Stat3 (79D7) Rabbit mAb 4904S from Cell Signaling Technology

Product Specs
ItemStat3 (79D7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number4904S
Quantity100 µl
ApplicationsW, W-S, IP, ChIP
ReactivityH, M, R, Mk
TargetSTAT3
HostRabbit
NCBI Gene AliasesADMIO, ADMIO1, APRF, HIES
ClonalityMonoclonal
NCBI Full Gene Namesignal transducer and activator of transcription 3
Research AreaImmunology and Inflammation
IsotypeIgG
Clone79D7
Molecular Weight79, 86

Questions and Answers

Can this antibody be used to study the role of STAT3 in cancer stem cells?

Yes, the Stat3 (79D7) Rabbit mAb has been shown to effectively detect STAT3 in studies investigating its role in cancer stem cell activation, particularly in neuroblastoma. For instance, G-CSF was found to activate STAT3 in neuroblastoma cancer stem cell subpopulations, promoting their expansion and tumorigenicity, as reported in the study by Agarwal et al. ().

Is this antibody suitable for use in Western blotting to analyze STAT3 phosphorylation?

Yes, the Stat3 (79D7) Rabbit mAb has been utilized in Western blotting to detect total STAT3 levels, as well as in studies examining the phosphorylation status of STAT3. For example, it was used in research to assess the activation of STAT3 in response to various stimuli, including inflammatory cytokines (; ).

What species can this antibody be used with for immunoprecipitation experiments?

The Stat3 (79D7) Rabbit mAb is reactive with multiple species, including human, mouse, rat, and non-human primates. This broad reactivity makes it suitable for immunoprecipitation experiments across various model organisms (; ).

Are there any specific applications where this antibody has been cited in the literature?

The Stat3 (79D7) Rabbit mAb has been cited in various applications, including Western blotting, immunoprecipitation, and chromatin immunoprecipitation (ChIP). It has been used to investigate the role of STAT3 in different biological contexts, such as its involvement in metabolic regulation and immune responses (; ).

Cell Signaling Technology

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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Lnk Governs chemokine-directed trafficking of CD8+ T cells in melanomaMol Ther OncolSeptember 17, 2026Yael Derdikman Ofir, Miran Aswad, Michal Hayun, Antonina Pechkovsky, Ghazal Kheshaiboun, Narmeen Ghanayiem, Yasmine Khier, Yaniv Zohar, Yishai Ofran, Igal Louria-Hayonp-ERK1/2 (Cell Signaling Technologies, Cat# 9101, RRID:AB_331646) were used, with total STAT3 (CST, Cat# 4904, RRID:AB_331269) and total ERK1/2 (CST, Cat# 4696, RRID: AB_390780) serving as loading controls. Band

(2) JI017 Sensitizes EGFR-T790M NSCLC to Erlotinib by Extinguishing the STAT3-Survivin AxisIntegr Cancer TherAugust 4, 2026Daeun Kim, Young-Ha Kim, Gaeun Choi, Chunhoo Cheon, Seong-Gyu KoRRID: AB_11217435), JAK2 (#3230; RRID: AB_2128522), p-JAK2 (Tyr1007; #4406; RRID: AB_10706164), STAT3 (#4904; RRID: AB_331269), p-STAT3 (Tyr705; #9145; RRID: AB_2491009) and GAPDH(#5174; RRID: AB_10622025; Cell Signaling Technology

(3) Mechanistic evaluation of NSC 57774 as a SHP2 inhibitor in gastric cancer: Multi-pathway signaling modulation in vitroPLoS OneJuly 30, 2026Ghalia Khoder, Rose Ghemrawi, Nour Sammani, Rania Harati, Mohamad Hamad, Jibran Sualeh Muhammad, Walaa Mousa, Mostafa Khair(Erk1/2) (#4695, Cell signaling, USA), Phospho-Stat3 (Tyr705) (#9145, Cell signaling, USA), Stat3 (79D7) (#4904, Cell signaling, USA), Caspase-3 (#9662, Cell signaling, USA), Phospho-Akt (Ser473) (#9271, Cell signaling,

