Anti-CD3 antibody [SP7] GTX16669 from GeneTex

Product Specs
ItemAnti-CD3 antibody [SP7]
CompanyGeneTex
Price $499.00Supplier Page
Catalog NumberGTX16669
Quantity500 µl
ReactivityHuman, Mouse, Rat, Pig
IsotypeIgG
Antibody TypePrimary Antibodies
TargetCD3
HostRabbit
CloneSP7
FormatTissue culture supernatant, 0.09% Sodium azide
ClonalityMonoclonal
ApplicationsICC/IF, IHC-P, IHC-Fr, FCM
Conjugate/TagUnconjugated
PurityUnpurified
ImmunogenA synthetic 13-mer peptide corresponding to aa 156-168 of the ε chain of human CD3 protein
Research AreaImmunology
NCBI Full Gene NameCD3d molecule
NCBI Gene AliasesCD3-DELTA, T3D, IMD19, CD3DELTA, CD3d molecule, CD3-DELTA, IMD19, T3D
Gene NameCD3D
Molecular Weight19

Questions and Answers

What species does this antibody work with in immunohistochemistry applications?

The Anti-CD3 antibody [SP7] has been shown to work with human, mouse, rat, and pig tissues in immunohistochemistry applications, as indicated in various studies.

Has this antibody been used in any specific research contexts?

Yes, the Anti-CD3 antibody [SP7] has been utilized in studies investigating immune responses, such as in the characterization of T lymphocyte infiltration in tumor microenvironments, as seen in the research by Chan et al. (2020) and Morita et al. (2023).

Can this antibody be used for flow cytometry applications?

The Anti-CD3 antibody [SP7] has been validated for use in flow cytometry, which is crucial for analyzing T cell populations and their activation states in various experimental setups.

What type of immunogen was used to generate this antibody?

The Anti-CD3 antibody [SP7] was generated using a synthetic 13-mer peptide corresponding to amino acids 156-168 of the ε chain of the human CD3 protein, which is essential for T cell receptor signaling.

GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) Enhancing Lung Recovery: Inhaled Poly(lactic-co-glycolic) Acid Encapsulating FTY720 and Nobiletin for Lipopolysaccharide-Induced Lung Injury, with Advanced Inhalation Tower TechnologyACS nanoMarch 4, 2025Zhang HH, Kuo WS, Tu PY, Lee CT, Wang HC, Huang YT, Shen MC, Lin TS, Su PL, Tsai JS, et al.for neutrophils, rabbit anti-CD68 (Abcam, ab303565) for macrophages, and rabbit anti-CD3 (GeneTex, GTX16669) for T cells. All immunostaining analyses were conducted by a pathologist (Chung-Ta Lee) who was unaware

(2) Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFANature communicationsDecember 3, 2024Lin HH, Yu IS, Cheng MS, Chang TJ, Lin HY, Chang YC, Ko CJ, Chen PH, Lin SW, Huang TC, et al.ProteinTech), anti-ZO-1 (33-9100, Thermo Fisher), anti-OCCLUDIN (71-1500, Thermo Fisher), anti-CD3 (GTX16669, GeneTex), and anti-insulin antibody (I2018, Merck Millipore). Antibodies were applied to the pancreas

(3) Use of a novel microbiome modulator improves anticancer immunity in a murine model of malignant pleural mesotheliomaJTCVS OpenApril 1, 2024Gattlen C, Frank KR, Marie DN, Trompette A, Chriqui LE, Hao Y, Abdelnour E, Gonzalez M, Krueger T, Dyson PJ, et al.Antibodies,Source,Reference,Dilution used Primary,,, Anti-CD3,GeneTex,GTX16669,1/100 Anti-CD4,BD Pharmingen,"550,280",1/50 Anti-CD8a,BD Pharmingen,"550,281",1/50 Anti-CD68,Cell Signaling Technology

(4) Inhibition of IL-25/IL-17RA improves immune-related adverse events of checkpoint inhibitors and reveals antitumor activityJournal for immunotherapy of cancerMarch 21, 2024Hu X, Bukhari SM, Tymm C, Adam K, Lerrer S, Henick BS, Winchester RJ, Mor A.anti-mouse CD279 (PD-1),BioLegend,109 10 APC anti-mouse CD69,BioLegend,104 514 CD3 antibody(SP7),GeneTex,GTX16669 Reagents,Reagents,Reagents "DMEM, 1X",Corning,10–013-CVvc HI FBS,Gibco,10 438-026 Penicillin–streptomycin,Corning,30-001 CI

(5) Immunomodulatory Prodrug Micelles Imitate Mild Heat Effects to Reshape Tumor Microenvironment for Enhanced Cancer ImmunotherapyACS nanoFebruary 20, 2024Ngo TL, Wang KL, Pan WY, Ruan T, Lin YJ.

