CDK2 (78B2) Rabbit mAb 2546S from Cell Signaling Technology

Product Specs
ItemCDK2 (78B2) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2546S
Quantity100 µl
ApplicationsW, W-S, IP, FC-FP
ReactivityH, M, R, Mk
TargetCdk2
HostRabbit
NCBI Gene AliasesCDKN2, p33(CDK2)
ClonalityMonoclonal
NCBI Full Gene Namecyclin dependent kinase 2
Research AreaCell Cycle / Checkpoint Control
Clone78B2
Molecular Weight33

Questions and Answers

Can this antibody be used to study the role of CDK2 in cell cycle regulation?

Yes, the CDK2 (78B2) Rabbit mAb has been shown to detect endogenous levels of total CDK2 protein, which is crucial for understanding its role in cell cycle regulation. For instance, studies have demonstrated that CDK2 phosphorylates the Notch intracellular domain, influencing cell cycle dynamics and somite formation in vertebrates ().

Is this antibody effective for use in immunoprecipitation assays?

The CDK2 (78B2) Rabbit mAb is suitable for immunoprecipitation, as indicated by its applications. It has been utilized in various studies to analyze protein interactions and modifications, such as in the regulation of NICD stability during the cell cycle ().

What species can this antibody be used with for research purposes?

This antibody is reactive with multiple species, including humans, mice, rats, and non-human primates. This broad reactivity allows for its application in comparative studies across different model organisms.

Are there any specific experimental contexts where this antibody has been cited?

Yes, the CDK2 (78B2) Rabbit mAb has been cited in studies investigating its role in cancer biology, such as in the context of pancreatic cancer, where it was involved in assessing the effects of CDK inhibitors on tumor cell apoptosis (). Additionally, it has been referenced in studies examining the regulation of cell proliferation and development in various cellular contexts ().

Cell Signaling Technology

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Phone: 978-867-2388
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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCCNeoplasiaMay 1, 2026Shoichiro Kuroda, Shintaro Funasaki, Hidekazu Nishizawa, Laura S. Schmidt, Ryoma Kurahashi, Takaaki Ito, Yuichiro Arima, Miwa Tanaka, Atsuya Kitada, Amy M. James, et al.(Ser807/811; #8516; CST), p16 (#92803; CST), p21 (#2947; CST), p53 (sc-99; Santa Cruz Biotechnology), CDK2 (#2546; CST), CDK4 (#12790; CST), β-actin (66009-1-Ig; Proteintech), and Cyclin C (#68179; CST). RNA extraction

(2) miRNA101a secreted by EATMs regulates atrial fibrillation through the PDGF-mediated PI3K/AKT pathwayFront PharmacolApril 16, 2026Zheng Sihao, Li Xiaoliang, Yue Honghua, Qin Xiaoli, Jiang Daisong, Zhang Zheng, Liang Weitao, Wu Zhongphosphorylated-PI3K (4228T; CST), total-Akt (9272; CST), phosphorylated-Akt (9271T; CST), totalCDK2 (2546T; CST), phosphorylated-CDK2 (2561S; CST), total-P70S6K (2708T; CST), phosphorylated-P70S6K (9234T; CST),

(3) RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibitionCell Death & DiseaseMarch 26, 2026Samuel E. Ross, Holly Holliday, Eyden Wang, Mahdi Zeraati, Maria Tsoli, David S. Ziegler, Marcel E. Dinger°C with the following primary antibodies (all from CST) diluted at 1:1000 in blocking buffer (CDK2 #2546, Cyclin E2 #4132, Cyclin B1 #4138, PLK1 #4513, p-Rb S807/811 #8526, total Rb #9039, p21 #2947, cleaved

(4) Myc and Skp2 overexpression promotes p27 ubiquitination and degradation in Ewing SarcomaPLoS OneMarch 9, 2026Yuta Kubota, Masanori Kawano, Ichiro Itonaga, Nobuhiro Kaku, Kazuhiro Tanaka(Tokyo, Japan) unless otherwise indicated: Myc (#18583), Skp2 (#2652), p21 (#2947), p27 (#3686), CDK2 (#2546), p-CDK2 (Thr160, #2561), CCNE (#4129), Lamin B1 (#13435), and GAPDH (#5174). Additional antibodies:

(5) Exploratory Proteomic Profiling Reveals Potential Mediators of 5-FU Response under p53 Deficiency in Colon Cancer CellsBiomolecules & TherapeuticsMarch 1, 2026Seonyong Lee, Jiwon Lee, Ga Seul Lee, Jeong Hee Moon, Joohee Jung(monoclonal, #2922), cyclin-dependent kinase (CDK)1 (POH1, monoclonal, #9116), CDK2 (78B2, monoclonal, #2546), CDK4 (D9G3E, monoclonal, #12790), CDK 6 (D4S8S, monoclonal, #13331)(1:1,000, Cell signaling, MA, USA),