(4) Predicting Clinical Sensitivities of PDGFRA Exon 18 Mutations to Imatinib and Avapritinib to Optimize Gastrointestinal Stromal Tumor TreatmentCancer Res CommunJuly 1, 2026Homma M. Khosroyani, Alina Teuber, Ajia Town, Lillian R. Klug, Denisse Evans, Jerry Call, Sara Rothschild, Neeta Somaiah, Prapassorn Thirasastr, Mengyuan Liu, et al.AB_331646), PDGFRA (Cell Signaling Technology #3174, RRID: AB_2162345), STAT3 (Cell Signaling Technology #4904, RRID: AB_331269), AKT (Cell Signaling Technology #9272, RRID: AB_329827), MAPK1/2 (Cell Signaling Technology

(5) Sigma 1 Receptor Activation Coordinates Metabolic Stress Responses to Protect Retinal Vasculature in Ischemic RetinopathyInvestigative Ophthalmology & Visual ScienceJune 30, 2026Jing Wang, Xiaowen Lu, Zhengyu Lu, Zhimin Xu, Sylvia B. Smith, Steven E. Brooks, Mitchell A. Watsky, Ruth B. Caldwell,Novus Biologicals,1:800 GFAP (MO389),Fuji Wako,1:1000 p-STAT3 (9145S),Cell Signaling Technology,1:1000 STAT3 (4904T),Cell Signaling Technology,1:1000 ZO-1 (617300),Invitrogen,1:1000 Occludin (331500),Invitrogen,1:1000 GAPDH

(6) Targeting PTP4A3 with KVX-053 mitigates alcohol-amplified SARS-CoV-2 spike protein–induced acute lung injuryFrontiers in PharmacologyJune 19, 2026Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Elizabeth R. Sharlow, John S. Lazo, John D. Catravaswere incubated with primary antibodies against phospho-STAT3 (Cell Signaling, #9145S), total STAT3 (#4904S), phospho-IκBα (#2859S), total IκBα (#9242S), NLRP3 (#15101), ACE2 (#4355), and β-actin (loading control,

(7) LIF and Oncostatin M mitigate LPS-induced acute endometritis via distinct immunoregulatory mechanisms in peritoneal macrophages in vivoiScienceJune 19, 2026Marion Ravelojaona, Julie Girouard, Cathy Vaillancourt, Céline Van Themsche, Carlos Reyes-MorenoTechnologies (Danvers, MA, USA)",#9145 total-STAT3,"Cell Signaling Technologies (Danvers, MA, USA)",#4904 phospho-SMAD2 pS465/467,"Cell Signaling Technologies (Danvers, MA, USA)",#3108 total-SMAD2,"Cell Signaling Technologies

(8) A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell stateImmunityJune 12, 2026Dandan Yang, Linglin Huang, Hanning Cheng, Nandini Acharya, Davide Mangani, Yong Hu, Dan Hu, Alissa J. Nelson, Jian Min Ren, Vicky Yang, et al.(CST 18338), SMAD2 (CST 5339), SMAD3 (CST 9523), SMAD4 (CST 46535), p-STAT3 (CST 9131), STAT3 (CST 4904), and ACTIN (Santa Cruz Biotechnology, sc-47778). The secondary antibodies were Goat anti-Rabbit IgG

(9) The complement C3-microglial axis in depression of Parkinson's disease: from mechanism to therapeutic interventionEBioMedicineJune 9, 2026Qiao Yin, Mengyang Ding, Yurui Tang, Yuwan Qi, Yuan Qin, Hong Jin, Yang Li, Jili Bao, Shuyang Ma, Ying Li, et al.p-STAT3 (Abcam Cat# ab32143, UK, 1:5000, RRID: AB_2286742), STAT3 (Cell Signalling Technology Cat# 4904, USA, 1:2000, RRID: AB_331269), p-P65 (Affinity Biosciences Cat# AF3387, USA, 1:1000, RRID: AB_2834818),

