Ras Antibody from Cell Signaling Technology

Yes, the Ras Antibody has been utilized in studies investigating KRAS mutations, such as the research by Gao et al. (2020), which focused on selectively targeting the KRAS G12S mutant allele using CRISPR/Cas9 to induce tumor regression. The antibody was employed in Western blot analyses to confirm the expression levels of mutant KRAS in tumor models.

The Ras Antibody is reactive with multiple species, including humans, mice, rats, and even non-human primates and yeast. This broad reactivity allows for its application in comparative studies across different biological systems, as demonstrated in various publications.

The Ras Antibody has been shown to work in the context of MAPK signaling pathways. For instance, in the study by Vareechon et al. (2017), the antibody was used to investigate the role of Ras in the signaling cascade that regulates reactive oxygen species production in neutrophils, highlighting its relevance in signaling research.

The Ras Antibody is primarily validated for use in Western blotting, as indicated in multiple studies. It has been effectively used to analyze protein expression levels and interactions in various experimental setups, including those examining oncogenic signaling pathways and cellular responses to treatments.