PBK/TOPK Antibody 4942S from Cell Signaling Technology

Product Specs
ItemPBK/TOPK Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number4942S
Quantity100 µl
ApplicationsW, IHC-P
ReactivityH, M, R
TargetPBK/TOPK
HostRabbit
NCBI Gene AliasesCT84, HEL164, Nori-3, SPK, TOPK
NCBI Full Gene NamePDZ binding kinase
ClonalityPolyclonal
Research AreaCell Cycle / Checkpoint Control
Molecular Weight40

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Cell Signaling Technology

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(1) Comprehensive analysis of mitophagy-related genes reveals prognostic signatures in breast cancer: based on immune landscapes and treatment target predictFrontiers in ImmunologyFebruary 5, 2026Hejia Zhao, Wanying Zhang, Yiheng Du, Zheng Kuang, Yilan Tan, Yanjun Chen, Yujie Ma, Fei Zoupenicillin-streptomycin combination (Gibco, USA). 2.14 Antibodies and reagents Antibodies against PBK(4942T), a-Tublin(3873T), b-Actin(4967T) were acquired from Cell Signaling Technology (Danvers, MA, USA); Antibodies

(2) TOPK promotes immune suppression in kidney renal clear cell carcinoma and emerges as a prognostic and therapeutic targetBMC CancerAugust 18, 2025Zeyuan Zheng, Renhui Xiong, Xiuyuan Sui, Liyan Li, Huimin Sun, Chen Shaoantibodies overnight at 4 °C. The primary antibodies used were TOPK (Cell Signaling Technology, Cat# 4942) and β-actin (β-actin, Cat# AC038). Following incubation with secondary antibodies, signal detection

(3) Integrated Multi-Omics Profiling Identifies PDZ-Binding Kinase (PBK) as a Novel Prognostic Biomarker in Hepatocellular CarcinomaJ Hepatocell CarcinomaJuly 17, 2025Juan Zhang, Yingyu Xu, Xiaojian Ni, Zhiyi Mao, Haitao Xiao, Maopei Chen, Youpei Lin, Jiaomeng Pan, Boheng Zhang, Lan Zhang, et al.Non-specific binding was blocked with 5% bovine serum albumin. Anti-PBK antibody (Cell Signaling Technology, 4942T) overnight at 4 °C, washed, and incubated with a species-appropriate secondary antibody. PBK protein

(4) Integrated Multi-Omics Profiling Identifies PDZ-Binding Kinase (PBK) as a Novel Prognostic Biomarker in Hepatocellular CarcinomaJ Hepatocell CarcinomaJuly 17, 2025Juan Zhang, Yingyu Xu, Xiaojian Ni, Zhiyi Mao, Haitao Xiao, Maopei Chen, Youpei Lin, Jiaomeng Pan, Boheng Zhang, Lan Zhang, et al.Non-specific binding was blocked with 5% bovine serum albumin. Anti-PBK antibody (Cell Signaling Technology, 4942T) overnight at 4 °C, washed, and incubated with a species-appropriate secondary antibody. PBK protein

(5) TOPK Drives IL19-Mediated Crosstalk Between Cancer Cells and Fibroblasts to Promote Solar UV-Induced Skin Damage and CarcinogenesisCancers (Basel)June 20, 2025Asad U. Khan, Qiushi Wang, Eunmiri Roh, Sally E. Dickinson, Georg T. Wondrak, Clara Curiel-Lewandowski, Ann M. Bode, Tianshun Zhangp44/42 MAPK (9102), JNK (9252), p38 MAPK (D13E1, 8690), PKA C-α (4782), PKCι/C83H11 (2998s), and TOPK (4942). Additional antibodies were obtained from Santa Cruz Biotechnology, including α-smooth muscle actin

(6) Sinomenine Inhibits TOPK To Ameliorate Psoriasiform DermatitisACS OmegaApril 8, 2025Hui Lu, Fanfan Zeng, Hongjian Gong, Juan Du, Wenqi Gao, Jia Xu, Xiaonan Cai, Yuan Yang, Han Xiaoanti-phospho-PARP (Cell Signaling Technology, 5625s), and rabbit anti-PBK/TOPK (Cell Signaling Technology, 4942). The phospho-TOPK (Y74) antibody was purchased from ProteinGene, Inc. (Wuhan, China). Protein bands

