VCP Antibody 2648S from Cell Signaling Technology

Product Specs
ItemVCP Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number2648S
NCBI Full Gene Namevalosin containing protein
ApplicationsWestern Blot (WB)
ReactivityHu, Ms, Rt, Mk
Molecular Weight89
Research AreaCell Cycle / Checkpoint Control
ClonalityPolyclonal
NCBI Gene AliasesCDC48, FTDALS6, TERA, p97
HostRabbit
TargetVCP
Quantity100 µl

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomersNeurobiology of DiseaseMarch 1, 2026Brianna Hnath, Srinivasan Ekambaram, Nikolay V. DokholyanT TDP-43,Proteintech,"10,782–1-AP" UBQLN2,Proteintech,"23,449–1-AP" VAMP7,Fisher,PIPA5116892 VAPB,VWR,"76,464–334" VCP,Cell Signaling,2648 Anti-Rabbit HRP,Fisher,A16096 Anti-Rat HRP,Fisher,AP202PMI Anti-Mouse HRP,Fisher,AP124PMI

(2) C1QL1 inhibits breast cancer through the HSP90α/VCP-ERS/UPR axisExperimental & molecular medicineJune 1, 2025Zhang N, Shao Q, Xiang X, Yan C, Tao D, Li Q, Rong H, Zhao Y, Xiang T, Zeng X.Santa Cruz), anti-C1QL1 (orb1260, Biorbyt), anti-Calnexin (2679, CST), anti-HSP90α (8165, CST), anti-VCP (2648, CST), anti-P4HB (3501, CST), anti-ERP57 (2881, CST), anti-GRP94 (2104, CST), anti-GRP78 (3177, CST),

(3) A telescopic microscope equipped with a quanta image sensor for live-cell bioluminescence imagingNature MethodsMay 29, 2025Ruyu Ma, Luciano M. Santino, Tomáš Chobola, Niklas Armbrust, Julian Geilenkeuser, Sapthagiri Sukumaran, Zhizi Jing, Anastasia Levkina, Korneel Ridderbeek, Tingying Peng, et al.Abcam; 1:10,000 dilution). Immunoblotting of valosin-containing protein was used as a loading control (2648S, Cell Signaling Technology). The presence of NLuc in EVs was confirmed by size-exclusion chromatography

(4) Jacaric Acid Empowers RSL3-Induced Ferroptotic Cell Death in Two- and Three-Dimensional Breast Cancer Cell ModelsInt J Mol SciApril 4, 2025Géraldine Cuvelier, Perrine Vermonden, Pauline Debisschop, Manon Martin, Françoise Derouane, Gerhard Liebisch, Josef Ecker, Marcus Hoering, Martine Berlière, Mieke Van Bockstal, et al.ab125066, 1:1000), anti-β-Actin (Merck, Darmstadt, Germany, A5441, 1:10,000), anti-VCP (Cell signaling, 2648, 1:1000), HRP-linked horse anti-mouse IgG (Cell Signaling, 7079, 1:5000), HRP-linked goat anti-rabbit

(5) Valosin-containing protein (VCP), a component of tumor-derived extracellular vesicles, impairs the barrier integrity of brain microvascular endothelial cellsBBA AdvancesJanuary 1, 2025Ramon Handerson Gomes Teles, Nicolas Jones Villarinho, Ana Sayuri Yamagata, Camila Tamy Hiroki, Murilo Camargo de Oliveira, Gisela Ramos Terçarioli, Ruy Gastaldoni Jaeger, Patrick Meybohm, Malgorzata Burek, Vanessa Morais Freitas#12599), Rab4A, Rab5A, Rab7, Rab11 from a sampler kit (CST, #9385), VEGFR1 (CST, #2893), VCP (CST, #2648), EEA1 (CST, #3288), LAMP1 (CST, #9091), Actin-Beta POD (Sigma, #A3854), Caspase 3 (CST, #96625), Phalloidin

