Fig 1: LMP1 activates the NF-?B pathway to induce MDM2-mediated p53 protein degradation. (A) NF-?B p65 phosphorylation levels and p53, MDM2, Bax and Bcl-2 protein expression in cells detected by Western blot (one-way ANOVA was used to compare the mean of samples among multiple groups, followed by Tukey’s multiple comparisons test); (B) MDM2 and p53 binding in KHYG-1 and SNT-8 cells detected by Co-IP; (C) Ubiquitination of p53 in KHYG-1 and SNT-8 cells detected by Co-IP. The data was performed as means ± SD of three independent experiments. *p < 0.05, **p < 0.01 vs. the Lv-NC group; #p < 0.05, ##p < 0.01 vs. the Scr group.