(7) Single-cell RNA sequencing analysis reveals potential key prognostic markers in hepatocellular carcinomaDiscover OncologyDecember 4, 2024Heteng Cui, Wenyuan YangPrimary antibodies experimented in the study were as follows: BSG (1:1000, 13,287) and PBK (1;1000, 4942) were purchased from Cell Signaling Technology (China), PIGZ (1:1000, 17,384–1-AP), CDCA8 (1:500, 12,465-1-AP),

(8) Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumorsGenome biologyDecember 2, 2024Merk DJ, Tsiami F, Hirsch S, Walter B, Haeusser LA, Maile JD, Stahl A, Jarboui MA, Lechado-Terradas A, Klose F, et al.(Cell Signaling, 5313), RPA2 p34 (Millipore, 04–1481), Survivin (Cell Signaling, 2802), TOPK (Cell Signaling, 4942), and TOPO 2 alpha (Santa Cruz, sc-13058). Mass spectrometry-coupled immunoprecipitations In order

(9) The LIN28B-let-7-PBK pathway is essential for group 3 medulloblastoma tumor growth and survivalMolecular oncologySeptember 1, 2023Shahab SW, Roggeveen CM, Sun J, Kunhiraman H, McSwain LF, Juraschka K, Kumar SA, Saulnier O, Taylor MD, Schniederjan M, et al.caspase‐3 (CST #9661), and anti‐c‐MYC (Abcam ab32072) antibodies diluted at 1 : 100 and anti‐PBK (CST #4942) diluted at 1 : 50 were applied and incubated for 40 min. DISCOVERY OmniMap anti‐Rb HRP was applied

(10) The role of the SGK3/TOPK signaling pathway in the transition from acute kidney injury to chronic kidney diseaseFrontiers in pharmacologyJanuary 1, 2023Shu H, Wang Y, Zhang H, Dong Q, Sun L, Tu Y, Liao Q, Feng L, Yao L.antibodies Polyclonal rabbit anti-SGK3 (#8573), anti-Arg1 (#93668), and polyclonal rabbit anti-TOPK (#4942) antibodies were provided by Cell Signaling Technology (Beverly, MA, United States). Polyclonal rabbit

(11) Identification of PBK as a hub gene and potential therapeutic target for medulloblastomaOncology ReportsMay 19, 2022Yuhao Deng et al.temperature, and incubated overnight at 4°C with the following primary antibodies: Anti-PBK (1:1,000; cat. no. 4942S, Cell Signaling Technology, Inc.), anti-phosphorylated (p-)p44/42 MAPK (ERK1/2) (Thr202/Tyr204, 1:1,000;

(12) Conversion of plastic waste into fuel oil using zeolite catalysts in a bench-scale pyrolysis reactorâ€ RSC AdvancesMarch 8, 2022Krishnasamy Sivagami, Keshav V. Kumar, Perumal Tamizhdurai, Dhivakar Govindarajan, Madhiyazhagan Kumar, Indumathi Nambipoint (°C)1LDPE with ZSM-511.741<0.1780312LDPE without catalyst1.0840∼0.0017811.9793LDPE with zeolite2.4942∼0.009814.7524Commercial diesel1–4.1145<0.1–0.679952–965Commercial foil-22–3.640–450.1–0.6900–101040–75 3.3.2. Effect

(13) 3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivoFrontiers in Cell and Developmental BiologyMarch 25, 2021Xiaorong Fu et al.(1:1,000, Cat#11989), rabbit anti-ERK1/2 (p44/p42 MAPK) (1:1,000, Cat#4695), rabbit anti-TOPK (1:1,000, Cat#4942), rabbit anti-c-Jun (1:1,000, Cat#9165), and rabbit anti-RSK2 (1:1,000, Cat#5528) were purchased from