(6) Caspar specifies primordial germ cell count and identity in Drosophila melanogasterElifeDecember 13, 2024Subhradip Das, Sushmitha Hegde, Neel Wagh, Jyothish Sudhakaran, Adheena Elsa Roy, Girish Deshpande, Girish S Ratnaparkhianti-Casp, 1:1000 (Tendulkar et al., 2022); Rat anti-α-vasa; 1:50 (DSHB); Rabbit anti-VCP, 1:200 (#2648, Cell Signaling Technology); Rabbit anti-Oskar, 1:1000 (generated by Mandy Jeske, Anne Ephrussi lab);

(7) Caspar specifies primordial germ cell count and identity in Drosophila melanogastereLifeDecember 13, 2024Subhradip Das, Sushmitha Hegde, Neel Wagh, Jyothish Sudhakaran, Adheena Elsa Roy, Girish Deshpande, Girish S Ratnaparkhianti-Casp, 1:1000 (Tendulkar et al., 2022); Rat anti-α-vasa; 1:50 (DSHB); Rabbit anti-VCP, 1:200 (#2648, Cell Signaling Technology); Rabbit anti-Oskar, 1:1000 (generated by Mandy Jeske, Anne Ephrussi lab);

(8) Loss of function of VCP/TER94 causes neurodegenerationDisease Models & MechanismsDecember 1, 2024Kohei Tsumaki, Christian J. F. Bertens, Minoru Nakayama, Saya Kato, Yuki Jonao, Ayu Kuribayashi, Konosuke Sato, Shota Ishiyama, Momoko Asakawa, Riko Aihara, et al.containing 5% skimmed milk for 1 h, and incubated with rabbit anti-VCP antibody (Cell Signaling Technology, 2648S; diluted 1:300), rabbit anti-TBPH antibody (a gift from Dr C.-K. James Shen, Academia Sinica, Taipei,

(9) Tau accumulation is cleared by the induced expression of VCP via autophagyActa neuropathologicaSeptember 24, 2024Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS.anti-cleaved Caspase-3 (1:50, Cell Signaling Technology, 9661S), Vcp (1:50, Cell Signaling Technology, #2648), and T22 (1:100, Invitrogen, ABN-454). Western blots were performed according to the standard SDS-PAGE

(10) TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2CellsApril 25, 2024Ahmed N, Preisinger C, Wilhelm T, Huber M.Chicago, IL, USA). The following antibodies were used: anti-IRE1α (#14C10), anti-BIP (#3183), anti-VCP (#2648), and anti-ubiquitin (#3936), which were purchased from Cell Signaling Technology (Leiden, The Netherland);

(11) Modulations in the host cell proteome by the hantavirus nucleocapsid proteinPLoS pathogensJanuary 1, 2024Royster A, Ren S, Ali S, Mir S, Mir M.blots were scanned using the Odyssey CLx imaging system from LI-COR. The primary antibodies for VCP (2648s) and GFP (2956s) were from Cell Signaling Technologies. The primary antibodies for Gn (Cat#7681) and

(12) Targeting endoplasmic reticulum associated degradation pathway combined with radiotherapy enhances the immunogenicity of esophageal cancer cellsCancer Biology & TherapyDecember 31, 2023Hui Luo, Yanan Sun, Liuxiang Wang, Hui Liu, Ran Zhao, Mengqiu Song, Hong GeAfter blocking with milk, the protein bands were incubated with diluted primary antibody (p97 Antibody #2648, calreticulin (D3E6) XP® Rabbit mAb #12238, GAPDH (14C10) Rabbit mAb #2118, β-Actin (13E5) Rabbit mAb

(13) The NRF2-p97-NRF2 negative feedback loopRedox biologySeptember 1, 2023Shakya A, Liu P, Godek J, McKee NW, Dodson M, Anandhan A, Ooi A, Garcia JGN, Costa M, Chapman E, et al.cell lines were a generous gift from the Max Costa lab. Anti-NRF2 (sc-13032), anti-p97 (Cell signaling 2648 S), anti-TKT (sc-390,179), anti-TRXR1 (sc-28321), anti–β-actin (Sigma Aldrich A5441-M), anti-NQO1 (sc-32793),

