YAP Antibody 4912S from Cell Signaling Technology

Product Specs
ItemYAP Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number4912S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R, Mk
TargetYAP (YAP1-2gamma)
HostRabbit
NCBI Gene AliasesCOB1, YAP, YAP-1, YAP2, YAP65, YKI
NCBI Full Gene NameYes1 associated transcriptional regulator
ClonalityPolyclonal
Research AreaDevelopmental Biology
Molecular Weight65-78

Questions and Answers

Can this YAP antibody be used to study its role in cancer stem cell survival?

Yes, the YAP antibody has been shown to be effective in studies investigating its role in cancer stem cell survival, particularly in epidermal squamous cell carcinoma. For instance, research demonstrated that YAP1 is a critical target in the context of sulforaphane treatment, which reduces YAP1 levels and subsequently decreases cancer stem cell survival and tumor formation ().

Is this antibody suitable for use in Western blotting applications?

The YAP antibody has been utilized in Western blotting applications, as evidenced by multiple studies. For example, it was employed to analyze YAP expression levels in various cancer cell lines and tissues, confirming its effectiveness in detecting YAP protein levels (, ).

What species can this antibody react with, and is it effective for human samples?

The YAP antibody is reactive with several species, including humans, mice, rats, and non-human primates. It has been successfully used in studies involving human samples, such as in the context of lung adenocarcinoma and other cancers (, ).

Has this antibody been used in any studies related to drug resistance in cancer?

Yes, the YAP antibody has been referenced in studies examining drug resistance mechanisms in cancer. For instance, it was found that YAP activation is associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer, highlighting its role in mediating therapeutic resistance ().

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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Emergence of invasive Escherichia coli pathobionts in gut microbiome promotes cancer stemness via targeting Hippo pathwaysGut MicrobesDecember 31, 2026Linda Chia-Hui Yu, Shu-Chen Wei, Been-Ren Lin, Yi-Hsuan Li, Yu-Chien Liao, Yu-Wen Peng, Chia-Hsien Lin, Pei-Tzu Hu, Yu-Chen Pai, Liang-Chuan Lai, et al.TEAD4 (Santa Cruz, Cat# sc-390578), polyclonal rabbit anti-human YAP (1:1000, Cell Signaling, Cat# 4912), monoclonal rabbit anti-mouse TAZ (1:1000, GeneTex, Cat# GTX637933), mouse anti-human VGLL3 (1:1000,

(2) A tailored in vivo CRISPR screen identifies BAP1 as a potent tumor suppressor of sarcomaJCI InsightAugust 24, 2026Jianguo Huang, Xingliang Liu, Warren Floyd, William Haugh, Zhaoyu Sun, Melissa J. Kasiewicz, Yaping Wu, Brian Piening, John T. Welle, Wesley K. Rosales, et al.(Agilent Technologies, GA63061-2), S100 (Agilent Technologies, GA50461-2), and Yap1 (Cell Signaling Technology, 4912S) (11). Tissue sections were stained with 3,30-diaminobenzidine and counterstained with hematoxylin (Sigma-Aldrich,

(3) Mapping of the hSOX10 Proximal Protein Interactome in Human MelanomaJournal of Proteome ResearchJune 5, 2026Catherine M. Newsom-Stewart, Dhaval P. Bhatt, Michael B. Major, Charles K. Kaufman(1:1000, Cell Signaling, 14C10), Anti-V5 antibody (Invitrogen, R960–25), YAP1 (1:1000, Cell Signaling, 4912S), ZNF609 (1:1000, SigmaMillipore, HPA040742), TRIM24 (1:2000, Bethyl, A300–815A-T), MAML1 (1:1000, Cell Signaling

