RagC (D8H5) Rabbit mAb 9480S from Cell Signaling Technology

Product Specs
ItemRagC (D8H5) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number9480S
Quantity100 µl
ApplicationsW, IP, IF-IC, FC-FP
ReactivityH, M, R, Mk
TargetRagC
HostRabbit
NCBI Gene AliasesGTR2, RAGC, TIB929
ClonalityMonoclonal
NCBI Full Gene NameRas related GTP binding C
Research AreaPI3K / Akt Signaling
IsotypeIgG
CloneD8H5
Molecular Weight50

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) FNIP1 Modulates B Cell Receptor Signaling Strength by Coordinating Metabolism During DevelopmentbioRxivApril 1, 2026Heon Park, Ryan Culbert, Dechen Sakya, Raynah R. Silprasert, Brian M. IritaniPhospho-GSK-3α/β (Ser21/9)(9327T), Rag and LAMTOR antibody sampler kit (RagA (4357), RagB (8150), RagC (9480), RagD (4470)), Histone H3 (4499P), TFE3 (14779s), TFEB (A303-673A, bethyl lab), α-rabbit IgG HRP (W4011,

(2) Amino Acid Signaling in Skeletal Muscle Is Blunted by Prematurity in a Piglet ModelThe Journal of NutritionFebruary 1, 2026Antonio C Ramos dos Santos, Agus Suryawan, Ki Beom Jang, Rosemarie D Parada, Mahmoud A Mohammad, Marta L Fiorotto, Teresa A Davis13075; Cell Signaling Technology), RagA (Cat. No. 4357; Cell Signaling Technology), RagC (Cat. No. 9480; Cell Signaling Technology), Raptor (Cat. No. 2280; Cell Signaling Technology), SAMTOR/BMT2 (Cat. No.

(3) SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesisNat CommunOctober 3, 2025Kaushal Asrani, Adrianna Amaral, Juhyung Woo, Sanaz Nourmohammadi Abadchi, Thiago Vidotto, Eddie Imada, Alyza Skaist, Kewen Feng, Hans B. Liu, Mithila Kasbe, et al.Pan-Keratin (Type1) (#83957 CST; 1:1000), RAB7 (#9367 CST; 1:1000), RHEB (#13879 CST; 1:1000), RRAGC (#9480 CST; 1:1000), RRAGD (#4470 CST; 1:1000), Synaptophysin (#5461 CST; 1:1000), S6 Ribosomal Protein (#2317

(4) The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEsMolecular cellFebruary 15, 2024Yang S, Ting CY, Lilly MA.,Cell Signaling Technology,"Cat# 4357, RRID:AB_10545136" RagC (D8H5) Rabbit mAb,Cell Signaling Technology,"Cat# 9480, RRID:AB_10614716" GFP (D5.1) Rabbit mAb,Cell Signaling Technology,"Cat# 2956, RRID:AB_1196615" Ubiquitin (P37) Antibody

(5) Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphomaBMC Complementary Medicine and TherapiesSeptember 26, 2023Ying Liu, Yanting Zhu, Huajiao Chen, Jintuo Zhou, Peiguang Niu, Daohua Shiphospho-S2448 mTOR (#2971), mTOR (#2972), phospho-T389 S6K1 (#9205), S6K1 (#9202), Raptor (#2114), RagC (#9480), β-actin (#8457), HRP-labeled anti-mouse (#7076) and anti-rabbit (#7074) secondary antibody, Protein A Agarose Beads

(6) Role of FLCN Phosphorylation in Insulin-Mediated mTORC1 Activation and TumorigenesisAdvanced science (Weinheim, Baden-Wurttemberg, Germany)June 1, 2023Wang G, Chen L, Lei X, Qin S, Geng H, Zheng Y, Xia C, Yao J, Meng T, Deng L.Rictor (9476), Raptor (2280), SIN1 (D7G1A), FLCN (3697), TFEB (37785), WDR59 (53385), RagA (4357), RagC (9480), RagD (4470), AKT‐substrate (10001), Ki‐67 (12202S), LAMP2 (49067), Histone (4499), and E‐Cadherin

(7) An affinity tool for the isolation of endogenous active mTORC1 from various cellular sourcesThe Journal of biological chemistryMay 1, 2023Ibrahim YH, Pantelios S, Mutvei AP.(#2280), Rictor (#2114), GbetaL/LST8 (#3274), phospho-4E-BP1 Thr37/46 (#2855), RagA (#4357), RagC (#9480). Anti-GST was purchased from Santa Cruz Biotechnology (#sc-138) and anti-Sin1 from Sigma-Aldrich (#07-2276-I).

(8) CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growthCell reportsApril 25, 2023Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W.,Cell Signaling Technology,Cat# 4357; RRID:AB_10545136 Rabbit monoclonal anti-RagC,Cell Signaling Technology,Cat# 9480; RRID:AB_10614716 Rabbit monoclonal anti-CDK5,Cell Signaling Technology,Cat# 14145; RRID:AB_2773717 Rabbit

(9) Arf5-mediated regulation of mTORC1 at the plasma membraneMolecular biology of the cellApril 1, 2023Makhoul C, Houghton FJ, Hinde E, Gleeson PA.ribosomal protein S6 (clone 5G10) (#2217; 1:500), 4E-BP1 (#9644; 1:500), and PRAGC/RagC (clone D8H5) (#9480S; 1:500) were purchased from Cell Signalling Technologies, Australia. Rabbit polyclonal antibody against