(14) VCP promotes tTAF-target gene expression and spermatocyte differentiation by downregulating mono-ubiquitylated H2ADevelopment (Cambridge, England)July 15, 2023Butsch TJ, Dubuisson O, Johnson AE, Bohnert KA.anti-H2Aub (1:100; Cell Signaling Technology, 8240S), rabbit anti-VCP (1:100; Cell Signaling Technology, 2648), rabbit anti-mCherry (1:100; Invitrogen, PA5-34975), mouse anti-fibrillarin (a kind gift from Pat DiMario,

(15) p97/VCP drives turnover of SUMOylated centromeric CCAN proteins and CENP-AMolecular Biology of the CellMay 1, 2023Sebastiaan J. W. van den Berg, Samuel East, Sreyoshi Mitra, Lars E. T. Jansenanti-SUMO2/3 (Abcam, ab81371) at 1:1000, rabbit polyclonal anti-p97 at 1:1000 (Cell Signaling Technology, #2648), goat polyclonal anti-RNF4 (Red System, AF7964) at 1:300, rabbit polyclonal anti-PIAS4 (Abcam, ab58416)

(16) p97/VCP drives turnover of SUMOylated centromeric CCAN proteins and CENP-AMol Biol CellApril 11, 2023Sebastiaan J. W. van den Berg, Samuel East, Sreyoshi Mitra, Lars E. T. Jansenanti-SUMO2/3 (Abcam, ab81371) at 1:1000, rabbit polyclonal anti-p97 at 1:1000 (Cell Signaling Technology, #2648), goat polyclonal anti-RNF4 (Red System, AF7964) at 1:300, rabbit polyclonal anti-PIAS4 (Abcam, ab58416)

(17) KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manneriScienceDecember 22, 2022Mendoza ML, Quigley LD, Dunham T, Volk LJ.polyclonal",Millipore,"Cat# AB2302, RRID:AB_10615768" "VCP, rabbit polyclonal",Cell Signaling Technology,"Cat# 2648, RRID:AB_2214632" ,, "Chemicals, peptides, and recombinant proteins","Chemicals, peptides, and recombinant

(18) Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human diseaseHuman Molecular GeneticsAugust 25, 2022Shweta Tendulkar, Sushmitha Hegde, Lovleen Garg, Aparna Thulasidharan, Bhagyashree Kaduskar, Anuradha Ratnaparkhi, Girish S Ratnaparkhianti-VAP, 1:10 000 (30,37); Mouse anti-α-Tubulin, 1:10 000 (T6074, Sigma-Aldrich); Rabbit anti-VCP, 1:1000 (2648, Cell Signaling Technology); Mouse anti-GFP, 1:5000 (11814460001, Roche); Goat anti-rabbit HRP and Goat

(19) VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathwayJournal of translational medicineMay 13, 2022Pu Z, Duda DG, Zhu Y, Pei S, Wang X, Huang Y, Yi P, Huang Z, Peng F, Hu X, et al.three to five times (5 min/time) and incubated with the indicated primary antibodies including VCP (2648, CST, USA), HMGB1 (ab18256, Abcam, USA), E-cadherin (20874-1-AP, Proteintech, China), β-catenin (51067-2-AP,

(20) Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neuronsNeuronMarch 16, 2022Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF.monoclonal antibody,Santa Cruz,Sc-130380 VCP Rabbit polyclonal antibody,Cell Signaling Techonology,2648S Tax1bp1 Mouse monoclonal antibody,Santa Cruz,Sc-393143 OPTN Rabbit polyclonal antibody,Abcam,Ab23666 BNIP3

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VCP Antibody

VCP Antibody from Cell Signaling Technology

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Cell Signaling Technology

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VCP Antibody from Cell Signaling Technology

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