(10) Mapping of the hSOX10 Proximal Protein Interactome in Human MelanomaJournal of Proteome ResearchJune 5, 2026Catherine M. Newsom-Stewart, Dhaval P. Bhatt, Michael B. Major, Charles K. Kaufman(1:2000, Bethyl, A300–815A-T), MAML1 (1:1000, Cell Signaling, 4608S), STAT3 (1:1000, Cell Signaling, 79D7 #4904), and KMT2A (1:1000, Cell Signaling, 14197). Membranes were washed four times for 5–10 min each with

(11) CD109 Drives Stemness and Chemoresistance in Colorectal Cancer via LRRC8A/AKAP12/PKCα-Mediated STAT3 Activation and WNT SignalingInt J Biol SciJune 4, 2026Rubén A. Bartolomé, Tania Calvo-López, Pablo Otero-Núñez, María Estaras, Asunción Fernández-Barral, Antonio Barbáchano, Issam Boukich, María Cuerda-López, Mª Jesús Fernández-Aceñero, Gorane Rodríguez-Urquirizar, et al.Santa Cruz Biotechnologies (Dallas, TX, USA). Anti-phospho-STAT3 (#9145), anti-phospho-SMAD2 (#3108), anti-STAT3 (#4904), anti-SMAD2/3 (#8585), anti-CD109 (#24765) and anti-LRRC8A (#24979) for immunoprecipitation and western blot

(12) Synovial macrophage-targeted hierarchical microspheres achieve cartilage preservation and pain relief in osteoarthritisMaterials Today BioJune 1, 2026Guojiang Zhang, Laibo Zhang, Xiangdong Wen, Guangxian Liu, Dengju Li, Chuanhong Qin, Senbo An, Yawei Sun, Shui SunR&D system), anti-CD206(24595, CST), anti-JAk1(ab47435, Abcam), anti-p-JAk1(ab138005, Abcam), anti-STAT3(4904T, CST), anti-p-STAT3 (9145S, CST). Then with HRP-conjugated secondary antibodies for 1 h at room temperature.

(13) Ceapin-A7 counteracts the protective effects of Lanreotide in endothelial cellsAspects of Molecular MedicineJune 1, 2026Md Matiur Rahman Sarker, Saikat Fakir, Madan Sigdel, Nektarios BarabutisP38 (9212S), pSTAT1 (9167S), STAT1 (9172S), pERK1/2 (9101S), ERK1/2 (9102S), pSTAT3 (9145S), STAT3 (4904S), BiP (3183S), and Grp94 (2104S) antibodies were acquired from Cell Signaling Technology (Danvers, MA).

(14) Cathepsin A deficiency exacerbates LPS-induced inflammatory liver injury and apoptosisAnim Cells Syst (Seoul)May 21, 2026Hee Young Chae, Ji Yeong Park, Hyejin Hyung, Jiwon Ko, Su-Geun Lim, Young Jin Lee, Myoung Ok Kim, Song Park, Dong Kyu Choi, Soyoung Jang, et al.sc-7480), Bcl-2 (1:2000, Santa Cruz Biotechnology, sc-509), STAT3 (1:2000, Cell Signaling Technology, 4904), p-STAT3 (1:2000, Cell Signaling Technology, 9145), β-actin (1:5000, Santa Cruz Biotechnology, sc-47778)

(15) G3BP1 is a SWI/SNF-bound regulator of transcription that modulates activation of STATsBiosci RepMay 6, 2026Natalia Papadopoulos, Niki Sarri, Johan Lennartsson, Carl-Henrik Heldinp-p44/p42 ERK1/2 MAPK (pThr202/pThr204, #9101), PLCγ1 (#2822), pPLCγ1 (pTyr783, #2821), STAT3 (79D7, #4904), pSTAT3 (pTyr705, D3A7, #9145), STAT1 (#9172), pSTAT1 (#9167), BAF155 (11956), BAF170 (#12760), and