(4) Vascular endothelial growth factor receptor-1 (VEGFR-1) knock-down is protective against hypoxia, Aβ1-42 oligomer and Aβ1-42 fibril -induced neuronal cell death: implications in AD pathogenesisFrontiers in NeuroscienceMay 29, 2026Debabrata Mukhopadhyay, Pritam Das, Ramcharan Singh Angom, Shamit Dutta, Zonghua Li, Monica Castanedes-Casey, Tanmay Kulkarni, Trisha Chakravarty, Enfeng Wang, Dennis Dickson, et al.cleaved caspase-3 (#9661) from Cell signaling technology (Danvers, Massachusetts, United States); YAP1 (#4912) from Cell signaling technology (Danvers, Massachusetts, United States);The anti-β actin antibody was

(5) YAP1 Upregulates Cytoskeleton Regulator ARHGEF1 and Tissue Regeneration Factor NEDD9 in a Multiplex Proteomic StudyNeurol IntMay 21, 2026Dinesh Devadoss, Juliet Akkaoui, Arti Vashist, Adriana Yndart Arias, Adel Nefzi, Madepalli K. Lakshmanafrom Thermo Fisher Scientific, Waltham, MA, USA. The rabbit polyclonal antibodies against YAP1 (cat # 4912) were from Cell Signaling. The rabbit polyclonal antibodies ARHGEF1 (cat # A4274) and NEDD9 (cat # A2521)

(6) Yes-Associated Protein Drives Helicobacter pylori–Induced Metaplastic Changes in Gastric EpitheliumCellular and Molecular Gastroenterology and HepatologyMay 21, 2026Byeong Min Yu, So Dam Lee, Bo Ram Hwang, Haengdueng Jeong, Jiseon Kim, Seokyoung Hwang, Minsoo Noh, Ki Taek Nam, Yong Chan Lee5′-AGGGGTCTACATGGCAACTG-3′ Antibodies The following primary antibodies were used for IHC, IF, or WB analysis: YAP (Cell Signaling, 4912S, RRID:AB_2218911), TAZ (BD, 560,235, RRID:AB_1645338), YAP/TAZ (Cell Signaling, 8418S, RRID:AB_10950494),

(7) HELLS Reduction Contributes to Compressive Force-Induced Functional Changes in PDLSCsInt J Mol SciMay 19, 2026Manqi Wang, Qian Li, Jiaqi Chen, Bing Han, Wei Huantibodies were used: HELLS (ProteinTech, 87169-1-RR, 1:2000), E2F1 (12171-1-AP, 1:1000), YAP (CST, #4912, 1:1000), GAPDH (CST, #2118, 1:2000). Primary antibodies were diluted in 5% BSA/TBST. HRP-conjugated

(8) Metabolic maintenance of breast cancer cells and metastases through E-cadherin/YAP–dependent pyruvate carboxylase expressionbioRxivMay 6, 2026Kuppusamy Balamurugan, Jonathan M. Weiss, Lois McKennett, Shikha Sharan, Brad A. Gouker, Donna O. Butcher, David A. Scheiblin, Elijah F. Edmondson, Duncan Donohue, Stephen J. Lockett, et al.Cell Signaling Technology (E-cadherin (24E10), #3195; pyruvate carboxylase, #66470; YAP/TAZ, #8418; YAP, #4912S; pYAPS127, #13008S; pAKTS473, #4060; AKT, #9272; Santa Cruz Biotechnology (GAPDH, #sc-47724); and DSHB

(9) SUN2 mediates epigenetic remodeling to drive mechanotransduction during skin fibrosisbioRxivApril 25, 2026Aya Nassereddine, Kerri Davidson, Sandra Sandria, Jyot D. Antani, Shreyasi Das, Rachel Rivera, Van Anh Tran, Monique Hinchcliff, Megan King, Valerie HorsleyPBS. Primary antibody diluted in blocking solution – SUN2, 1:200 (Abcam, AB124916), YAP, 1:200 (CST, 4912S), LaminA/C (Abcam, AB133256), and/or Ezh2, 1:200 (CST, 5246T) was incubated overnight at 4°C. Primary

