Thermo Fisher Scientific's P-Glycoprotein Recom Antibody is a Rabbit monoclonal antibody. The P-Glycoprotein Recom Antibody was generated using ABCB1, Abcb1a, Abcb1b, and ATP-binding cassette, sub-family B (MDR/TAP), member 1A as the antigen. It reacts with Homo Sapiens, Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Thermo Scientific™ P-Glycoprotein Recombinant Rabbit Monoclonal Antibody (Clone SN06-42) is a recombinant rabbit IgG antibody developed for the specific detection of P-glycoprotein (ABCB1/MDR1), an ATP-dependent transmembrane efflux transporter associated with multidrug resistance and xenobiotic transport. Generated against a recombinant protein corresponding to amino acids 373–730 of human P-glycoprotein, this antibody recognizes endogenous ABCB1 in human, mouse, and rat samples, with published reactivity in additional species. Recombinant expression in HEK293 cells ensures excellent lot-to-lot consistency, high specificity, and reproducible performance across experiments. Validated for Western blotting (WB), immunohistochemistry on paraffin-embedded tissues (IHC-P), and immunocytochemistry/immunofluorescence (ICC/IF), this antibody is well suited for investigating drug transport mechanisms, cancer multidrug resistance, blood-brain barrier biology, pharmacology, toxicology, and ABC transporter function. It has been verified using CRISPR-mediated ABCB1 knockout models, providing additional confidence in target specificity. Affinity purified using Protein A and supplied as an unconjugated liquid antibody, it is an excellent choice for studies of chemotherapy resistance, transporter expression, and cellular drug efflux. For research use only.