(6) CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockadeNature communicationsNovember 18, 2023Morita TY, Yu J, Kashima Y, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, et al.Morphotechnology, Co. Ltd., Hokkaido, Japan) using primary antibodies against anti-CD3 (SP7) (GeneTex, #GTX16669), anti-CD4 (D7D2Z) (#25229, Cell Signaling Technology), anti-CD8 (D4W2Z) (#98941, Cell Signaling Technology),

(7) Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cellsThe Journal of cell biologyMay 1, 2023Mascarau R, Woottum M, Fromont L, Gence R, Cantaloube-Ferrieu V, Vahlas Z, Lévêque K, Bertrand F, Beunon T, Métais A, et al.and stained ON at 4°C with antibodies to p24 (Kal1, mouse IgG, M0857, 1:10; DAKO), CD3 (SP7, rabbit, GTX16669, 1:100; Genetex), and CD68 Alexa Fluor 647 (KP1, mouse IgG1, sc-20060 AF647, 1:50; Santacruz). Goat

(8) Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironmentMatrix biology : journal of the International Society for Matrix BiologyMarch 1, 2022Jang B, Song HK, Hwang J, Lee S, Park E, Oh A, Hwang ES, Sung JY, Kim YN, Park K, et al.

(9) IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosionCellular & molecular immunologySeptember 1, 2021Umar S, Palasiewicz K, Van Raemdonck K, Volin MV, Romay B, Amin MA, Zomorrodi RK, Arami S, Gonzalez M, Rao V, et al.

(10) Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cellsImmunityJune 8, 2021Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, et al.PARP,Cell Signaling,Cat# 9542S Rabbit anti CD11b,Abcam,Cat# ab133357 Rabbit anti CD3,GeneTex,Cat# GTX16669 Rabbit anti CD11b,Abcam,Cat# ab133357 "Chemicals, Peptides, and Recombinant Proteins","Chemicals,

(11) Hydroxysafflor Yellow A Inhibits Staphylococcus aureus-Induced Mouse Endometrial Inflammation via TLR2-Mediated NF-kB and MAPK PathwayInflammationJune 1, 2021He S, Wang X, Liu Z, Zhang W, Fang J, Xue J, Bao H.

(12) Developing an enhanced 7-color multiplex IHC protocol to dissect immune infiltration in human cancersPloS oneJanuary 1, 2021Sun Z, Nyberg R, Wu Y, Bernard B, Redmond WL.

(13) TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal TumorigenesisCancersJuly 8, 2020Chan YL, Lai WC, Chen JS, Tseng JT, Chuang PC, Jou J, Lee CT, Sun HS.anti-CD45R (14-0452-81, RA3-6B2, eBioscience, Thermo Fisher Scientific Inc., Waltham, MA), anti-CD3 (GTX16669, Genetex, Irvine, CA, USA), anti-PAX5 (GTX54532, Genetex, Irvine, CA, USA), anti-serotonin (S5545, Sigma-Aldrich),

(14) A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE CellsTranslational vision science & technologyJune 1, 2020Heffer A, Wang V, Sridhar J, Feldon SE, Libby RT, Woeller CF, Kuriyan AE.

(15) CCL21/CCR7 signaling in macrophages promotes joint inflammation and Th17-mediated osteoclast formation in rheumatoid arthritisCellular and molecular life sciences : CMLSApril 1, 2020Van Raemdonck K, Umar S, Palasiewicz K, Volkov S, Volin MV, Arami S, Chang HJ, Zanotti B, Sweiss N, Shahrara S.

(16) Modulation of tumor microenvironment using a TLR-7/8 agonist-loaded nanoparticle system that exerts low-temperature hyperthermia and immunotherapy for in situ cancer vaccinationBiomaterialsFebruary 1, 2020Chen PM, Pan WY, Wu CY, Yeh CY, Korupalli C, Luo PK, Chou CJ, Chia WT, Sung HW.

(17) Up-regulation of syndecan-2 in proximal colon correlates with acute inflammationFASEB journal : official publication of the Federation of American Societies for Experimental BiologyOctober 1, 2019Hong H, Song HK, Hwang ES, Lee AR, Han DS, Kim SE, Oh ES.

(18) Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelinationNature communicationsAugust 29, 2019Kirby L, Jin J, Cardona JG, Smith MD, Martin KA, Wang J, Strasburger H, Herbst L, Alexis M, Karnell J, et al.

(19) Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell CarcinomaCancer researchNovember 1, 2018Baird JR, Bell RB, Troesch V, Friedman D, Bambina S, Kramer G, Blair TC, Medler T, Wu Y, Sun Z, et al.

(20) Induction of precocious intestinal maturation in T-cell deficient athymic neonatal ratsWorld journal of gastroenterologyNovember 14, 2017Sureda EA, Gidlund C, Weström B, Prykhodko O.

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Anti-CD3 antibody [SP7]

Anti-CD3 antibody [SP7]

Anti-CD3 antibody [SP7] from GeneTex

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Anti-CD3 antibody [SP7] from GeneTex

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