(10) NRF3 activates mTORC1 arginine-dependently for cancer cell viabilityiScienceFebruary 17, 2023Hirose S, Waku T, Tani M, Masuda H, Endo K, Ashitani S, Aketa I, Kitano H, Nakada S, Wada A, et al.HPA043785; RRID:AB_10961859 Rabbit monoclonal RagC (D8H5) antibody,Cell Signaling Technology,Cat# 9480; RRID:AB_10614716 Rabbit polyclonal SLC36A1 antibody,Abcam,Cat# ab189441 Mouse monoclonal TOM20 (F-10) antibody

(11) Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro modelsCurr Res NeurobiolJanuary 1, 2023Seidel M, Rajkumar S, Steffke C, Noeth V, Agarwal S, Roger K, Lipecka J, Ludolph A, Guerrera CI, Boeckers T, et al.ab7254), anti-C9orf72 (Genetex, GTX632041, anti-β-actin (Sigma-Aldrich, A5441), anti-RagC (Cell Signaling, 9480), anti-FLCN (Proteintech, 11236-2-AP), anti-NPRL2 (Cell Signaling, 37 344). For western blot experiments,

(12) A Rag GTPase dimer code defines the regulation of mTORC1 by amino acidsNature cell biologySeptember 1, 2022Gollwitzer P, Grützmacher N, Wilhelm S, Kümmel D, Demetriades C.phospho-ULK1 (Ser757) (#14202), DYKDDDDK (FLAG) tag (#2368), mTOR (#2983), RagA (#4357), RagB (#8150), RagC (#9480), RagD (#4470), FLCN (#3697) and CTSD (#2284) proteins were purchased from Cell Signaling Technology.

(13) Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibitionNature cell biologySeptember 1, 2022Figlia G, Müller S, Hagenston AM, Kleber S, Roiuk M, Quast JP, Ten Bosch N, Carvajal Ibañez D, Mauceri D, Martin-Villalba A, et al.(recognizing also both RagB isoforms) (Cell Signaling Technology #4357), RagC (Cell Signaling Technology #9480), RagD (Cell Signaling Technology #4470), phospho-S6K1 T389 (Cell Signaling Technology #9205), S6K1

(14) O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucineNature communicationsMay 25, 2022Kim K, Yoo HC, Kim BG, Kim S, Sung Y, Yoon I, Yu YC, Park SJ, Kim JH, Myung K, et al.(53H11) (WB dilution 1:1000, Cell signaling, #9644), RagC (D8H5) (WB dilution 1:1000, Cell signaling, #9480), RagB (D18F3) (WB dilution 1:1000, Cell signaling, #8150), mTOR (7C10) (WB dilution 1:1000, Cell signaling,

(15) The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EBThe Journal of biological chemistryMarch 1, 2022Kimura T, Hayama Y, Okuzaki D, Nada S, Okada M.(#8168), Lamtor4 (#12284), Lamtor5 (#14633), mTOR (#2983), p-mTOR (Ser2448, #5536), Raptor (#2280), RagC (#9480), Rheb (#13879), TSC2 (#4308), and p-TSC2 (Thr1462, #3617) were purchased from Cell Signaling Technology;

(16) TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanismNature CommunicationsDecember 1, 2021Nicola Alesi et al.(Cell Signaling Technology, 37681), phosphorylated TFEB S142 (Millipore Sigma, ABE1971), RAGC (Cell Signaling Technology, 9480), MYC-Tag (Cell Signaling Technology, 2276), HA-tag (Cell Signaling Technology Inc., 3724S), GPNMB (Cell Signaling Technology

(17) The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by YersiniaScience (New York, N.Y.)June 25, 2021Zheng Z, Deng W, Bai Y, Miao R, Mei S, Zhang Z, Pan Y, Wang Y, Min R, Deng F, et al.(#4927), caspase-3 (#9665), caspase-7 (#12827), RIPK1 (#3493), Phospho-RIPK1 (#31122), RagC (#3360, #9480), Lamtor1 (#8975), Lamtor4 (#12284) and FLCN (#3697) were from Cell Signaling Technology. Monoclonal

(18) Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complexThe Journal of cell biologyFebruary 1, 2021Hirst J, Hesketh GG, Gingras AC, Robinson MS.antibodies were used in this study: rabbit anti-mTOR (2983; Cell Signaling Technology), rabbit anti-RagC (9480; Cell Signaling Technology), rabbit anti-RagA (4357; Cell Signaling Technology), rabbit anti-RAPTOR

(19) Ciliary localization of folliculin mediated via a kinesin-2-binding motif is required for its functions in mTOR regulation and tumor suppressionFEBS lettersJanuary 1, 2021Zhang Y, Liu Y, Dai Y, Ren Y, Bao G, Ai B, Jiang Y.(#2317) and phospho-S6 at S235/236 (Cat# 2211), 4EBP1 (#9452) and phospho-4EBP1at S65 (#9451), RagC (#9480) antibodies were purchased from Cell Signaling Technology. Anti-KIF3A (Cat#376680) and KIF3B (Cat# sc-50456)

(20) Differential regulation of mTORC1 activation by leucine and β-hydroxy-β-methylbutyrate in skeletal muscle of neonatal pigsJournal of applied physiology (Bethesda, Md. : 1985)February 1, 2020Suryawan A, Rudar M, Fiorotto ML, Davis TA.Sestrin2 (catalog no. 8487), GATOR2/Mios (catalog no. 13557), RagA (catalog no. 4357), RagC (catalog no. 9480), RagD (catalog no. 4470), and Vps34 (catalog no. 4263) were obtained from Cell Signaling Technology

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RagC (D8H5) Rabbit mAb

RagC (D8H5) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (26)

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RagC (D8H5) Rabbit mAb from Cell Signaling Technology

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