Fig 1: PAK1 protein abundance is decreased in type 2 diabetic human skeletal muscle. (A) Immunoblot analysis of cadaveric skeletal muscle tissue from type 2 diabetic (T2D) and non-diabetic (ND) individuals. (B) PAK1 protein abundance quantification in ND and T2D individuals; n=7-8 per group. (C) PAK1 mRNA expression normalized to HPRT in skeletal muscle RNA. T2D: n=8: ND: n=7. (D) ARPC1B protein abundance; n=7 per group. (E) ARPC1B relative mRNA expression (normalized to HPRT); n=7 per group. *p < 0.05, **p < 0.01, ns; not statistically significant, Two-tailed unpaired student’s t-test.