(6) FASN-mediated metabolic reprogramming drives CD4+ T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylationArthritis Research & TherapyFebruary 13, 2026Lei Ye, Xijun Wang, Junhao Yin, Huan Shi, Jiayao Fu, Baoli Wang, Lingyan Zhengdetected overnight at 4 ℃ with primary antibodies targeting cell cycle regulators, including CDK2 (2546, CST, USA) and CDK4 (12790, CST, USA), oxidative phosphorylation related proteins, including COXIV (ab16056,

(7) Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cellsJournal of Advanced ResearchFebruary 1, 2026Xiaohui Zhu, Xiaojing Zhang, Ying Qin, Yang Chen, Xianling Feng, Shiqi Deng, Fan Hu, Yuan Yuan, Xiaonuan Luo, Kaining Du, et al.RRID:AB_823586), p27 (Cell Signaling Technology Cat# 3686, RRID:AB_2077850), CDK2 (Cell Signaling Technology Cat# 2546, RRID:AB_2276129), cyclin A2 (Cell Signaling Technology Cat# 4656, RRID:AB_2071958), ATM (Cell Signaling Technology

(8) Elimusertib, a Novel ATR Inhibitor, Induces Anti-tumor Effects through Replication Catastrophe in Breast CancersCancer Research and TreatmentJanuary 15, 2026Mudong Kim, Ahrum Min, Sohyeon Kim, Seongyeong Kim, Yu-jin Kim, Sujin Ham, Miso Lee, Eunice Yoojin Lee, Jinyong Kim, Dae-Won Lee, et al.(mouse, #A300-245A, Bethyl Laboratories), anti-pCDK2(Tyr15) (rabbit, ab76146, Abcam), anti-CDK2 (rabbit, #2546, Cell Signaling Technology), and anti-actin (mouse, A3853, Millipore). 5. Cell cycle analysis Cells

(9) Anti-Cancer Effects of the Ethyl Acetate Fraction From Opuntia humifusa on Human Triple-Negative Breast Cancer CellsIntegr Cancer TherDecember 15, 2025Myung Chul Cha, Eonji Yeo, Dong Seok LeeAB_2798711), cyclin A2 (Cat# 67955, RRID: AB_2909603), CDK4 (Cat# 12790, RRID: AB_2631166), and CDK2 (Cat# 2546, RRID: AB_2276129), all from Cell Signaling Technology (Danvers, MA, USA). The antibody against pro-caspase-12

(10) Anti-Invasive and Apoptotic Effect of Eupatilin on YD-10B Human Oral Squamous Carcinoma CellsMoleculesDecember 5, 2025Gaeun Kim, Hyun-Jung Park, Suk-Yul Jung, Eun-Jung KimmM NaCl, 0.1% Tween-20) containing 5% skim milk. Cyclin D1 (#A19038; Abclonal, Wuhan, China), CDK2 (#2546; Cell Signaling Technology, Danvers, MA, USA), p21 (#2947; Cell Signaling Technology), Bax (#14796,

(11) Dinaciclib improves treatment response in chemoresistant hepatoblastomaScientific ReportsDecember 5, 2025Brian T. Hickner, Andres F. Espinoza, Rohit K. Srivastava, Roma H. Patel, Priyanka Rao, Nicholas A. O’Brien, Kalyani R. Patel, Andrew A. Badachhape, Abhishek Kona, Dolores H. López-Terrada, et al.Cell Signaling, Danvers, MA, USA), CDK1 (cat. no. 9116 Cell Signaling, Danvers, MA, USA), CDK2 (cat. no. 2546 Cell Signaling, Danvers, MA, USA), RNA pol-II (cat. no. A300-653A, Thermo Fisher Scientific, Waltham,

(12) Anti-tumor efficacy of RAF/MEK inhibitor VS6766 in KRAS-mutated colorectal cancer cellsCancer Chemotherapy and PharmacologyDecember 1, 2025Haixin Zhu, Gezi Yan, Junjie Ma, Bo Zhang, Youyou Yan, Lulin Zhu, Rong Dong, Nengming Lin, Biqin TanERK (4695 S), p-MEK1/2 (9154 S), MEK (4694 S), RB (9313 S), p-RB (8516 S), Cyclin E1 (4129 S), CDK2 (2546 S) and CDK6 (13331 S) were purchased from CST (Cell Signaling Technology, Beverly, MA, USA), and GAPDH

(13) Hsp90 co-chaperone FKBP4 facilitates CCT8 folding and connects Hsp90 to chaperonin-dependent proteostasisJournal of Biological ChemistryDecember 1, 2025Yun-Yu Huang, Ya-Lan Chang, Yun Chen, Wei-Yu Chiang, Ai-Tao Chiang, Pang-Hung Hsu, Shu-Chun TengCalbiochem), DDX3 (1:1000, GTX110614, GeneTex), TCP1 theta (CCT8) (1:1000, GTX105725, GeneTex), CDK2 (1:500, 2546, Cell Signaling), CCT1 (1:250, sc-53454, Santa-cruz Biotechnology), HSP90 (1:1000, sc-13119, Santa-cruz Biotechnology

