MMP-12 Antibody

Product Specs
ItemMMP-12 Antibody - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $469.00Supplier Page View Company Product Page
Catalog NumberNBP1-31225
TargetMMP-12
ImmunogenCarrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MMP12. The exact sequence is proprietary
Format0.1M Tris, 0.1M Glycine, 10% Glycerol
HostRabbit
ReactivityHu, Ms, Rt
ClonalityPolyclonal
PurityAntigen Affinity-purified
IsotypeIgG
Molecular Weight54 kDa
Antibody TypePrimary Antibodies
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles
NCBI Gene AliasesHME, ME, MME, MMP-12
NCBI Full Gene Namematrix metallopeptidase 12
ApplicationsWB, ICC, IF, IHC, IHC-p
Conjugate/TagUnconjugated
Quantity100 ul

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Sizes Available: 100 ul

Questions and Answers

Can this antibody be used for immunohistochemistry in renal cell carcinoma studies?

Yes, the MMP-12 antibody has been shown to work in immunohistochemistry applications, as demonstrated in a study where it was used to analyze MMP-12 expression in a multi-tissue array of renal cell carcinoma patients. The study found that MMP-12 expression was associated with postoperative tumor relapse, indicating its potential as a biomarker in this context ().

Is there any evidence supporting the use of this antibody in lung cancer research?

Yes, the MMP-12 antibody has been utilized in lung cancer research, specifically in a study investigating tumor-associated macrophages. The antibody was employed to confirm protein expression of MMP-12, which was linked to the modulation of tissue-resident memory T cells and associated with better survival outcomes in early lung cancer ().

What role does MMP-12 play in head and neck cancer, and how has this antibody been applied in related research?

MMP-12 has been implicated in the progression of head and neck cancer, with studies indicating that its expression correlates with poor patient survival. The MMP-12 antibody was used in Western blot assays to assess its expression levels in cancer tissues, contributing to the understanding of its role in tumor growth and metabolism through the modulation of the FOXM1/MMP12 axis ().

What species can this antibody react with, and how might that influence its application in research?

The MMP-12 antibody is reactive with mouse, human, and rat tissues. This broad reactivity allows for its application in various experimental models, making it suitable for comparative studies across species, which can be particularly useful in translational research settings.

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Új biomarkerek a konvencionális veserák progressziójának megítéléséreMagyar UrológiaJanuary 1, 2017András Jávorházy, László Farkas, Árpád Szántó, Gyula Kovácsantitest (PA5-22310, Thermo Fisher Scientific, Budapest, Hungary), 1:500 higításban; nyúl anti-MMP12 antitest (NBP1-31225, Novus Biologicals, Littleton, CO, USA), 1:250 hígításban. Harminc percig történő HRP konjugált anti-nyúl

(2) M1^hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancerJournal for immunotherapy of cancerJanuary 1, 0001"Garrido-Martin EM, Mellows TWP, Clarke J, Ganesan AP, Wood O, Cazaly A, Seumois G, Chee SJ, Alzetani A, King EV, et al."antihuman CD68, clone PG-M1, #M0876, Dako; dilution 1/100), MMP12 (rabbit polyclonal antihuman MMP12 #NBP1-31225, Novus Biologicals; diluted 1/100) and CXCL9 (goat polyclonal antihuman CXCL9 #AF392, Novus Biologicals;

(3) Down-regulation of Toll-like Receptor TLR4 Is Associated with HPV DNA Integration in Penile CarcinomaAnticancer researchJanuary 1, 0001"Damasdi M, Kovacs K, Farkas N, Jakab F, Kovacs G."

(4) Matrix metalloproteinase 12 is an independent prognostic factor predicting postoperative relapse of conventional renal cell carcinoma - a short reportCellular oncology (Dordrecht)January 1, 0001"Beres B, Yusenko M, Peterfi L, Kovacs G, Banyai D."resulting slides were subsequently incubated for one hour in a moist chamber with an anti-MMP12 antibody (NBP1-31225, Novus Biologicals, Littleton, CO, USA) at 1:250 dilution. EnVision, followed by a FLEX horse-radish-peroxydase

(5) DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axisMolecular oncologyJanuary 1, 0001"Huang TL, Chang CR, Chien CY, Huang GK, Chen YF, Su LJ, Tsai HT, Lin YS, Fang FM, Chen CH."(1 : 1000, Cell Signaling #8570), anti‐FOXM1 (1 : 1000, GeneTex GTX100276), anti‐MMP12 (1 : 1000, Novus NBP1‐31225) and β‐actin (1 : 5000, 8H10D10, Cell Signaling Technology, Danvers, MA, USA) at 4 °C overnight. Next

(6) "End-stage kidney disease: a never healing wound leading to another never healing wound, renal cancer"Journal of nephrologyJanuary 1, 0001"Docs J, Kovacs G, Peterfi L."HPA024638,Rabbit,Poly,1.1000,Sigma-Aldrich MMP9,Anti-MMP9 AV33090,Rabbit,Poly,1:200,Sigma-Aldrich MMP12,Anti-MMP12 NBP1-31225,Rabbit,Poly,1:400,Novus Biol Primary antibodies used for immunohistochemistry

(7) Embryonal Origin of Metanephric Adenoma and its Differential DiagnosisAnticancer researchJanuary 1, 0001"Sarlos DP, Banyai D, Peterfi L, Szanto A, Kovacs G."were then incubated overnight at 4˚C in moist chamber with rabbit polyclonal anti- CDH17 antibody (NBP131225, Novus Biologicals, Littleton, CO, USA) at the dilution of 1:500 and anti SCEL antibody (HPA040154,

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MMP-12 Antibody

MMP-12 Antibody

MMP-12 Antibody

MMP-12 Antibody

MMP-12 Antibody - BSA Free from Novus Biologicals, a Bio-Techne Brand

Specifications/Features

Questions and Answers

Novus Biologicals, a Bio-Techne Brand

Citations (7)

Reviews

MMP-12 Antibody - BSA Free from Novus Biologicals, a Bio-Techne Brand

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