MMP-2 Antibody 4022S from Cell Signaling Technology

Product Specs
ItemMMP-2 Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number4022S
Quantity100 µl
ApplicationsW
ReactivityH
TargetMMP2
HostRabbit
NCBI Gene AliasesCLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1
NCBI Full Gene Namematrix metallopeptidase 2
ClonalityPolyclonal
Research AreaAdhesion/ECM
Molecular Weight64, 72

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal MetastasisCancer ResApril 16, 2026Amal T. Elhaw, Priscilla W. Tang, Ya-Yun Cheng, Shriya Kamlapurkar, Zaineb Javed, Sarah Al-Saad, Sierra R. White, Ahmed Emam Abdelnaby, Hannah Khan, Alex Seok Choi, et al.SMAD2/3 (Cell Signaling Technology, 8685, RRID:AB_10889933; 1:1000), MMP2 (Cell Signaling Technology, 4022, RRID:AB_2266622; 1:1000), TGFBI (Proteintech, 10188–1-AP, RRID:AB_2202311; 1:1000), INHBA (Santa Cruz Biotechnology

(2) RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal MetastasisCancer ResApril 16, 2026Amal T. Elhaw, Priscilla W. Tang, Ya-Yun Cheng, Shriya Kamlapurkar, Zaineb Javed, Sarah Al-Saad, Sierra R. White, Ahmed Emam Abdelnaby, Hannah Khan, Alex Seok Choi, et al.SMAD2/3 (Cell Signaling Technology, 8685, RRID:AB_10889933; 1:1000), MMP2 (Cell Signaling Technology, 4022, RRID:AB_2266622; 1:1000), TGFBI (Proteintech, 10188–1-AP, RRID:AB_2202311; 1:1000), INHBA (Santa Cruz Biotechnology

(3) Knockdown of Lymphoid Enhancer-binding Factor 1 Inhibits Pancreatic Adenocarcinoma Growth and Neoangiogenesis by Curbing Notch1 and Nuclear Factor Kappa B Signaling PathwaysPancreasApril 1, 2026Guanglun Ping, Guoyong Cai, Ying Wei, Xiangli Mo, Li Liu, Wencui Zhu, Yi ZhangLEF1 (ab137872, 1:1000, Abcam), proliferating cell nuclear antigen (PCNA, ab29, 1:1000, Abcam), MMP-2 (4022S, 1:1000, CST), MMP-9 (3852S, 1:1000, CST), BAX (2772S, 1:1000, CST), Bcl-2 (15071S, 1:1000, CST), Cleaved

(4) RAB25 promotes hepatitis B virus-induced liver fibrosis progression through activation of the PI3K/AKT signaling pathwayVirus ResearchMarch 1, 2026Jing Liu, Bingjie Liu, Xia Xie, Xin Yang, Qiong Liu1:500, Proteintech, Wuhan, China), α-SMA (#19245, 1:1000, CST), Collagen I (#72026, 1:1000, CST), MMP2 (#4022, 1:1000, CST), PCNA (#13110, 1:1000, CST), p-PI3K (ab182651, 1:200, Abcam, Cambridge, USA), PI3K (ab302958,

(5) HOXB8 promotes invasion and metastasis of high-grade serous ovarian cancer via suppression of the KDM6B/C/EBPα signaling axisTranslational Cancer ResearchFebruary 28, 2026Li Xiang, Yanqin Lou, Ping Wang, Yajun Hu, Donghua Wanghttps://tcr.amegroups.com/article/view/10.21037/tcr-2025-aw-2272/rc). Methods Materials and reagents Primary antibodies against MMP-2 (4022, 1:1,000), Slug (9585, 1:1,000), KDM6B (3457, 1:1,000), C/EBPα (2843, 1:1,000), H3K27me3 (9733, 1:1,000),

(6) Suppressive Potential of Ethanolic Extracts of Parkia speciosa Hassk. Empty Pods Against Colon Cancer Cell Migration and InvasionInternational Journal of Molecular SciencesFebruary 23, 2026Athit Chaiwichien, Supawadee Osotprasit, Tepparit Samrit, Pornanan Kueakhai, Narin Changklungmoaprimary antibody overnight at 4 °C. The primary antibodies used were rabbit polyclonal anti-human MMP2 (#4022), MMP9 (#3852), N-cadherin (#4061), and GAPDH (#2118) (dilution 1:500; Cell Signaling Technology, Danvers,

(7) Anticancer Effects of Sacha Inchi (Plukenetia volubilis) Shell Extract on Colon Cancer Cells: Integrated GC-MS, LC-MS, Transcriptomic, and Proteomic AnalysesInternational Journal of Molecular SciencesDecember 25, 2025Supawadee Osotprasit, Saowaros Suwansa-Ard, Scott F. Cummins, Tianfang Wang, Stuart J. Smith, Tepparit Samrit, Athit Chaiwichien, Narin Changklungmoa, Pornanan Kueakhaih and then incubated with primary antibodies overnight at 4 °C: rabbit polyclonal anti-human MMP2 (#4022), MMP9 (#3852) and N-cadherin (#4061) (1:500 dilution; Cell Signaling Technology, Danvers, MA, USA).