(10) Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activityNature CommunicationsApril 21, 2026Hyunwook Lee, Abigail Jaquish, Sharlene Fernandes, Barbara Zhao, Amber Elitz, Kathleen Cook, Sarah Trovillion, Natalia Bottasso-Arias, Simon J. Y. Han, Samantha Goodwin, et al.mounting medium (Invitrogen, P36930). Immunofluorescence for Yap (Rabbit, Cell Signaling Technology, 4912 - 1:100), Taz (Rabbit, Cell Signaling Technology, 83669 - 1:200), p-Smad1/5/9 (Rabbit, Cell Signaling Technology

(11) Integrin-Binding Matricellular Protein Fibulin-5 Maintains Epidermal Stem Cell Heterogeneity During Skin AgingAging CellApril 10, 2026Wenxin Fan, Mizuho Ishikawa, Erna Raja, Ahmed M. Hegazy, Hinata Date, Yen Xuan Ngo, Yoshifumi Sato, Kazuya Yamagata, Hiromi Yanagisawa, Aiko Sadaguinea pig anti‐K36 (1:100; Proteintech, 14309‐1‐AP), rabbit anti‐YAP (1:100; Cell Signaling Technology, 4912S), rabbit anti‐ASS1 (1:1000; Cell Signaling Technology, 05‐665), and guinea pig anti‐SLC1A3 (1:100; Frontier

(12) MYRF controls mesothelium specification, signaling, and plasticity in lung developmentDevelopmental CellMarch 11, 2026Gidsela Luna, Jamie M. Verheyden, Chunting Tan, Estelle Kim, Ziai Zhu, Michelle Hwa, Jugraj Sahi, Yufeng Shen, Wendy K. Chung, David J. McCulley, et al.1:200",abcam,ab227566 "rabbit anti-WT1, 1:100",Abcam,ab89901 "rabbit anti-YAP, 1:100",Cell Signaling Technology,4912S "rat anti-Ki67, 1:200",Invitrogen,14–5698-82 "syrian hamster anti-Podoplanin, 1:400",Invitrogen,14–5381-82 "APC/Cyanine7

(13) Topology Outweighs Stiffness: Self-Reinforced Cell Mechanotransduction via Multiaxial Curvature Engineering of Ultrasoft HydrogelsACS NanoMarch 10, 2026Yong Hou, Xinhao Hu, Cheng Qian, Wenyan Xie, Linjie Ma, Luyao Zhang, Xiaomei Han, Youhua Tan, Yuan Lin, Chao Fang, et al.monoclonal Lamin A/C antibody (Invitrogen, MA535284, 1:50), rabbit polyclonal YAP antibody (Cell Signaling, 4912S, 1:50), goat polyclonal MYPT1Antibody (Invitrogen, PA5-142374, 1:50), and rabbit monoclonal Anti-Sp7/Osterix

(14) Stress fiber traction force reshapes chromatin accessibility and YAP binding to direct diverse transcriptional programs in mesenchymal stem cellsMechanobiol MedMarch 4, 2026Jiacheng Lei, Yicen Long, Xiaojing Liu, Zhiqin Chu, Qiang Wei#95777; 1:400), Lamin A/C (Cell Signaling Technology, #4777; 1:400), and YAP (Cell Signaling Technology, #4912; 1:500). After washing twice with PBST and three times with PBS, cells were incubated with Alexa Fluor

(15) TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid ReceptorEndocrinol Metab (Seoul)February 10, 2026Hongxiang Huang, Jinhong Chen, Xingyu Tao, Peiyuan Zhong, Yanqiu Meng, Sujuan Peng, Wanying Luo, Zhiyong He, Shuai Luo, Xie Zhu, et al.(1:1,000; Cat#A20865; ABclonal), Forkhead box O1 (FoxO1) (1:1,000; Cat#A2934; ABclonal), YAP (1:1,000; Cat#4912; CST), PGC1α (1:1,000; Cat#A12348; ABclonal), and β-actin (1:80,000; Cat#AC026; ABclonal). After incubation,

