbB‐3) (CST, 12708T), HER4 (ErbB4) (receptor tyrosine‐protein kinase erbB‐4) (CST, 4795T), Bcl‐2 (B‐cell lymphoma 2) (CST, 3498T), Bax (Bcl‐2‐associated X protein) (CST, 2772T), and β‐actin

(10) SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasisNature CommunicationsJuly 4, 2024Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, et al.(Cell Signaling Technology, Cat# 3025, Clone 4B8, 1:1000), anti-HER4 (Cell Signaling Technology, Cat# 4795, Clone 111B2, 1:1000), anti-SRC (Cell Signaling Technology, Cat# 2108 S, 1:1000), anti-MYC (Cell Signaling Technology

(11) Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasisbioRxivFebruary 28, 2024Danyyl Ippolitov, Yi-Han Lin, Jeremy Spence, Aleksandra Glogowska, Thatchawan Thanasupawat, Jason Beiko, Marc R. Del Bigio, Xin Xu, Amy Wang, Raul Calvo, et al.5% NGS - 4C overnight,4% PFA in PBS - 15min; 1:200 in 5% NGS - 4C overnight HER4/ErbB4 (111B2),CST/4795,4795,AB_2099883,Rabbit,Monoclonal,H M,1:1000 in 5% BSA - 4C overnight,N/A,N/A Ki67 [SP6],Abcam,16667,AB_302459,Rabbit,Monoclonal,H

(12) Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer's diseaseCell communication and signaling : CCSFebruary 22, 2024Mao R, Hu M, Liu X, Ye L, Xu B, Sun M, Xu S, Shao W, Tan Y, Xu Y, et al.follows: mouse-anti β-actin (1:2000, Sigma, A5441), rabbit-anti ErbB4 (1:1000, Cell Signaling Technology, 4795), mouse-anti NRG1 (1:200, Santa Cruz Biotechnology, sc-393006), rabbit-anti GAD65 + 67 (1:2000, Abcam,

(13) Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivityCell reports. MedicineOctober 17, 2023Wurm AA, Brilloff S, Kolovich S, Schäfer S, Rahimian E, Kufrin V, Bill M, Carrero ZI, Drukewitz S, Krüger A, et al.,Cell Signaling Technology,Cat# 2179; RRID: AB_823449 HER4/ErbB4 (111B2) Rabbit mAb,Cell Signaling Technology,Cat# 4795; RRID: AB_2099883 Rac1/2/3 Antibody,Cell Signaling Technology,Cat# 2465; RRID: AB_2176152 GAPDH (D16H11) XP Rabbit mAb

(14) Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic HomeostasisAdvanced science (Weinheim, Baden-Wurttemberg, Germany)June 1, 2023Zhang Y, Zhu Y, Wang J, Jin L, Guo M, Chen L, Zhang L, Li Y, Wan B, Zhang R, et al.Membranes were blocked with 5% non‐fat milk (CST) and incubated with rabbit anti‐ErbB4 (1:1000, CST, #4795), rabbit anti‐His (1:1000, CST, #12 698), rabbit anti‐pErbB4 (1:100, CST, #4757), rabbit anti‐HSP90

(15) Betacellulin regulates gap junction intercellular communication by inducing the phosphorylation of connexin 43 in human granulosa-lutein cellsJournal of ovarian researchMay 25, 2023Li Y, Chang HM, Sung YW, Zhu H, Leung PCK, Sun YP.(#52,559), polyclonal rabbit anti-EGFR (#2232) (1:1000) and monoclonal rabbit anti- HER4/ErbB4 (111B2) (#4795) (1:1000) antibodies were obtained from Cell Signaling Technology (Beverly, MA). A monoclonal mouse

(16) Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV(+) Interneurons, Synaptic Plasticity and Working MemoryInternational journal of molecular sciencesDecember 28, 2022Spahic H, Parmar P, Miller S, Emerson PC, Lechner C, St Pierre M, Rastogi N, Nugent M, Duck SA, Kirkwood A, et al.relative to ponceau S [6,7]. Antibodies for WB (Supplementary Table S1) (i)ErbB4 (Cell Signaling, 4795S; RRID: AB_2099883) Rabbit monoclonal IgG antibody raised against synthetic peptide corresponding to

(17) Cortical wiring by synapse type-specific control of local protein synthesisScience (New York, N.Y.)November 25, 2022Bernard C, Exposito-Alonso D, Selten M, Sanalidou S, Hanusz-Godoy A, Aguilera A, Hamid F, Oozeer F, Maeso P, Allison L, et al.(Tyr1284, 1:1000, Cell Signaling Technology #4757), rabbit anti-ErbB4 (1:1000, Cell Signaling Technology #4795), rabbit anti-P-S6rp (Ser240/244, 1:5000, Cell Signaling Technology #5364), rabbit anti-S6rp (1:5000,

(18) Targeted RNA-sequencing analysis for fusion transcripts detection in tumor diagnostics: assessment of bioinformatic tools reliability in FFPE samplesExploration of Targeted Anti-tumor TherapyOctober 27, 2022Iolanda Capone, Fabio Bozzi, Gian Paolo Dagrada, Paolo Verderio, Elena Conca, Adele Busico, Maria Adele Testi, Valentina Monti, Matteo Duca, Claudia Proto, et al.tropomyosin receptor kinase (TRK)-pan (Ventana, cat: 790-4795), and their negative control (Ventana, cat: 790-4795) were diluted, incubated, and developed according to manufacturer instructions. ROS-1 (Cell Signaling,

(19) HB-EGF upregulates StAR expression and stimulates progesterone production through ERK1/2 signaling in human granulosa-lutein cellsCell communication and signaling : CCSOctober 25, 2022Cheng JC, Han X, Meng Q, Guo Y, Liu B, Song T, Jia Y, Fang L, Sun YP.granulosa cells. Methods Antibodies and reagents The p-EGFR (#3777), p-HER2 (#2243), HER2 (#2165), p-HER4 (#4757), HER4 (#4795), p-ERK1/2 (#9106), ERK1/2 (#9102), phospho-AKT (#9271), and AKT (#9272) antibodies were purchased from

(20) Neuregulin 4 Boosts the Efficacy of Anti-ERBB2 Neutralizing AntibodiesFrontiers in OncologyMay 18, 2022Carmen Miano et al.(1:500 dilution; #3790 Cell Signaling Technology, Inc., Danvers, MA, USA), anti-ERBB4 (1:500 dilution; #4795 Cell Signaling Technology, Inc., Danvers, MA, USA), and anti-GAPDH (1:1000 dilution; #G9545 Sigma-Aldrich,

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HER4/ErbB4 (111B2) Rabbit mAb

HER4/ErbB4 (111B2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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HER4/ErbB4 (111B2) Rabbit mAb from Cell Signaling Technology

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