(8) Choroidal Mast Cells and Their Degranulation Are a Pivotal Trigger for Myopia DevelopmentInvestigative Ophthalmology & Visual ScienceNovember 14, 2025Jue Shi, Shin-ichi Ikeda, Tomokazu Fukuchi, Junhan Chen, Kate Gettinger, Satoshi Imanishi, Kazuno Negishi, Kazuo Tsubota, Toshihide Kuriharamembranes were incubated with anti-COL1A1 (1:5000, #72026T; Cell Signaling Technology), anti-MMP2 (1:5000, #4022S; Cell Signaling Technology), and β-actin mAb. After incubation with appropriate horseradish peroxidase–conjugated

(9) Anti-Metastatic Effects of Plukenetia volubilis (Sacha Inchi) Husk Extract via EGFR and EMT Pathways and Other Antitumor Effects in Colon CancerInternational Journal of Molecular SciencesOctober 29, 2025Supawadee Osotprasit, Saowaros Suwansa-Ard, Scott F. Cummins, Tianfang Wang, Tepparit Samrit, Athit Chaiwichien, Stuart J. Smith, Narin Changklungmoa, Pornanan Kueakhaiprimary antibody overnight at 4 °C. The primary antibodies used were rabbit polyclonal anti-human MMP2 (#4022), MMP9 (#3852), N-cadherin (#4061), and GAPDH (#2118) (dilution 1:500; Cell Signaling Technology). Then,

(10) Cardamonin attenuates angiotensin II-induced abdominal aortic aneurysms through activation of the Nrf2/HO-1 pathwayInt J Cardiol Heart VascOctober 6, 2025Hsiao-Ya Tsai, Yu-Juei Hsu, Chih-Yuan Lin, Po-Hsun Huang, Chin-Wang Hsu, Shih-Hung Tsaip65 (CST, #3033), HO-1 (Abcam, ab68477), SOD-1 (Abcam, ab51254), SOD-2 (Abcam, ab13533), MMP-2 (CST, #4022), MMP-9 (CST, #G657), NADPH oxidase-1 (NOX1, GeneTex, GTX103888) and β-actin (GeneTex, GTX629630). The

(11) Knockdown of Lymphoid Enhancer-binding Factor 1 Inhibits Pancreatic Adenocarcinoma Growth and Neoangiogenesis by Curbing Notch1 and Nuclear Factor Kappa B Signaling PathwaysPancreasSeptember 11, 2025Guanglun Ping, Guoyong Cai, Ying Wei, Xiangli Mo, Li Liu, Wencui Zhu, Yi ZhangLEF1 (ab137872, 1:1000, Abcam), proliferating cell nuclear antigen (PCNA, ab29, 1:1000, Abcam), MMP-2 (4022S, 1:1000, CST), MMP-9 (3852S, 1:1000, CST), BAX (2772S, 1:1000, CST), Bcl-2 (15071S, 1:1000, CST), Cleaved

(12) NCOA4 inhibits glioma progression by suppressing the Sonic Hedgehog pathway and its overexpression indicates a better glioma prognosisGenes & GenomicsSeptember 1, 2025Kaining Liu, Hu Wang, Tian Qiu, Guangxiu Wang, Anling Zhang, Zhifan Jia, Xiaoguang Tongobtained from Abcam (Cambridge, UK). Antibodies against histone H3 (cat. no. 4499S) and MMP2 (cat. no. 4022S) were obtained from Cell Signaling Technology (Boston, USA). The immunohistochemistry (IHC) kit (cat.

(13) Mechanisms of AGE-induced VSMC phenotypic switching and macrophage modulation in human abdominal aortic aneurysmsExp Biol Med (Maywood)August 7, 2025Xiaoying Ma, Jinfang Xu, Huiying Sun, Jiajun Liu, Shibo Xia, Hao Zhang, Chaoyi Cui, Chao SongWuhan, China), NLRP3 Polyclonal antibody (Proteintech, Cat. No. 27458-1-AP), MMP-2 Antibody (Cat. No. 4022S, CST, MA, United states), Phospho-IκBα (Ser32) (14D4) Rabbit mAb (CST, Cat. No. 2859T), and GAPDH (14C10) Rabbit mAb