(14) Reactive Oxygen Species-Mediated Autophagy by Ursolic Acid Inhibits Growth and Metastasis of Esophageal Cancer CellsInternational Journal of Molecular SciencesDecember 10, 2020Na-Ri Lee, Ruo Yu Meng, So-Young Rah, Hua Jin, Navin Ray, Seong-Hun Kim, Byung Hyun Park, Soo Mi KimMultiple Cell Signaling Pathways: Chemosensitization with Capecitabine. Clin. Cancer Res. 2012, 18, 4942–4953. [CrossRef] Doherty, J.; Baehrecke, E.H. Life, death and autophagy. Nat. Cell Biol. 2018, 20, 1110–1117.

(15) Are FDA-Approved Sunscreen Components Effective in Preventing Solar UV-Induced Skin Cancer?CellsJuly 11, 2020Bode AM, Roh E.12233) was purchased from Signalway Antibody LLC (College Park, MD, USA). The TOPK (Catalog no. CST-4942), phospho-EGFR (Tyr1068, Catalog no. CST-3777), and keratin 17 (Catalog no. CST-4543) antibodies were

(16) Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T‐lymphokine‐activated killer cell‐originated protein kinase.British Journal of PharmacologyMay 1, 2020Ran Zhao et al.https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1994, rabbit anti‐TOPK (1:1,000, Cell Signaling Technology, Cat#4942, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1994, rabbit anti‐phosphorylated

(17) Targeting PDZ-binding kinase is anti-tumorigenic in novel preclinical models of ACCEndocrine-Related CancerOctober 1, 2019Adwitiya Kar et al.FOXM1 (# SC-500) from Santa Cruz; β tubulin (#ab6046), PBK (# ab75983) from Abcam. For IHC anti-PBK (#4942S) was purchased from Cell Signaling. The FOXM1 inhibitor, thiostrepton, was obtained from EMD Millipore

(18) Targeting PDZ Binding Kinase Is Anti-tumorigenic in Novel Preclinical Models of ACCEndocr. Relat. CancerOctober 1, 2019Adwitiya Kar, Yu Zhang, Betelehem W. Yacob, Jordan Saeed, Kenneth D. Tompkins, Stacey M. Bagby, Todd M. Pitts, Hilary Somerset, Stephen Leong, Margaret E. Wierman, et al.FOXM1 (# SC-500) from Santa Cruz; β tubulin (#ab6046), PBK (# ab75983) from Abcam. For IHC anti-PBK (#4942S) was purchased from Cell Signaling. The FOXM1 inhibitor, thiostrepton, was obtained from EMD Millipore (Burlington,

(19) TOPK is regulated by PP2A and BCR/ABL in leukemia and enhances cell proliferationInternational journal of oncologyMay 1, 2019Uchida E, Suwa S, Yoshimoto R, Watanabe K, Kasama T, Miura O, Fukuda T.sc‑2354; Santa Cruz Biotechnology, Inc., Dallas, TX, USA), rabbit anti‑PBK/TOPK (1:5,000; cat. no. #4942), rabbit anti‑phosphorylated (p)‑PBK/TOPK (Thr9; 1:5,000; cat. no. #4941), rabbit anti‑HA‑tag (C29F4;

(20) MicroRNA-216b-3p inhibits lung adenocarcinoma cell growth via regulating PDZ binding kinase/T-LAK-cell-originated protein kinaseExperimental and therapeutic medicineJune 1, 2018Chai Y, Xue H, Wu Y, Du X, Zhang Z, Zhang Y, Zhang L, Zhang S, Zhang Z, Xue Z.room temperature for 1.5 h to block non-specific binding and were incubated with PBK/TOPK (cat no. 4942), p53 (Cat no. 2527), p21 (cat no. 2947), p-p38 (cat no. 4511) and β-actin (cat no. 4970) primary antibodies

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PBK/TOPK Antibody

PBK/TOPK Antibody from Cell Signaling Technology

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Cell Signaling Technology

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PBK/TOPK Antibody from Cell Signaling Technology

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