The LDLR Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to LDLR. This antibody recognizes Human, Mouse, and Rat antigen. The LDLR Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Function: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
Subunit Structure: Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity). Interacts (via NPXY motif) with LDLRAP1 (via PID domain) (PubMed:12221107, PubMed:22509010). Interacts with ARRB1 (PubMed:12944399). Interacts with SNX17 (PubMed:14739284). Interacts with the full-length immature form of PCSK9 (via C-terminus) (PubMed:17461796, PubMed:21149300).
Post-translational Modifications: N-and O-glycosylated. Ubiquitinated by MYLIP leading to degradation.
Similarity: The NPXY motif mediates the interaction with the clathrin adapter DAB2 and with LDLRAP1 which are involved in receptor internalization. A few residues outside the motif also play a role in the interaction. Belongs to the LDLR family