(14) TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasisCell Death DisAugust 6, 2025Donatella Delle Cave, Annalisa Di Domenico, Marco Fantuz, Marianna Ciotola, Maria Mangini, Silvia Buonaiuto, Brunella Corrado, Marco Corona, Federica Saracino, Gennaro Andolfi, et al.IF, antibodies against human L1CAM (HPA005830, SIGMA), human COL17A1 (MA5-31984, Invitrogen), MMP2 (4022S, Cell Signaling) and murine COL1A1 (AB765P, Millepore) were used at a 1:100 dilution overnight at 4oC

(15) Tumor-Specific AAV Delivery of Interleukin-12 Enhances Antitumor Immunity and Safety in Ovarian Cancer Xenograft Mouse ModelMolecular Therapy OncologyJune 18, 2025Chuyuan Chen, Yongji Jiang, Chuan Feng, Qingyun Zhou, Xingrong Luo, Lili Cai, Lei Zhaoimmunohistochemistry staining kit (absin, Cat#abs50029), harris (Baso, Cat# BA-4097), and eosin (Baso, Cat# BA-4022) were for IHC. Plasmid construction, AAV production, protein expression, and purification The modified

(16) Raddeanin A exerts potent efficacy against non-small cell lung cancer by inhibiting cyclin-dependent kinase 6Transl OncolApril 11, 2025Xian Wang, Xiao Lin, Yuxin Liu, Chunbo Ma, Mengchu Liu, Jiayu Bai, Yihan Ye, Chengguang Zhao, Lehe Yang, Xiaoying Huang, et al.Cell Signaling Technology, 1:1000), anti-Vimentin (#5741, Cell Signaling Technology, 1:1000), anti-MMP2 (#4022, Cell Signaling Technology, 1:1000), anti-CDK4 (ab199728, Abcam, 1:1000), anti-Rb (ab226979, Abcam,

(17) Scoparone suppresses proliferation and cell cycle of hepatocellular carcinoma cells via inhibiting AKT/GSK-3β/cyclin D1 signaling pathwayTranslational Cancer ResearchMarch 30, 2025Mei Hong, Hao Zhu, Weikang Liu, Pengyu Zhang, Song Yu, Quangen Gao, Genhai Shen, Bin Li, Gang WangCST), anti-AKT (1:1,000, #9272, CST), anti-p-AKT (Ser473) (1:1,000, #9271, CST), anti-MMP-2 (1:1,000, #4022, CST), anti-MMP-9 (1:1,000, #3852, CST), anti-p-GSK-3β (Ser9) (1:1,000, #9336, CST), anti-GSK-3β (1:1,000,

(18) Huafengdan Inhibits Glioblastoma Cell Growth and Mobility by Acting on PLAU and CAV1 TargetsPharmaceuticals (Basel)March 18, 2025Dengxiao Lin, Wenfeng Yu, Jia Yu, Sha Cheng, Yu Song, Xiaoqing Wan, Yingjiang Xu, Heng Luo, Baofei Sun(PCNA; #13110), Cyclin A2 (#91500), E-cadherin (#3195), Vimentin (#5741), N-cadherin (#13116), MMP2 (#4022), MMP9 (#13667), and β-actin (#4967) were acquired from CST (Shanghai, China); Cyclin-dependent kinase

(19) PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancerThe Journal of biological chemistryMarch 1, 2025Bagchi A, Bhattacharya A, Bera A, Basak D, Chatterji U, Biswas A.(Cell Signaling Technology; catalog no.: 2367, RRID: AB_10691311), MMP2 (Cell Signaling Technology; catalog no.: 4022, RRID: AB_2266622), MMP9 (Cell Signaling Technology; catalog no.: 3852, RRID: AB_2144868), E-cadherin

(20) Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate canceriScienceFebruary 21, 2025Yanlong Wang, Yulin Peng, Wenjun Hao, Chengjian He, Xiang Gao, Peng Liang, Haolin Zhao, Ying Wang, Liang Wang, Zhenlong Yu, et al.RRID:AB_2631166 Cyclin D1,Cell Signaling Technology,Cat#55506; RRID:AB_2827374 MMP-2,Cell Signaling Technology,Cat#4022 MMP-9,Cell Signaling Technology,Cat#2270 E-Cadherin,Cell Signaling Technology,Cat#14472 N-Cadherin,Cell Signaling Technology

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12/16/2022Western Blot on Fibroblast Gherardo BaudoI used this antibody for the WB. I stimulated the MRC-5 with TGF-b for 24 h. I incubated the primary antibody overnight at 4 °C (1:1000) and the secondary antibody at RT for 2 h.

MMP-2 Antibody

MMP-2 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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MMP-2 Antibody from Cell Signaling Technology

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