(14) Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded librariesnpj Breast CancerNovember 12, 2025Anil Kumar Devakrishnan, Chandrashekhar Madasu, Yong Wang, Ramkumar Modukuri, Kurt M. Bohren, Kevin R. MacKenzie, Damian W. Young, Suzanne A. W. Fuqua, Martin M. Matzuk, Murugesan Palaniappan# 8757S), anti-c-MYC (CST, Cat. # 5605S), anti-GREB1 (Sigma, Cat. # MABS62), anti-CDK2 (CST, Cat. # 2546T) anti-β-actin (SCB; Cat. # SC-4778) and anti-GAPDH (SCB; Cat. # SC-32233). Docking studies The ERα

(15) BATF2-mediated control of astrocyte proliferationJournal of Biological ChemistryNovember 1, 2025Rachel A. Tinkey, Benjamin J. Frostino, Maria L. Habean, Jessica L. WilliamsPA5-37138), cyclin D1 (Santa Cruz, SC717 and Proteintech, 60186-I-Ig), CDK2 (78B2) (Cell Signaling, 2546S), cyclin B1 (D5C10) (Cell Signaling, 12231S), and vinculin (Invitrogen, 700062). The following day,

(16) Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cellsThe EMBO JournalSeptember 8, 2025Chun-Fui Lai, Victoria I Cushing, Ellen Olden, Charlotte L Bevan, R Charles Coombes, Basil J Greber, Laki Buluwela, Simak Alias described (Patel et al, 2018), using antibodies diluted 1:1000 for P-CDK2 (Thr160; 2561S), CDK2 (2546S), P-Rb (Ser807/811; 9308), Rb (9309), CDK7 (2916) and CDK12 (11973S), from Cell Signalling Technology.

(17) Estrogen-like Activity of Scrophularia buergeriana Root Extracts in MCF-7 CellsBiomedicinesSeptember 4, 2025Hye-Yeong Song, Jinsu Choi, Eunwoo Jeong, Harang Park, Juyeong Moon, Min-ah Kim, Javokhir Rustamov, Hwan-Soo Yoo, Tack-Joong KimDanvers, MA, USA; #2978), cyclin-dependent kinase 2 (CDK2; Cell Signaling Technology, Danvers, MA, USA; #2546), CDK4 (Cell Signaling Technology, Danvers, MA, USA; #12790), and glyceraldehyde-3-phosphate dehydrogenase

(18) Comprehensive profiling of RNA modification-related genes identifies RNA m7G binding protein CBP20 as a therapeutic target for tumor growth inhibitionExperimental & Molecular MedicineSeptember 1, 2025Yoonsung Cho, Sang Eun Lee, Jaeik Oh, Dongjun Jang, Seungjae Shin, Soo-Jin Lee, Jiwon Kim, Yoojin Yang, Dohee Kim, Hae Rim Jung, et al.follows: anti-CBP20 (SantaCruz #sc-137123), β-actin (Sigma #A5441), anti-CDK2 (Cell Signaling Technology #2546), anti-CDK4 (Cell Signaling Technology #12790), anti-CDK6 (Cell Signaling Technology #3136), anti-Cyclin

(19) Inhibiting UNC13B Suppresses Cell Proliferation by Upregulating the Apoptotic Pathway in Multiple MyelomaBiomedicinesAugust 27, 2025Yuan Tao, Lihua Yuan, Yuntian Ding, Rongli Xie, Fangjie Liu, Zhongming Zhang, Xiaojun Xu, Xiaobo WangCST, #2772, 1:1000), p21 (CST, #2947, 1:1000), PKC-PAN (#9371, 1:1000), PINK1 (#6946, 1:1000), CDK2 (#2546, 1:1000), AKR7A3 (Abcam, ab227231, 1:1000), and Bim (#2933, 1:1000). 2.9. Data Analysis All statistical

(20) Integrative proteogenomic characterization of Wilms tumorNat CommunAugust 19, 2025Cheng Cheng, Li Zhang, Xiaofeng Chang, Kai Chen, Tian He, Jia Shi, Fan Lv, Lijia Pan, Yangkun Wu, Qianqian Cheng, et al.8180, 1:1000), p-RB S795 (Cat No. 9301, 1:1000), p-RB S807/811 (Cat No. 8516, 1:1000), CDK2 (Cat No. 2546, 1:1000), Histone H3 (Cat No. 4499, 1:1000), Di-Methyl-Histone H3 (Lys9) (Cat No. 4658, 1:1000), and

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CDK2 (78B2) Rabbit mAb

CDK2 (78B2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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CDK2 (78B2) Rabbit mAb from Cell Signaling Technology

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