(16) A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal MelanomaCancer ResearchFebruary 9, 2026Xiaonan Xu, Xiaoxian Liu, Vinesh Jarajapu, Sathya Neelature Neelature Sriramareddy, Filip Konecny, Benjamin Posorske, James J. Dollar, Xiao Liu, Neel Jasani, Kaizhen Wang, et al.(1:1,000, Cell Signaling Technology, 4370, RRID:AB_2315112), YAP (1:1,000, Cell Signaling Technology, 4912, RRID:AB_2218911), p-YAP (Ser127) (1:1,000, Cell Signaling Technology, 4911, RRID:AB_2218913), BAP1

(17) A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal MelanomaCancer ResFebruary 9, 2026Xiaonan Xu, Xiaoxian Liu, Vinesh Jarajapu, Sathya Neelature Sriramareddy, Filip Konecny, Benjamin Posorske, James J. Dollar, Xiao Liu, Neel Jasani, Kaizhen Wang, et al.(1:1,000, Cell Signaling Technology, 4370, RRID:AB_2315112), YAP (1:1,000, Cell Signaling Technology, 4912, RRID:AB_2218911), p-YAP (Ser127) (1:1,000, Cell Signaling Technology, 4911, RRID:AB_2218913), BAP1

(18) HCV infection induces ubiquitin-dependent degradation of LATS1, inactivating the Hippo pathway and upregulating transcription of the CYR61 and CTGF genesJ Gen VirolFebruary 5, 2026Maria Alethea Septianastiti, Chieko Matsui, Zihan Xu, Fransisca Puspitasari, Dewa Nyoman Murti Adyaksa, Lin Deng, Takayuki Abe, Ikuo Shoji(H-6908; Sigma-Aldrich), anti-phospho-LATS1 (Ser909) pAb (9157; Cell Signaling Technology), anti-YAP pAb (4912; Cell Signaling Technology), anti-phospho-YAP (Ser127) (4911; Cell Signaling Technology), anti-NS5A

(19) Pervanadate-induced oxidation relieves autoinhibition of the protein tyrosine kinase SRCScience SignalingJanuary 20, 2026Katie E. Mulholland, Maxime Bourguet, Nuo Cheng, Oisharja Rahman, Daria Ezeriņa, Leonard A. Daly, Tiffany Lai, Silvia Aldaz Aldaz Casanova, Therese Featherston, Pau Creixell, et al.Cortactin (CST #3503), Cortactin pY421 (CST #4569), LATS1 (CST #3477), LATS1 pY909 (CST#9157) , YAP (CST #4912), YAP pS127 (CST #13008), AKT (CST #9272), AKT pS473 (CST #4060), ERK pT202/pY204 (CST #4370), ERK (CST

(20) Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomasbioRxivJanuary 16, 2026Maxwell T. Laws, Dhruval Bhatt, Debjani Mandal, Nikhil Ramavenkat, David T. Asuzu, Stefan Stoica, Ihika Rampalli, Dustin Mullaney, Liyam Laraba, Hannah Odom, et al.this study were primarily from Cell Signaling Technology, including anti-pan-TEAD (S13295), anti-YAP (4912S), anti-TAZ (83669S), anti-VEGF-A (50661S), anti-rabbit (7074S), and anti-mouse (7076S). Additional antibodies

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8/31/2015Antibody Can be Used for Immunohistochemistry Staining and Western Blot junyan taoThis antibody is very good for checking YAP protein expression levels via Western blot especially for an experiment in which I overexpressed YAP in mouse liver in vivo and used this antibody to check ... Read Review

YAP Antibody

YAP Antibody from Cell Signaling Technology

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YAP Antibody from Cell Signaling Technology

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