(16) IL-11 receptor is a novel target for drug development with pharmacological activity in fibro-inflammatory diseaseScientific ReportsMay 2, 2026David J. King, James S. Swaney, Cadmus Rich, H. Toni Jun, Yasmin Vasquez, Shira Geller, Christine Chidester, Merrick Chai, Eric Elliott, Deborah Witherden, et al.for chemiluminescence according to manufacturer’s instructions. STAT3 (79D7) Rabbit antibody (Cat# 4904; 1:50 dilution), Phospho-STAT3 (Tyr705) (D3A7) XP® Rabbit antibody (Cat# 9145; 1:50 dilution) were purchased

(17) Targeting the TIGIT/CD155-induced metabolic checkpoint in NK cells restores anti-tumor immunity and suppresses hepatocellular carcinoma growthFront ImmunolMay 1, 2026Jiaojie Shu, Wei Yu, Yaping Shen, Xiaolin LiuAbcam, UK, 1:1000), rabbit anti-SHP-2 (3397, Cell Signaling Technology, USA, 1:1000), rabbit anti-STAT3 (4904, Cell Signaling Technology, USA, 1:1000), rabbit anti-p-STAT3 (Tyr705) (9145, Cell Signaling Technology,

(18) Octreotide Counteracts IFN-γ-Induced Endothelial InflammationJ Biochem Mol ToxicolApril 19, 2026Saikat Fakir, Madan Sigdel, Md Matiur Rahman Sarker, Nektarios BarabutisP38 (9212S), pJAK2 (3776S), JAK2 (3230S), pSTAT1 (9167S), STAT1 (9172S), pSTAT3 (9145S), and STAT3 (4904S) antibodies were available from Cell Signaling Technology (Danvers, MA). 2.2 | Cell Cultures Bovine

(19) A Novel Niclosamide Sulfate Prodrug with Enhanced Bioavailability Suppresses Hepatocellular Carcinoma via Inhibition of Multiple Signaling PathwaysbioRxivApril 18, 2026Mingdian Tan, Steve Schow, Yi Liu, Robert Lum, Dawiyat Massoudi, Renumathy Dhanasekaran, Samuel So, Mei-Sze Chua(Cell Signaling Technology; cat. no. 8480, RRID: AB_11127855, 1:1000 dilution), STAT3 (Cell Signaling Technology, cat. no. 4904, RRID: AB_331269, 1:1000 dilution), phospho-STAT3 (Tyr705) (Cell Signaling Technology, cat. no. 9145,

(20) A distinct TCR+CD19+ population in the peritoneal cavity: B1a cells as precursors of extrathymic T cellsiScienceApril 17, 2026Su-Min Yee, Jeong-Eun Seon, Jae-Eun Seo, Hae-Jin Seo, Ja-Hun Seo, Seo-Hee Moon, Hyun-Su Koo, Ha-Rim Choi, Su-Man Kim, Hyung-Sik Kang(14995; Cell Signaling Technology), anti-phospho STAT3 (94994; Cell Signaling Technology), anti-STAT3 (4904; Cell Signaling Technology), anti-phospho STAT5 (9359, Cell Signaling Technology), anti-STAT5 (sc-835-G;

Write a Review

(1)

5/11/2022Excellent Total STAT3 Antibody Vanessa KelleyThis is an excellent antibody for detection of the STAT3 protein. We used CRISPR-Cas9 to knockout a JAK protein that is upstream of STAT3. We then wanted to determine whether there was a decrease in ... Read Review
(1)

3/1/2016Great STAT3 Antibody A MOur lab works with all of the STAT proteins in the context of kidney cancer, and we are often blotting for STAT3. We chose to give this Cell Signaling antibody a try for western blotting 786-0 cell ... Read Review
(1)

1/27/2016Very Good STAT3 Antibody Franz RicklefsI am investing the levels of phospho-STAT3 in different cancerous cell lines. I needed a good total STAT3 control
(1)

9/10/2015Product to Study Stat3 Role in Proteasomal Degradation. bala bhaskarOur study mainly focused on aberrations in proteosomal degradation and how Stat3 is helpful for cell proliferation.

Stat3 (79D7) Rabbit mAb

Stat3 (79D7) Rabbit mAb from Cell Signaling Technology

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Stat3 (79D7) Rabbit mAb from Cell Signaling Technology

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